Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DMRTB1	63948	broad.mit.edu	37	1	53927304	53927304	+	Missense_Mutation	SNP	C	C	A			TCGA-ET-A39P-01A-21D-A19J-08	TCGA-ET-A39P-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34172376-3070-445a-af3c-29481e93ac41	0ebea3ce-cb3b-4026-98a1-486b6d1e2e06	g.chr1:53927304C>A	ENST00000371445.3	+	2	791	c.736C>A	c.(736-738)Caa>Aaa	p.Q246K	DMRTB1_ENST00000463126.1_3'UTR	NM_033067.1	NP_149056.1	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal, 1	246	Pro-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(3)|lung(5)|ovary(1)|skin(1)	10						CAGCCAGTACCAAGGCGGAGG	0.662000													19	20					1.01871e-10	5.98493e-10	0.00121646	1	0
ITGA8	8516	broad.mit.edu	37	10	15688984	15688984	+	Silent	SNP	T	T	C			TCGA-ET-A39P-01A-21D-A19J-08	TCGA-ET-A39P-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34172376-3070-445a-af3c-29481e93ac41	0ebea3ce-cb3b-4026-98a1-486b6d1e2e06	g.chr10:15688984T>C	ENST00000378076.3	-	12	1421	c.1068A>G	c.(1066-1068)gaA>gaG	p.E356E		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	356					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						TTTGCCCTACTTCTCTGGGGT	0.502000													8	60					0	0	0.00307968	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102471238	102471238	+	Missense_Mutation	SNP	C	C	A			TCGA-ET-A39P-01A-21D-A19J-08	TCGA-ET-A39P-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34172376-3070-445a-af3c-29481e93ac41	0ebea3ce-cb3b-4026-98a1-486b6d1e2e06	g.chr14:102471238C>A	ENST00000360184.4	+	25	5353	c.5189C>A	c.(5188-5190)gCa>gAa	p.A1730E		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	1730	Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						TTTGGTAAAGCAACTTCAATT	0.418000													27	35					1.32003e-05	6.89349e-05	0.000878237	1	0
C1orf146	388649	broad.mit.edu	37	1	92711147	92711147	+	Silent	SNP	T	T	G			TCGA-ET-A39P-01A-21D-A19J-08	TCGA-ET-A39P-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34172376-3070-445a-af3c-29481e93ac41	0ebea3ce-cb3b-4026-98a1-486b6d1e2e06	g.chr1:92711147T>G	ENST00000370373.2	+	7	746	c.282T>G	c.(280-282)gcT>gcG	p.A94A	C1orf146_ENST00000370375.3_Silent_p.A153A			Q5VVC0	CA146_HUMAN	chromosome 1 open reading frame 146	153										breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	8		all_lung(203;0.00528)|Lung NSC(277;0.0193)		all cancers(265;0.00846)|Epithelial(280;0.0952)		TGATAACAGCTAAAGCTTACA	0.328000													23	38					0	0	0.00229938	0	0
SLC35E3	55508	broad.mit.edu	37	12	69140182	69140182	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A39P-01A-21D-A19J-08	TCGA-ET-A39P-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34172376-3070-445a-af3c-29481e93ac41	0ebea3ce-cb3b-4026-98a1-486b6d1e2e06	g.chr12:69140182C>T	ENST00000398004.2	+	1	297	c.25C>T	c.(25-27)Cgg>Tgg	p.R9W		NM_018656.2	NP_061126.2	Q7Z769	S35E3_HUMAN	solute carrier family 35, member E3	9						integral to membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12	Breast(13;2.31e-06)|Renal(347;0.0684)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00372)			GGACCGAGTGCGGGGCCACTG	0.632000													13	12					0	0	0.00244969	0	0
