Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HIGD1A	25994	broad.mit.edu	37	3	42845665	42845665	+	Splice_Site	SNP	C	C	T			TCGA-ET-A25G-01A-11D-A16O-08	TCGA-ET-A25G-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5fe7249-10b3-4a0b-96dc-be4c7d3e5c8c	41324b55-de97-4320-b264-4073c08443e1	g.chr3:42845665C>T	uc010hid.3	-	1	271	c.20_splice	c.e1+1	p.E7_splice	CCBP2_uc003cmc.1_5'Flank|HIGD1A_uc003cma.4_Intron|HIGD1A_uc003cmb.4_Intron	NM_001099668	NP_054775	Q9Y241	HIG1A_HUMAN	Homo sapiens HIG1 hypoxia inducible domain family, member 1A (HIGD1A), transcript variant 1, mRNA.	0	HIG1.				response to stress	integral to membrane|protein complex	protein binding			lung(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.217)		GCAACTCACTCCACAAGCTTC	0.672000													46	109					0	0	1	0	0
ZMIZ2	83637	broad.mit.edu	37	7	44805072	44805072	+	Silent	SNP	C	C	G			TCGA-ET-A25G-01A-11D-A16O-08	TCGA-ET-A25G-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5fe7249-10b3-4a0b-96dc-be4c7d3e5c8c	41324b55-de97-4320-b264-4073c08443e1	g.chr7:44805072C>G	uc003tlr.3	+	15	2259	c.2136C>G	c.(2134-2136)ctC>ctG	p.L712L	ZMIZ2_uc003tlq.3_Silent_p.L654L|ZMIZ2_uc003tls.3_Silent_p.L686L|ZMIZ2_uc003tlt.3_Silent_p.L335L|ZMIZ2_uc010kyj.3_Silent_p.L234L|ZMIZ2_uc003tlu.3_5'Flank	NM_031449	NP_113637	Q8NF64	ZMIZ2_HUMAN	Homo sapiens zinc finger, MIZ-type containing 2 (ZMIZ2), transcript variant 1, mRNA.	712					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			breast(3)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						CCCACGTGCTCATGCCCAGCG	0.701000													13	23					0	0	1	0	0
CLCA1	1179	broad.mit.edu	37	1	86959123	86959123	+	Silent	SNP	C	C	T			TCGA-ET-A25G-01A-11D-A16O-08	TCGA-ET-A25G-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5fe7249-10b3-4a0b-96dc-be4c7d3e5c8c	41324b55-de97-4320-b264-4073c08443e1	g.chr1:86959123C>T	uc001dlt.3	+	9	1781	c.1521C>T	c.(1519-1521)atC>atT	p.I507I	CLCA1_uc001dls.1_Silent_p.I446I	NM_001285	NP_001276	A8K7I4	CLCA1_HUMAN	Homo sapiens chloride channel accessory 1 (CLCA1), mRNA.	507					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		GCACAGTGATCGTGGACAGCA	0.493000													8	86					0	0	1	0	0
C11orf63	79864	broad.mit.edu	37	11	122805462	122805462	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A25G-01A-11D-A16O-08	TCGA-ET-A25G-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5fe7249-10b3-4a0b-96dc-be4c7d3e5c8c	41324b55-de97-4320-b264-4073c08443e1	g.chr11:122805462C>T	uc001pym.3	+	4	1610	c.1313C>T	c.(1312-1314)aCc>aTc	p.T438I		NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	Homo sapiens chromosome 11 open reading frame 63 (C11orf63), transcript variant 1, mRNA.	438										breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(13)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	47		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		CTCAAAGAAACCTCCAATACA	0.398000													30	40					0	0	1	0	0
