Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
WDR6	11180	broad.mit.edu	37	3	49050828	49050828	+	Missense_Mutation	SNP	A	A	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr3:49050828A>G	ENST00000395474.3	+	2	2231	c.1951A>G	c.(1951-1953)Ata>Gta	p.I651V	WDR6_ENST00000415265.2_Missense_Mutation_p.I69V|WDR6_ENST00000448293.1_Missense_Mutation_p.I570V	NM_018031.3	NP_060501.3	Q9NNW5	WDR6_HUMAN	WD repeat domain 6	621				V -> I (in Ref. 2; BAG58164).	cell cycle arrest|negative regulation of cell proliferation	cytoplasm				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		TGGGCTCCGTATAGTGCCCGA	0.557000													27	56					0	0	1	0	0
SCAPER	49855	broad.mit.edu	37	15	76995317	76995317	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr15:76995317C>T	ENST00000538941.2	-	19	2475	c.1536G>A	c.(1534-1536)atG>atA	p.M512I	SCAPER_ENST00000324767.7_Missense_Mutation_p.M758I|SCAPER_ENST00000563290.1_Missense_Mutation_p.M758I	NM_001145923.1	NP_001139395.1	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	757	Glu-rich.					endoplasmic reticulum|nucleus	zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(16)|ovary(2)|prostate(2)|skin(1)|urinary_tract(2)	39						CAATCTGTTCCATGTGCCTTC	0.353000													26	65					0	0	1	0	0
TCF7L1	83439	broad.mit.edu	37	2	85529723	85529723	+	Missense_Mutation	SNP	G	G	C			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr2:85529723G>C	ENST00000282111.3	+	5	917	c.642G>C	c.(640-642)gaG>gaC	p.E214D		NM_031283.2	NP_112573.1	Q9HCS4	TF7L1_HUMAN	transcription factor 7-like 1 (T-cell specific, HMG-box)	214	Pro-rich.				chromatin organization|regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|skin(4)|upper_aerodigestive_tract(1)	18						TCTCCCCAGAGATCGATCCAA	0.587000													11	169					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3647621	3647621	+	Missense_Mutation	SNP	C	C	T	rs145194745		TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr16:3647621C>T	ENST00000294008.3	-	7	2082	c.1442G>A	c.(1441-1443)cGa>cAa	p.R481Q		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	481	Interaction with C20orf94, ERCC4 and MSH2.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						CTCTATCTGTCGGCCTGTGGT	0.517000								Direct reversal of damage					27	126					0	0	1	0	0
CEACAM8	1088	broad.mit.edu	37	19	43098036	43098036	+	Silent	SNP	G	G	A	rs146608676	by1000genomes	TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr19:43098036G>A	ENST00000244336.5	-	2	182	c.81C>T	c.(79-81)ttC>ttT	p.F27F	CEACAM8_ENST00000599005.1_Intron|LIPE-AS1_ENST00000594688.1_RNA|LIPE-AS1_ENST00000594624.2_RNA	NM_001816.3	NP_001807.2	P31997	CEAM8_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 8	27					immune response	anchored to membrane|extracellular space|integral to plasma membrane				endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	16		Prostate(69;0.00899)				GCGGGTTCCAGAAGGTGAAAA	0.498000													24	169					0	0	1	0	0
FHL2	2274	broad.mit.edu	37	2	105984158	105984158	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr2:105984158C>T	ENST00000409177.1	-	4	839	c.718G>A	c.(718-720)Gag>Aag	p.E240K	FHL2_ENST00000393353.3_Missense_Mutation_p.E124K|FHL2_ENST00000408995.1_Missense_Mutation_p.E124K|FHL2_ENST00000358129.4_Missense_Mutation_p.E124K|FHL2_ENST00000336660.5_Missense_Mutation_p.M65I|FHL2_ENST00000393352.3_Missense_Mutation_p.E124K|FHL2_ENST00000344213.4_Missense_Mutation_p.E234K|FHL2_ENST00000409807.1_Missense_Mutation_p.E124K|AC012360.6_ENST00000457290.2_RNA|FHL2_ENST00000322142.8_Missense_Mutation_p.E124K			Q14192	FHL2_HUMAN	four and a half LIM domains 2	124	LIM zinc-binding 4.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription, DNA-dependent|response to hormone stimulus|transcription, DNA-dependent	actin cytoskeleton|focal adhesion|nucleus	androgen receptor binding|identical protein binding|transcription coactivator activity|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	9						AAGCAGGTCTCATGCCAGCTG	0.522000													31	139					0	0	1	0	0
SRP68	6730	broad.mit.edu	37	17	74057636	74057636	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr17:74057636G>A	ENST00000307877.2	-	5	742	c.581C>T	c.(580-582)tCa>tTa	p.S194L	SRP68_ENST00000539137.1_Missense_Mutation_p.S156L|SRP68_ENST00000355113.5_Missense_Mutation_p.S93L	NM_014230.3	NP_055045.2	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	194					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			NS(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(5)|lung(4)|ovary(2)|prostate(3)	23						TAGCATTCCTGAGAGGTAAGC	0.438000													6	41					0	0	1	0	0
CDC7	8317	broad.mit.edu	37	1	91985807	91985807	+	Missense_Mutation	SNP	G	G	C			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr1:91985807G>C	ENST00000428239.1	+	11	1560	c.1301G>C	c.(1300-1302)aGa>aCa	p.R434T	CDC7_ENST00000234626.6_Missense_Mutation_p.R434T|CDC7_ENST00000430031.2_Missense_Mutation_p.R406T	NM_001134420.1	NP_001127892.1	O00311	CDC7_HUMAN	cell division cycle 7	434	Protein kinase.				cell cycle checkpoint|cell division|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|positive regulation of cell proliferation|regulation of S phase	cytoplasm|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|stomach(2)	23		all_lung(203;0.0165)|Lung NSC(277;0.0562)		all cancers(265;0.00108)|Epithelial(280;0.0184)|KIRC - Kidney renal clear cell carcinoma(1967;0.124)		AGGGGATCCAGAGAAACTATC	0.328000													6	52					0	0	1	0	0
LHFPL5	222662	broad.mit.edu	37	6	35782404	35782404	+	Missense_Mutation	SNP	C	C	T	rs104893976		TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr6:35782404C>T	ENST00000360215.1	+	2	871	c.494C>T	c.(493-495)aCg>aTg	p.T165M	LHFPL5_ENST00000373853.1_Missense_Mutation_p.T165M|LHFPL5_ENST00000496656.1_3'UTR	NM_182548.3	NP_872354.1	Q8TAF8	TMHS_HUMAN	lipoma HMGIC fusion partner-like 5	165			T -> M (in DFNB67).			integral to membrane				endometrium(4)|large_intestine(4)|lung(7)|prostate(2)|skin(2)|urinary_tract(1)	20						GGGGAGCAGACGGGCAAGTAC	0.627000													37	70					0	0	1	0	0
KIAA0907	22889	broad.mit.edu	37	1	155887393	155887393	+	Missense_Mutation	SNP	T	T	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr1:155887393T>G	ENST00000368320.3	-	11	1362	c.1337A>C	c.(1336-1338)cAg>cCg	p.Q446P	KIAA0907_ENST00000368321.3_Missense_Mutation_p.Q446P			Q7Z7F0	K0907_HUMAN	KIAA0907	446	Pro-rich.									breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|urinary_tract(1)	21	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			gggctggggctggggctgggg	0.567000													11	61					0	0	1	0	0
RNF113A	7737	broad.mit.edu	37	X	119005506	119005506	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chrX:119005506C>T	ENST00000371442.2	-	1	285	c.71G>A	c.(70-72)cGg>cAg	p.R24Q	NDUFA1_ENST00000371437.4_5'UTR	NM_006978.2	NP_008909.1	O15541	R113A_HUMAN	ring finger protein 113A	24							nucleic acid binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(6)	15						AGCCCCTTTCCGCCCAGGCTT	0.602000													17	224					0	0	1	0	0
NPY4R	0	broad.mit.edu	37	10	47087440	47087440	+	Silent	SNP	C	C	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr10:47087440C>G	ENST00000374312.1	+	3	1076	c.657C>G	c.(655-657)ctC>ctG	p.L219L	NPY4R_ENST00000395716.1_Silent_p.L219L	NM_005972.4	NP_005963.3			neuropeptide Y receptor Y4																		CCTTCCTGCTCCTCTTCCAGT	0.602000													13	305					0	0	1	0	0
