Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CDHR1	92211	broad.mit.edu	37	10	85972879	85972879	+	Silent	SNP	C	C	T			TCGA-EM-A2CN-01A-11D-A19J-08	TCGA-EM-A2CN-10B-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c02d399-07af-4573-a568-bc1b256bc8f8	06dfc16a-ca37-46ca-8abb-20c1295e8f3a	g.chr10:85972879C>T	uc001kcv.3	+	15	1920	c.1815C>T	c.(1813-1815)aaC>aaT	p.N605N	CDHR1_uc001kcw.3_Silent_p.N605N|CDHR1_uc009xst.3_Silent_p.N309N|CDHR1_uc001kcx.3_5'UTR	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	Homo sapiens cadherin-related family member 1 (CDHR1), transcript variant 1, mRNA.	605	Cadherin 6.				homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						AACCCAACAACCTGGTGGACT	0.557000													60	59					0	0	1	0	0
LAMC3	10319	broad.mit.edu	37	9	133917103	133917103	+	Nonsense_Mutation	SNP	G	G	T			TCGA-EM-A2CN-01A-11D-A19J-08	TCGA-EM-A2CN-10B-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c02d399-07af-4573-a568-bc1b256bc8f8	06dfc16a-ca37-46ca-8abb-20c1295e8f3a	g.chr9:133917103G>T	uc004caa.1	+	6	1461	c.1363G>T	c.(1363-1365)Gaa>Taa	p.E455*		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	Homo sapiens laminin, gamma 3 (LAMC3), mRNA.	455	Laminin EGF-like 4.				cell adhesion	basement membrane|membrane	structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(31)|ovary(3)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	69	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		AGAGAATGTGGAAGGCAACCT	0.582000													13	43					0	0	1	0	0
SF3A1	10291	broad.mit.edu	37	22	30734812	30734812	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A2CN-01A-11D-A19J-08	TCGA-EM-A2CN-10B-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c02d399-07af-4573-a568-bc1b256bc8f8	06dfc16a-ca37-46ca-8abb-20c1295e8f3a	g.chr22:30734812G>A	uc003ahl.3	-	10	1841	c.1709C>T	c.(1708-1710)gCt>gTt	p.A570V	SF3A1_uc021wnt.1_Missense_Mutation_p.A505V	NM_005877	NP_005868	Q15459	SF3A1_HUMAN	Homo sapiens splicing factor 3a, subunit 1, 120kDa (SF3A1), transcript variant 1, mRNA.	570					nuclear mRNA 3'-splice site recognition	U2-type spliceosomal complex|catalytic step 2 spliceosome|nucleoplasm	RNA binding|protein binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|urinary_tract(1)	29						GATGGGTGGAGCCGAGCTGGG	0.542000													95	102					0	0	1	0	0
GAS8	2622	broad.mit.edu	37	16	90103675	90103675	+	Silent	SNP	C	C	T			TCGA-EM-A2CN-01A-11D-A19J-08	TCGA-EM-A2CN-10B-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c02d399-07af-4573-a568-bc1b256bc8f8	06dfc16a-ca37-46ca-8abb-20c1295e8f3a	g.chr16:90103675C>T	uc002fqi.1	+	6	914	c.792C>T	c.(790-792)caC>caT	p.H264H	GAS8_uc010vps.1_Silent_p.H239H|GAS8_uc002fqh.2_Silent_p.H181H|GAS8_uc010vpt.1_3'UTR|GAS8_uc010vpu.1_3'UTR|GAS8_uc010vpv.1_Silent_p.H235H|GAS8_uc010cjc.1_Silent_p.H181H|GAS8_uc010vpw.1_Silent_p.H181H|GAS8_uc002fqj.1_Silent_p.H72H	NM_001481	NP_001472	O95995	GAS8_HUMAN	Homo sapiens growth arrest-specific 8 (GAS8), transcript variant 1, mRNA.	264					negative regulation of cell proliferation|sperm motility	Golgi apparatus|cilium|microtubule|microtubule basal body|microtubule-based flagellum	protein binding			endometrium(3)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	14		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.029)		AGGAGGACCACCTGGAGAGGG	0.627000													4	21					0	0	1	0	0
