Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZXDB	158586	broad.mit.edu	37	X	57619114	57619114	+	Silent	SNP	G	G	C			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chrX:57619114G>C	ENST00000374888.1	+	1	846	c.633G>C	c.(631-633)ccG>ccC	p.P211P		NM_007157.3	NP_009088.1	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	211					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(2)|skin(6)	27						TGATCGCCCCGCAAGCTGGGT	0.736000													3	18					0	0	1	0	0
LPP	4026	broad.mit.edu	37	3	188426115	188426115	+	Missense_Mutation	SNP	G	G	C			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr3:188426115G>C	ENST00000312675.4	+	7	1420	c.1174G>C	c.(1174-1176)Gag>Cag	p.E392Q	LPP_ENST00000448637.1_Missense_Mutation_p.E392Q|LPP_ENST00000543006.1_Missense_Mutation_p.E392Q|LPP_ENST00000471917.1_3'UTR	NM_001167672.1|NM_005578.3	NP_001161144.1|NP_005569.1	Q93052	LPP_HUMAN	LIM domain containing preferred translocation partner in lipoma	392					cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	NS(1)|breast(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		CCCAGAGGATGAGCTTGAGCA	0.512000			T	"""HMGA2, MLL, C12orf9"""	"""lipoma, leukemia"""								8	67					0	0	1	0	0
ULBP1	80329	broad.mit.edu	37	6	150290338	150290338	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr6:150290338G>A	ENST00000229708.2	+	3	510	c.467G>A	c.(466-468)aGa>aAa	p.R156K	ULBP1_ENST00000367345.1_Missense_Mutation_p.R156K	NM_025218.2	NP_079494.1	Q9BZM6	N2DL1_HUMAN	UL16 binding protein 1	156	MHC class I alpha-2 like.				antigen processing and presentation|immune response|natural killer cell activation|regulation of immune response	anchored to membrane|endoplasmic reticulum|MHC class I protein complex	MHC class I receptor activity			large_intestine(3)|lung(5)|pancreas(1)|skin(1)	10		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.14e-11)		TCAAACAACAGAAAGTGGACA	0.493000													5	65					0	0	1	0	0
ZNF852	285346	broad.mit.edu	37	3	44540766	44540766	+	Silent	SNP	C	C	T	rs62251380	by1000genomes	TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr3:44540766C>T	ENST00000436261.1	-	4	1663	c.1503G>A	c.(1501-1503)gtG>gtA	p.V501V				B6EU87	B6EU87_HUMAN	zinc finger protein 852	0					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|lung(5)	8						AAGGCTTTCCCACACTCAATA	0.473000													3	39					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102303843	102303843	+	RNA	SNP	T	T	C			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr15:102303843T>C	ENST00000561463.1	+	0	11889																											GTCCAACCTGTACTCGCGTGG	0.592000													2	1					0	0	1	0	0
EFTUD2	9343	broad.mit.edu	37	17	42941049	42941049	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr17:42941049C>T	ENST00000426333.2	-	15	1684	c.1387G>A	c.(1387-1389)Gag>Aag	p.E463K	EFTUD2_ENST00000591382.1_Missense_Mutation_p.E463K|EFTUD2_ENST00000402521.3_Missense_Mutation_p.E428K|EFTUD2_ENST00000592576.1_Missense_Mutation_p.E453K	NM_001142605.1|NM_001258354.1|NM_004247.3	NP_001136077.1|NP_001245283.1|NP_004238.3	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain containing 2	463						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	32		Prostate(33;0.109)				CTCATAGCCTCGCCGAGGTCG	0.552000													5	57					0	0	1	0	0
MET	0	broad.mit.edu	37	7	116436137	116436137	+	Missense_Mutation	SNP	G	G	C			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr7:116436137G>C	ENST00000397752.3	+	21	4332	c.4132G>C	c.(4132-4134)Gag>Cag	p.E1378Q	MET_ENST00000539704.1_Missense_Mutation_p.E248Q|MET_ENST00000318493.6_Missense_Mutation_p.E1396Q	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	1378	Interaction with RANBP9.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			CGCTGATGATGAGGTGGACAC	0.463000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				11	133					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				24	41					0	0	1	0	0