THOC6	79228	broad.mit.edu	37	16	3076528	3076528	+	Silent	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr16:3076528C>T	ENST00000326266.8	+	7	719	c.423C>T	c.(421-423)ctC>ctT	p.L141L	THOC6_ENST00000575576.1_Silent_p.L117L|THOC6_ENST00000574549.1_Silent_p.L117L|THOC6_ENST00000253952.9_Silent_p.L141L	NM_024339.3	NP_077315.2	Q86W42	THOC6_HUMAN	THO complex 6 homolog (Drosophila)	141					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	RNA binding			central_nervous_system(1)|endometrium(4)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	13						AGAATTCCCTCATCCTGGCTG	0.527000													5	32					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158592868	158592868	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr1:158592868G>A	ENST00000368148.3	-	43	6205	c.6025C>T	c.(6025-6027)Cgt>Tgt	p.R2009C	SPTA1_ENST00000368147.3_Missense_Mutation_p.R2006C|SPTA1_ENST00000461624.1_5'UTR	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2009					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GCGGCATAACGCTCTTCAATG	0.502000													172	509					0	0	1	0	0
FARP2	9855	broad.mit.edu	37	2	242396303	242396303	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr2:242396303G>A	ENST00000264042.3	+	14	1723	c.1553G>A	c.(1552-1554)gGa>gAa	p.G518E	FARP2_ENST00000545004.1_Missense_Mutation_p.G518E|FARP2_ENST00000373287.4_Missense_Mutation_p.G518E	NM_014808.2	NP_055623.1	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	518					axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	43		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		GATGCTGGCGGAGCCGGGATG	0.622000													10	67					0	0	1	0	0
APPL2	55198	broad.mit.edu	37	12	105591668	105591668	+	Silent	SNP	G	G	A			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr12:105591668G>A	ENST00000258530.3	-	11	1152	c.927C>T	c.(925-927)ctC>ctT	p.L309L	APPL2_ENST00000551662.1_Silent_p.L315L|APPL2_ENST00000549573.1_Intron|APPL2_ENST00000539978.2_Silent_p.L266L	NM_001251904.1|NM_018171.3	NP_001238833.1|NP_060641.2	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	309	PH.|Required for RAB5A binding (By similarity).				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						GCTGACACATGAGATTCCCGC	0.547000													8	60					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41081411	41081411	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr19:41081411C>G	ENST00000352632.3	+	36	7717	c.7631C>G	c.(7630-7632)tCc>tGc	p.S2544C	SPTBN4_ENST00000598249.1_Missense_Mutation_p.S2544C|SPTBN4_ENST00000593816.1_3'UTR|SPTBN4_ENST00000392025.1_Missense_Mutation_p.S1287C			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	2544					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			ACTACTTCATCCACAGATGAG	0.637000													6	39					0	0	1	0	0
CNOT1	23019	broad.mit.edu	37	16	58621113	58621113	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr16:58621113C>G	ENST00000317147.5	-	6	757	c.425G>C	c.(424-426)aGa>aCa	p.R142T	CNOT1_ENST00000569240.1_Missense_Mutation_p.R142T|CNOT1_ENST00000441024.2_Missense_Mutation_p.R142T	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	142					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		ACCGAAACCTCTAAGATCTGA	0.358000													9	54					0	0	1	0	0
LTN1	26046	broad.mit.edu	37	21	30339475	30339475	+	Silent	SNP	G	G	C			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr21:30339475G>C	ENST00000361371.4	-	10	1488	c.1338C>G	c.(1336-1338)ctC>ctG	p.L446L	LTN1_ENST00000389194.2_Silent_p.L492L|LTN1_ENST00000389195.2_Silent_p.L492L	NM_015565.2	NP_056380.2	O94822	LTN1_HUMAN	listerin E3 ubiquitin protein ligase 1	446							ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(19)|ovary(5)|pancreas(1)|prostate(2)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)	60						CTGGGTCTTTGAGAACTGCAT	0.388000													8	62					0	0	1	0	0
MYH10	4628	broad.mit.edu	37	17	8381712	8381712	+	Nonsense_Mutation	SNP	C	C	A			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr17:8381712C>A	ENST00000360416.3	-	41	5788	c.5650G>T	c.(5650-5652)Gaa>Taa	p.E1884*	MYH10_ENST00000396239.1_Nonsense_Mutation_p.E1874*|NDEL1_ENST00000299734.7_Intron|MYH10_ENST00000269243.4_Nonsense_Mutation_p.E1853*|MYH10_ENST00000379980.4_Nonsense_Mutation_p.E1869*	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	1853					actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						ATGAAGATTTCTTTCAGCTTC	0.493000													14	108					7.93312e-07	8.40323e-07	1	1	0
DMD	1756	broad.mit.edu	37	X	31792217	31792217	+	Nonsense_Mutation	SNP	C	C	A	rs128626253		TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chrX:31792217C>A	ENST00000357033.4	-	51	7608	c.7402G>T	c.(7402-7404)Gag>Tag	p.E2468*	DMD_ENST00000359836.1_Nonsense_Mutation_p.E8*|DMD_ENST00000378707.3_Nonsense_Mutation_p.E8*|DMD_ENST00000474231.1_Nonsense_Mutation_p.E8*|DMD_ENST00000541735.1_Nonsense_Mutation_p.E8*|DMD_ENST00000343523.2_Nonsense_Mutation_p.E8*|DMD_ENST00000378677.2_Nonsense_Mutation_p.E2464*	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2468					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GCAGGTACCTCCAACATCAAG	0.458000													9	87					1.12685e-05	1.18485e-05	1	1	0
PTPRZ1	5803	broad.mit.edu	37	7	121680999	121680999	+	Missense_Mutation	SNP	C	C	T	rs142748552		TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr7:121680999C>T	ENST00000393386.2	+	21	6178	c.5767C>T	c.(5767-5769)Cgc>Tgc	p.R1923C	PTPRZ1_ENST00000449182.1_Missense_Mutation_p.R1056C	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	1923	Tyrosine-protein phosphatase 1.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						CTATGCCAAGCGCCATGCAGT	0.512000													12	86					0	0	1	0	0
C3orf62	375341	broad.mit.edu	37	3	49313987	49313987	+	Missense_Mutation	SNP	G	G	C			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr3:49313987G>C	ENST00000343010.3	-	1	1355	c.319C>G	c.(319-321)Ctg>Gtg	p.L107V		NM_198562.2	NP_940964.1	Q6ZUJ4	CC062_HUMAN	chromosome 3 open reading frame 62	107										breast(1)|kidney(1)|large_intestine(1)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TCGGGGCACAGAGCATGTGGT	0.498000													38	77					0	0	1	0	0
CHD1	1105	broad.mit.edu	37	5	98232910	98232910	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr5:98232910G>A	ENST00000284049.3	-	10	1629	c.1480C>T	c.(1480-1482)Cat>Tat	p.H494Y		NM_001270.2	NP_001261.2	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	494	Helicase ATP-binding.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	49		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	CACCAAGAATGAGCAAGCCAA	0.348000													33	56					0	0	1	0	0
ITGA10	8515	broad.mit.edu	37	1	145537478	145537478	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr1:145537478C>G	ENST00000369304.3	+	20	2663	c.2488C>G	c.(2488-2490)Ctg>Gtg	p.L830V	ITGA10_ENST00000539363.1_Missense_Mutation_p.L687V|ITGA10_ENST00000538811.1_Missense_Mutation_p.L699V	NM_003637.3	NP_003628.2	O75578	ITA10_HUMAN	integrin, alpha 10	830					cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			NS(1)|breast(2)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ATCTACAACTCTGGAGAACAG	0.522000													41	450					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145365372	145365372	+	Missense_Mutation	SNP	C	C	G	rs4126496		TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr1:145365372C>G	ENST00000342960.5	+	80	10032	c.9997C>G	c.(9997-9999)Ctt>Gtt	p.L3333V	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3333										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TTCAGGTTGTCTTGAACTGTG	0.488000													6	118					0	0	1	0	0
ATAD5	79915	broad.mit.edu	37	17	29203482	29203482	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr17:29203482C>G	ENST00000321990.4	+	15	4076	c.3698C>G	c.(3697-3699)cCt>cGt	p.P1233R		NM_024857.3	NP_079133.3	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1233					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(18)|lung(13)|ovary(3)|pancreas(1)	51		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				CGAGCACTTCCTCCCAAAACC	0.353000													27	53					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10466364	10466364	+	Silent	SNP	C	C	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr8:10466364C>G	ENST00000382483.3	-	4	5467	c.5244G>C	c.(5242-5244)ggG>ggC	p.G1748G		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1748					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GTCTCTGGCTCCCCTCGCCAT	0.622000													38	239					0	0	1	0	0