O3FAR1	338557	broad.mit.edu	37	10	95347003	95347003	+	Silent	SNP	C	C	T			TCGA-ET-A25G-01A-11D-A16O-08	TCGA-ET-A25G-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5fe7249-10b3-4a0b-96dc-be4c7d3e5c8c	41324b55-de97-4320-b264-4073c08443e1	g.chr10:95347003C>T	uc010qnt.2	+	3	827	c.771C>T	c.(769-771)ctC>ctT	p.L257L	O3FAR1_uc010qnu.2_Silent_p.L241L	NM_181745	NP_859529	Q5NUL3	O3FA1_HUMAN	Homo sapiens omega-3 fatty acid receptor 1 (O3FAR1), transcript variant 1, mRNA.	257					negative regulation of cytokine secretion|negative regulation of inflammatory response|regulation of glucose transport	integral to membrane|plasma membrane	fatty acid binding			breast(1)|endometrium(1)|kidney(2)|lung(6)|prostate(2)	12						GGAAGAGGCTCACGGTAAGCC	0.567000													4	68					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110396357	110396357	+	Splice_Site	SNP	G	G	A			TCGA-ET-A25G-01A-11D-A16O-08	TCGA-ET-A25G-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5fe7249-10b3-4a0b-96dc-be4c7d3e5c8c	41324b55-de97-4320-b264-4073c08443e1	g.chr8:110396357G>A	uc003yne.3	+	5	579	c.475_splice	c.e5+1	p.G159_splice		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	Homo sapiens polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 (PKHD1L1), mRNA.	159	IPT/TIG 2.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GGAACTCCAGGTCTGTTATAT	0.279000										HNSCC(38;0.096)			8	171					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-ET-A25G-01A-11D-A16O-08	TCGA-ET-A25G-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5fe7249-10b3-4a0b-96dc-be4c7d3e5c8c	41324b55-de97-4320-b264-4073c08443e1	g.chr7:140453136A>T	uc003vwc.4	-	14	1860	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(41204)|p.V600K(615)|p.V600?(377)|p.V600R(99)|p.V600D(40)|p.V600_K601>E(30)|p.V600L(28)|p.V600A(24)|p.V600G(22)|p.V600M(22)|p.A598_T599insV(7)|p.T599_V600insT(7)|p.T599I(5)|p.V600Q(4)|p.T599_R603>I(4)|p.T599_V600insTT(3)|p.T599_V600insDFGLAT(2)|p.T599_V600>IAL(2)|p.V600_S605>EK(2)|p.T599T(2)|p.V600_S605>DV(2)|p.V600_S605>D(2)|p.V600_W604del(1)|p.V600V(1)|p.T599_V600insV(1)|p.V600>DLAT(1)|p.D594_T599del(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				34	53					0	0	1	0	0
PABPC3	5042	broad.mit.edu	37	13	25670442	25670442	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A25G-01A-11D-A16O-08	TCGA-ET-A25G-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5fe7249-10b3-4a0b-96dc-be4c7d3e5c8c	41324b55-de97-4320-b264-4073c08443e1	g.chr13:25670442C>T	uc001upy.3	+	0	167	c.106C>T	c.(106-108)Ccc>Tcc	p.P36S		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	Homo sapiens poly(A) binding protein, cytoplasmic 3 (PABPC3), mRNA.	36	RRM 1.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|pancreas(1)|skin(3)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		CCCGGCAGGGCCCATCCTCTC	0.627000													30	45					0	0	1	0	0
MIR1275	100302123	broad.mit.edu	37	6	33967792	33967792	+	RNA	SNP	C	C	T			TCGA-ET-A25G-01A-11D-A16O-08	TCGA-ET-A25G-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5fe7249-10b3-4a0b-96dc-be4c7d3e5c8c	41324b55-de97-4320-b264-4073c08443e1	g.chr6:33967792C>T	uc021yyr.1	-	0		c.37G>A								Homo sapiens microRNA 1275 (MIR1275), microRNA.																		CTTACAGACACAAGACAGCCT	0.522000													24	42					0	0	1	0	0