GPANK1	7918	broad.mit.edu	37	6	31630196	31630196	+	Silent	SNP	C	C	T	rs146741893	byFrequency	TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr6:31630196C>T	ENST00000375906.1	-	4	1602	c.918G>A	c.(916-918)gtG>gtA	p.V306V	GPANK1_ENST00000375895.2_Silent_p.V306V|GPANK1_ENST00000375893.2_Silent_p.V306V|GPANK1_ENST00000375900.4_Silent_p.V306V|GPANK1_ENST00000375896.4_Silent_p.V306V	NM_001199237.1	NP_001186166.1	O95872	GPAN1_HUMAN	G patch domain and ankyrin repeats 1	306						intracellular	nucleic acid binding			central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(7)	12						GGAAATGTGTCACTCGGGGCT	0.647000													4	53					0	0	1	0	0
CYP1A2	1544	broad.mit.edu	37	15	75042337	75042337	+	Silent	SNP	G	G	A			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr15:75042337G>A	ENST00000343932.4	+	2	321	c.258G>A	c.(256-258)ctG>ctA	p.L86L		NM_000761.3	NP_000752.2	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 2	86					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	CGCCCGTGCTGGTGCTGAGCC	0.652000													5	55					0	0	1	0	0
CHRNA10	57053	broad.mit.edu	37	11	3687763	3687763	+	Silent	SNP	G	G	A			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr11:3687763G>A	ENST00000250699.2	-	5	998	c.927C>T	c.(925-927)gtC>gtT	p.V309V	CHRNA10_ENST00000534359.1_3'UTR	NM_020402.2	NP_065135.2	Q9GZZ6	ACH10_HUMAN	cholinergic receptor, nicotinic, alpha 10 (neuronal)	309					elevation of cytosolic calcium ion concentration|regulation of cell proliferation|synaptic transmission, cholinergic	cell junction|postsynaptic membrane	calcium channel activity|receptor activity|receptor binding			breast(1)|endometrium(2)|lung(3)|ovary(1)	7		Medulloblastoma(188;0.0075)|Breast(177;0.0164)|all_neural(188;0.0577)		BRCA - Breast invasive adenocarcinoma(625;0.0344)|LUSC - Lung squamous cell carcinoma(625;0.192)	Chloroprocaine(DB01161)|Methadone(DB00333)|Nicotine(DB00184)|Pentolinium(DB01090)|Procaine(DB00721)|Trimethaphan(DB01116)	TTGAGAATGTGACCATGGTCA	0.537000													3	28					0	0	1	0	0
GLE1	2733	broad.mit.edu	37	9	131296128	131296128	+	Missense_Mutation	SNP	G	G	C			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr9:131296128G>C	ENST00000309971.4	+	11	1650	c.1544G>C	c.(1543-1545)aGa>aCa	p.R515T	RP11-216B9.6_ENST00000434999.1_RNA|GLE1_ENST00000372770.4_Missense_Mutation_p.R515T|GLE1_ENST00000539582.1_Missense_Mutation_p.R261T	NM_001003722.1	NP_001003722.1	Q53GS7	GLE1_HUMAN	GLE1 RNA export mediator	515					poly(A)+ mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear pore	protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	16						CTCCACCCCAGAGTGGGGGAC	0.507000													7	90					0	0	1	0	0
KRTAP4-9	100132386	broad.mit.edu	37	17	39261693	39261693	+	Missense_Mutation	SNP	A	A	T	rs113059833	by1000genomes	TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr17:39261693A>T	ENST00000391415.1	+	1	110	c.53A>T	c.(52-54)gAc>gTc	p.D18V		NM_001146041.1	NP_001139513.1	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	18						keratin filament		p.D18V(1)		central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|urinary_tract(3)	14						TGCGGCCAAGACCTCTGTCAG	0.627000													6	20					0	0	1	0	0