ARHGEF2	9181	broad.mit.edu	37	1	155931629	155931629	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr1:155931629C>T	ENST00000368316.1	-	15	1677	c.1207G>A	c.(1207-1209)Gag>Aag	p.E403K	ARHGEF2_ENST00000368315.3_Missense_Mutation_p.E432K|ARHGEF2_ENST00000313667.4_Missense_Mutation_p.E430K|ARHGEF2_ENST00000361247.4_Missense_Mutation_p.E431K|ARHGEF2_ENST00000313695.7_Missense_Mutation_p.E403K			Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 2	431	DH.				actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding	p.E403*(1)		breast(4)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|skin(2)	40	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					TAAATACCCTCGTCCACATTG	0.632000													10	168					0	0	1	0	0
HIST1H1C	3006	broad.mit.edu	37	6	26056240	26056240	+	Silent	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr6:26056240C>T	ENST00000343677.2	-	1	459	c.417G>A	c.(415-417)aaG>aaA	p.K139K		NM_005319.3	NP_005310.1	P16403	H12_HUMAN	histone cluster 1, H1c	139					nucleosome assembly	nucleosome|nucleus	DNA binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(1)|large_intestine(1)|lung(8)|ovary(4)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	34						CAGCCGCCTTCTTGGGCTTCT	0.567000													24	172					0	0	1	0	0
VSTM4	196740	broad.mit.edu	37	10	50285331	50285331	+	Silent	SNP	G	G	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr10:50285331G>T	ENST00000332853.3	-	4	590	c.567C>A	c.(565-567)atC>atA	p.I189I		NM_001031746.3	NP_001026916.2	Q8IW00	CJ072_HUMAN	V-set and transmembrane domain containing 4	189						integral to membrane|plasma membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(14)|skin(2)	31						GAATGCTGAGGATCCCCACGC	0.527000													7	69					0.000442599	0.000458636	1	1	0
PCDHB5	0	broad.mit.edu	37	5	140516600	140516600	+	Silent	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr5:140516600C>T	ENST00000231134.5	+	1	1801	c.1584C>T	c.(1582-1584)ttC>ttT	p.F528F		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		528	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGTTCGAGTTCCGCGTGGGAG	0.687000													48	158					0	0	1	0	0
ABCD4	5826	broad.mit.edu	37	14	74757084	74757084	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr14:74757084C>T	ENST00000356924.4	-	12	1380	c.1237G>A	c.(1237-1239)Gag>Aag	p.E413K	ABCD4_ENST00000298816.7_Missense_Mutation_p.E309K|AC005519.4_ENST00000554532.2_RNA|ABCD4_ENST00000557554.1_5'UTR	NM_005050.3	NP_005041.1	O14678	ABCD4_HUMAN	ATP-binding cassette, sub-family D (ALD), member 4	413	ABC transporter.					ATP-binding cassette (ABC) transporter complex|integral to membrane|peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			cervix(2)|endometrium(3)|kidney(3)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	27				BRCA - Breast invasive adenocarcinoma(234;0.00153)		CTCTGTCCCTCGGAGATCTTT	0.592000											OREG0022800	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	211					0	0	1	0	0
NFAT5	10725	broad.mit.edu	37	16	69727140	69727140	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr16:69727140C>T	ENST00000349945.1	+	14	4682	c.3130C>T	c.(3130-3132)Caa>Taa	p.Q1044*	NFAT5_ENST00000567239.1_Nonsense_Mutation_p.Q1137*|NFAT5_ENST00000432919.1_Nonsense_Mutation_p.Q1138*|NFAT5_ENST00000393742.2_Nonsense_Mutation_p.Q1044*|NFAT5_ENST00000354436.2_Nonsense_Mutation_p.Q1120*|NFAT5_ENST00000566899.1_Nonsense_Mutation_p.Q1044*	NM_138714.3	NP_619728.2	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5, tonicity-responsive	1120					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.Q1044K(1)|p.Q1138K(1)		NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						GTTTCACTCTCAAAGTACCAT	0.428000													8	176					0	0	1	0	0
ZNF733P	0	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													4	27					0	0	1	0	0
PIK3R1	5295	broad.mit.edu	37	5	67593325	67593325	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr5:67593325C>G	ENST00000521381.1	+	16	2687	c.2071C>G	c.(2071-2073)Ctg>Gtg	p.L691V	PIK3R1_ENST00000320694.8_Missense_Mutation_p.L391V|PIK3R1_ENST00000336483.5_Missense_Mutation_p.L421V|PIK3R1_ENST00000396611.1_Missense_Mutation_p.L699V|PIK3R1_ENST00000523872.1_Missense_Mutation_p.L328V|PIK3R1_ENST00000521657.1_Missense_Mutation_p.L691V|PIK3R1_ENST00000274335.5_Missense_Mutation_p.L691V	NM_181523.2	NP_852664.1	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	691	SH2 2.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.0?(1)|p.?(1)		breast(12)|central_nervous_system(31)|cervix(1)|endometrium(68)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(32)|lung(10)|ovary(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	178		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	GTACAGCTCTCTGAAAGAACT	0.493000			"""Mis, F, O"""		"""gliobastoma, ovarian, colorectal"""					TCGA GBM(4;<1E-08)			36	227					0	0	1	0	0
TMEM171	134285	broad.mit.edu	37	5	72427547	72427547	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr5:72427547C>T	ENST00000454765.2	+	4	1438	c.965C>T	c.(964-966)tCc>tTc	p.S322F	TMEM171_ENST00000287773.5_Missense_Mutation_p.S321F			Q8WVE6	TM171_HUMAN	transmembrane protein 171	322						integral to membrane				endometrium(5)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|stomach(1)	15		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.87e-54)|Lung(70;0.115)		TCTGAGCCTTCCCCACCGTAA	0.353000													26	175					0	0	1	0	0
LGSN	51557	broad.mit.edu	37	6	63990030	63990030	+	Missense_Mutation	SNP	G	G	C			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr6:63990030G>C	ENST00000370657.4	-	4	1459	c.1426C>G	c.(1426-1428)Cta>Gta	p.L476V	LGSN_ENST00000370658.5_3'UTR			Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase domain	476					glutamine biosynthetic process		glutamate-ammonia ligase activity			NS(1)|endometrium(2)|large_intestine(5)|lung(16)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	34					L-Glutamic Acid(DB00142)	GTTTCTCCTAGAGCCTGTCTC	0.383000													12	87					0	0	1	0	0
C7	730	broad.mit.edu	37	5	40947793	40947793	+	Silent	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr5:40947793C>T	ENST00000313164.9	+	8	1187	c.828C>T	c.(826-828)ttC>ttT	p.F276F		NM_000587.2	NP_000578.2	P10643	CO7_HUMAN	complement component 7	276	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex							Ovarian(839;0.0112)				CTGAGCCATTCTGGAAGGAGC	0.448000													5	92					0	0	1	0	0
PCDHGA2	0	broad.mit.edu	37	5	140718777	140718777	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr5:140718777G>A	ENST00000394576.2	+	1	239	c.239G>A	c.(238-240)cGa>cAa	p.R80Q	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGAACCCGCGAAGCGGCAGC	0.572000													20	135					0	0	1	0	0
ANKRD6	22881	broad.mit.edu	37	6	90276782	90276782	+	Silent	SNP	C	C	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr6:90276782C>G	ENST00000369408.5	+	2	436	c.87C>G	c.(85-87)ctC>ctG	p.L29L	ANKRD6_ENST00000520793.1_Silent_p.L29L|ANKRD6_ENST00000520886.2_Intron|ANKRD6_ENST00000485637.1_Silent_p.L29L|ANKRD6_ENST00000339746.4_Silent_p.L29L|ANKRD6_ENST00000447838.2_Silent_p.L29L|ANKRD6_ENST00000522441.1_Silent_p.L29L	NM_001242813.1	NP_001229742.1	Q9Y2G4	ANKR6_HUMAN	ankyrin repeat domain 6	29							protein binding			NS(1)|endometrium(3)|large_intestine(7)|lung(3)|ovary(3)|pancreas(1)|prostate(1)|stomach(2)	21		all_cancers(76;1.22e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;1.83e-05)|Lung NSC(302;0.239)		BRCA - Breast invasive adenocarcinoma(108;0.0209)		TGGTTCAGCTCATCAACAAGG	0.498000													4	7					0	0	1	0	0
CATSPERG	57828	broad.mit.edu	37	19	38853443	38853443	+	Missense_Mutation	SNP	C	C	A			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr19:38853443C>A	ENST00000409235.3	+	20	2561	c.2446C>A	c.(2446-2448)Ctg>Atg	p.L816M	CATSPERG_ENST00000215069.4_3'UTR|CATSPERG_ENST00000410018.1_Missense_Mutation_p.L776M	NM_021185.4	NP_067008.3	Q6ZRH7	CTSRG_HUMAN	catsper channel auxiliary subunit gamma	816					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|pancreas(2)|prostate(6)|skin(3)|stomach(1)|urinary_tract(2)	40						GCAGGAGGTCCTGATTAATCG	0.567000													54	123					2.75338e-15	3.02872e-15	1	1	0
