Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KBTBD10	10324	broad.mit.edu	37	2	170367329	170367329	+	Silent	SNP	A	A	T			TCGA-ET-A39I-01A-11D-A19J-08	TCGA-ET-A39I-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9cc1725-7bdb-49a3-bbd7-b3cae63ef41d	18c8e8c6-9edf-4421-869c-bb7d800c659e	g.chr2:170367329A>T	uc002ueu.1	+	0	1118	c.1041A>T	c.(1039-1041)atA>atT	p.I347I	KBTBD10_uc010zdh.1_Intron	NM_006063	NP_006054	O60662	KBTBA_HUMAN	Homo sapiens kelch repeat and BTB (POZ) domain containing 10 (KBTBD10), mRNA.	347					striated muscle contraction	centrosome|nucleolus|plasma membrane|pseudopodium|ruffle				breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|urinary_tract(1)	19						AAAATCAGATATATGTGGTAG	0.413000													16	85					0	0	1	0	0
BPTF	2186	broad.mit.edu	37	17	65941716	65941716	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ET-A39I-01A-11D-A19J-08	TCGA-ET-A39I-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9cc1725-7bdb-49a3-bbd7-b3cae63ef41d	18c8e8c6-9edf-4421-869c-bb7d800c659e	g.chr17:65941716G>T	uc002jgf.3	+	20	6953	c.6892G>T	c.(6892-6894)Gaa>Taa	p.E2298*	BPTF_uc002jge.3_Nonsense_Mutation_p.E2424*|BPTF_uc021uca.1_Nonsense_Mutation_p.E98*|BPTF_uc002jgg.3_Nonsense_Mutation_p.E98*|BPTF_uc002jgh.3_5'Flank	NM_182641	NP_872579	Q12830	BPTF_HUMAN	Homo sapiens bromodomain PHD finger transcription factor (BPTF), transcript variant 1, mRNA.	2424					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex|cytoplasm	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			GACTCAGCCTGAAGTTCAGAC	0.582000													3	19					0	0	1	0	0
MEPCE	56257	broad.mit.edu	37	7	100028059	100028059	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A39I-01A-11D-A19J-08	TCGA-ET-A39I-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9cc1725-7bdb-49a3-bbd7-b3cae63ef41d	18c8e8c6-9edf-4421-869c-bb7d800c659e	g.chr7:100028059C>T	uc003uuw.3	+	0	806	c.418C>T	c.(418-420)Cgg>Tgg	p.R140W	ZCWPW1_uc003uut.3_5'Flank|ZCWPW1_uc011kjr.2_5'Flank|ZCWPW1_uc003uuu.1_5'Flank|ZCWPW1_uc011kjt.1_5'Flank|ZCWPW1_uc011kju.1_5'Flank|MEPCE_uc022ain.1_Intron|MEPCE_uc022aio.1_Intron|MEPCE_uc003uuv.3_Intron	NM_019606	NP_062552	Q7L2J0	MEPCE_HUMAN	Homo sapiens methylphosphate capping enzyme (MEPCE), transcript variant 1, mRNA.	140	Gly-rich.						methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(2)|lung(9)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TCAGCCCCACCGGCCACCTGG	0.706000													4	9					0	0	1	0	0
ATG2B	55102	broad.mit.edu	37	14	96794755	96794755	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A39I-01A-11D-A19J-08	TCGA-ET-A39I-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9cc1725-7bdb-49a3-bbd7-b3cae63ef41d	18c8e8c6-9edf-4421-869c-bb7d800c659e	g.chr14:96794755G>A	uc001yfi.3	-	13	2457	c.2092C>T	c.(2092-2094)Cca>Tca	p.P698S		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	Homo sapiens ATG2 autophagy related 2 homolog B (S. cerevisiae) (ATG2B), mRNA.	698										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		AGTTTCTGTGGTTGAAGCAAG	0.358000													10	51					0	0	1	0	0
