Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NRAS	4893	broad.mit.edu	37	1	115256529	115256529	+	Missense_Mutation	SNP	T	T	C	rs11554290		TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr1:115256529T>C	ENST00000369535.4	-	3	435	c.182A>G	c.(181-183)cAa>cGa	p.Q61R		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(817)|p.Q61L(175)|p.Q61P(23)|p.Q61K(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458000	Q61L(C3A_LIVER)|Q61L(HEPG2_LIVER)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MELJUSO_SKIN)|Q61L(MHHES1_BONE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(HT1197_URINARY_TRACT)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(KU1919_URINARY_TRACT)|Q61R(NCIH2347_LUNG)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(SKMEL2_SKIN)|Q61R(SW1271_LUNG)|Q61R(TT2609C02_THYROID)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			60	88					0	0	0.000147903	0	0
ATP11A	23250	broad.mit.edu	37	13	113487317	113487317	+	Silent	SNP	G	G	C			TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr13:113487317G>C	ENST00000487903.1	+	14	1627	c.1539G>C	c.(1537-1539)gcG>gcC	p.A513A	ATP11A_ENST00000375645.3_Silent_p.A513A|ATP11A_ENST00000283558.8_Silent_p.A513A|ATP11A_ENST00000375630.2_Silent_p.A513A			P98196	AT11A_HUMAN	ATPase, class VI, type 11A	513					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(12)|lung(17)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	51	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				ACGAGGTGGCGCTGGTCGAAG	0.627000													18	180					0	0	7.07596e-05	0	0
PHC1	1911	broad.mit.edu	37	12	9092053	9092053	+	Nonstop_Mutation	SNP	T	T	C			TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr12:9092053T>C	ENST00000433083.2	+	14	3023	c.2878T>C	c.(2878-2880)Taa>Caa	p.*960Q	PHC1_ENST00000544916.1_Nonstop_Mutation_p.*1005Q|PHC1_ENST00000536844.1_Nonstop_Mutation_p.*611Q|PHC1_ENST00000543824.1_Nonstop_Mutation_p.*1005Q			P78364	PHC1_HUMAN	polyhomeotic homolog 1 (Drosophila)	0	SAM.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|large_intestine(8)|liver(2)|lung(3)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	27						CAAGGAGACCTAAGGTGGCCC	0.478000													2	11					0	0	6.4e-05	0	0
MAU2	23383	broad.mit.edu	37	19	19446536	19446536	+	Missense_Mutation	SNP	T	T	C			TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr19:19446536T>C	ENST00000392313.5	+	2	332	c.286T>C	c.(286-288)Tca>Cca	p.S96P	MAU2_ENST00000262815.8_Intron	NM_015329.3	NP_056144.3	Q9Y6X3	SCC4_HUMAN	MAU2 sister chromatid cohesion factor	96	Sufficient for interaction with NIPBL.				cell division|maintenance of mitotic sister chromatid cohesion	chromatin|nucleoplasm|SMC loading complex	protein N-terminus binding			NS(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	18						GTGGTTGATATCACAGCAAGT	0.438000													24	68					0	0	0.000117367	0	0
DIDO1	11083	broad.mit.edu	37	20	61524262	61524262	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr20:61524262G>A	ENST00000266070.4	-	13	3479	c.3154C>T	c.(3154-3156)Cga>Tga	p.R1052*	DIDO1_ENST00000395335.2_Nonsense_Mutation_p.R1052*|DIDO1_ENST00000395340.1_Nonsense_Mutation_p.R1052*|DIDO1_ENST00000395343.1_Nonsense_Mutation_p.R1052*	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1052					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding	p.R1052*(1)		NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					GTGCTGAGTCGAGACAAAAAG	0.423000													15	41					0	0	0.000219431	0	0
