Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ANXA3	306	broad.mit.edu	37	4	79517010	79517010	+	Silent	SNP	G	G	A			TCGA-DJ-A2PY-01A-11D-A18F-08	TCGA-DJ-A2PY-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05020be-81ae-4f46-a0d8-3edcc31776ab	9df33b2b-f35b-4f88-b444-68a862b36451	g.chr4:79517010G>A	ENST00000264908.6	+	9	982	c.603G>A	c.(601-603)ctG>ctA	p.L201L	ANXA3_ENST00000503570.2_Silent_p.L162L|ANXA3_ENST00000512884.1_Silent_p.L162L	NM_005139.2	NP_005130.1	P12429	ANXA3_HUMAN	annexin A3	201					defense response to bacterium|neutrophil degranulation|phagocytosis|positive regulation of angiogenesis|positive regulation of endothelial cell migration|positive regulation of sequence-specific DNA binding transcription factor activity	phagocytic vesicle membrane|plasma membrane|specific granule	calcium ion binding|calcium-dependent phospholipid binding|phospholipase A2 inhibitor activity			NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						CTGAGATCCTGTGTTTAAGGA	0.328000													3	26					0	0	0.004672	0	0
DNM1P47	0	broad.mit.edu	37	15	102296140	102296140	+	RNA	SNP	C	C	T			TCGA-DJ-A2PY-01A-11D-A18F-08	TCGA-DJ-A2PY-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05020be-81ae-4f46-a0d8-3edcc31776ab	9df33b2b-f35b-4f88-b444-68a862b36451	g.chr15:102296140C>T	ENST00000561463.1	+	0	4186																											GTCCAACCTGCACTCGCGTGG	0.602000													5	4					0	0	0.001168	0	0
FAM98C	147965	broad.mit.edu	37	19	38895653	38895653	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A2PY-01A-11D-A18F-08	TCGA-DJ-A2PY-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05020be-81ae-4f46-a0d8-3edcc31776ab	9df33b2b-f35b-4f88-b444-68a862b36451	g.chr19:38895653G>A	ENST00000252530.5	+	4	474	c.455G>A	c.(454-456)gGc>gAc	p.G152D	FAM98C_ENST00000585954.1_3'UTR|FAM98C_ENST00000588262.1_Intron|FAM98C_ENST00000343358.7_Missense_Mutation_p.G152D	NM_174905.3	NP_777565.3	Q17RN3	FA98C_HUMAN	family with sequence similarity 98, member C	152										endometrium(2)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	15	all_cancers(60;3.95e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GAGGGAGCCGGCATGGTCCAA	0.652000													4	117					0	0	0.000248	0	0
FMO3	2328	broad.mit.edu	37	1	171079976	171079976	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A2PY-01A-11D-A18F-08	TCGA-DJ-A2PY-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05020be-81ae-4f46-a0d8-3edcc31776ab	9df33b2b-f35b-4f88-b444-68a862b36451	g.chr1:171079976G>A	ENST00000367755.4	+	6	776	c.665G>A	c.(664-666)aGc>aAc	p.S222N	FMO3_ENST00000542847.1_Missense_Mutation_p.S202N|FMO3_ENST00000538429.1_Missense_Mutation_p.S159N|FMO3_ENST00000392085.2_Missense_Mutation_p.S222N	NM_001002294.2	NP_001002294.1	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	222					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			endometrium(1)|kidney(1)|large_intestine(12)|lung(12)|skin(1)|stomach(2)|urinary_tract(2)	31	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGGGTGATGAGCCGGGTCTGG	0.463000													5	120					0	0	0.001168	0	0