REV1	51455	broad.mit.edu	37	2	100079058	100079058	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr2:100079058C>G	ENST00000258428.3	-	3	309	c.81G>C	c.(79-81)caG>caC	p.Q27H	REV1_ENST00000393445.3_Missense_Mutation_p.Q27H	NM_001037872.1|NM_016316.2	NP_001032961.1|NP_057400.1	Q9UBZ9	REV1_HUMAN	REV1, polymerase (DNA directed)	27					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(12)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CCTCCAATTTCTGGACCTTGG	0.378000								Direct reversal of damage					10	134					0	0	1	0	0
USP26	83844	broad.mit.edu	37	X	132161783	132161783	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chrX:132161783G>A	ENST00000511190.1	-	6	935	c.466C>T	c.(466-468)Cag>Tag	p.Q156*	USP26_ENST00000406273.1_Nonsense_Mutation_p.Q156*|USP26_ENST00000370832.1_Nonsense_Mutation_p.Q156*	NM_031907.1	NP_114113.1	Q9BXU7	UBP26_HUMAN	ubiquitin specific peptidase 26	156					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	60	Acute lymphoblastic leukemia(192;0.000127)					GGCATCCTCTGAAGGACACCT	0.388000													19	49					0	0	1	0	0
TRPS1	7227	broad.mit.edu	37	8	116616440	116616440	+	Missense_Mutation	SNP	T	T	A			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr8:116616440T>A	ENST00000395715.3	-	4	2333	c.1756A>T	c.(1756-1758)Agc>Tgc	p.S586C	TRPS1_ENST00000519076.1_Intron|TRPS1_ENST00000220888.5_Missense_Mutation_p.S573C|TRPS1_ENST00000520276.1_Missense_Mutation_p.S577C|TRPS1_ENST00000519674.1_Missense_Mutation_p.S573C	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	573					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TTTTCTGGGCTGCAAAGTCCT	0.448000									Langer-Giedion syndrome				5	61					0	0	1	0	0
HSPA13	6782	broad.mit.edu	37	21	15746494	15746494	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr21:15746494C>G	ENST00000285667.3	-	5	927	c.860G>C	c.(859-861)aGa>aCa	p.R287T	HSPA13_ENST00000544452.1_Missense_Mutation_p.R79T	NM_006948.4	NP_008879.3	P48723	HSP13_HUMAN	heat shock protein 70kDa family, member 13	287						endoplasmic reticulum|microsome	ATP binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						TTGTCTCAATCTGTGGATTTC	0.418000													6	52					0	0	1	0	0
RAVER1	125950	broad.mit.edu	37	19	10439465	10439465	+	Silent	SNP	G	G	C			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr19:10439465G>C	ENST00000293677.6	-	3	741	c.660C>G	c.(658-660)ctC>ctG	p.L220L		NM_133452.2	NP_597709.2	Q8IY67	RAVR1_HUMAN	ribonucleoprotein, PTB-binding 1	203						cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(3)|large_intestine(1)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	18			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			AGTGCACGTAGAGGGTGCGTG	0.637000													4	41					0	0	1	0	0
SPG11	80208	broad.mit.edu	37	15	44864971	44864971	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr15:44864971G>A	ENST00000261866.7	-	33	6269	c.6253C>T	c.(6253-6255)Cag>Tag	p.Q2085*	SPG11_ENST00000535302.2_Nonsense_Mutation_p.Q1972*|SPG11_ENST00000427534.2_Nonsense_Mutation_p.Q2085*	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)	2085					cell death	cytosol|integral to membrane|nucleus	protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		GTGGTCAGCTGAAGAAATGTC	0.468000													11	86					0	0	1	0	0
SLC17A7	57030	broad.mit.edu	37	19	49935868	49935868	+	Missense_Mutation	SNP	A	A	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr19:49935868A>G	ENST00000221485.3	-	9	1229	c.1058T>C	c.(1057-1059)aTc>aCc	p.I353T	SLC17A7_ENST00000600601.1_Missense_Mutation_p.I286T|SLC17A7_ENST00000543531.1_Missense_Mutation_p.I341T	NM_020309.3	NP_064705.1	Q9P2U7	VGLU1_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 7	353					glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(7)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	26		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		GGGCACGATGATGGTCATGAC	0.662000													15	40					0	0	1	0	0
LY75	4065	broad.mit.edu	37	2	160738665	160738665	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr2:160738665C>T	ENST00000263636.4	-	7	1243	c.1216G>A	c.(1216-1218)Gag>Aag	p.E406K	LY75-CD302_ENST00000504764.1_Missense_Mutation_p.E406K|LY75_ENST00000554112.1_Missense_Mutation_p.E406K|LY75_ENST00000553424.1_Missense_Mutation_p.E406K|LY75-CD302_ENST00000505052.1_Missense_Mutation_p.E406K	NM_002349.3	NP_002340.2			lymphocyte antigen 75											NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		ACAACCACCTCCACATCTGCT	0.388000													29	125					0	0	1	0	0
CAMK2B	816	broad.mit.edu	37	7	44302632	44302632	+	Translation_Start_Site	SNP	G	G	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr7:44302632G>T	ENST00000502837.2	-	0	245				CAMK2B_ENST00000395749.2_Silent_p.I64I|CAMK2B_ENST00000346990.4_Silent_p.I64I|CAMK2B_ENST00000258682.6_Silent_p.I64I|CAMK2B_ENST00000358707.3_Silent_p.I64I|CAMK2B_ENST00000440254.2_Silent_p.I64I|CAMK2B_ENST00000457475.1_Silent_p.I64I|CAMK2B_ENST00000353625.4_Silent_p.I64I|CAMK2B_ENST00000347193.4_Silent_p.I64I|CAMK2B_ENST00000350811.3_Silent_p.I64I|CAMK2B_ENST00000395747.2_Silent_p.I64I			Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II beta						interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)	18						GAAGGCGGCAGATCCGAGCCT	0.617000													12	88					4.3838e-07	4.67824e-07	1	1	0
GGCT	79017	broad.mit.edu	37	7	30538517	30538517	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr7:30538517C>G	ENST00000275428.4	-	3	459	c.325G>C	c.(325-327)Gaa>Caa	p.E109Q	GGCT_ENST00000409436.1_Missense_Mutation_p.E109Q|GGCT_ENST00000598361.1_Missense_Mutation_p.E24Q|GGCT_ENST00000409390.1_Intron|GGCT_ENST00000409144.1_Intron|GGCT_ENST00000005374.6_Intron	NM_024051.3	NP_076956.1	O75223	GGCT_HUMAN	gamma-glutamylcyclotransferase	109					release of cytochrome c from mitochondria	cytosol	acyltransferase activity|gamma-glutamylcyclotransferase activity|protein homodimerization activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)	8						ACTTTAACTTCTATTACAACA	0.388000													13	91					0	0	1	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58253454	58253454	+	Silent	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr15:58253454C>T	ENST00000249750.4	-	11	2057	c.1290G>A	c.(1288-1290)acG>acA	p.T430T	ALDH1A2_ENST00000347587.3_Silent_p.T392T|ALDH1A2_ENST00000559517.1_Silent_p.T334T|ALDH1A2_ENST00000537372.1_Silent_p.T409T|ALDH1A2_ENST00000558231.1_Silent_p.T401T	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	430					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	CTTCATCCATCGTCTTAAATC	0.408000													7	38					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48523067	48523067	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr4:48523067C>T	ENST00000537810.1	-	55	8291	c.7687G>A	c.(7687-7689)Gag>Aag	p.E2563K	FRYL_ENST00000507873.2_5'UTR|FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000503238.1_Missense_Mutation_p.E2563K|FRYL_ENST00000358350.4_Missense_Mutation_p.E2563K			O94915	FRYL_HUMAN	FRY-like	2563					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						CTCCCCACCTCAGGCAGCCGG	0.468000													7	54					0	0	1	0	0
DDIT4	54541	broad.mit.edu	37	10	74034832	74034832	+	Silent	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr10:74034832C>T	ENST00000307365.3	+	3	786	c.585C>T	c.(583-585)tcC>tcT	p.S195S	RP11-442H21.2_ENST00000491934.2_RNA	NM_019058.2	NP_061931.1	Q9NX09	DDIT4_HUMAN	DNA-damage-inducible transcript 4	195					apoptosis					cervix(1)|endometrium(2)|lung(5)|pancreas(1)|prostate(2)|urinary_tract(1)	12						TGTTTAGCTCCGCCAACTCTC	0.617000											OREG0020262	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	38					0	0	1	0	0