SUSD1	64420	broad.mit.edu	37	9	114886546	114886546	+	Missense_Mutation	SNP	T	T	C			TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr9:114886546T>C	ENST00000374270.3	-	6	1049	c.877A>G	c.(877-879)Aca>Gca	p.T293A	SUSD1_ENST00000374263.3_Missense_Mutation_p.T293A|SUSD1_ENST00000374264.2_Missense_Mutation_p.T293A	NM_022486.3	NP_071931.2	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1	293	Sushi 2.					integral to membrane	calcium ion binding		SUSD1/ROD1(2)	central_nervous_system(1)|endometrium(4)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28						CCTGTGCATGTTAAAGTACTT	0.507000													4	147					0	0	0.00024832	0	0
CNTN3	5067	broad.mit.edu	37	3	74315640	74315640	+	Missense_Mutation	SNP	C	C	G			TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr3:74315640C>G	ENST00000263665.6	-	21	3005	c.2978G>C	c.(2977-2979)cGa>cCa	p.R993P	CNTN3_ENST00000477856.1_5'UTR	NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	993					cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		ACTGGTTATTCGTGGAATCCT	0.428000													3	73					0	0	6.4e-05	0	0
ADH4	127	broad.mit.edu	37	4	100047817	100047817	+	Missense_Mutation	SNP	T	T	A			TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr4:100047817T>A	ENST00000508393.1	-	9	1268	c.1103A>T	c.(1102-1104)gAt>gTt	p.D368V	ADH4_ENST00000265512.7_Missense_Mutation_p.D349V|ADH4_ENST00000423445.1_Missense_Mutation_p.D368V|RP11-696N14.1_ENST00000500358.2_RNA|ADH4_ENST00000505590.1_Missense_Mutation_p.D368V			P08319	ADH4_HUMAN	alcohol dehydrogenase 4 (class II), pi polypeptide	349					alcohol catabolic process|cellular aldehyde metabolic process|ethanol oxidation|quinone cofactor metabolic process|retinol metabolic process|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	alcohol dehydrogenase activity, zinc-dependent|all-trans retinal binding|benzaldehyde dehydrogenase activity|NAD binding|NADPH:quinone reductase activity|retinol binding|retinol dehydrogenase activity|zinc ion binding			NS(1)|cervix(1)|large_intestine(2)|liver(2)|lung(8)|prostate(2)|skin(2)	18				OV - Ovarian serous cystadenocarcinoma(123;4.48e-08)	NADH(DB00157)	CACCAGTGCATCCAGATTGAA	0.373000													20	56					0	0	0.000132079	0	0
IL16	3603	broad.mit.edu	37	15	81517814	81517814	+	Missense_Mutation	SNP	T	T	C			TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr15:81517814T>C	ENST00000394660.2	+	2	434	c.74T>C	c.(73-75)cTc>cCc	p.L25P	IL16_ENST00000302987.4_Missense_Mutation_p.L25P	NM_001172128.1|NM_172217.3	NP_001165599.1|NP_757366.2	Q14005	IL16_HUMAN	interleukin 16	25					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(3)|skin(3)|stomach(1)|urinary_tract(1)	57						TCCCTGATGCTCTGTAATGCT	0.498000													15	25					0	0	0.000308642	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45128742	45128742	+	RNA	SNP	T	T	G	rs34655963	by1000genomes	TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr17:45128742T>G	ENST00000575173.1	-	0	418																											TAATGATTTTTATTATACTTT	0.328000													4	108					0	0	1.23904e-05	0	0
