Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
BOD1L1	259282	broad.mit.edu	37	4	13597501	13597501	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A4KN-01A-11D-A257-08	TCGA-ET-A4KN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	178d0486-cb0d-4979-8bdf-bb3fe99149bd	e3d4072c-07ef-4978-a687-43828578a9b3	g.chr4:13597501C>T	uc003gmz.1	-	11	8204	c.8087G>A	c.(8086-8088)gGa>gAa	p.G2696E		NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	Homo sapiens biorientation of chromosomes in cell division 1-like (BOD1L), mRNA.	2696							DNA binding										ACTTGGCTTTCCCCCACACAG	0.378000													16	123					0	0	1	0	0
PTK2B	2185	broad.mit.edu	37	8	27291612	27291612	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A4KN-01A-11D-A257-08	TCGA-ET-A4KN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	178d0486-cb0d-4979-8bdf-bb3fe99149bd	e3d4072c-07ef-4978-a687-43828578a9b3	g.chr8:27291612G>A	uc003xfn.2	+	16	1916	c.1108G>A	c.(1108-1110)Ggt>Agt	p.G370S	PTK2B_uc022ate.1_Missense_Mutation_p.G370S|PTK2B_uc003xfp.2_Missense_Mutation_p.G370S|PTK2B_uc003xfq.2_Missense_Mutation_p.G370S|PTK2B_uc010luq.1_Missense_Mutation_p.G128S|PTK2B_uc003xfr.1_Missense_Mutation_p.G116S	NM_173174	NP_775268	Q14289	FAK2_HUMAN	Homo sapiens PTK2B protein tyrosine kinase 2 beta (PTK2B), transcript variant 1, mRNA.	370					apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(17)|ovary(4)|skin(12)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		CTTCCTAGATGGTGAGAAGCG	0.582000													22	89					0	0	1	0	0
MMP2	4313	broad.mit.edu	37	16	55516924	55516924	+	Missense_Mutation	SNP	C	C	G			TCGA-ET-A4KN-01A-11D-A257-08	TCGA-ET-A4KN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	178d0486-cb0d-4979-8bdf-bb3fe99149bd	e3d4072c-07ef-4978-a687-43828578a9b3	g.chr16:55516924C>G	uc002ehz.4	+	1	568	c.257C>G	c.(256-258)aCa>aGa	p.T86R	MMP2_uc010vhd.2_Missense_Mutation_p.T10R|MMP2_uc010ccc.3_Missense_Mutation_p.T36R	NM_004530	NP_004521	P08253	MMP2_HUMAN	Homo sapiens matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (MMP2), transcript variant 1, mRNA.	86					angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding	p.T86T(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|liver(2)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	58		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	CTGCCCCAGACAGGTGATCTT	0.532000													12	81					0	0	1	0	0
MON2	23041	broad.mit.edu	37	12	62986421	62986421	+	Silent	SNP	C	C	T			TCGA-ET-A4KN-01A-11D-A257-08	TCGA-ET-A4KN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	178d0486-cb0d-4979-8bdf-bb3fe99149bd	e3d4072c-07ef-4978-a687-43828578a9b3	g.chr12:62986421C>T	uc001sre.3	+	34	5437	c.5046C>T	c.(5044-5046)tgC>tgT	p.C1682C	MON2_uc010ssn.2_Silent_p.C1676C|MON2_uc009zqj.3_3'UTR|MON2_uc010ssl.2_Silent_p.C1610C|MON2_uc010ssm.2_Silent_p.C1653C|MON2_uc001srf.3_Silent_p.C1445C|MON2_uc001srg.3_Silent_p.C551C	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	Homo sapiens MON2 homolog (S. cerevisiae) (MON2), mRNA.	1683					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		TAGTAGAATGCATCACCTGTT	0.393000													22	43					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70900084	70900084	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A4KN-01A-11D-A257-08	TCGA-ET-A4KN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	178d0486-cb0d-4979-8bdf-bb3fe99149bd	e3d4072c-07ef-4978-a687-43828578a9b3	g.chr2:70900084G>A	uc021vjc.1	-	14	2061	c.1796C>T	c.(1795-1797)gCt>gTt	p.A599V	ADD2_uc010fds.2_Non-coding_Transcript|ADD2_uc002sgy.3_Missense_Mutation_p.L628F|ADD2_uc002sgz.3_Missense_Mutation_p.A599V	NM_001185054	NP_001608	P35612	ADDB_HUMAN	Homo sapiens adducin 2 (beta) (ADD2), transcript variant 5, mRNA.	599					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	F-actin capping protein complex|cytoplasm|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						CACTGGAGAAGCAGGTGCAGA	0.512000													6	29					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56091578	56091578	+	Missense_Mutation	SNP	T	T	G			TCGA-ET-A4KN-01A-11D-A257-08	TCGA-ET-A4KN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	178d0486-cb0d-4979-8bdf-bb3fe99149bd	e3d4072c-07ef-4978-a687-43828578a9b3	g.chr12:56091578T>G	uc001shh.3	-	8	1542	c.1322A>C	c.(1321-1323)aAg>aCg	p.K441T	ITGA7_uc001shg.3_Missense_Mutation_p.K437T|ITGA7_uc010sps.2_Missense_Mutation_p.K344T|ITGA7_uc009znw.3_5'Flank|ITGA7_uc009znx.3_Missense_Mutation_p.K324T	NM_001144996	NP_001138468	Q13683	ITA7_HUMAN	Homo sapiens integrin, alpha 7 (ITGA7), transcript variant 1, mRNA.	481					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						GCCGAAGCTCTTGATGCCCAC	0.622000													7	121					0	0	1	0	0
