Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SP1	6667	broad.mit.edu	37	12	53804795	53804795	+	Missense_Mutation	SNP	A	A	G			TCGA-EM-A3FN-01A-11D-A21A-08	TCGA-EM-A3FN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d25bba0-29fc-4fe2-b891-d71fb3554dd3	03ff508f-ed60-4df8-9d9a-ca834a8b4073	g.chr12:53804795A>G	uc001scw.3	+	5	2226	c.2129A>G	c.(2128-2130)aAt>aGt	p.N710S	SP1_uc021qyf.1_Missense_Mutation_p.N662S|SP1_uc010sog.2_Missense_Mutation_p.N703S	NM_138473	NP_612482	P08047	SP1_HUMAN	Homo sapiens Sp1 transcription factor (SP1), transcript variant 1, mRNA.	710	Domain D.|VZV IE62-binding.				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	HMG box domain binding|double-stranded DNA binding|histone deacetylase binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.00527)		ACCCACCAGAATAAGAAGGGA	0.532000													7	65					0	0	1	0	0
RASGEF1B	153020	broad.mit.edu	37	4	82366917	82366917	+	Missense_Mutation	SNP	C	C	A			TCGA-EM-A3FN-01A-11D-A21A-08	TCGA-EM-A3FN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d25bba0-29fc-4fe2-b891-d71fb3554dd3	03ff508f-ed60-4df8-9d9a-ca834a8b4073	g.chr4:82366917C>A	uc003hmi.1	-	6	949	c.805G>T	c.(805-807)Gtt>Ttt	p.V269F	RASGEF1B_uc003hmj.1_Missense_Mutation_p.V268F|RASGEF1B_uc010ijq.1_Missense_Mutation_p.V227F	NM_152545	NP_689758	Q0VAM2	RGF1B_HUMAN	Homo sapiens RasGEF domain family, member 1B (RASGEF1B), mRNA.	269	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			endometrium(2)|kidney(5)|large_intestine(4)|lung(13)|prostate(1)|skin(1)	26						TCTGTAGCAACCAAGTAGCTG	0.363000													4	44					0	0	1	0	0
PRPF8	10594	broad.mit.edu	37	17	1579616	1579616	+	Missense_Mutation	SNP	T	T	C			TCGA-EM-A3FN-01A-11D-A21A-08	TCGA-EM-A3FN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d25bba0-29fc-4fe2-b891-d71fb3554dd3	03ff508f-ed60-4df8-9d9a-ca834a8b4073	g.chr17:1579616T>C	uc002fte.3	-	16	2551	c.2437A>G	c.(2437-2439)Aca>Gca	p.T813A		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	Homo sapiens PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) (PRPF8), mRNA.	813						U5 snRNP|catalytic step 2 spliceosome|nuclear speck	RNA binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		CAATGCACTGTGGTGGTATAT	0.537000													8	114					0	0	1	0	0
SATL1	340562	broad.mit.edu	37	X	84363501	84363501	+	Silent	SNP	G	G	A			TCGA-EM-A3FN-01A-11D-A21A-08	TCGA-EM-A3FN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d25bba0-29fc-4fe2-b891-d71fb3554dd3	03ff508f-ed60-4df8-9d9a-ca834a8b4073	g.chrX:84363501G>A	uc004een.3	-	0	474	c.474C>T	c.(472-474)acC>acT	p.T158T		NM_001012980	NP_001012998	Q86VE3	SATL1_HUMAN	Homo sapiens spermidine/spermine N1-acetyl transferase-like 1 (SATL1), mRNA.	214	Gln-rich.						N-acetyltransferase activity			NS(1)|breast(5)|endometrium(2)|large_intestine(3)|lung(13)|skin(3)|stomach(1)|urinary_tract(1)	29						CTAATTGGCTGGTGCCTACTT	0.532000											OREG0019887	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	81					0	0	1	0	0