PCDHB5	0	broad.mit.edu	37	5	140516258	140516258	+	Silent	SNP	C	C	T			TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr5:140516258C>T	ENST00000231134.5	+	1	1459	c.1242C>T	c.(1240-1242)gcC>gcT	p.A414A		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		414	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGAGCCAAGCCGAGTACAACA	0.498000													42	72					0	0	0.000374591	0	0
CLDN15	24146	broad.mit.edu	37	7	100880845	100880845	+	Silent	SNP	T	T	C			TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr7:100880845T>C	ENST00000401528.1	-	2	1143	c.18A>G	c.(16-18)gaA>gaG	p.E6E	CLDN15_ENST00000433422.1_5'UTR|CLDN15_ENST00000308344.5_Silent_p.E6E	NM_001185080.1	NP_001172009.1	P56746	CLD15_HUMAN	claudin 15	6					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	10	Lung NSC(181;0.168)|all_lung(186;0.215)					AGCCAAAGGTTTCCACAGCCA	0.622000													4	38					0	0	0.00024832	0	0
PPM1J	333926	broad.mit.edu	37	1	113256123	113256123	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr1:113256123C>T	ENST00000309276.6	-	2	612	c.437G>A	c.(436-438)gGc>gAc	p.G146D	PPM1J_ENST00000464951.1_5'UTR	NM_005167.5	NP_005158.5	Q5JR12	PPM1J_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1J	146	PP2C-like.									breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)	14	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCTTACCTGGCCTCGGCTAGG	0.562000													5	59					0	0	8.12818e-05	0	0
FRG1B	0	broad.mit.edu	37	20	29625947	29625947	+	Missense_Mutation	SNP	T	T	C			TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr20:29625947T>C	ENST00000278882.3	+	5	571	c.191T>C	c.(190-192)aTt>aCt	p.I64T	FRG1B_ENST00000439954.2_Missense_Mutation_p.I69T|FRG1B_ENST00000358464.4_Missense_Mutation_p.I64T														p.I64T(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TCAGATGCAATTGGACCAAGA	0.343000													3	32					0	0	0.00024832	0	0
FBN2	2201	broad.mit.edu	37	5	127638774	127638774	+	Silent	SNP	A	A	G			TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr5:127638774A>G	ENST00000508053.1	-	52	6782	c.5808T>C	c.(5806-5808)gaT>gaC	p.D1936D	FBN2_ENST00000262464.4_Silent_p.D1936D			P35556	FBN2_HUMAN	fibrillin 2	1936	EGF-like 32; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GCTCGCACTCATCAACATCTA	0.338000													27	40					0	0	0.000117367	0	0
LILRB1	0	broad.mit.edu	37	19	55085362	55085362	+	Missense_Mutation	SNP	C	C	T	rs145704089	byFrequency	TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr19:55085362C>T	ENST00000396321.2	+	1	17	c.17C>T	c.(16-18)aCg>aTg	p.T6M	LILRB1_ENST00000418536.2_Missense_Mutation_p.T6M|LILRA2_ENST00000495786.1_Intron|LILRA2_ENST00000391737.1_Missense_Mutation_p.T6M|LILRA2_ENST00000251377.3_Missense_Mutation_p.T6M|LILRB1_ENST00000448689.1_Missense_Mutation_p.T6M|LILRA2_ENST00000391738.3_Missense_Mutation_p.T6M|LILRA2_ENST00000251376.3_Missense_Mutation_p.T6M			Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	6					regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		CCCATCCTCACGGTCCTGATC	0.602000										HNSCC(37;0.09)			28	83					0	0	0.000147802	0	0