KCNA4	3739	broad.mit.edu	37	11	30033056	30033056	+	Nonsense_Mutation	SNP	G	G	T			TCGA-EM-A2CN-01A-11D-A19J-08	TCGA-EM-A2CN-10B-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c02d399-07af-4573-a568-bc1b256bc8f8	06dfc16a-ca37-46ca-8abb-20c1295e8f3a	g.chr11:30033056G>T	uc001msk.3	-	1	2411	c.1170C>A	c.(1168-1170)tgC>tgA	p.C390*	KCNA4_uc021qfi.1_Nonsense_Mutation_p.C390*	NM_002233	NP_002224	P22459	KCNA4_HUMAN	Homo sapiens potassium voltage-gated channel, shaker-related subfamily, member 4 (KCNA4), mRNA.	390						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						GACAAGCAAAGCAGCGAACCA	0.448000													47	73					0	0	1	0	0
MOB3B	79817	broad.mit.edu	37	9	27359236	27359236	+	Splice_Site	SNP	T	T	C			TCGA-EM-A2CN-01A-11D-A19J-08	TCGA-EM-A2CN-10B-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c02d399-07af-4573-a568-bc1b256bc8f8	06dfc16a-ca37-46ca-8abb-20c1295e8f3a	g.chr9:27359236T>C	uc003zqn.3	-	3	915	c.419_splice	c.e3-1	p.G140_splice		NM_024761	NP_079037	Q86TA1	MOL2B_HUMAN	Homo sapiens MOB kinase activator 3B (MOB3B), mRNA.	140							metal ion binding|protein binding										AGGGAACACCTAGAGAAGAAA	0.453000													59	71					0	0	1	0	0
HIST2H3D	653604	broad.mit.edu	37	1	149785212	149785212	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A2CN-01A-11D-A19J-08	TCGA-EM-A2CN-10B-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c02d399-07af-4573-a568-bc1b256bc8f8	06dfc16a-ca37-46ca-8abb-20c1295e8f3a	g.chr1:149785212G>A	uc010pbl.2	-	0	25	c.25C>T	c.(25-27)Cgc>Tgc	p.R9C	HIST2H2BF_uc010pbj.2_5'Flank|HIST2H2BF_uc010pbk.2_5'Flank|HIST2H2BF_uc001esr.3_5'Flank	NM_001123375	NP_001116847	Q71DI3	H32_HUMAN	Homo sapiens histone cluster 2, H3d (HIST2H3D), mRNA.	9					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding|protein binding	p.A8V(1)|p.A8A(1)		biliary_tract(1)|endometrium(1)|large_intestine(1)|liver(1)|lung(3)	7						GTCGACTTGCGGGCAGTCTGC	0.602000													37	49					0	0	1	0	0
C6orf47	57827	broad.mit.edu	37	6	31627090	31627090	+	Missense_Mutation	SNP	C	C	A			TCGA-EM-A2CN-01A-11D-A19J-08	TCGA-EM-A2CN-10B-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c02d399-07af-4573-a568-bc1b256bc8f8	06dfc16a-ca37-46ca-8abb-20c1295e8f3a	g.chr6:31627090C>A	uc003nvm.1	-	0	1460	c.635G>T	c.(634-636)cGt>cTt	p.R212L		NM_021184	NP_067007	O95873	CF047_HUMAN	Homo sapiens chromosome 6 open reading frame 47 (C6orf47), mRNA.	212										NS(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	9						CAGCGGTCCACGCAGGCCCAG	0.637000													45	34					0	0	1	0	0
KLHL24	54800	broad.mit.edu	37	3	183397022	183397022	+	Missense_Mutation	SNP	A	A	G	rs143529905		TCGA-EM-A2CN-01A-11D-A19J-08	TCGA-EM-A2CN-10B-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c02d399-07af-4573-a568-bc1b256bc8f8	06dfc16a-ca37-46ca-8abb-20c1295e8f3a	g.chr3:183397022A>G	uc003flv.3	+	7	2046	c.1751A>G	c.(1750-1752)tAt>tGt	p.Y584C	KLHL24_uc003flw.3_Missense_Mutation_p.Y584C	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	Homo sapiens kelch-like 24 (Drosophila) (KLHL24), mRNA.	584						axon|cytoplasm|perikaryon				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			CCAGTGTCCTATCATGGCTGT	0.463000													33	36					0	0	1	0	0