EIF1AX	1964	broad.mit.edu	37	X	20156735	20156735	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A3FN-01A-11D-A21A-08	TCGA-EM-A3FN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d25bba0-29fc-4fe2-b891-d71fb3554dd3	03ff508f-ed60-4df8-9d9a-ca834a8b4073	g.chrX:20156735C>T	uc004czt.3	-	1	230	c.22G>A	c.(22-24)Gga>Aga	p.G8R	SCARNA9L_uc010nfp.3_5'Flank	NM_001412	NP_001403	P47813	IF1AX_HUMAN	Homo sapiens eukaryotic translation initiation factor 1A, X-linked (EIF1AX), mRNA.	8						cytosol	translation initiation factor activity			endometrium(2)|lung(1)|ovary(1)|prostate(1)	5						TTTTTACCTCCTTTACCTGAT	0.308000													30	67					0	0	1	0	0
ARX	170302	broad.mit.edu	37	X	25031220	25031220	+	Missense_Mutation	SNP	G	G	T			TCGA-EM-A3FN-01A-11D-A21A-08	TCGA-EM-A3FN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d25bba0-29fc-4fe2-b891-d71fb3554dd3	03ff508f-ed60-4df8-9d9a-ca834a8b4073	g.chrX:25031220G>T	uc004dbp.4	-	1	1103	c.892C>A	c.(892-894)Cac>Aac	p.H298N		NM_139058	NP_620689	Q96QS3	ARX_HUMAN	Homo sapiens aristaless related homeobox (ARX), mRNA.	298						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(2)|lung(1)	4						TCTTCCGGGTGCAGCAGCAGC	0.697000													6	12					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18688246	18688246	+	Silent	SNP	G	G	A			TCGA-EM-A3FN-01A-11D-A21A-08	TCGA-EM-A3FN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d25bba0-29fc-4fe2-b891-d71fb3554dd3	03ff508f-ed60-4df8-9d9a-ca834a8b4073	g.chr7:18688246G>A	uc003sui.3	+	9	1448	c.1407G>A	c.(1405-1407)caG>caA	p.Q469Q	HDAC9_uc003sue.3_Silent_p.Q466Q|HDAC9_uc011jyd.2_Silent_p.Q466Q|HDAC9_uc003suh.3_Silent_p.Q466Q|HDAC9_uc003suj.3_Silent_p.Q425Q|HDAC9_uc011jya.2_Silent_p.Q464Q|HDAC9_uc003sua.1_Silent_p.Q444Q|HDAC9_uc003sud.2_Silent_p.Q466Q|HDAC9_uc011jyc.2_Silent_p.Q425Q|HDAC9_uc011jyb.2_Silent_p.Q422Q|HDAC9_uc003suf.2_Silent_p.Q497Q|HDAC9_uc010kud.2_Silent_p.Q469Q|HDAC9_uc011jye.2_Silent_p.Q438Q|HDAC9_uc011jyf.2_Silent_p.Q389Q|HDAC9_uc010kue.1_Silent_p.Q209Q	NM_178425	NP_848512	Q9UKV0	HDAC9_HUMAN	Homo sapiens histone deacetylase 9 (HDAC9), transcript variant 5, mRNA.	466					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	TCATTCAACAGCAACACCAGC	0.507000													3	80					0	0	1	0	0
CMA1	1215	broad.mit.edu	37	14	24976707	24976707	+	Missense_Mutation	SNP	T	T	C			TCGA-EM-A3FN-01A-11D-A21A-08	TCGA-EM-A3FN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d25bba0-29fc-4fe2-b891-d71fb3554dd3	03ff508f-ed60-4df8-9d9a-ca834a8b4073	g.chr14:24976707T>C	uc001wpp.1	-	1	94	c.64A>G	c.(64-66)Atc>Gtc	p.I22V	CMA1_uc010alx.1_Intron	NM_001836	NP_001827	P23946	CMA1_HUMAN	Homo sapiens chymase 1, mast cell (CMA1), mRNA.	22	Peptidase S1.				interleukin-1 beta biosynthetic process|proteolysis	extracellular region	serine-type endopeptidase activity	p.E21D(1)		kidney(1)|lung(8)|pancreas(1)|prostate(1)	11				GBM - Glioblastoma multiforme(265;0.0271)		CCCCCGATGATCTCCCCTGGA	0.507000													5	203					0	0	1	0	0