STK25	10494	broad.mit.edu	37	2	242439602	242439602	+	Missense_Mutation	SNP	T	T	C			TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr2:242439602T>C	ENST00000316586.4	-	5	762	c.413A>G	c.(412-414)cAc>cGc	p.H138R	STK25_ENST00000401869.1_Missense_Mutation_p.H138R|STK25_ENST00000405883.3_Missense_Mutation_p.H61R|STK25_ENST00000543554.1_Missense_Mutation_p.H44R|STK25_ENST00000535007.1_Missense_Mutation_p.H44R|STK25_ENST00000405585.1_Missense_Mutation_p.H61R|STK25_ENST00000403346.3_Missense_Mutation_p.H138R	NM_001271977.1|NM_001271978.1	NP_001258906.1|NP_001258907.1	O00506	STK25_HUMAN	serine/threonine kinase 25	138	Protein kinase.				response to oxidative stress|signal transduction	Golgi apparatus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			breast(1)|kidney(1)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	10		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;8.24e-34)|all cancers(36;3.46e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.1e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		GATGTCTCGGTGGATCTTGCG	0.582000													5	57					0	0	1.23904e-05	0	0
SLC35B1	10237	broad.mit.edu	37	17	47780295	47780295	+	Missense_Mutation	SNP	T	T	C	rs80203972	byFrequency	TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr17:47780295T>C	ENST00000240333.6	-	8	962	c.841A>G	c.(841-843)Att>Gtt	p.I281V	SLC35B1_ENST00000415270.2_Missense_Mutation_p.I318V			P78383	S35B1_HUMAN	solute carrier family 35, member B1	281						endoplasmic reticulum membrane|integral to membrane|microsome	UDP-galactose transmembrane transporter activity			endometrium(1)|large_intestine(2)|lung(3)|urinary_tract(1)	7						GAGGCCAAAATTGTGAAGAAC	0.493000													17	68					0	0	9.7654e-05	0	0
MTIF2	4528	broad.mit.edu	37	2	55470598	55470598	+	Silent	SNP	T	T	C			TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr2:55470598T>C	ENST00000394600.3	-	13	2254	c.1518A>G	c.(1516-1518)aaA>aaG	p.K506K	MTIF2_ENST00000263629.4_Silent_p.K506K|MTIF2_ENST00000403721.1_Silent_p.K506K	NM_001005369.1	NP_001005369.1	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	506					regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	24						CCCTTTTCTCTTTTGGCTTTA	0.313000													3	89					0	0	0.00024832	0	0
NLRP4	147945	broad.mit.edu	37	19	56373368	56373368	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr19:56373368G>A	ENST00000301295.6	+	5	2451	c.2029G>A	c.(2029-2031)Gtt>Att	p.V677I	NLRP4_ENST00000346986.5_Missense_Mutation_p.V677I|NLRP4_ENST00000587891.1_Missense_Mutation_p.V602I	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	677							ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		AATAAATAACGTTTCCTTTTC	0.423000													33	63					0	0	0.00058488	0	0
RGPD8	727851	broad.mit.edu	37	2	113127775	113127775	+	Missense_Mutation	SNP	G	G	C			TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr2:113127775G>C	ENST00000302558.3	-	23	5469	c.5278C>G	c.(5278-5280)Cct>Gct	p.P1760A	RGPD8_ENST00000409750.1_Missense_Mutation_p.P1620A	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8									p.P1760A(12)		endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						GAACGGGAAGGATTTTCTTCC	0.308000													3	79					0	0	6.4e-05	0	0
FNDC3A	22862	broad.mit.edu	37	13	49772502	49772502	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr13:49772502C>T	ENST00000492622.2	+	23	3084	c.2779C>T	c.(2779-2781)Cga>Tga	p.R927*	FNDC3A_ENST00000541916.1_Nonsense_Mutation_p.R927*|FNDC3A_ENST00000398316.3_Nonsense_Mutation_p.R871*	NM_001079673.1	NP_001073141.1	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	927	Fibronectin type-III 7.					Golgi membrane|integral to membrane				endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|prostate(5)|skin(2)|urinary_tract(1)	41		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		ACTTAGAATACGAATTCAAGC	0.368000													6	64					0	0	3.59834e-05	0	0