SYNCRIP	10492	broad.mit.edu	37	6	86324743	86324743	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A2CN-01A-11D-A19J-08	TCGA-EM-A2CN-10B-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c02d399-07af-4573-a568-bc1b256bc8f8	06dfc16a-ca37-46ca-8abb-20c1295e8f3a	g.chr6:86324743C>T	uc003pla.2	-	10	2144	c.1603G>A	c.(1603-1605)Gtt>Att	p.V535I	SYNCRIP_uc003pku.3_Missense_Mutation_p.V535I|SYNCRIP_uc003pkv.3_Missense_Mutation_p.V535I|SYNCRIP_uc003pkw.3_Missense_Mutation_p.V500I|SYNCRIP_uc003pkx.3_Missense_Mutation_p.V383I|SYNCRIP_uc003pky.3_Missense_Mutation_p.V437I|SYNCRIP_uc003pkz.2_Missense_Mutation_p.V500I	NM_006372	NP_006363	O60506	HNRPQ_HUMAN	Homo sapiens synaptotagmin binding, cytoplasmic RNA interacting protein (SYNCRIP), transcript variant 1, mRNA.	535	8 X 3 AA repeats of R-G-G.|Interaction with APOBEC1.|Interaction with SMN.				CRD-mediated mRNA stabilization|interspecies interaction between organisms	CRD-mediated mRNA stability complex|catalytic step 2 spliceosome|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding	p.G534S(1)		autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	33		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)		GCACCTCGAACGCCTCTTGCT	0.627000													39	177					0	0	1	0	0
ADCY9	115	broad.mit.edu	37	16	4164144	4164144	+	Missense_Mutation	SNP	T	T	G			TCGA-EM-A2CN-01A-11D-A19J-08	TCGA-EM-A2CN-10B-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c02d399-07af-4573-a568-bc1b256bc8f8	06dfc16a-ca37-46ca-8abb-20c1295e8f3a	g.chr16:4164144T>G	uc002cvx.3	-	1	1839	c.1300A>C	c.(1300-1302)Aag>Cag	p.K434Q		NM_001116	NP_001107	O60503	ADCY9_HUMAN	Homo sapiens adenylate cyclase 9 (ADCY9), mRNA.	434	Guanylate cyclase 1.				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	ATP binding|adenylate cyclase activity|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						TTCTCACACTTGGTCTCCTCA	0.612000													6	136					0	0	1	0	0
NRAS	4893	broad.mit.edu	37	1	115256529	115256529	+	Missense_Mutation	SNP	T	T	C	rs11554290		TCGA-EM-A2CN-01A-11D-A19J-08	TCGA-EM-A2CN-10B-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c02d399-07af-4573-a568-bc1b256bc8f8	06dfc16a-ca37-46ca-8abb-20c1295e8f3a	g.chr1:115256529T>C	uc009wgu.3	-	2	436	c.182A>G	c.(181-183)cAa>cGa	p.Q61R		NM_002524	NP_002515	P01111	RASN_HUMAN	Homo sapiens neuroblastoma RAS viral (v-ras) oncogene homolog (NRAS), mRNA.	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		Ras protein signal transduction|activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(1713)|p.Q61K(635)|p.Q61L(370)|p.Q61H(123)|p.Q61P(46)|p.Q61E(9)|p.G60E(6)|p.Q61?(5)|p.Q61Q(3)|p.G60R(1)|p.G60>?(1)|p.Q61*(1)|p.Q61_E62>HK(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458000	Q61L(C3A_LIVER)|Q61L(HEPG2_LIVER)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MELJUSO_SKIN)|Q61L(MHHES1_BONE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(HT1197_URINARY_TRACT)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(KU1919_URINARY_TRACT)|Q61R(NCIH2347_LUNG)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(SKMEL2_SKIN)|Q61R(SW1271_LUNG)|Q61R(TT2609C02_THYROID)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			116	172					0	0	1	0	0