CPOX	1371	broad.mit.edu	37	3	98304370	98304370	+	Missense_Mutation	SNP	G	G	T			TCGA-EM-A3FN-01A-11D-A21A-08	TCGA-EM-A3FN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d25bba0-29fc-4fe2-b891-d71fb3554dd3	03ff508f-ed60-4df8-9d9a-ca834a8b4073	g.chr3:98304370G>T	uc003dsx.3	-	4	1194	c.1087C>A	c.(1087-1089)Cct>Act	p.P363T		NM_000097	NP_000088	P36551	HEM6_HUMAN	Homo sapiens coproporphyrinogen oxidase (CPOX), mRNA.	363						mitochondrial intermembrane space	coproporphyrinogen oxidase activity|protein homodimerization activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)	16						ATGTAAGAAGGAACTACAGCC	0.507000													13	208					0	0	1	0	0
OR5AU1	390445	broad.mit.edu	37	14	21623307	21623307	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A3FN-01A-11D-A21A-08	TCGA-EM-A3FN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d25bba0-29fc-4fe2-b891-d71fb3554dd3	03ff508f-ed60-4df8-9d9a-ca834a8b4073	g.chr14:21623307G>A	uc010tlp.2	-	0	878	c.878C>T	c.(877-879)gCa>gTa	p.A293V		NM_001004731	NP_001004731	Q8NGC0	O5AU1_HUMAN	Homo sapiens olfactory receptor, family 5, subfamily AU, member 1 (OR5AU1), mRNA.	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(12)|pancreas(1)	21	all_cancers(95;0.00238)		Epithelial(56;6.88e-07)|all cancers(55;6.02e-06)	GBM - Glioblastoma multiforme(265;0.0192)		GAGGTGGGATGCACAGGTGGA	0.522000													3	53					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121238917	121238917	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A3FN-01A-11D-A21A-08	TCGA-EM-A3FN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d25bba0-29fc-4fe2-b891-d71fb3554dd3	03ff508f-ed60-4df8-9d9a-ca834a8b4073	g.chr8:121238917G>A	uc003yox.3	+	15	2181	c.1916G>A	c.(1915-1917)aGt>aAt	p.S639N	COL14A1_uc003yoy.3_Missense_Mutation_p.S317N	NM_021110	NP_066933	Q05707	COEA1_HUMAN	Homo sapiens collagen, type XIV, alpha 1 (COL14A1), mRNA.	639	Fibronectin type-III 5.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			ACGACAGACAGTTTTAGGGTG	0.473000													3	57					0	0	1	0	0
MOV10L1	54456	broad.mit.edu	37	22	50582545	50582545	+	Missense_Mutation	SNP	A	A	G			TCGA-EM-A3FN-01A-11D-A21A-08	TCGA-EM-A3FN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d25bba0-29fc-4fe2-b891-d71fb3554dd3	03ff508f-ed60-4df8-9d9a-ca834a8b4073	g.chr22:50582545A>G	uc003bjj.3	+	17	2461	c.2378A>G	c.(2377-2379)gAc>gGc	p.D793G	MOV10L1_uc003bjk.4_Missense_Mutation_p.D793G|MOV10L1_uc011arp.2_Missense_Mutation_p.D773G|MOV10L1_uc003bjl.3_5'Flank	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	Homo sapiens Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse) (MOV10L1), transcript variant 1, mRNA.	793					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|RNA binding|magnesium ion binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		GCCTTGCCGGACAGTCGGATT	0.562000													78	158					0	0	1	0	0
ADCK1	57143	broad.mit.edu	37	14	78365449	78365449	+	Missense_Mutation	SNP	G	G	C			TCGA-EM-A3FN-01A-11D-A21A-08	TCGA-EM-A3FN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d25bba0-29fc-4fe2-b891-d71fb3554dd3	03ff508f-ed60-4df8-9d9a-ca834a8b4073	g.chr14:78365449G>C	uc001xui.3	+	5	688	c.589G>C	c.(589-591)Gtt>Ctt	p.V197L	ADCK1_uc010tvo.1_Non-coding_Transcript|ADCK1_uc001xuj.3_Missense_Mutation_p.V129L|ADCK1_uc001xuk.1_Missense_Mutation_p.V71L	NM_020421	NP_065154	Q86TW2	ADCK1_HUMAN	Homo sapiens aarF domain containing kinase 1 (ADCK1), transcript variant 1, mRNA.	204	Protein kinase.					extracellular region	ATP binding|protein serine/threonine kinase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|skin(2)|stomach(2)	25			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0376)		TCAGGTGCTCGTTCTGGCTGT	0.507000													48	117					0	0	1	0	0