LDLRAD3	143458	broad.mit.edu	37	11	36248871	36248871	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr11:36248871G>A	ENST00000315571.5	+	5	712	c.691G>A	c.(691-693)Gtc>Atc	p.V231I	LDLRAD3_ENST00000528989.1_Missense_Mutation_p.V182I|LDLRAD3_ENST00000524419.1_Missense_Mutation_p.V221I|LDLRAD3_ENST00000529759.1_3'UTR	NM_174902.2	NP_777562.1	Q86YD5	LRAD3_HUMAN	low density lipoprotein receptor class A domain containing 3	231						integral to membrane	receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(14)|prostate(7)|skin(1)	28	all_lung(20;0.089)|Lung NSC(22;0.175)|all_epithelial(35;0.177)	all_hematologic(20;0.124)				CCACTGCAACGTCACCTACAA	0.632000													27	56					0	0	0.000409698	0	0
C6orf223	221416	broad.mit.edu	37	6	43970504	43970518	+	In_Frame_Del	DEL	GCGGCGGCGGCGGCG	GCGGCGGCGGCGGCG	-	rs72369323		TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr6:43970504_43970518delGCGGCGGCGGCGGCG	ENST00000336600.5	+	4	390_404	c.370_384delGCGGCGGCGGCGGCG	c.(370-384)del	p.AAAAA124del	C6orf223_ENST00000439969.2_3'UTR|RP5-1120P11.1_ENST00000422059.1_RNA|C6orf223_ENST00000448947.2_3'UTR|RP5-1120P11.1_ENST00000607590.1_RNA	NM_001171992.1|NM_153246.4	NP_001165463.1|NP_694978.2	Q8N319	CF223_HUMAN	chromosome 6 open reading frame 223	124	Ala-rich.									central_nervous_system(1)|lung(2)|pancreas(1)|prostate(1)|urinary_tract(1)	6	all_cancers(18;2.28e-07)|all_epithelial(2;1.62e-08)|Lung NSC(15;0.000172)|all_lung(25;0.000533)|Hepatocellular(11;0.00309)|Ovarian(13;0.0437)		all cancers(41;0.00141)|Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.217)			GGTAGAGCGCgcggcggcggcggcggcggcggcgg	0.758													6	5	---	---	---	---					
BCAT1	586	broad.mit.edu	37	12	24985718	24985719	+	Frame_Shift_Ins	INS	-	-	TC			TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr12:24985718_24985719insTC	ENST00000261192.7	-	9	1508_1509	c.982_983insGA	c.(982-984)gttfs	p.V328fs	BCAT1_ENST00000539780.1_Frame_Shift_Ins_p.V291fs|BCAT1_ENST00000538118.1_Frame_Shift_Ins_p.V327fs|BCAT1_ENST00000539282.1_Frame_Shift_Ins_p.V340fs|RP11-625L16.3_ENST00000545410.1_RNA|BCAT1_ENST00000342945.5_Frame_Shift_Ins_p.V267fs	NM_001178091.1|NM_005504.6	NP_001171562.1|NP_005495.2	P54687	BCAT1_HUMAN	branched chain amino-acid transaminase 1, cytosolic	328					branched chain family amino acid biosynthetic process|branched chain family amino acid catabolic process|cell proliferation|G1/S transition of mitotic cell cycle	cytosol	L-isoleucine transaminase activity|L-leucine transaminase activity|L-valine transaminase activity			breast(1)|large_intestine(1)|lung(3)|prostate(2)	7	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Ovarian(17;0.107)|Colorectal(261;0.196)				Gabapentin(DB00996)|L-Glutamic Acid(DB00142)|L-Isoleucine(DB00167)|L-Leucine(DB00149)|L-Valine(DB00161)|Pyridoxal Phosphate(DB00114)	AGAGCCAAACATCTCTCTCACT	0.431													9	7	---	---	---	---					
RP11-19N8.4	0	broad.mit.edu	37	16	33070215	33070216	+	RNA	INS	-	-	T			TCGA-EM-A22J-01A-11D-A17V-08	TCGA-EM-A22J-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d2ff7369-a4f6-413f-9543-6a17cf47a6fd	e8741687-a6ba-46e2-80d3-37d5de7b5bbd	g.chr16:33070215_33070216insT	ENST00000561541.1	-	0	291																											TTTGCCCCCCCGTCGCCGCGGC	0.604													6	6	---	---	---	---