PSMA6	5687	broad.mit.edu	37	14	35761712	35761712	+	Missense_Mutation	SNP	C	C	A			TCGA-EM-A2CN-01A-11D-A19J-08	TCGA-EM-A2CN-10B-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c02d399-07af-4573-a568-bc1b256bc8f8	06dfc16a-ca37-46ca-8abb-20c1295e8f3a	g.chr14:35761712C>A	uc001wtd.3	+	0	139	c.30C>A	c.(28-30)gaC>gaA	p.D10E	KIAA0391_uc001wta.3_Intron|PSMA6_uc010tpt.2_5'UTR|PSMA6_uc010tpu.2_5'UTR	NM_002791	NP_002782	P60900	PSA6_HUMAN	Homo sapiens proteasome (prosome, macropain) subunit, alpha type, 6 (PSMA6), mRNA.	10					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|viral reproduction	mitochondrion|nuclear matrix|polysome|proteasome core complex, alpha-subunit complex|sarcomere	NF-kappaB binding|RNA binding|purine ribonucleoside triphosphate binding|threonine-type endopeptidase activity			kidney(2)|large_intestine(1)|lung(5)|prostate(1)|urinary_tract(1)	10	Breast(36;0.0519)|Hepatocellular(127;0.158)		Lung(238;3.81e-05)|LUAD - Lung adenocarcinoma(48;5.59e-05)|Epithelial(34;0.00342)|all cancers(34;0.00973)	GBM - Glioblastoma multiforme(112;0.0234)		CCGGTTTTGACCGCCACATTA	0.562000													9	115					0	0	1	0	0
GRAMD2	196996	broad.mit.edu	37	15	72457708	72457708	+	Missense_Mutation	SNP	T	T	G			TCGA-EM-A2CN-01A-11D-A19J-08	TCGA-EM-A2CN-10B-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c02d399-07af-4573-a568-bc1b256bc8f8	06dfc16a-ca37-46ca-8abb-20c1295e8f3a	g.chr15:72457708T>G	uc002atq.3	-	7	611	c.587A>C	c.(586-588)gAa>gCa	p.E196A	GRAMD2_uc010bis.2_Missense_Mutation_p.E196A|GRAMD2_uc010ukh.2_5'Flank	NM_001012642	NP_001012660	Q8IUY3	GRAM2_HUMAN	Homo sapiens GRAM domain containing 2 (GRAMD2), mRNA.	196						integral to membrane		p.G195V(1)		cervix(2)|endometrium(1)|large_intestine(4)|lung(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	13						AGACTCAGGTTCCCCTGAAAA	0.552000													7	118					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92577600	92577600	+	Silent	SNP	C	C	T			TCGA-EM-A2CN-01A-11D-A19J-08	TCGA-EM-A2CN-10B-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c02d399-07af-4573-a568-bc1b256bc8f8	06dfc16a-ca37-46ca-8abb-20c1295e8f3a	g.chr11:92577600C>T	uc001pdj.4	+	17	11084	c.11067C>T	c.(11065-11067)agC>agT	p.S3689S	FAT3_uc001pdi.4_Silent_p.S129S	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	Homo sapiens FAT tumor suppressor homolog 3 (Drosophila) (FAT3), mRNA.	3689					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCATCATCAGCATCCAGCCCG	0.602000										TCGA Ovarian(4;0.039)			16	24					0	0	1	0	0