USP34	9736	broad.mit.edu	37	2	61438933	61438933	+	Silent	SNP	G	G	A			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr2:61438933G>A	ENST00000398571.2	-	69	8890	c.8814C>T	c.(8812-8814)ggC>ggT	p.G2938G	USP34_ENST00000472689.1_5'UTR	NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	2938					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			AGCAGGAGCGGCCATCTAAGC	0.343000													3	21					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10546211	10546211	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr17:10546211C>A	ENST00000583535.1	-	15	1600	c.1513G>T	c.(1513-1515)Gaa>Taa	p.E505*	MYH3_ENST00000226209.7_Nonsense_Mutation_p.E505*	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	505	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						TCGATGCCTTCCTTCTTGTAC	0.517000													5	92					1.23904e-05	1.31413e-05	1	1	0
SPTA1	6708	broad.mit.edu	37	1	158618337	158618337	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr1:158618337C>T	ENST00000368148.3	-	26	3856	c.3676G>A	c.(3676-3678)Gag>Aag	p.E1226K	SPTA1_ENST00000368147.3_Missense_Mutation_p.E1226K	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1226					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TCAAAGCCCTCATGCCGTCGC	0.498000													8	75					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79031080	79031080	+	Silent	SNP	G	G	A			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr5:79031080G>A	ENST00000446378.2	+	2	6523	c.6492G>A	c.(6490-6492)ccG>ccA	p.P2164P		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2164						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TGGCTAAGCCGGACCTTCCTG	0.458000													4	53					0	0	1	0	0
CAPN9	10753	broad.mit.edu	37	1	230898481	230898481	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr1:230898481C>T	ENST00000354537.1	+	4	567	c.485C>T	c.(484-486)tCt>tTt	p.S162F	CAPN9_ENST00000271971.2_Missense_Mutation_p.S162F|RP11-99J16__A.2_ENST00000412344.1_RNA|CAPN9_ENST00000366666.2_Missense_Mutation_p.S99F	NM_016452.1	NP_057536.1	O14815	CAN9_HUMAN	calpain 9	162	Calpain catalytic.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	25	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				TTCCTCCACTCTGCCGACCAC	0.587000													4	29					0	0	1	0	0
OR5M10	390167	broad.mit.edu	37	11	56344739	56344739	+	Silent	SNP	G	G	A			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr11:56344739G>A	ENST00000526812.2	-	1	524	c.459C>T	c.(457-459)ttC>ttT	p.F153F		NM_001004741.1	NP_001004741.1	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M, member 10	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(2)	25						GCCCATTAAGGAAGCCATACA	0.458000													4	70					0	0	1	0	0
SRBD1	55133	broad.mit.edu	37	2	45801777	45801777	+	Silent	SNP	G	G	A			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr2:45801777G>A	ENST00000263736.4	-	8	1220	c.1158C>T	c.(1156-1158)ttC>ttT	p.F386F		NM_018079.4	NP_060549.4	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	386					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(13)|large_intestine(8)|lung(15)|skin(2)|stomach(1)|urinary_tract(1)	49		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			AGTTCCGAATGAAGTCAAGCG	0.388000													4	60					0	0	1	0	0
BTBD2	55643	broad.mit.edu	37	19	1987243	1987243	+	Silent	SNP	G	G	A			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr19:1987243G>A	ENST00000255608.4	-	7	1207	c.1191C>T	c.(1189-1191)gtC>gtT	p.V397V		NM_017797.3	NP_060267.2	Q9BX70	BTBD2_HUMAN	BTB (POZ) domain containing 2	397						cytoplasmic mRNA processing body	protein binding			endometrium(5)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|stomach(1)	12		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGCGCTTGTTGACTGAGAACC	0.617000													4	28					0	0	1	0	0