SLC25A13	10165	broad.mit.edu	37	7	95822462	95822462	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A3FN-01A-11D-A21A-08	TCGA-EM-A3FN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d25bba0-29fc-4fe2-b891-d71fb3554dd3	03ff508f-ed60-4df8-9d9a-ca834a8b4073	g.chr7:95822462C>T	uc003uog.4	-	5	693	c.502G>A	c.(502-504)Gtg>Atg	p.V168M	SLC25A13_uc003uof.4_Missense_Mutation_p.V168M|SLC25A13_uc011kik.2_Missense_Mutation_p.V60M	NM_001160210	NP_001153682	Q9UJS0	CMC2_HUMAN	Homo sapiens solute carrier family 25, member 13 (citrin) (SLC25A13), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	168	EF-hand 4.				ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|calcium ion binding			breast(4)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|prostate(1)|skin(4)	42	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)	TCCCGTTGCACAAAGGCTTGC	0.413000													37	55					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10071487	10071487	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A3FN-01A-11D-A21A-08	TCGA-EM-A3FN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d25bba0-29fc-4fe2-b891-d71fb3554dd3	03ff508f-ed60-4df8-9d9a-ca834a8b4073	g.chr19:10071487C>T	uc002mmq.1	-	65	5017	c.4931G>A	c.(4930-4932)cGc>cAc	p.R1644H		NM_015719	NP_056534	P25940	CO5A3_HUMAN	Homo sapiens collagen, type V, alpha 3 (COL5A3), mRNA.	1644	Fibrillar collagen NC1.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GAAGTTCTGGCGAGCTGTGGC	0.607000													4	84					0	0	1	0	0
TP53BP1	7158	broad.mit.edu	37	15	43712831	43712831	+	Silent	SNP	G	G	T			TCGA-EM-A3FN-01A-11D-A21A-08	TCGA-EM-A3FN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d25bba0-29fc-4fe2-b891-d71fb3554dd3	03ff508f-ed60-4df8-9d9a-ca834a8b4073	g.chr15:43712831G>T	uc001zrr.4	-	20	4466	c.4353C>A	c.(4351-4353)tcC>tcA	p.S1451S	TP53BP1_uc010udp.2_Silent_p.S1446S|TP53BP1_uc001zrq.4_Silent_p.S1451S|TP53BP1_uc001zrs.3_Silent_p.S1446S|TP53BP1_uc010udq.1_Silent_p.S1451S	NM_001141980	NP_005648	Q12888	TP53B_HUMAN	Homo sapiens tumor protein p53 binding protein 1 (TP53BP1), transcript variant 1, mRNA.	1446					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity|p53 binding	p.D1451Y(1)		breast(4)|endometrium(5)|kidney(7)|large_intestine(22)|lung(13)|ovary(4)|pancreas(2)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(3)	72		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		TTCGTCTGGTGGAGTCTGGCA	0.542000								Other conserved DNA damage response genes					41	55					0	0	1	0	0