KCNS2	3788	broad.mit.edu	37	8	99440359	99440359	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr8:99440359C>G	ENST00000287042.4	+	2	502	c.152C>G	c.(151-153)tCg>tGg	p.S51W	KCNS2_ENST00000521839.1_Missense_Mutation_p.S51W	NM_020697.2	NP_065748.1	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	51						voltage-gated potassium channel complex	voltage-gated potassium channel activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	31	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			CTCTGCCACTCGCGCGAGGCC	0.637000													14	108					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235887339	235887339	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr1:235887339C>G	ENST00000389794.3	-	39	9478	c.9304G>C	c.(9304-9306)Gat>Cat	p.D3102H	LYST_ENST00000473037.1_5'UTR|LYST_ENST00000389793.2_Missense_Mutation_p.D3102H			Q99698	LYST_HUMAN	lysosomal trafficking regulator	3102					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TTGGTGTTATCAAATGCCAAC	0.343000													5	77					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				21	55					0	0	1	0	0
HPDL	84842	broad.mit.edu	37	1	45793409	45793409	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr1:45793409C>G	ENST00000334815.3	+	1	865	c.589C>G	c.(589-591)Ccc>Gcc	p.P197A		NM_032756.2	NP_116145.1	Q96IR7	HPDL_HUMAN	4-hydroxyphenylpyruvate dioxygenase-like	197					aromatic amino acid family metabolic process		4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)	4	Acute lymphoblastic leukemia(166;0.155)					AGGTGAGGATCCCGAGCTGGG	0.642000													11	99					0	0	1	0	0
IPO9	55705	broad.mit.edu	37	1	201843979	201843979	+	Missense_Mutation	SNP	G	G	C			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr1:201843979G>C	ENST00000361565.4	+	22	2922	c.2853G>C	c.(2851-2853)tgG>tgC	p.W951C		NM_018085.4	NP_060555.2	Q96P70	IPO9_HUMAN	importin 9	951					protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity			cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	38						ATGATATGTGggaggaccagg	0.438000													16	153					0	0	1	0	0
ZKSCAN4	387032	broad.mit.edu	37	6	28213044	28213044	+	Silent	SNP	G	G	A			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr6:28213044G>A	ENST00000377294.2	-	5	1731	c.1488C>T	c.(1486-1488)ttC>ttT	p.F496F	ZKSCAN4_ENST00000423974.2_Silent_p.F341F	NM_019110.3	NP_061983.2	Q969J2	ZKSC4_HUMAN	zinc finger with KRAB and SCAN domains 4	496					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|large_intestine(2)|lung(10)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	18						TATTCCGTGTGAAACTTCTCT	0.453000													17	93					0	0	1	0	0
KCNH4	23415	broad.mit.edu	37	17	40321507	40321507	+	Silent	SNP	G	G	A			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr17:40321507G>A	ENST00000264661.3	-	9	1910	c.1578C>T	c.(1576-1578)atC>atT	p.I526I	KCNH4_ENST00000607371.1_Silent_p.I526I	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	526					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CGTTGGCGTCGATGCCGCTGT	0.637000													27	50					0	0	1	0	0
TMEM192	201931	broad.mit.edu	37	4	166000862	166000862	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr4:166000862C>T	ENST00000306480.5	-	6	909	c.764G>A	c.(763-765)cGa>cAa	p.R255Q	TMEM192_ENST00000506087.1_Missense_Mutation_p.R251Q	NM_001100389.1	NP_001093859.1	Q8IY95	TM192_HUMAN	transmembrane protein 192	255						Golgi apparatus|integral to membrane|late endosome|lysosomal membrane|nucleus				NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	7	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0926)		AGCCAACAATCGCTTACTCAG	0.463000													7	36					0	0	1	0	0
ANO7	50636	broad.mit.edu	37	2	242157786	242157786	+	Missense_Mutation	SNP	C	C	A			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr2:242157786C>A	ENST00000274979.8	+	21	2576	c.2473C>A	c.(2473-2475)Cgc>Agc	p.R825S	ANO7_ENST00000402430.3_Missense_Mutation_p.R824S	NM_001001891.3	NP_001001891.2	Q6IWH7	ANO7_HUMAN	anoctamin 7	825						cell junction|chloride channel complex|cytosol	chloride channel activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(14)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	32						CGCGCACAACCGCACGTGCAG	0.776000													2	5					0.0784	0.0789521	1	1	0
SMG8	55181	broad.mit.edu	37	17	57288927	57288927	+	Silent	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr17:57288927C>T	ENST00000543872.2	+	2	1779	c.1515C>T	c.(1513-1515)ccC>ccT	p.P505P	SMG8_ENST00000578922.1_Silent_p.P505P|CTD-2510F5.6_ENST00000577660.1_Intron|SMG8_ENST00000300917.5_Silent_p.P505P|SMG8_ENST00000580498.1_Intron			Q8ND04	SMG8_HUMAN	SMG8 nonsense mediated mRNA decay factor	505					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding			NS(1)|breast(5)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	33						AAGCTTTACCCATGGCCCACA	0.403000													11	64					0	0	1	0	0
PSMD7	5713	broad.mit.edu	37	16	74336136	74336136	+	Silent	SNP	G	G	A			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr16:74336136G>A	ENST00000219313.4	+	5	524	c.384G>A	c.(382-384)ccG>ccA	p.P128P	PSMD7_ENST00000568615.2_Silent_p.P128P|PSMD7_ENST00000540379.1_Silent_p.P51P|PSMD7_ENST00000567958.1_Silent_p.P128P	NM_002811.4	NP_002802.2	P51665	PSD7_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	128					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)	15						ATGTGAAGCCGAAGGACCTAG	0.458000													11	88					0	0	1	0	0
NDUFA7	4701	broad.mit.edu	37	19	8381393	8381393	+	Missense_Mutation	SNP	T	T	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr19:8381393T>G	ENST00000301457.2	-	3	275	c.238A>C	c.(238-240)Aag>Cag	p.K80Q	NDUFA7_ENST00000598884.1_Missense_Mutation_p.K80Q	NM_005001.3	NP_004992.2	O95182	NDUA7_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa	80					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			NS(1)|central_nervous_system(1)|lung(2)|ovary(1)	5					NADH(DB00157)	TCTGCTGGCTTGCCTGACACC	0.592000													11	147					0	0	1	0	0
NAB2	4665	broad.mit.edu	37	12	57485446	57485446	+	Missense_Mutation	SNP	T	T	C			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr12:57485446T>C	ENST00000300131.3	+	2	1000	c.622T>C	c.(622-624)Ttc>Ctc	p.F208L	NAB2_ENST00000554718.1_3'UTR|NAB2_ENST00000357680.4_Missense_Mutation_p.F208L|NAB2_ENST00000342556.6_Missense_Mutation_p.F208L	NM_005967.3	NP_005958.1	Q15742	NAB2_HUMAN	NGFI-A binding protein 2 (EGR1 binding protein 2)	208					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity	p.F208L(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	20						CTCGCCCCCCTTCTCCCCCCC	0.716000													7	45					0	0	1	0	0
CLMN	79789	broad.mit.edu	37	14	95677084	95677084	+	Silent	SNP	T	T	C			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr14:95677084T>C	ENST00000298912.4	-	7	854	c.741A>G	c.(739-741)ctA>ctG	p.L247L		NM_024734.3	NP_079010.2	Q96JQ2	CLMN_HUMAN	calmin (calponin-like, transmembrane)	247	Actin-binding.|CH 2.					integral to membrane	actin binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(17)|prostate(3)|skin(3)	44				Epithelial(152;0.193)		AAGCCTTCTCTAGATTTTCTC	0.512000													82	142					0	0	1	0	0
WASH3P	0	broad.mit.edu	37	15	102515299	102515299	+	RNA	SNP	G	G	A			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr15:102515299G>A	ENST00000557932.1	+	0	1145																		p.G374S(10)		central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						TGGGGGCATCGGCAAGGCCAA	0.652000													3	27					0	0	1	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73021165	73021165	+	Silent	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr11:73021165C>T	ENST00000263674.3	+	1	1832	c.1482C>T	c.(1480-1482)tcC>tcT	p.S494S		NM_014786.3	NP_055601.2	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	494					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(2)	32						GTGGGAGCTCCGGGGACCGTG	0.597000													16	84					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126707544	126707544	+	Silent	SNP	T	T	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr3:126707544T>G	ENST00000393409.2	+	1	108	c.108T>G	c.(106-108)ggT>ggG	p.G36G	PLXNA1_ENST00000251772.4_Silent_p.G13G	NM_032242.3	NP_115618.3	Q9UIW2	PLXA1_HUMAN	plexin A1	36	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity	p.G13G(4)		breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		CAGGCGGGGGTTCACAGCCCC	0.682000													12	38					0	0	1	0	0