LPP	4026	broad.mit.edu	37	3	188426115	188426115	+	Missense_Mutation	SNP	G	G	C			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	85f7f6d9-9498-409c-99fc-d0853b075689	g.chr3:188426115G>C	ENST00000312675.4	+	7	1420	c.1174G>C	c.(1174-1176)Gag>Cag	p.E392Q	LPP_ENST00000471917.1_3'UTR|LPP_ENST00000448637.1_Missense_Mutation_p.E392Q|LPP_ENST00000543006.1_Missense_Mutation_p.E392Q	NM_001167672.1|NM_005578.3	NP_001161144.1|NP_005569.1	Q93052	LPP_HUMAN	LIM domain containing preferred translocation partner in lipoma	392					cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	NS(1)|breast(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		CCCAGAGGATGAGCTTGAGCA	0.512000			T	"""HMGA2, MLL, C12orf9"""	"""lipoma, leukemia"""								8	67					0	0	1	0	0
C9orf172	389813	broad.mit.edu	37	9	139740266	139740266	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	85f7f6d9-9498-409c-99fc-d0853b075689	g.chr9:139740266G>A	ENST00000436881.1	+	1	1400	c.1400G>A	c.(1399-1401)cGc>cAc	p.R467H		NM_001080482.2	NP_001073951.2	C9J069	CI172_HUMAN	chromosome 9 open reading frame 172	467										endometrium(2)|large_intestine(1)|lung(6)	9						GGCCGCGGCCGCAGCTACGAG	0.746000													2	1					0	0	1	0	0
ULBP1	80329	broad.mit.edu	37	6	150290338	150290338	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	85f7f6d9-9498-409c-99fc-d0853b075689	g.chr6:150290338G>A	ENST00000229708.2	+	3	510	c.467G>A	c.(466-468)aGa>aAa	p.R156K	ULBP1_ENST00000367345.1_Missense_Mutation_p.R156K	NM_025218.2	NP_079494.1	Q9BZM6	N2DL1_HUMAN	UL16 binding protein 1	156	MHC class I alpha-2 like.				antigen processing and presentation|immune response|natural killer cell activation|regulation of immune response	anchored to membrane|endoplasmic reticulum|MHC class I protein complex	MHC class I receptor activity			large_intestine(3)|lung(5)|pancreas(1)|skin(1)	10		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.14e-11)		TCAAACAACAGAAAGTGGACA	0.493000													5	65					0	0	1	0	0
BTBD2	55643	broad.mit.edu	37	19	1987243	1987243	+	Silent	SNP	G	G	A			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	85f7f6d9-9498-409c-99fc-d0853b075689	g.chr19:1987243G>A	ENST00000255608.4	-	7	1207	c.1191C>T	c.(1189-1191)gtC>gtT	p.V397V		NM_017797.3	NP_060267.2	Q9BX70	BTBD2_HUMAN	BTB (POZ) domain containing 2	397						cytoplasmic mRNA processing body	protein binding			endometrium(5)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|stomach(1)	12		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGCGCTTGTTGACTGAGAACC	0.617000													4	28					0	0	1	0	0
ZNF852	285346	broad.mit.edu	37	3	44540766	44540766	+	Silent	SNP	C	C	T	rs62251380	by1000genomes	TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	85f7f6d9-9498-409c-99fc-d0853b075689	g.chr3:44540766C>T	ENST00000436261.1	-	4	1663	c.1503G>A	c.(1501-1503)gtG>gtA	p.V501V				B6EU87	B6EU87_HUMAN	zinc finger protein 852	0					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|lung(5)	8						AAGGCTTTCCCACACTCAATA	0.473000													3	39					0	0	1	0	0
EFTUD2	9343	broad.mit.edu	37	17	42941049	42941049	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	85f7f6d9-9498-409c-99fc-d0853b075689	g.chr17:42941049C>T	ENST00000426333.2	-	15	1684	c.1387G>A	c.(1387-1389)Gag>Aag	p.E463K	EFTUD2_ENST00000591382.1_Missense_Mutation_p.E463K|EFTUD2_ENST00000592576.1_Missense_Mutation_p.E453K|EFTUD2_ENST00000402521.3_Missense_Mutation_p.E428K	NM_001142605.1|NM_001258354.1|NM_004247.3	NP_001136077.1|NP_001245283.1|NP_004238.3	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain containing 2	463						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	32		Prostate(33;0.109)				CTCATAGCCTCGCCGAGGTCG	0.552000													5	57					0	0	1	0	0