ZNF777	27153	broad.mit.edu	37	7	149129526	149129526	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A39I-01A-11D-A19J-08	TCGA-ET-A39I-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9cc1725-7bdb-49a3-bbd7-b3cae63ef41d	18c8e8c6-9edf-4421-869c-bb7d800c659e	g.chr7:149129526G>A	uc003wfv.3	-	5	2000	c.1837C>T	c.(1837-1839)Ccc>Tcc	p.P613S		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	Homo sapiens zinc finger protein 777 (ZNF777), mRNA.	613					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(5)|lung(17)|ovary(1)|skin(2)|urinary_tract(1)	26	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			GCGTGCTTGGGGTTGAACGTG	0.672000													42	66					0	0	1	0	0
TCF7L1	83439	broad.mit.edu	37	2	85536172	85536172	+	Nonsense_Mutation	SNP	A	A	T			TCGA-ET-A39I-01A-11D-A19J-08	TCGA-ET-A39I-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9cc1725-7bdb-49a3-bbd7-b3cae63ef41d	18c8e8c6-9edf-4421-869c-bb7d800c659e	g.chr2:85536172A>T	uc002soy.3	+	11	1579	c.1354A>T	c.(1354-1356)Aag>Tag	p.K452*		NM_031283	NP_112573	Q9HCS4	TF7L1_HUMAN	Homo sapiens transcription factor 7-like 1 (T-cell specific, HMG-box) (TCF7L1), mRNA.	452					Wnt receptor signaling pathway|chromatin organization|regulation of Wnt receptor signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|skin(4)|upper_aerodigestive_tract(1)	18						CTCCAAGAGCAAGAAGCCATG	0.602000													112	160					0	0	1	0	0
SLC6A16	28968	broad.mit.edu	37	19	49812977	49812977	+	Silent	SNP	G	G	A			TCGA-ET-A39I-01A-11D-A19J-08	TCGA-ET-A39I-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9cc1725-7bdb-49a3-bbd7-b3cae63ef41d	18c8e8c6-9edf-4421-869c-bb7d800c659e	g.chr19:49812977G>A	uc002pmz.3	-	4	1041	c.807C>T	c.(805-807)gtC>gtT	p.V269V	SLC6A16_uc002pna.3_Silent_p.V269V|MIR4324_uc021uxj.1_5'Flank	NM_014037	NP_054756	Q9GZN6	S6A16_HUMAN	Homo sapiens solute carrier family 6, member 16 (SLC6A16), mRNA.	269						integral to membrane|intracellular	neurotransmitter:sodium symporter activity			NS(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00099)|GBM - Glioblastoma multiforme(486;0.0336)		AGAAGGGCAGGACCAGACTGT	0.502000													23	43					0	0	1	0	0
ZNF148	7707	broad.mit.edu	37	3	124951687	124951687	+	Missense_Mutation	SNP	A	A	C			TCGA-ET-A39I-01A-11D-A19J-08	TCGA-ET-A39I-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9cc1725-7bdb-49a3-bbd7-b3cae63ef41d	18c8e8c6-9edf-4421-869c-bb7d800c659e	g.chr3:124951687A>C	uc003ehx.4	-	8	2369	c.1883T>G	c.(1882-1884)cTt>cGt	p.L628R	SLC12A8_uc003ehw.4_Intron|ZNF148_uc003ehz.4_Missense_Mutation_p.L628R|ZNF148_uc010hsa.3_Missense_Mutation_p.L628R|ZNF148_uc003eia.4_Missense_Mutation_p.L628R|ZNF148_uc003ehy.3_Intron	NM_021964	NP_068799	Q9UQR1	ZN148_HUMAN	Homo sapiens zinc finger protein 148 (ZNF148), mRNA.	628					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|liver(1)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)	28						CACAAAGTTAAGGCTCGGGCT	0.453000													28	162					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533874	533874	+	Missense_Mutation	SNP	T	T	C	rs121913233		TCGA-ET-A39I-01A-11D-A19J-08	TCGA-ET-A39I-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9cc1725-7bdb-49a3-bbd7-b3cae63ef41d	18c8e8c6-9edf-4421-869c-bb7d800c659e	g.chr11:533874T>C	uc001lpv.3	-	2	370	c.182A>G	c.