MED11	400569	broad.mit.edu	37	17	4634849	4634849	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A4KN-01A-11D-A257-08	TCGA-ET-A4KN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	178d0486-cb0d-4979-8bdf-bb3fe99149bd	e3d4072c-07ef-4978-a687-43828578a9b3	g.chr17:4634849G>A	uc002fyp.3	+	0	127	c.65G>A	c.(64-66)gGc>gAc	p.G22D		NM_001001683	NP_001001683	Q9P086	MED11_HUMAN	Homo sapiens mediator complex subunit 11 (MED11), mRNA.	22					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex	protein binding			lung(2)|ovary(2)	4						CGGGAAATCGGCGCCATCCTT	0.577000											OREG0024104	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	37					0	0	1	0	0
C16orf5	29965	broad.mit.edu	37	16	4563025	4563025	+	Silent	SNP	G	G	A			TCGA-ET-A4KN-01A-11D-A257-08	TCGA-ET-A4KN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	178d0486-cb0d-4979-8bdf-bb3fe99149bd	e3d4072c-07ef-4978-a687-43828578a9b3	g.chr16:4563025G>A	uc002cwv.3	-	4	532	c.282C>T	c.(280-282)taC>taT	p.Y94Y	C16orf5_uc002cww.3_Silent_p.Y94Y|C16orf5_uc010uxl.2_Intron|C16orf5_uc010uxm.2_Intron|C16orf5_uc010btu.3_Intron|C16orf5_uc002cwu.3_Silent_p.Y94Y	NM_001199054	NP_001185983	Q9H305	LITFL_HUMAN	Homo sapiens chromosome 16 open reading frame 5 (C16orf5), transcript variant 1, mRNA.	94	Pro-rich.				DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|apoptosis|tumor necrosis factor-mediated signaling pathway	nucleus				NS(1)|endometrium(1)|lung(2)|ovary(1)	5		Ovarian(90;0.17)				CTGGGGGGTAGTAGCCCATGG	0.657000													3	3					0	0	1	0	0
PRC1	9055	broad.mit.edu	37	15	91517940	91517940	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ET-A4KN-01A-11D-A257-08	TCGA-ET-A4KN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	178d0486-cb0d-4979-8bdf-bb3fe99149bd	e3d4072c-07ef-4978-a687-43828578a9b3	g.chr15:91517940G>A	uc002bqm.3	-	9	1382	c.1225C>T	c.(1225-1227)Cga>Tga	p.R409*	PRC1_uc002bqn.3_Nonsense_Mutation_p.R409*|PRC1_uc002bqo.3_Nonsense_Mutation_p.R409*|PRC1_uc010uqs.2_Nonsense_Mutation_p.R368*	NM_003981	NP_003972	O43663	PRC1_HUMAN	Homo sapiens protein regulator of cytokinesis 1 (PRC1), transcript variant 1, mRNA.	409	Spectrin-fold.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(3)|prostate(1)|skin(2)	25	Lung NSC(78;0.0987)|all_lung(78;0.175)					AATTCAATTCGTGCCTTCAAC	0.413000													9	199					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121729541	121729541	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A4KN-01A-11D-A257-08	TCGA-ET-A4KN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	178d0486-cb0d-4979-8bdf-bb3fe99149bd	e3d4072c-07ef-4978-a687-43828578a9b3	g.chr2:121729541G>A	uc010flp.3	+	6	1114	c.1084G>A	c.(1084-1086)Gtc>Atc	p.V362I	GLI2_uc002tmq.1_Missense_Mutation_p.V34I|GLI2_uc002tmr.1_Missense_Mutation_p.V34I|GLI2_uc002tmt.4_Missense_Mutation_p.V34I|GLI2_uc002tmu.4_Missense_Mutation_p.V34I|GLI2_uc010flo.1_Missense_Mutation_p.V237I|GLI2_uc002tmw.1_Missense_Mutation_p.V362I	NM_005270	NP_005261	P10070	GLI2_HUMAN	Homo sapiens GLI family zinc finger 2 (GLI2), mRNA.	362					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				TGAGTCGGCCGTCAGCAGCAC	0.592000													12	47					0	0	1	0	0
CDKN1A	1026	broad.mit.edu	37	6	36651904	36651904	+	Missense_Mutation	SNP	G	G	C	rs143419412	byFrequency	TCGA-ET-A4KN-01A-11D-A257-08	TCGA-ET-A4KN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	178d0486-cb0d-4979-8bdf-bb3fe99149bd	e3d4072c-07ef-4978-a687-43828578a9b3	g.chr6:36651904G>C	uc011dtq.2	+	1	154	c.128G>C	c.(127-129)cGt>cCt	p.R43P	CDKN1A_uc021yzb.1_Missense_Mutation_p.R9P|CDKN1A_uc021yzc.1_Missense_Mutation_p.R9P|CDKN1A_uc003omm.4_Missense_Mutation_p.R9P|CDKN1A_uc003omn.3_Missense_Mutation_p.R9P	NM_078467	NP_510867	P38936	CDN1A_HUMAN	Homo sapiens cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A), transcript variant 2, mRNA.	9					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|Ras protein signal transduction|S phase of mitotic cell cycle|cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|stress-induced premature senescence	PCNA-p21 complex|cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|urinary_tract(5)	15						GGGGATGTCCGTCAGAACCCA	0.632000													7	32					0	0	1	0	0