PARP10	84875	broad.mit.edu	37	8	145060266	145060266	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr8:145060266C>G	ENST00000313028.7	-	2	232	c.138G>C	c.(136-138)caG>caC	p.Q46H	PARP10_ENST00000533665.1_Intron|PARP10_ENST00000524918.1_Missense_Mutation_p.Q46H|PARP10_ENST00000525773.1_Missense_Mutation_p.Q58H	NM_032789.3	NP_116178.2	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	46						Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|pancreas(1)|upper_aerodigestive_tract(2)	27	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AGCCCAGTCTCTGCCAGCTCA	0.622000													21	111					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125022933	125022933	+	Silent	SNP	G	G	A			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr8:125022933G>A	ENST00000522917.1	+	14	2006	c.1800G>A	c.(1798-1800)ctG>ctA	p.L600L	FER1L6-AS1_ENST00000518567.1_RNA|FER1L6_ENST00000399018.1_Silent_p.L600L	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	600						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CCAACATGCTGGAGAAAATGG	0.473000													49	157					0	0	1	0	0
FAM46B	115572	broad.mit.edu	37	1	27333107	27333107	+	Silent	SNP	G	G	C			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr1:27333107G>C	ENST00000289166.5	-	2	771	c.606C>G	c.(604-606)ctC>ctG	p.L202L		NM_052943.3	NP_443175.2	Q96A09	FA46B_HUMAN	family with sequence similarity 46, member B	202										breast(1)|central_nervous_system(1)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	10		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;7.71e-51)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|STAD - Stomach adenocarcinoma(196;0.00114)|READ - Rectum adenocarcinoma(331;0.0419)		CCACAAACTTGAGCTCCACGT	0.542000													19	132					0	0	1	0	0
GRIN2A	0	broad.mit.edu	37	16	9858772	9858772	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr16:9858772C>T	ENST00000396573.2	-	14	2938	c.2629G>A	c.(2629-2631)Gaa>Aaa	p.E877K	GRIN2A_ENST00000396575.2_Missense_Mutation_p.E877K|GRIN2A_ENST00000404927.2_Missense_Mutation_p.E877K|GRIN2A_ENST00000330684.3_Missense_Mutation_p.E877K|GRIN2A_ENST00000535259.1_Missense_Mutation_p.E720K|GRIN2A_ENST00000562109.1_Missense_Mutation_p.E877K	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	877					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TTCTTTTCTTCAATGTGCACT	0.468000													38	95					0	0	1	0	0
KRT25	147183	broad.mit.edu	37	17	38907519	38907519	+	Silent	SNP	G	G	A			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr17:38907519G>A	ENST00000312150.4	-	4	789	c.729C>T	c.(727-729)gcC>gcT	p.A243A		NM_181534.3	NP_853512.1	Q7Z3Z0	K1C25_HUMAN	keratin 25	243	Linker 12.|Rod.					cytoplasm|intermediate filament	structural molecule activity			endometrium(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(4)	16		Breast(137;0.00526)				CCACCCCGGGGGCTGCGTTCA	0.572000													29	75					0	0	1	0	0
SLC50A1	55974	broad.mit.edu	37	1	155110531	155110531	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr1:155110531C>G	ENST00000368404.4	+	5	583	c.521C>G	c.(520-522)tCc>tGc	p.S174C	SLC50A1_ENST00000484157.1_Missense_Mutation_p.S109C|SLC50A1_ENST00000368405.3_3'UTR|SLC50A1_ENST00000368401.5_Missense_Mutation_p.S119C|SLC50A1_ENST00000303343.8_Missense_Mutation_p.S120C	NM_018845.3	NP_061333.2	Q9BRV3	SWET1_HUMAN	solute carrier family 50 (sugar efflux transporter), member 1	174	Mediates interaction with TRPV2 (By similarity).|MtN3/slv 2.				positive regulation of gene expression, epigenetic	Golgi membrane|integral to membrane|plasma membrane	glucoside transmembrane transporter activity			endometrium(1)|lung(1)|ovary(1)|skin(1)	4						ACCTCTGCCTCCTGGTGCCTC	0.502000													10	138					0	0	1	0	0
HLA-DPB1	3115	broad.mit.edu	37	6	33052895	33052895	+	Missense_Mutation	SNP	G	G	C			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr6:33052895G>C	ENST00000418931.2	+	3	649	c.533G>C	c.(532-534)gGa>gCa	p.G178A		NM_002121.5	NP_002112.3	P04440	DPB1_HUMAN	major histocompatibility complex, class II, DP beta 1	178	Beta-2.|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to membrane|lysosomal membrane|MHC class II protein complex				cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	11						ATCCGTAATGGAGACTGGACC	0.557000													20	127					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133900464	133900464	+	Silent	SNP	G	G	A			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr8:133900464G>A	ENST00000220616.4	+	10	2452	c.2412G>A	c.(2410-2412)gtG>gtA	p.V804V	TG_ENST00000377869.1_Silent_p.V804V	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	804	Thyroglobulin type-1 7.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGCTGCTAGTGAAGATCATGA	0.522000													10	54					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38983246	38983246	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr19:38983246G>A	ENST00000355481.4	+	38	6375	c.6244G>A	c.(6244-6246)Gag>Aag	p.E2082K	RYR1_ENST00000359596.3_Missense_Mutation_p.E2082K|RYR1_ENST00000360985.3_Missense_Mutation_p.E2082K	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	2082	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GAAACCTGAGGAGGAGCGGTC	0.632000													9	49					0	0	1	0	0
KDM2B	84678	broad.mit.edu	37	12	121958892	121958892	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr12:121958892C>G	ENST00000377069.4	-	9	1256	c.850G>C	c.(850-852)Gcc>Ccc	p.A284P	KDM2B_ENST00000543852.1_Missense_Mutation_p.A84P|KDM2B_ENST00000538046.2_Intron|KDM2B_ENST00000377071.4_Missense_Mutation_p.A315P|KDM2B_ENST00000536437.1_Missense_Mutation_p.A198P	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	315	JmjC.				embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						GTGTAGACGGCATGGATCCAA	0.612000													5	43					0	0	1	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20903757	20903757	+	Silent	SNP	T	T	C	rs10841611	by1000genomes	TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr12:20903757T>C	ENST00000381552.1	+	14	2315	c.1947T>C	c.(1945-1947)caT>caC	p.H649H	SLCO1C1_ENST00000266509.2_Intron|SLCO1C1_ENST00000545604.1_Silent_p.H649H|SLCO1C1_ENST00000545102.1_Silent_p.H531H|SLCO1C1_ENST00000540354.1_Intron			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	0					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity	p.H649H(1)		NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					CCGCATCTCATTGCTACAGCA	0.378000													5	57					0	0	1	0	0
ATAD2	29028	broad.mit.edu	37	8	124373884	124373884	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr8:124373884C>T	ENST00000287394.5	-	9	1159	c.1052G>A	c.(1051-1053)cGa>cAa	p.R351Q	ATAD2_ENST00000534257.1_5'UTR|ATAD2_ENST00000521903.1_5'UTR	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	351					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			TGCATGCCTTCGCCTAAAGTA	0.403000													21	79					0	0	1	0	0
PTPN3	0	broad.mit.edu	37	9	112189342	112189342	+	Silent	SNP	A	A	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr9:112189342A>G	ENST00000412145.1	-	7	3049	c.496T>C	c.(496-498)Ttg>Ctg	p.L166L	PTPN3_ENST00000446349.1_Silent_p.L166L|PTPN3_ENST00000262539.3_Silent_p.L188L|PTPN3_ENST00000374541.2_Silent_p.L297L	NM_001145369.1|NM_001145371.1	NP_001138841.1|NP_001138843.1	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type 3	297	FERM.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						GATTTCCACAAGTTTTTGCAA	0.448000													9	53					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121698953	121698953	+	Missense_Mutation	SNP	G	G	C			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr7:121698953G>C	ENST00000393386.2	+	28	7039	c.6628G>C	c.(6628-6630)Gaa>Caa	p.E2210Q	PTPRZ1_ENST00000449182.1_Missense_Mutation_p.E1343Q	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	2210	Tyrosine-protein phosphatase 2.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						TGTTATAAAAGAAGAAGCTGC	0.383000													9	78					0	0	1	0	0