ITGA8	8516	broad.mit.edu	37	10	15655757	15655757	+	Silent	SNP	C	C	A			TCGA-DJ-A2PY-01A-11D-A18F-08	TCGA-DJ-A2PY-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05020be-81ae-4f46-a0d8-3edcc31776ab	9df33b2b-f35b-4f88-b444-68a862b36451	g.chr10:15655757C>A	ENST00000378076.3	-	15	1808	c.1455G>T	c.(1453-1455)ccG>ccT	p.P485P		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	485					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CAGTCACAACCGGTCTTGCTC	0.463000													25	50					0.000375601	0.000734871	0.002780	1	0
MYOM2	9172	broad.mit.edu	37	8	2046799	2046799	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A2PY-01A-11D-A18F-08	TCGA-DJ-A2PY-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05020be-81ae-4f46-a0d8-3edcc31776ab	9df33b2b-f35b-4f88-b444-68a862b36451	g.chr8:2046799C>T	ENST00000262113.4	+	19	2567	c.2426C>T	c.(2425-2427)aCc>aTc	p.T809I	MYOM2_ENST00000523438.1_Missense_Mutation_p.T234I	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	809					muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		GAGGCCTGGACCATGCCGGAG	0.657000													3	18					0	0	0.004672	0	0
SGK1	6446	broad.mit.edu	37	6	134495197	134495197	+	Silent	SNP	C	C	T			TCGA-DJ-A2PY-01A-11D-A18F-08	TCGA-DJ-A2PY-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05020be-81ae-4f46-a0d8-3edcc31776ab	9df33b2b-f35b-4f88-b444-68a862b36451	g.chr6:134495197C>T	ENST00000367858.5	-	5	1056	c.459G>A	c.(457-459)ttG>ttA	p.L153L	SGK1_ENST00000367857.5_Silent_p.L48L|SGK1_ENST00000489458.2_5'UTR|SGK1_ENST00000237305.7_Silent_p.L58L|SGK1_ENST00000413996.3_Silent_p.L72L|SGK1_ENST00000475719.2_Silent_p.L58L|SGK1_ENST00000528577.1_Silent_p.L86L	NM_001143676.1	NP_001137148.1	O00141	SGK1_HUMAN	serum/glucocorticoid regulated kinase 1	58	Protein kinase.				apoptosis|response to stress|sodium ion transport	endoplasmic reticulum|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity	p.L86F(1)|p.L153F(1)|p.L48F(1)|p.L58F(1)		central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(21)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|skin(4)|stomach(1)	46	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00317)|GBM - Glioblastoma multiforme(68;0.00847)		GGGAGATCTTCAAGATGGACT	0.498000													30	75					0	0	0.008361	0	0
ARMCX2	9823	broad.mit.edu	37	X	100911291	100911291	+	Silent	SNP	T	T	C			TCGA-DJ-A2PY-01A-11D-A18F-08	TCGA-DJ-A2PY-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05020be-81ae-4f46-a0d8-3edcc31776ab	9df33b2b-f35b-4f88-b444-68a862b36451	g.chrX:100911291T>C	ENST00000328766.5	-	5	1737	c.1284A>G	c.(1282-1284)ggA>ggG	p.G428G	ARMCX2_ENST00000356824.4_Silent_p.G428G|ARMCX2_ENST00000330154.2_Silent_p.G428G	NM_014782.5	NP_055597.1	Q7L311	ARMX2_HUMAN	armadillo repeat containing, X-linked 2	428						integral to membrane	binding			NS(1)|breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(6)|prostate(1)|skin(1)	29						TTGGGAGGCCTCCCAATTTGC	0.388000													3	134					0	0	0.004672	0	0
ST6GALNAC4	27090	broad.mit.edu	37	9	130672244	130672244	+	Silent	SNP	G	G	A			TCGA-DJ-A2PY-01A-11D-A18F-08	TCGA-DJ-A2PY-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05020be-81ae-4f46-a0d8-3edcc31776ab	9df33b2b-f35b-4f88-b444-68a862b36451	g.chr9:130672244G>A	ENST00000335791.5	-	5	980	c.705C>T	c.(703-705)agC>agT	p.S235S	ST6GALNAC4_ENST00000495983.1_5'UTR|ST6GALNAC4_ENST00000343609.2_Silent_p.S151S	NM_175039.3	NP_778204.1	Q9H4F1	SIA7D_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4	235					glycolipid metabolic process|protein glycosylation	integral to Golgi membrane|nucleus|soluble fraction	(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(2)	7						AGTAGCTGTCGCTGACCATCC	0.647000													20	21					0	0	0.001882	0	0