MET	0	broad.mit.edu	37	7	116436137	116436137	+	Missense_Mutation	SNP	G	G	C			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	85f7f6d9-9498-409c-99fc-d0853b075689	g.chr7:116436137G>C	ENST00000397752.3	+	21	4332	c.4132G>C	c.(4132-4134)Gag>Cag	p.E1378Q	MET_ENST00000539704.1_Missense_Mutation_p.E248Q|MET_ENST00000318493.6_Missense_Mutation_p.E1396Q	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	1378	Interaction with RANBP9.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			CGCTGATGATGAGGTGGACAC	0.463000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				11	133					0	0	1	0	0
GPANK1	7918	broad.mit.edu	37	6	31630196	31630196	+	Silent	SNP	C	C	T	rs146741893	byFrequency	TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	85f7f6d9-9498-409c-99fc-d0853b075689	g.chr6:31630196C>T	ENST00000375906.1	-	4	1602	c.918G>A	c.(916-918)gtG>gtA	p.V306V	GPANK1_ENST00000375895.2_Silent_p.V306V|GPANK1_ENST00000375893.2_Silent_p.V306V|GPANK1_ENST00000375896.4_Silent_p.V306V|GPANK1_ENST00000375900.4_Silent_p.V306V	NM_001199237.1	NP_001186166.1	O95872	GPAN1_HUMAN	G patch domain and ankyrin repeats 1	306						intracellular	nucleic acid binding			central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(7)	12						GGAAATGTGTCACTCGGGGCT	0.647000													4	53					0	0	1	0	0
CYP1A2	1544	broad.mit.edu	37	15	75042337	75042337	+	Silent	SNP	G	G	A			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	85f7f6d9-9498-409c-99fc-d0853b075689	g.chr15:75042337G>A	ENST00000343932.4	+	2	321	c.258G>A	c.(256-258)ctG>ctA	p.L86L		NM_000761.3	NP_000752.2	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 2	86					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	CGCCCGTGCTGGTGCTGAGCC	0.652000													5	55					0	0	1	0	0
SRBD1	55133	broad.mit.edu	37	2	45801777	45801777	+	Silent	SNP	G	G	A			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	85f7f6d9-9498-409c-99fc-d0853b075689	g.chr2:45801777G>A	ENST00000263736.4	-	8	1220	c.1158C>T	c.(1156-1158)ttC>ttT	p.F386F		NM_018079.4	NP_060549.4	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	386					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(13)|large_intestine(8)|lung(15)|skin(2)|stomach(1)|urinary_tract(1)	49		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			AGTTCCGAATGAAGTCAAGCG	0.388000													4	60					0	0	1	0	0
CHRNA10	57053	broad.mit.edu	37	11	3687763	3687763	+	Silent	SNP	G	G	A			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	85f7f6d9-9498-409c-99fc-d0853b075689	g.chr11:3687763G>A	ENST00000250699.2	-	5	998	c.927C>T	c.(925-927)gtC>gtT	p.V309V	CHRNA10_ENST00000534359.1_3'UTR	NM_020402.2	NP_065135.2	Q9GZZ6	ACH10_HUMAN	cholinergic receptor, nicotinic, alpha 10 (neuronal)	309					elevation of cytosolic calcium ion concentration|regulation of cell proliferation|synaptic transmission, cholinergic	cell junction|postsynaptic membrane	calcium channel activity|receptor activity|receptor binding			breast(1)|endometrium(2)|lung(3)|ovary(1)	7		Medulloblastoma(188;0.0075)|Breast(177;0.0164)|all_neural(188;0.0577)		BRCA - Breast invasive adenocarcinoma(625;0.0344)|LUSC - Lung squamous cell carcinoma(625;0.192)	Chloroprocaine(DB01161)|Methadone(DB00333)|Nicotine(DB00184)|Pentolinium(DB01090)|Procaine(DB00721)|Trimethaphan(DB01116)	TTGAGAATGTGACCATGGTCA	0.537000													3	28					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79031080	79031080	+	Silent	SNP	G	G	A			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	85f7f6d9-9498-409c-99fc-d0853b075689	g.chr5:79031080G>A	ENST00000446378.2	+	2	6523	c.6492G>A	c.(6490-6492)ccG>ccA	p.P2164P		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2164						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TGGCTAAGCCGGACCTTCCTG	0.458000													4	53					0	0	1	0	0