SEC62	7095	broad.mit.edu	37	3	169694764	169694764	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr3:169694764C>T	ENST00000337002.4	+	3	234	c.176C>T	c.(175-177)tCa>tTa	p.S59L	SEC62_ENST00000480708.1_Missense_Mutation_p.S59L	NM_003262.3	NP_003253.1	Q99442	SEC62_HUMAN	SEC62 homolog (S. cerevisiae)	59					cotranslational protein targeting to membrane|transmembrane transport	aggresome|endoplasmic reticulum membrane|integral to membrane|intermediate filament cytoskeleton|rough endoplasmic reticulum	protein transporter activity|receptor activity			NS(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	9						CTTTTGGATTCAAAGTGGGCA	0.343000													13	29					0	0	1	0	0
DPF1	0	broad.mit.edu	37	19	38713285	38713285	+	Silent	SNP	G	G	A			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr19:38713285G>A	ENST00000416611.1	-	2	219	c.96C>T	c.(94-96)tgC>tgT	p.C32C	DPF1_ENST00000456296.1_Silent_p.C32C|DPF1_ENST00000414789.1_5'UTR|DPF1_ENST00000412732.1_5'UTR|DPF1_ENST00000355526.4_Silent_p.C58C|DPF1_ENST00000420980.2_Silent_p.C58C			Q92782	DPF1_HUMAN	D4, zinc and double PHD fingers family 1	58					induction of apoptosis|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nBAF complex	zinc ion binding			large_intestine(1)|lung(4)|ovary(1)|skin(1)	7	all_cancers(60;1.24e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			TGCGCTCGGCGCACAGGCGCG	0.677000													6	19					0	0	1	0	0
CREBZF	58487	broad.mit.edu	37	11	85375852	85375852	+	Missense_Mutation	SNP	G	G	C			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr11:85375852G>C	ENST00000527447.1	-	1	294	c.68C>G	c.(67-69)cCg>cGg	p.P23R	CREBZF_ENST00000531515.1_Intron|CREBZF_ENST00000534224.1_Intron	NM_001039618.2	NP_001034707.1	Q9NS37	ZHANG_HUMAN	CREB/ATF bZIP transcription factor	23					negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|response to virus	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	9		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)				AGCCGGCTCCGGGCTCTCACT	0.726000													21	33					0	0	1	0	0
VWA2	340706	broad.mit.edu	37	10	116021037	116021037	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr10:116021037C>G	ENST00000603594.1	+	5	675	c.354C>G	c.(352-354)atC>atG	p.I118M	VWA2_ENST00000392982.3_Missense_Mutation_p.I118M	NM_001272046.1	NP_001258975.1	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	118	VWFA 1.					extracellular region				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Epithelial(162;0.036)|all cancers(201;0.0793)		AGGCAAGAATCAAGAGGATGG	0.463000													13	97					0	0	1	0	0
SRC	6714	broad.mit.edu	37	20	36012660	36012660	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr20:36012660C>T	ENST00000373578.2	+	4	453	c.104C>T	c.(103-105)tCg>tTg	p.S35L	SRC_ENST00000373558.2_Missense_Mutation_p.S35L|SRC_ENST00000445403.1_Missense_Mutation_p.S35L|SRC_ENST00000360723.4_Missense_Mutation_p.S35L|SRC_ENST00000358208.4_Missense_Mutation_p.S35L|SRC_ENST00000373567.2_Missense_Mutation_p.S35L	NM_198291.1	NP_938033.1	P12931	SRC_HUMAN	v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog	35					axon guidance|bone resorption|cell junction assembly|cellular membrane organization|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular protein kinase cascade|leukocyte migration|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of integrin activation|Ras protein signal transduction|regulation of bone resorption|regulation of vascular permeability|response to interleukin-1|signal complex assembly|T cell costimulation	caveola|cytosol|mitochondrial inner membrane	ATP binding|heme binding|integrin binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|SH3/SH2 adaptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(16)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)			Dasatinib(DB01254)	TTCCCCGCCTCGCAGACCCCC	0.746000													4	17					0	0	1	0	0
KRT8P12	0	broad.mit.edu	37	3	160285957	160285957	+	RNA	SNP	C	C	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr3:160285957C>G	ENST00000468527.1	+	0	968																											AAGTTTGCCTCCTTCACAGAC	0.552000													25	103					0	0	1	0	0
TET1	80312	broad.mit.edu	37	10	70405889	70405889	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr10:70405889C>T	ENST00000373644.4	+	4	3612	c.3403C>T	c.(3403-3405)Cat>Tat	p.H1135Y		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	1135					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						ACACAATAATCATGGTTCATC	0.393000													8	52					0	0	1	0	0
ZNF655	79027	broad.mit.edu	37	7	99170671	99170671	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr7:99170671C>T	ENST00000424881.1	+	4	1265	c.1045C>T	c.(1045-1047)Cgt>Tgt	p.R349C	ZNF655_ENST00000493277.1_Missense_Mutation_p.R349C|ZNF655_ENST00000425063.1_3'UTR|ZNF655_ENST00000419215.2_3'UTR|ZNF655_ENST00000394163.2_Missense_Mutation_p.R314C|ZNF655_ENST00000252713.4_Missense_Mutation_p.R314C	NM_001083956.1|NM_001085368.1	NP_001077425.1|NP_001078837.1	Q8N720	ZN655_HUMAN	zinc finger protein 655	314					G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding	p.R314C(1)		NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	16	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					AGTCTTCAGTCGTAGTGTCCA	0.403000													6	97					0	0	1	0	0
CRISPLD2	83716	broad.mit.edu	37	16	84911073	84911073	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr16:84911073G>A	ENST00000262424.5	+	12	1410	c.1186G>A	c.(1186-1188)Gct>Act	p.A396T	CRISPLD2_ENST00000564567.1_Missense_Mutation_p.A396T|CRISPLD2_ENST00000567845.1_Missense_Mutation_p.A395T	NM_031476.3	NP_113664.1	Q9H0B8	CRLD2_HUMAN	cysteine-rich secretory protein LCCL domain containing 2	396	LCCL 2.					extracellular region|transport vesicle				endometrium(3)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)	18						CACGACCGTTGCTCAGCTGTG	0.537000													6	105					0	0	1	0	0
PSG9	5678	broad.mit.edu	37	19	43772209	43772209	+	Silent	SNP	G	G	A	rs144736946		TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr19:43772209G>A	ENST00000244293.7	-	2	223	c.157C>T	c.(157-159)Cta>Tta	p.L53L	PSG9_ENST00000418820.2_Silent_p.L53L|PSG9_ENST00000443718.3_Silent_p.L53L|PSG9_ENST00000270077.3_Silent_p.L53L|PSG9_ENST00000291752.5_Silent_p.L53L|PSG9_ENST00000596730.1_Silent_p.L53L|PSG9_ENST00000593948.1_Silent_p.L53L			Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	53	Ig-like V-type.				female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Prostate(69;0.00682)				TGGACAAGTAGAAGAACATCC	0.473000													72	185					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3640002	3640002	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr16:3640002C>G	ENST00000294008.3	-	12	4277	c.3637G>C	c.(3637-3639)Gtg>Ctg	p.V1213L		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	1213	Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						TGCTGCAGCACAGCTTCGCTT	0.577000								Direct reversal of damage					25	142					0	0	1	0	0
BRD7	29117	broad.mit.edu	37	16	50354303	50354303	+	Splice_Site	SNP	C	C	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr16:50354303C>T	ENST00000394688.3	-	15	1772		c.e15-1		BRD7_ENST00000394689.2_Splice_Site			Q9NPI1	BRD7_HUMAN	bromodomain containing 7						cell cycle|negative regulation of cell proliferation|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of histone acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleus	histone acetyl-lysine binding|p53 binding|transcription coactivator activity|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|prostate(2)|urinary_tract(2)	22		all_cancers(37;0.0127)				ATTTCAGCTTCTGTGTGGTAA	0.463000													11	81					0	0	1	0	0