(181-183)cAg>cGg	p.Q61R	HRAS_uc010qvw.2_Missense_Mutation_p.Q61R|HRAS_uc010qvx.2_Missense_Mutation_p.Q61R|HRAS_uc010qvy.2_Non-coding_Transcript	NM_005343	NP_005334	P01112	RASH_HUMAN	Homo sapiens v-Ha-ras Harvey rat sarcoma viral oncogene homolog (HRAS), transcript variant 1, mRNA.	61			Q -> K (in follicular thyroid carcinoma samples; somatic mutation; increases transformation of cultured cell lines; dbSNP:rs28933406).|Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).		Ras protein signal transduction|activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|synaptic transmission	Golgi membrane|cytosol|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(265)|p.Q61L(230)|p.Q61K(59)|p.Q61H(20)|p.Q61P(6)|p.Q61?(1)|p.Q61Q(1)|p.Q61E(1)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GTACTCCTCCTGGCCGGCGGT	0.597000	Q61L(KNS62_LUNG)|Q61L(KYSE30_OESOPHAGUS)|Q61L(NCIH1915_LUNG)	6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			39	52					0	0	1	0	0
EPG5	57724	broad.mit.edu	37	18	43469775	43469775	+	Missense_Mutation	SNP	T	T	C			TCGA-ET-A39I-01A-11D-A19J-08	TCGA-ET-A39I-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9cc1725-7bdb-49a3-bbd7-b3cae63ef41d	18c8e8c6-9edf-4421-869c-bb7d800c659e	g.chr18:43469775T>C	uc002lbm.3	-	27	5040	c.4940A>G	c.(4939-4941)gAa>gGa	p.E1647G	EPG5_uc010xcr.1_Non-coding_Transcript|EPG5_uc010xcs.1_Non-coding_Transcript|EPG5_uc010xcq.1_Missense_Mutation_p.E201G|EPG5_uc002lbn.2_Missense_Mutation_p.E522G	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	Homo sapiens ectopic P-granules autophagy protein 5 homolog (C. elegans) (EPG5), mRNA.	1647					autophagy					NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(35)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	95						GATCAAGTTTTCTGCATGTAC	0.398000													50	69					0	0	1	0	0
MLLT1	4298	broad.mit.edu	37	19	6230657	6230657	+	Missense_Mutation	SNP	T	T	C			TCGA-ET-A39I-01A-11D-A19J-08	TCGA-ET-A39I-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9cc1725-7bdb-49a3-bbd7-b3cae63ef41d	18c8e8c6-9edf-4421-869c-bb7d800c659e	g.chr19:6230657T>C	uc002mek.3	-	3	508	c.344A>G	c.(343-345)aAc>aGc	p.N115S		NM_005934	NP_005925	Q03111	ENL_HUMAN	Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 (MLLT1), mRNA.	115					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|protein binding	p.V114M(1)|p.N115K(1)		endometrium(3)|kidney(3)|large_intestine(2)|lung(5)|prostate(2)|skin(2)	17						GCGCAGGTGGTTCACGGGCGG	0.617000			T	MLL	AL								61	93					0	0	1	0	0
SLC24A6	80024	broad.mit.edu	37	12	113745553	113745553	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A39I-01A-11D-A19J-08	TCGA-ET-A39I-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9cc1725-7bdb-49a3-bbd7-b3cae63ef41d	18c8e8c6-9edf-4421-869c-bb7d800c659e	g.chr12:113745553G>A	uc001tvc.3	-	12	1564	c.1354C>T	c.(1354-1356)Cgg>Tgg	p.R452W	SLC24A6_uc001tuz.3_Missense_Mutation_p.R157W|SLC24A6_uc001tva.3_Non-coding_Transcript|SLC24A6_uc001tvb.3_Missense_Mutation_p.R190W	NM_024959	NP_079235	Q6J4K2	NCKX6_HUMAN	Homo sapiens solute carrier family 24 (sodium/potassium/calcium exchanger), member 6 (SLC24A6), mRNA.	452					response to stimulus|sodium ion transport	integral to membrane|plasma membrane	calcium:cation antiporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(3)|skin(1)	16						TTGCTCAGCCGGAAGACCACA	0.642000													3	45					0	0	1	0	0