EDEM3	80267	broad.mit.edu	37	1	184671950	184671950	+	Missense_Mutation	SNP	T	T	C			TCGA-ET-A39P-01A-21D-A19J-08	TCGA-ET-A39P-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34172376-3070-445a-af3c-29481e93ac41	0ebea3ce-cb3b-4026-98a1-486b6d1e2e06	g.chr1:184671950T>C	ENST00000318130.8	-	19	2650	c.2384A>G	c.(2383-2385)gAt>gGt	p.D795G	EDEM3_ENST00000466392.1_5'UTR|EDEM3_ENST00000367512.3_Missense_Mutation_p.D752G	NM_025191.3	NP_079467.3	Q9BZQ6	EDEM3_HUMAN	ER degradation enhancer, mannosidase alpha-like 3	795					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CTTACCTCGATCTTTTGCTTT	0.373000													16	34					0	0	0.00400662	0	0
ADAR	103	broad.mit.edu	37	1	154574423	154574423	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A39P-01A-21D-A19J-08	TCGA-ET-A39P-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34172376-3070-445a-af3c-29481e93ac41	0ebea3ce-cb3b-4026-98a1-486b6d1e2e06	g.chr1:154574423C>T	ENST00000368474.4	-	2	894	c.695G>A	c.(694-696)aGa>aAa	p.R232K	ADAR_ENST00000368471.3_5'UTR|ADAR_ENST00000292205.5_Missense_Mutation_p.R275K	NM_001111.4|NM_015840.3|NM_015841.3	NP_001102.2|NP_056655.2|NP_056656.2	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific	232					adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(4)|prostate(2)|skin(2)	51	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		TGTGGAGTTTCTGTCTTCCGG	0.527000													32	86					0	0	0.00209593	0	0
FOXR2	139628	broad.mit.edu	37	X	55650232	55650232	+	Missense_Mutation	SNP	T	T	A			TCGA-ET-A39P-01A-21D-A19J-08	TCGA-ET-A39P-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34172376-3070-445a-af3c-29481e93ac41	0ebea3ce-cb3b-4026-98a1-486b6d1e2e06	g.chrX:55650232T>A	ENST00000339140.3	+	1	400	c.88T>A	c.(88-90)Tta>Ata	p.L30I		NM_198451.3	NP_940853.1	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	30					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	19						GAGGAATGAGTTATTTCTGCC	0.468000													27	56					0	0	0.00209593	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-ET-A39P-01A-21D-A19J-08	TCGA-ET-A39P-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34172376-3070-445a-af3c-29481e93ac41	0ebea3ce-cb3b-4026-98a1-486b6d1e2e06	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				23	36					0	0	0.00332997	0	0
IGHV1-46	0	broad.mit.edu	37	14	106967198	106967198	+	RNA	SNP	C	C	T			TCGA-ET-A39P-01A-21D-A19J-08	TCGA-ET-A39P-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34172376-3070-445a-af3c-29481e93ac41	0ebea3ce-cb3b-4026-98a1-486b6d1e2e06	g.chr14:106967198C>T	ENST00000390622.2	-	0	505																											TTGATTATTCCCATCCACTCA	0.547000													34	90					0	0	0.0024448	0	0
KRTCAP3	200634	broad.mit.edu	37	2	27666263	27666263	+	Splice_Site	SNP	A	A	C			TCGA-ET-A39P-01A-21D-A19J-08	TCGA-ET-A39P-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34172376-3070-445a-af3c-29481e93ac41	0ebea3ce-cb3b-4026-98a1-486b6d1e2e06	g.chr2:27666263A>C	ENST00000543753.1	+	5	527		c.e5-1		KRTCAP3_ENST00000407293.1_Splice_Site|KRTCAP3_ENST00000288873.3_Splice_Site	NM_001168364.1	NP_001161836.1	Q53RY4	KCP3_HUMAN	keratinocyte associated protein 3							integral to membrane				large_intestine(1)|lung(2)	3	Acute lymphoblastic leukemia(172;0.155)					CTTGCTTTTCAGGATACAGCC	0.517000													48	74					0	0	0.00361006	0	0