USP34	9736	broad.mit.edu	37	2	61438933	61438933	+	Silent	SNP	G	G	A			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	85f7f6d9-9498-409c-99fc-d0853b075689	g.chr2:61438933G>A	ENST00000398571.2	-	69	8890	c.8814C>T	c.(8812-8814)ggC>ggT	p.G2938G	USP34_ENST00000472689.1_5'UTR	NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	2938					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			AGCAGGAGCGGCCATCTAAGC	0.343000													3	21					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10546211	10546211	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	85f7f6d9-9498-409c-99fc-d0853b075689	g.chr17:10546211C>A	ENST00000583535.1	-	15	1600	c.1513G>T	c.(1513-1515)Gaa>Taa	p.E505*	MYH3_ENST00000226209.7_Nonsense_Mutation_p.E505*	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	505	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						TCGATGCCTTCCTTCTTGTAC	0.517000													5	92					1.23904e-05	1.36294e-05	1	1	0
SPTA1	6708	broad.mit.edu	37	1	158618337	158618337	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	85f7f6d9-9498-409c-99fc-d0853b075689	g.chr1:158618337C>T	ENST00000368148.3	-	26	3856	c.3676G>A	c.(3676-3678)Gag>Aag	p.E1226K	SPTA1_ENST00000368147.3_Missense_Mutation_p.E1226K	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1226					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TCAAAGCCCTCATGCCGTCGC	0.498000													8	75					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	85f7f6d9-9498-409c-99fc-d0853b075689	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				24	41					0	0	1	0	0
GLE1	2733	broad.mit.edu	37	9	131296128	131296128	+	Missense_Mutation	SNP	G	G	C			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	85f7f6d9-9498-409c-99fc-d0853b075689	g.chr9:131296128G>C	ENST00000309971.4	+	11	1650	c.1544G>C	c.(1543-1545)aGa>aCa	p.R515T	GLE1_ENST00000539582.1_Missense_Mutation_p.R261T|RP11-216B9.6_ENST00000434999.1_RNA|GLE1_ENST00000372770.4_Missense_Mutation_p.R515T	NM_001003722.1	NP_001003722.1	Q53GS7	GLE1_HUMAN	GLE1 RNA export mediator	515					poly(A)+ mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear pore	protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	16						CTCCACCCCAGAGTGGGGGAC	0.507000													7	90					0	0	1	0	0
CAPN9	10753	broad.mit.edu	37	1	230898481	230898481	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	85f7f6d9-9498-409c-99fc-d0853b075689	g.chr1:230898481C>T	ENST00000354537.1	+	4	567	c.485C>T	c.(484-486)tCt>tTt	p.S162F	CAPN9_ENST00000271971.2_Missense_Mutation_p.S162F|CAPN9_ENST00000366666.2_Missense_Mutation_p.S99F|RP11-99J16__A.2_ENST00000412344.1_RNA	NM_016452.1	NP_057536.1	O14815	CAN9_HUMAN	calpain 9	162	Calpain catalytic.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	25	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				TTCCTCCACTCTGCCGACCAC	0.587000													4	29					0	0	1	0	0
OR5M10	390167	broad.mit.edu	37	11	56344739	56344739	+	Silent	SNP	G	G	A			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	85f7f6d9-9498-409c-99fc-d0853b075689	g.chr11:56344739G>A	ENST00000526812.2	-	1	524	c.459C>T	c.(457-459)ttC>ttT	p.F153F		NM_001004741.1	NP_001004741.1	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M, member 10	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(2)	25						GCCCATTAAGGAAGCCATACA	0.458000													4	70					0	0	1	0	0
AC018890.6	0	broad.mit.edu	37	2	175585079	175585079	+	RNA	DEL	A	A	-			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr2:175585079delA	ENST00000442996.1	+	0	217																											TTTCATTCTCAAAAAAAAAAA	0.368											OREG0015078	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
U8	0	broad.mit.edu	37	5	15110993	15110994	+	RNA	DEL	AA	AA	-			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr5:15110993_15110994delAA	ENST00000365399.1	-	0	35_36																											tctgccctccaaaaggagaaac	0.391													2	4	---	---	---	---					