GANAB	23193	broad.mit.edu	37	11	62400170	62400170	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A2PY-01A-11D-A18F-08	TCGA-DJ-A2PY-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05020be-81ae-4f46-a0d8-3edcc31776ab	9df33b2b-f35b-4f88-b444-68a862b36451	g.chr11:62400170T>C	ENST00000346178.4	-	10	944	c.929A>G	c.(928-930)gAg>gGg	p.E310G	GANAB_ENST00000540933.1_Missense_Mutation_p.E191G|GANAB_ENST00000534779.1_Missense_Mutation_p.E196G|GANAB_ENST00000356638.3_Missense_Mutation_p.E288G	NM_001278192.1|NM_198335.2	NP_001265121.1|NP_938149.2	Q14697	GANAB_HUMAN	glucosidase, alpha; neutral AB	288					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|skin(2)|urinary_tract(3)	35						GTTGTACAGCTCATACTGGAA	0.552000													3	208					0	0	0.004672	0	0
SRR	63826	broad.mit.edu	37	17	2224836	2224836	+	Splice_Site	SNP	G	G	T	rs147900333		TCGA-DJ-A2PY-01A-11D-A18F-08	TCGA-DJ-A2PY-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05020be-81ae-4f46-a0d8-3edcc31776ab	9df33b2b-f35b-4f88-b444-68a862b36451	g.chr17:2224836G>T	ENST00000344595.5	+	6	838	c.519_splice	c.e6-1	p.V174_splice	SRR_ENST00000576848.1_Intron	NM_021947.1	NP_068766.1	Q9GZT4	SRR_HUMAN	serine racemase	174					D-serine biosynthetic process|L-serine metabolic process|protein homotetramerization|pyruvate biosynthetic process|response to lipopolysaccharide	cytoplasm|neuronal cell body|soluble fraction	ATP binding|calcium ion binding|D-serine ammonia-lyase activity|glycine binding|L-serine ammonia-lyase activity|magnesium ion binding|PDZ domain binding|protein homodimerization activity|pyridoxal phosphate binding|serine racemase activity|threonine racemase activity			NS(1)|large_intestine(3)|lung(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	8		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;3.24e-06)|READ - Rectum adenocarcinoma(1115;0.0649)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	TTCACTAAAGGTTCCTTTGGT	0.388000													24	37					4.26978e-12	9.14952e-12	0.003330	1	0
VDAC3	7419	broad.mit.edu	37	8	42260882	42260882	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A2PY-01A-11D-A18F-08	TCGA-DJ-A2PY-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05020be-81ae-4f46-a0d8-3edcc31776ab	9df33b2b-f35b-4f88-b444-68a862b36451	g.chr8:42260882T>C	ENST00000392935.3	+	8	751	c.608T>C	c.(607-609)aTt>aCt	p.I203T	VDAC3_ENST00000022615.4_Missense_Mutation_p.I202T|VDAC3_ENST00000522572.1_Intron|VDAC3_ENST00000521158.1_Missense_Mutation_p.I203T	NM_001135694.2|NM_005662.6	NP_001129166.1|NP_005653.3	Q9Y277	VDAC3_HUMAN	voltage-dependent anion channel 3	202					adenine transport	mitochondrial outer membrane|pore complex	nucleotide binding|porin activity|protein binding|voltage-gated anion channel activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	7	all_cancers(6;3.86e-23)|all_lung(13;6.47e-12)|Lung NSC(13;1.08e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;3.48e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00266)|Lung(22;0.00849)|LUSC - Lung squamous cell carcinoma(45;0.024)		Dihydroxyaluminium(DB01375)	AATGAGAAGATTGAAACATCC	0.398000													3	70					0	0	0.000248	0	0