PDIK1L	149420	broad.mit.edu	37	1	26448486	26448486	+	Silent	SNP	G	G	C			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr1:26448486G>C	ENST00000374271.4	+	4	731	c.444G>C	c.(442-444)ctG>ctC	p.L148L	PDIK1L_ENST00000374269.1_Silent_p.L148L	NM_001243532.1|NM_001243533.1|NM_152835.4	NP_001230461.1|NP_001230462.1|NP_690048.1	Q8N165	PDK1L_HUMAN	PDLIM1 interacting kinase 1 like	148	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity			large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	7		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00239)|all_lung(284;0.00366)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.32e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000735)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.015)|READ - Rectum adenocarcinoma(331;0.0649)		TGCTTCAGCTGAGCAGTGCCC	0.438000													17	109					0	0	1	0	0
WASL	8976	broad.mit.edu	37	7	123332450	123332450	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr7:123332450C>G	ENST00000223023.4	-	9	1630	c.1298G>C	c.(1297-1299)gGa>gCa	p.G433A		NM_003941.2	NP_003932.3	O00401	WASL_HUMAN	Wiskott-Aldrich syndrome-like	433	WH2 2.				actin polymerization or depolymerization|axon guidance|cellular component movement|nitric oxide metabolic process|protein complex assembly|regulation of nitric-oxide synthase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|cytosol|nucleolus|plasma membrane	actin binding|small GTPase regulator activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						TGCATCTCGTCCAGAGCAGGA	0.398000													18	99					0	0	1	0	0
POLQ	10721	broad.mit.edu	37	3	121230820	121230820	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr3:121230820G>A	ENST00000264233.5	-	10	1653	c.1525C>T	c.(1525-1527)Cag>Tag	p.Q509*		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	509	Helicase C-terminal.				DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		AGAGAACCCTGAAGGAGAGCT	0.408000								DNA polymerases (catalytic subunits)					20	105					0	0	1	0	0
ZNF883	169834	broad.mit.edu	37	9	115760586	115760586	+	RNA	SNP	C	C	T	rs75939690	byFrequency	TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr9:115760586C>T	ENST00000427548.1	-	0	1227							P0CG24	ZN883_HUMAN	zinc finger protein 883						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding										TCATTTTTGTCGGTATGTAAT	0.289000													3	22					0	0	1	0	0
STAG3L4	0	broad.mit.edu	37	7	66767610	66767611	+	RNA	INS	-	-	G	rs71293166	by1000genomes	TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr7:66767610_66767611insG	ENST00000416602.2	+	0	3_4					NR_040586.1		Q8TBR4	STG34_HUMAN												endometrium(2)|lung(5)	7		Lung NSC(55;0.0839)|all_lung(88;0.181)				CACCGGACTGCTTTTTTTTTTT	0.545													3	5	---	---	---	---					
FAM3C	10447	broad.mit.edu	37	7	121002954	121002955	+	Frame_Shift_Ins	INS	-	-	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr7:121002954_121002955insT	ENST00000359943.3	-	7	591_592	c.378_379insA	c.(376-381)gggagafs	p.R127fs		NM_001040020.1|NM_014888.2	NP_001035109.1|NP_055703.1	Q92520	FAM3C_HUMAN	family with sequence similarity 3, member C	127					multicellular organismal development	cytoplasmic membrane-bounded vesicle|extracellular region	cytokine activity			kidney(1)|lung(8)	9	all_neural(327;0.117)					TGCTTACCTCCTCCCCACATGT	0.332													7	49	---	---	---	---					
CADM1	23705	broad.mit.edu	37	11	115375030	115375035	+	In_Frame_Del	DEL	AGCCGG	AGCCGG	-			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr11:115375030_115375035delAGCCGG	ENST00000542447.2	-	1	206_211	c.78_83delCCGGCT	c.(76-84)ctt>ct	p.LRL26del	CADM1_ENST00000452722.2_In_Frame_Del_p.LRL26del|CADM1_ENST00000537140.1_5'UTR|CADM1_ENST00000536727.1_In_Frame_Del_p.LRL26del|CADM1_ENST00000331581.6_In_Frame_Del_p.LRL26del|CADM1_ENST00000537058.1_In_Frame_Del_p.LRL26del	NM_001098517.1	NP_001091987.1	Q9BY67	CADM1_HUMAN	cell adhesion molecule 1	26					adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(9)|ovary(2)|skin(1)	32	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		CAACAGCAGAAGCCGGAGCCGGAGCC	0.694													3	6	---	---	---	---					
CLIP1	6249	broad.mit.edu	37	12	122812690	122812691	+	Frame_Shift_Ins	INS	-	-	T			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr12:122812690_122812691insT	ENST00000358808.2	-	16	3173_3174	c.3019_3020insA	c.(3019-3021)ccafs	p.P1007fs	CLIP1_ENST00000302528.7_Frame_Shift_Ins_p.P1007fs|CLIP1_ENST00000545889.1_Frame_Shift_Ins_p.P593fs|CLIP1_ENST00000540338.1_Frame_Shift_Ins_p.P1018fs|CLIP1_ENST00000537178.1_Frame_Shift_Ins_p.P972fs|CLIP1_ENST00000361654.4_Frame_Shift_Ins_p.P896fs	NM_001247997.1|NM_002956.2	NP_001234926.1|NP_002947.1	P30622	CLIP1_HUMAN	CAP-GLY domain containing linker protein 1	1018					mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			NS(1)|breast(5)|endometrium(4)|kidney(5)|large_intestine(16)|liver(1)|lung(21)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		CTGGTTGTGGCTTGTTTCCATT	0.505													8	292	---	---	---	---					
OR4N2	390429	broad.mit.edu	37	14	20296055	20296056	+	Frame_Shift_Ins	INS	-	-	T	rs149523724	by1000genomes	TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr14:20296055_20296056insT	ENST00000315947.1	+	1	448_449	c.448_449insT	c.(448-450)tggfs	p.W150fs	OR4N2_ENST00000568211.1_Frame_Shift_Ins_p.W150fs	NM_001004723.1	NP_001004723.1	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N, member 2	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GGCTCTGTGGCTTGGGGGTTTT	0.530													62	431	---	---	---	---					
TRAV24	0	broad.mit.edu	37	14	22573824	22573825	+	RNA	INS	-	-	A	rs112427980	by1000genomes	TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr14:22573824_22573825insA	ENST00000390453.1	+	0	55																											TGACTCTTTTTTAAAAAAACAG	0.450													8	12	---	---	---	---					
FSCB	84075	broad.mit.edu	37	14	44974154	44974155	+	In_Frame_Ins	INS	-	-	GGGGCCTCCTCAGCTGGTGGAGGCTGAACTTCAGAG	rs71108655	byFrequency	TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr14:44974154_44974155insGGGGCCTCCTCAGCTGGTGGAGGCTGAACTTCAGAG	ENST00000340446.4	-	1	2327_2328	c.2036_2037insCTCTGAAGTTCAGCCTCCACCAGCTGAGGAGGCCCC	c.(2035-2037)cgc>cCTCTGAAGTTCAGCCTCCACCAGCTGAGGAGGCCCCgc	p.678_679insPLKFSLHQLRRP		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	678	Ala-rich.					cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		GAACTTCAGCAGGGGCCTCCTC	0.604													8	50	---	---	---	---					
BRSK1	84446	broad.mit.edu	37	19	55815035	55815036	+	Splice_Site	INS	-	-	C			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr19:55815035_55815036insC	ENST00000309383.1	+	12	1404_1405	c.1126_splice	c.e12-1	p.A376_splice	BRSK1_ENST00000590333.1_Splice_Site_p.A392_splice|BRSK1_ENST00000326848.7_Splice_Site_p.A71_splice	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	376					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity	p.R379fs*9(2)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		TGTCCCTCAGACCCCCCCCGGA	0.579													7	162	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11085863	11085864	+	RNA	INS	-	-	C			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr21:11085863_11085864insC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		catcaccaccaccaccatcacc	0.579													2	4	---	---	---	---					
ANKRD20A11P	0	broad.mit.edu	37	21	15343746	15343749	+	RNA	DEL	TCTG	TCTG	-			TCGA-EL-A3ZO-01A-11D-A23M-08	TCGA-EL-A3ZO-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21a5295b-4bfd-44d5-8013-41a2767b00d5	334efff1-8d40-4737-9810-b9586895deef	g.chr21:15343746_15343749delTCTG	ENST00000344693.5	-	0	736					NR_027270.1																						CTCTGTGCTTTCTGATGTGCTGCT	0.407													3	5	---	---	---	---