C11orf87	399947	broad.mit.edu	37	11	109294829	109294829	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A2CN-01A-11D-A19J-08	TCGA-EM-A2CN-10B-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c02d399-07af-4573-a568-bc1b256bc8f8	06dfc16a-ca37-46ca-8abb-20c1295e8f3a	g.chr11:109294829C>T	uc010rwb.2	+	1	873	c.470C>T	c.(469-471)cCg>cTg	p.P157L	C11orf87_uc021qqf.1_Missense_Mutation_p.P157L	NM_207645	NP_997528	Q6NUJ2	CK087_HUMAN	Homo sapiens chromosome 11 open reading frame 87 (C11orf87), mRNA.	157						integral to membrane		p.P157R(2)		breast(2)|endometrium(1)|large_intestine(5)|lung(5)|ovary(2)|prostate(1)|urinary_tract(1)	17						CCTGGCCTCCCGTGCCAGGGT	0.672000													48	55					0	0	1	0	0
TBC1D7	51256	broad.mit.edu	37	6	13307860	13307860	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A2CN-01A-11D-A19J-08	TCGA-EM-A2CN-10B-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c02d399-07af-4573-a568-bc1b256bc8f8	06dfc16a-ca37-46ca-8abb-20c1295e8f3a	g.chr6:13307860C>T	uc003naj.3	-	5	745	c.637G>A	c.(637-639)Gga>Aga	p.G213R	TBC1D7_uc011dis.2_Intron|TBC1D7_uc003nal.3_Missense_Mutation_p.G213R|TBC1D7_uc003nan.3_Missense_Mutation_p.G213R|TBC1D7_uc003nam.3_Missense_Mutation_p.G213R|TBC1D7_uc003nao.3_Missense_Mutation_p.G186R|TBC1D7_uc010jpd.3_Missense_Mutation_p.G167R	NM_016495	NP_057579	Q9P0N9	TBCD7_HUMAN	Homo sapiens TBC1 domain family, member 7 (TBC1D7), transcript variant 1, mRNA.	213	Rab-GAP TBC.				positive regulation of protein ubiquitination	cytoplasmic membrane-bounded vesicle	Rab GTPase activator activity|protein binding			breast(1)|endometrium(1)|large_intestine(4)|lung(14)|ovary(1)|stomach(1)	22	Breast(50;0.0296)|Ovarian(93;0.0339)	all_hematologic(90;0.135)	Epithelial(50;0.0784)|BRCA - Breast invasive adenocarcinoma(129;0.13)|all cancers(50;0.21)			GGCAAACATCCCGCAAAGCAC	0.483000													40	56					0	0	1	0	0
ARVCF	421	broad.mit.edu	37	22	19969230	19969230	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A2CN-01A-11D-A19J-08	TCGA-EM-A2CN-10B-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c02d399-07af-4573-a568-bc1b256bc8f8	06dfc16a-ca37-46ca-8abb-20c1295e8f3a	g.chr22:19969230G>A	uc002zqz.3	-	4	670	c.400C>T	c.(400-402)Cgg>Tgg	p.R134W	ARVCF_uc002zqy.3_5'Flank	NM_001670	NP_001661	O00192	ARVC_HUMAN	Homo sapiens armadillo repeat gene deleted in velocardiofacial syndrome (ARVCF), mRNA.	134					cell adhesion|multicellular organismal development		protein binding			NS(1)|cervix(1)|endometrium(3)|liver(1)|lung(4)|prostate(1)|urinary_tract(2)	13	Colorectal(54;0.0993)					CGTACTGTCCGAGTGGTCACC	0.622000													38	58					0	0	1	0	0
WBP1	23559	broad.mit.edu	37	2	74685770	74685770	+	Frame_Shift_Del	DEL	G	G	-			TCGA-EM-A2CN-01A-11D-A19J-08	TCGA-EM-A2CN-10B-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c02d399-07af-4573-a568-bc1b256bc8f8	06dfc16a-ca37-46ca-8abb-20c1295e8f3a	g.chr2:74685770delG	uc002slj.2	+	0	244	c.41delG	c.(40-42)tggfs	p.W14fs	INO80B_uc002sli.2_Intron|WBP1_uc002sll.2_Non-coding_Transcript	NM_012477	NP_036609	Q96G27	WBP1_HUMAN	Homo sapiens WW domain binding protein 1 (WBP1), mRNA.	14							WW domain binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|ovary(1)|urinary_tract(1)	8						GAGGAGGCCTGGGGGGCACTT	0.632													2	4	---	---	---	---