OR5K1	26339	broad.mit.edu	37	3	98189173	98189173	+	Missense_Mutation	SNP	C	C	A			TCGA-EM-A3FN-01A-11D-A21A-08	TCGA-EM-A3FN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d25bba0-29fc-4fe2-b891-d71fb3554dd3	03ff508f-ed60-4df8-9d9a-ca834a8b4073	g.chr3:98189173C>A	uc003dsm.3	+	0	753	c.753C>A	c.(751-753)ttC>ttA	p.F251L		NM_001004736	NP_001004736	Q8NHB7	OR5K1_HUMAN	Homo sapiens olfactory receptor, family 5, subfamily K, member 1 (OR5K1), mRNA.	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(21)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TTTCATTATTCTATGGATCTC	0.343000													13	36					0	0	1	0	0
AVP	551	broad.mit.edu	37	20	3065238	3065238	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A3FN-01A-11D-A21A-08	TCGA-EM-A3FN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d25bba0-29fc-4fe2-b891-d71fb3554dd3	03ff508f-ed60-4df8-9d9a-ca834a8b4073	g.chr20:3065238C>T	uc002whu.3	-	0	133	c.83G>A	c.(82-84)gGc>gAc	p.G28D		NM_000490	NP_000481	P01185	NEU2_HUMAN	Homo sapiens arginine vasopressin (AVP), mRNA.	28					ERK1 and ERK2 cascade|cell-cell signaling|generation of precursor metabolites and energy|negative regulation of apoptosis|negative regulation of release of cytochrome c from mitochondria|positive regulation of gene expression|positive regulation of peptidyl-serine phosphorylation|protein kinase C signaling cascade|sodium-independent organic anion transport|transmembrane transport|vasoconstriction|water transport	cytosol|soluble fraction	V1A vasopressin receptor binding|caspase inhibitor activity|neurohypophyseal hormone activity|protein kinase activity|signal transducer activity			central_nervous_system(1)|prostate(1)|skin(1)	3				COAD - Colon adenocarcinoma(99;0.00643)		CCTCTTGCCGCCCCTCGGGCA	0.647000													7	195					0	0	1	0	0
KRTAP12-3	386683	broad.mit.edu	37	21	46078031	46078031	+	Silent	SNP	C	C	T			TCGA-EM-A3FN-01A-11D-A21A-08	TCGA-EM-A3FN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d25bba0-29fc-4fe2-b891-d71fb3554dd3	03ff508f-ed60-4df8-9d9a-ca834a8b4073	g.chr21:46078031C>T	uc002zft.3	+	0	183	c.135C>T	c.(133-135)tgC>tgT	p.C45C	TSPEAR_uc002zfe.1_Intron|TSPEAR_uc010gpv.1_Intron	NM_198697	NP_941970	P60328	KR123_HUMAN	Homo sapiens keratin associated protein 12-3 (KRTAP12-3), mRNA.	45	14 X 5 AA approximate repeats.					intermediate filament				central_nervous_system(1)|lung(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	7						GCATTGTGTGCGTGGCTCCCT	0.642000													6	267					0	0	1	0	0
NDUFA9	4704	broad.mit.edu	37	12	4791380	4791380	+	Silent	SNP	G	G	A			TCGA-EM-A3FN-01A-11D-A21A-08	TCGA-EM-A3FN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d25bba0-29fc-4fe2-b891-d71fb3554dd3	03ff508f-ed60-4df8-9d9a-ca834a8b4073	g.chr12:4791380G>A	uc001qnc.3	+	8	839	c.810G>A	c.(808-810)cgG>cgA	p.R270R	NDUFA9_uc010ses.2_Silent_p.R51R	NM_005002	NP_004993	Q16795	NDUA9_HUMAN	Homo sapiens NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa (NDUFA9), nuclear gene encoding mitochondrial protein, mRNA.	270					mitochondrial electron transport, NADH to ubiquinone|sodium ion transport	mitochondrial matrix|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity|protein binding	p.R270L(1)|p.R270Q(1)		NS(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21					NADH(DB00157)	GTCCCAGTCGGTACCTCCTTT	0.398000													4	152					0	0	1	0	0