AP005901.1	0	broad.mit.edu	37	18	15323276	15323276	+	RNA	SNP	A	A	T			TCGA-DJ-A2PY-01A-11D-A18F-08	TCGA-DJ-A2PY-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05020be-81ae-4f46-a0d8-3edcc31776ab	9df33b2b-f35b-4f88-b444-68a862b36451	g.chr18:15323276A>T	ENST00000455308.2	-	0	572					NR_027417.1																						ATCAACTGCAATTGCATTTGC	0.308000													4	11					0	0	0.001168	0	0
AC011308.1	0	broad.mit.edu	37	2	157352615	157352615	+	Splice_Site	SNP	T	T	G			TCGA-DJ-A2PY-01A-11D-A18F-08	TCGA-DJ-A2PY-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05020be-81ae-4f46-a0d8-3edcc31776ab	9df33b2b-f35b-4f88-b444-68a862b36451	g.chr2:157352615T>G	ENST00000601086.1	-	2	23	c.22_splice	c.e2-1	p.G8_splice	GPD2_ENST00000310454.6_Silent_p.P54P|GPD2_ENST00000409674.1_Silent_p.P54P|GPD2_ENST00000540309.1_Silent_p.P54P|GPD2_ENST00000409125.4_Intron|GPD2_ENST00000438166.2_Silent_p.P54P																							ACAGGGAGCCTCCTTCCAGAG	0.443000													4	42					0	0	0.000248	0	0
TG	7038	broad.mit.edu	37	8	133895156	133895156	+	Missense_Mutation	SNP	G	G	T			TCGA-DJ-A2PY-01A-11D-A18F-08	TCGA-DJ-A2PY-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05020be-81ae-4f46-a0d8-3edcc31776ab	9df33b2b-f35b-4f88-b444-68a862b36451	g.chr8:133895156G>T	ENST00000220616.4	+	8	1027	c.987G>T	c.(985-987)caG>caT	p.Q329H	TG_ENST00000377869.1_Missense_Mutation_p.Q329H	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	329	Thyroglobulin type-1 4.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGGCGGTGCAGTGCCAGACGG	0.597000													3	39					0.00024832	0.000507927	0.000248	1	0
CNGB1	1258	broad.mit.edu	37	16	57921841	57921841	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A2PY-01A-11D-A18F-08	TCGA-DJ-A2PY-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05020be-81ae-4f46-a0d8-3edcc31776ab	9df33b2b-f35b-4f88-b444-68a862b36451	g.chr16:57921841C>T	ENST00000564448.1	-	32	3422	c.3362G>A	c.(3361-3363)gGc>gAc	p.G1121D	CNGB1_ENST00000251102.8_Missense_Mutation_p.G1127D			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	1127					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity	p.G1127D(1)		breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						AGCAAGTTTGCCGCCTTTTGC	0.612000													4	142					0	0	0.000248	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-DJ-A2PY-01A-11D-A18F-08	TCGA-DJ-A2PY-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05020be-81ae-4f46-a0d8-3edcc31776ab	9df33b2b-f35b-4f88-b444-68a862b36451	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				24	40					0	0	0.002780	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12885289	12885289	+	Silent	SNP	G	G	T	rs148273194	by1000genomes	TCGA-DJ-A2PY-01A-11D-A18F-08	TCGA-DJ-A2PY-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05020be-81ae-4f46-a0d8-3edcc31776ab	9df33b2b-f35b-4f88-b444-68a862b36451	g.chr1:12885289G>T	ENST00000535591.1	-	4	1017	c.822C>A	c.(820-822)ctC>ctA	p.L274L		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	274								p.L274L(3)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						GGCACTGGGAGAGATGCTTCA	0.458000													6	203					0.00307968	0.0057744	0.003080	1	0