CTC-338M12.9	0	broad.mit.edu	37	5	180708697	180708698	+	RNA	INS	-	-	A	rs1815381		TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr5:180708697_180708698insA	ENST00000412295.2	+	0	238																											ggggcggtaggcgggggctgga	0.718													5	4	---	---	---	---					
DHX37	57647	broad.mit.edu	37	12	125465270	125465272	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr12:125465270_125465272delCTC	ENST00000308736.2	-	4	600_602	c.502_504delGAG	c.(502-504)del	p.E168del		NM_032656.3	NP_116045.2	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	168							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding	p.E168delE(3)		breast(5)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|liver(1)|lung(27)|ovary(1)|prostate(2)|skin(3)	65	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		CCGATTCCGActcctcctcctcc	0.690													3	6	---	---	---	---					
RRN3P2	0	broad.mit.edu	37	16	29113498	29113498	+	RNA	DEL	T	T	-	rs11366120		TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr16:29113498delT	ENST00000564580.1	+	0	1360																											AGGAGGTGGAttttttttttc	0.542													5	7	---	---	---	---					
PDF	64146	broad.mit.edu	37	16	69364026	69364028	+	In_Frame_Del	DEL	GGG	GGG	-			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	05324ee2-6eb5-4fa0-9c09-b78c3b257c10	g.chr16:69364026_69364028delGGG	ENST00000288022.1	-	1	470_472	c.446_448delCCC	c.(445-450)ctg>c	p.PL149del	COG8_ENST00000306875.4_Intron	NM_022341.1	NP_071736.1	Q9HBH1	DEFM_HUMAN	peptide deformylase (mitochondrial)	149					N-terminal protein amino acid modification|peptidyl-methionine modification|positive regulation of cell proliferation|translation	mitochondrion	iron ion binding|peptide deformylase activity			NS(1)|prostate(1)	2						AACACGCGCAGGGGGAAGGGCTC	0.734													3	4	---	---	---	---					
PADI6	353238	broad.mit.edu	37	1	17721722	17721723	+	RNA	DEL	GA	GA	-	rs58784721		TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	85f7f6d9-9498-409c-99fc-d0853b075689	g.chr1:17721722_17721723delGA	ENST00000434762.2	+	0	1545							Q6TGC4	PADI6_HUMAN	peptidyl arginine deiminase, type VI						peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(2)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	tttgttttttgagagtcttgct	0.485													3	6	---	---	---	---					
U8	0	broad.mit.edu	37	5	15110993	15110994	+	RNA	DEL	AA	AA	-			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	85f7f6d9-9498-409c-99fc-d0853b075689	g.chr5:15110993_15110994delAA	ENST00000365399.1	-	0	35_36																											tctgccctccaaaaggagaaac	0.391													2	4	---	---	---	---					
IGHV4OR15-8	0	broad.mit.edu	37	15	22473268	22473268	+	RNA	DEL	G	G	-			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	85f7f6d9-9498-409c-99fc-d0853b075689	g.chr15:22473268delG	ENST00000557788.2	-	0	46																											ATCAGAGGCAGCCTCCCCTAT	0.582													8	93	---	---	---	---					
PDF	64146	broad.mit.edu	37	16	69364026	69364028	+	In_Frame_Del	DEL	GGG	GGG	-			TCGA-BJ-A45J-01A-11D-A23U-08	TCGA-BJ-A45J-11A-11D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b17eaad-3496-4bdc-8eac-abe6cec00111	85f7f6d9-9498-409c-99fc-d0853b075689	g.chr16:69364026_69364028delGGG	ENST00000288022.1	-	1	470_472	c.446_448delCCC	c.(445-450)ctg>c	p.PL149del	COG8_ENST00000306875.4_Intron	NM_022341.1	NP_071736.1	Q9HBH1	DEFM_HUMAN	peptide deformylase (mitochondrial)	149					N-terminal protein amino acid modification|peptidyl-methionine modification|positive regulation of cell proliferation|translation	mitochondrion	iron ion binding|peptide deformylase activity			NS(1)|prostate(1)	2						AACACGCGCAGGGGGAAGGGCTC	0.734													3	4	---	---	---	---