FOXJ2	55810	broad.mit.edu	37	12	8202170	8202170	+	Missense_Mutation	SNP	A	A	C			TCGA-EM-A3FN-01A-11D-A21A-08	TCGA-EM-A3FN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d25bba0-29fc-4fe2-b891-d71fb3554dd3	03ff508f-ed60-4df8-9d9a-ca834a8b4073	g.chr12:8202170A>C	uc001qtt.1	+	8	2625	c.1540A>C	c.(1540-1542)Act>Cct	p.T514P	FOXJ2_uc001qtu.3_Intron	NM_018416	NP_060886	Q9P0K8	FOXJ2_HUMAN	Homo sapiens forkhead box J2 (FOXJ2), mRNA.	321					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	nucleolus|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			autonomic_ganglia(1)|large_intestine(2)|lung(6)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	16				Kidney(36;0.0944)		GAGCCAAGGTACTGCACCAAG	0.557000													6	19					0	0	1	0	0
SYTL3	94120	broad.mit.edu	37	6	159184419	159184419	+	Nonsense_Mutation	SNP	C	C	G			TCGA-EM-A3FN-01A-11D-A21A-08	TCGA-EM-A3FN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d25bba0-29fc-4fe2-b891-d71fb3554dd3	03ff508f-ed60-4df8-9d9a-ca834a8b4073	g.chr6:159184419C>G	uc003qrp.3	+	17	2000	c.1601C>G	c.(1600-1602)tCa>tGa	p.S534*	SYTL3_uc003qrr.3_Nonsense_Mutation_p.S534*|SYTL3_uc003qro.3_Nonsense_Mutation_p.S466*|SYTL3_uc003qrs.3_Nonsense_Mutation_p.S466*|SYTL3_uc011efq.2_Nonsense_Mutation_p.S260*	NM_001242384	NP_001229313	Q4VX76	SYTL3_HUMAN	Homo sapiens synaptotagmin-like 3 (SYTL3), transcript variant 1, mRNA.	534	C2 2.				intracellular protein transport	endomembrane system|membrane	Rab GTPase binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|urinary_tract(1)	20		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		TGGAAACACTCATTTGTCTTC	0.527000													35	65					0	0	1	0	0
ACTB	60	broad.mit.edu	37	7	5568116	5568116	+	Missense_Mutation	SNP	A	A	C			TCGA-EM-A3FN-01A-11D-A21A-08	TCGA-EM-A3FN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d25bba0-29fc-4fe2-b891-d71fb3554dd3	03ff508f-ed60-4df8-9d9a-ca834a8b4073	g.chr7:5568116A>C	uc003sot.4	-	3	682	c.598T>G	c.(598-600)Ttc>Gtc	p.F200V	ACTB_uc003sor.4_Missense_Mutation_p.F78V|ACTB_uc003soq.4_Missense_Mutation_p.F78V	NM_001101	NP_001092	P60709	ACTB_HUMAN	Homo sapiens actin, beta (ACTB), mRNA.	200					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	MLL5-L complex|NuA4 histone acetyltransferase complex|cytoskeleton|cytosol|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(2)|prostate(2)	8		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		GTGGTGGTGAAGCTGTAGCCG	0.622000													43	55					0	0	1	0	0
ANKRD54	129138	broad.mit.edu	37	22	38240354	38240357	+	Splice_Site	DEL	GGGC	GGGC	-			TCGA-EM-A3FN-01A-11D-A21A-08	TCGA-EM-A3FN-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d25bba0-29fc-4fe2-b891-d71fb3554dd3	03ff508f-ed60-4df8-9d9a-ca834a8b4073	g.chr22:38240354_38240357delGGGC	uc003auc.3	-	1	1	c.-107_splice	c.e1-1		ANKRD54_uc003aud.3_Splice_Site|ANKRD54_uc021wpj.1_Non-coding_Transcript	NM_138797	NP_620152	Q6NXT1	ANR54_HUMAN	Homo sapiens ankyrin repeat domain 54 (ANKRD54), transcript variant 1, mRNA.											lung(1)	1	Melanoma(58;0.045)					CGGGCGGGCAGGGCCCGCAACCAC	0.686													8	8	---	---	---	---