IL7R	3575	broad.mit.edu	37	5	35874644	35874644	+	Splice_Site	SNP	G	G	T			TCGA-ET-A39P-01A-21D-A19J-08	TCGA-ET-A39P-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34172376-3070-445a-af3c-29481e93ac41	0ebea3ce-cb3b-4026-98a1-486b6d1e2e06	g.chr5:35874644G>T	ENST00000303115.3	+	6	929	c.800_splice	c.e6+1	p.R267_splice	IL7R_ENST00000506850.1_Intron|IL7R_ENST00000343305.4_Intron	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	267					immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			TGGAAAAAAAGGTGACCTTCT	0.423000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						33	51					5.09552e-08	2.87387e-07	0.00209593	1	0
AC093642.5	0	broad.mit.edu	37	2	243056818	243056818	+	RNA	SNP	C	C	T	rs140719525	by1000genomes	TCGA-ET-A39P-01A-21D-A19J-08	TCGA-ET-A39P-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34172376-3070-445a-af3c-29481e93ac41	0ebea3ce-cb3b-4026-98a1-486b6d1e2e06	g.chr2:243056818C>T	ENST00000456398.1	+	0	339																											TGGAGAAATACTCAATAATGA	0.269000													4	33					0	0	0.000602214	0	0
OR10A7	121364	broad.mit.edu	37	12	55615054	55615054	+	Silent	SNP	T	T	A			TCGA-ET-A39P-01A-21D-A19J-08	TCGA-ET-A39P-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34172376-3070-445a-af3c-29481e93ac41	0ebea3ce-cb3b-4026-98a1-486b6d1e2e06	g.chr12:55615054T>A	ENST00000326258.1	+	1	246	c.246T>A	c.(244-246)ctT>ctA	p.L82L		NM_001005280.1	NP_001005280.1	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A, member 7	82					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|lung(11)|ovary(4)|prostate(2)|skin(3)	24						CAAAAATGCTTGTAGATCTAG	0.413000													90	123					0	0	0.00361006	0	0
TTLL3	26140	broad.mit.edu	37	3	9876847	9876847	+	Missense_Mutation	SNP	G	G	C			TCGA-ET-A39P-01A-21D-A19J-08	TCGA-ET-A39P-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34172376-3070-445a-af3c-29481e93ac41	0ebea3ce-cb3b-4026-98a1-486b6d1e2e06	g.chr3:9876847G>C	ENST00000547186.1	+	13	2209	c.1993G>C	c.(1993-1995)Gaa>Caa	p.E665Q	TTLL3_ENST00000383827.1_3'UTR|TTLL3_ENST00000397241.1_3'UTR|TTLL3_ENST00000430793.1_3'UTR|ARPC4-TTLL3_ENST00000397256.1_3'UTR|TTLL3_ENST00000455274.1_Intron|TTLL3_ENST00000426895.4_Missense_Mutation_p.E808Q	NM_001025930.3	NP_001021100.3	Q9Y4R7	TTLL3_HUMAN	tubulin tyrosine ligase-like family, member 3	665					axoneme assembly|cilium assembly|protein polyglycylation	cilium axoneme|cytoplasm|microtubule	protein-glycine ligase activity, initiating|tubulin-tyrosine ligase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(2)|skin(1)	26	Medulloblastoma(99;0.227)					TTTGAAGTCGGAACAATTCCT	0.587000													16	55					0	0	0.00400662	0	0
SLC35E3	55508	broad.mit.edu	37	12	69140181	69140181	+	Silent	SNP	G	G	T			TCGA-ET-A39P-01A-21D-A19J-08	TCGA-ET-A39P-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34172376-3070-445a-af3c-29481e93ac41	0ebea3ce-cb3b-4026-98a1-486b6d1e2e06	g.chr12:69140181G>T	ENST00000398004.2	+	1	296	c.24G>T	c.(22-24)gtG>gtT	p.V8V		NM_018656.2	NP_061126.2	Q7Z769	S35E3_HUMAN	solute carrier family 35, member E3	8						integral to membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12	Breast(13;2.31e-06)|Renal(347;0.0684)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00372)			TGGACCGAGTGCGGGGCCACT	0.632000													13	12					1.49906e-05	7.54883e-05	0.00244969	1	0