MPDZ	8777	broad.mit.edu	37	9	13217196	13217196	+	Missense_Mutation	SNP	A	A	G			TCGA-ET-A25G-01A-11D-A16O-08	TCGA-ET-A25G-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5fe7249-10b3-4a0b-96dc-be4c7d3e5c8c	41324b55-de97-4320-b264-4073c08443e1	g.chr9:13217196A>G	uc010mhy.3	-	7	1241	c.1184T>C	c.(1183-1185)aTt>aCt	p.I395T	MPDZ_uc010mhz.3_Missense_Mutation_p.I395T|MPDZ_uc011lmn.2_Missense_Mutation_p.I395T|MPDZ_uc003zlb.4_Missense_Mutation_p.I395T|MPDZ_uc010mia.1_Missense_Mutation_p.I395T	NM_003829	NP_003820	O75970	MPDZ_HUMAN	Homo sapiens multiple PDZ domain protein (MPDZ), mRNA.	395	PDZ 3.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(15)|ovary(5)|prostate(7)|stomach(1)|urinary_tract(2)	61				GBM - Glioblastoma multiforme(50;2.03e-06)		TTTATCTCCAATGTAGCCAGC	0.303000													15	17					0	0	1	0	0
ARHGAP18	93663	broad.mit.edu	37	6	129920497	129920497	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A25G-01A-11D-A16O-08	TCGA-ET-A25G-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5fe7249-10b3-4a0b-96dc-be4c7d3e5c8c	41324b55-de97-4320-b264-4073c08443e1	g.chr6:129920497G>A	uc003qbr.3	-	11	1666	c.1577C>T	c.(1576-1578)cCc>cTc	p.P526L	ARHGAP18_uc011ebw.2_Missense_Mutation_p.P526L	NM_033515	NP_277050	Q8N392	RHG18_HUMAN	Homo sapiens Rho GTPase activating protein 18 (ARHGAP18), mRNA.	526					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			NS(2)|endometrium(1)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(3)	18				OV - Ovarian serous cystadenocarcinoma(136;0.0621)|GBM - Glioblastoma multiforme(226;0.0638)|all cancers(137;0.074)		AATAAACTTGGGAATCTATAG	0.294000													12	36					0	0	1	0	0
ZSCAN20	7579	broad.mit.edu	37	1	33944900	33944900	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A25G-01A-11D-A16O-08	TCGA-ET-A25G-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5fe7249-10b3-4a0b-96dc-be4c7d3e5c8c	41324b55-de97-4320-b264-4073c08443e1	g.chr1:33944900C>T	uc001bxj.4	+	1	178	c.11C>T	c.(10-12)gCc>gTc	p.A4V	ZSCAN20_uc001bxk.2_Missense_Mutation_p.A4V|ZSCAN20_uc009vui.3_Missense_Mutation_p.A4V	NM_145238	NP_660281	P17040	ZSC20_HUMAN	Homo sapiens zinc finger and SCAN domain containing 20 (ZSCAN20), mRNA.	4					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(2)|pancreas(1)|stomach(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				ATGGCTATGGCCCTGGAATTG	0.512000													38	56					0	0	1	0	0
COL6A2	1292	broad.mit.edu	37	21	47538972	47538972	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A25G-01A-11D-A16O-08	TCGA-ET-A25G-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5fe7249-10b3-4a0b-96dc-be4c7d3e5c8c	41324b55-de97-4320-b264-4073c08443e1	g.chr21:47538972G>A	uc002zia.1	+	13	1290	c.1208G>A	c.(1207-1209)gGa>gAa	p.G403E	COL6A2_uc002zhz.1_Missense_Mutation_p.G403E|COL6A2_uc002zhy.1_Missense_Mutation_p.G403E	NM_001849	NP_001840	P12110	CO6A2_HUMAN	Homo sapiens collagen, type VI, alpha 2 (COL6A2), transcript variant 2C2, mRNA.	403	Triple-helical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		GGAGCCCCAGGAAGTCCTGGT	0.677000													10	17					0	0	1	0	0