CLSTN1	22883	broad.mit.edu	37	1	9804008	9804008	+	Silent	SNP	G	G	A			TCGA-DJ-A2PY-01A-11D-A18F-08	TCGA-DJ-A2PY-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05020be-81ae-4f46-a0d8-3edcc31776ab	9df33b2b-f35b-4f88-b444-68a862b36451	g.chr1:9804008G>A	ENST00000377298.4	-	9	2082	c.1290C>T	c.(1288-1290)ctC>ctT	p.L430L	CLSTN1_ENST00000361311.4_Silent_p.L420L|CLSTN1_ENST00000377288.3_Silent_p.L430L	NM_001009566.1	NP_001009566.1	O94985	CSTN1_HUMAN	calsyntenin 1	430					homophilic cell adhesion	cell junction|cell projection|endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus|postsynaptic membrane	calcium ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(9)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	36	all_lung(157;0.222)	all_lung(284;4.03e-05)|Lung NSC(185;6.93e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;8.36e-08)|COAD - Colon adenocarcinoma(227;1.93e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)		CCTGACGGAAGAGGAAGATCA	0.483000													6	110					0	0	0.001168	0	0
STAG3L4	0	broad.mit.edu	37	7	66767610	66767611	+	RNA	INS	-	-	G	rs71293166	by1000genomes	TCGA-DJ-A2PY-01A-11D-A18F-08	TCGA-DJ-A2PY-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05020be-81ae-4f46-a0d8-3edcc31776ab	9df33b2b-f35b-4f88-b444-68a862b36451	g.chr7:66767610_66767611insG	ENST00000416602.2	+	0	3_4					NR_040586.1		Q8TBR4	STG34_HUMAN												endometrium(2)|lung(5)	7		Lung NSC(55;0.0839)|all_lung(88;0.181)				CACCGGACTGCTTTTTTTTTTT	0.545													3	3	---	---	---	---					
ARHGAP33	115703	broad.mit.edu	37	19	36276206	36276224	+	Frame_Shift_Del	DEL	GGGGGCACCCGTGCCCCAC	GGGGGCACCCGTGCCCCAC	-	rs145114644		TCGA-DJ-A2PY-01A-11D-A18F-08	TCGA-DJ-A2PY-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05020be-81ae-4f46-a0d8-3edcc31776ab	9df33b2b-f35b-4f88-b444-68a862b36451	g.chr19:36276206_36276224delGGGGGCACCCGTGCCCCAC	ENST00000007510.4	+	18	1981_1999	c.1837_1855delGGGGGCACCCGTGCCCCAC	c.(1837-1857)cgfs	p.GGTRAPP613fs	ARHGAP33_ENST00000378944.5_Frame_Shift_Del_p.GGTRAPP477fs|ARHGAP33_ENST00000314737.5_Frame_Shift_Del_p.GGTRAPP613fs			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	613					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding	p.T615T(1)		endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						GCCCTGGCTGGGGGGCACCCGTGCCCCACCGCAGCCTTC	0.685													14	37	---	---	---	---					
NDUFA6	4700	broad.mit.edu	37	22	42482290	42482293	+	Frame_Shift_Del	DEL	TTAA	TTAA	-			TCGA-DJ-A2PY-01A-11D-A18F-08	TCGA-DJ-A2PY-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05020be-81ae-4f46-a0d8-3edcc31776ab	9df33b2b-f35b-4f88-b444-68a862b36451	g.chr22:42482290_42482293delTTAA	ENST00000498737.2	-	3	491_494	c.359_362delTTAA	c.(358-363)aafs	p.IK120fs	NDUFA6_ENST00000470753.1_Frame_Shift_Del_p.IK37fs|NDUFA6_ENST00000602404.1_Frame_Shift_Del_p.IK94fs|SMDT1_ENST00000547929.1_Intron	NM_002490.3	NP_002481.2	P56556	NDUA6_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa	120					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			kidney(1)|lung(3)|upper_aerodigestive_tract(1)	5					NADH(DB00157)	CTTCCATACTTTAATTGTTTCTTC	0.451													23	34	---	---	---	---