FRG1B	0	broad.mit.edu	37	20	29628300	29628300	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A39P-01A-21D-A19J-08	TCGA-ET-A39P-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34172376-3070-445a-af3c-29481e93ac41	0ebea3ce-cb3b-4026-98a1-486b6d1e2e06	g.chr20:29628300G>A	ENST00000278882.3	+	6	682	c.302G>A	c.(301-303)aGt>aAt	p.S101N	FRG1B_ENST00000439954.2_Missense_Mutation_p.S106N|FRG1B_ENST00000358464.4_Missense_Mutation_p.S101N														p.S101N(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GAAGCAAAAAGTAAAACAGCA	0.358000													9	111					0	0	0.000978159	0	0
ZNF668	79759	broad.mit.edu	37	16	31072858	31072858	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A39P-01A-21D-A19J-08	TCGA-ET-A39P-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34172376-3070-445a-af3c-29481e93ac41	0ebea3ce-cb3b-4026-98a1-486b6d1e2e06	g.chr16:31072858G>A	ENST00000538906.1	-	3	2175	c.1391C>T	c.(1390-1392)cCg>cTg	p.P464L	ZNF668_ENST00000300849.4_Missense_Mutation_p.P464L|ZNF668_ENST00000535577.1_Missense_Mutation_p.P464L|ZNF668_ENST00000539836.3_Missense_Mutation_p.P487L|ZNF668_ENST00000417110.2_Missense_Mutation_p.G16R|ZNF668_ENST00000426488.2_Missense_Mutation_p.P487L|ZNF668_ENST00000394983.2_Missense_Mutation_p.P464L	NM_001172668.1	NP_001166139.1	Q96K58	ZN668_HUMAN	zinc finger protein 668	464					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						ACCTGACTCCGGGGGCAGCCC	0.697000													31	65					0	0	0.00375469	0	0
TUBBP5	0	broad.mit.edu	37	9	141070768	141070768	+	RNA	SNP	C	C	T	rs4609262	by1000genomes	TCGA-ET-A39P-01A-21D-A19J-08	TCGA-ET-A39P-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34172376-3070-445a-af3c-29481e93ac41	0ebea3ce-cb3b-4026-98a1-486b6d1e2e06	g.chr9:141070768C>T	ENST00000503395.1	+	0	1543																											GCTGTGACTGCCTGCAGGGTT	0.617000													3	17					0	0	0.00024832	0	0
ATP2B2	491	broad.mit.edu	37	3	10413502	10413502	+	Silent	SNP	G	G	C			TCGA-ET-A39P-01A-21D-A19J-08	TCGA-ET-A39P-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34172376-3070-445a-af3c-29481e93ac41	0ebea3ce-cb3b-4026-98a1-486b6d1e2e06	g.chr3:10413502G>C	ENST00000397077.1	-	11	2090	c.1515C>G	c.(1513-1515)acC>acG	p.T505T	ATP2B2_ENST00000383800.4_Silent_p.T505T|ATP2B2_ENST00000352432.4_Silent_p.T550T|ATP2B2_ENST00000343816.4_Silent_p.T536T|ATP2B2_ENST00000360273.2_Silent_p.T550T			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	550					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						CCAGAATCTTGGTGGTGTAGG	0.532000													12	31					0	0	0.000978159	0	0
CSMD3	114788	broad.mit.edu	37	8	113358377	113358377	+	Missense_Mutation	SNP	A	A	G			TCGA-ET-A39P-01A-21D-A19J-08	TCGA-ET-A39P-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34172376-3070-445a-af3c-29481e93ac41	0ebea3ce-cb3b-4026-98a1-486b6d1e2e06	g.chr8:113358377A>G	ENST00000297405.5	-	41	6635	c.6391T>C	c.(6391-6393)Tat>Cat	p.Y2131H	CSMD3_ENST00000343508.3_Missense_Mutation_p.Y2091H|CSMD3_ENST00000455883.2_Missense_Mutation_p.Y2027H|CSMD3_ENST00000352409.3_Missense_Mutation_p.Y2061H	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2131	CUB 12.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CTGCTGGGATAGTTTCCAGGA	0.388000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			41	62					0	0	0.00195071	0	0
TRO	7216	broad.mit.edu	37	X	54955736	54955736	+	Missense_Mutation	SNP	G	G	T			TCGA-ET-A39P-01A-21D-A19J-08	TCGA-ET-A39P-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34172376-3070-445a-af3c-29481e93ac41	0ebea3ce-cb3b-4026-98a1-486b6d1e2e06	g.chrX:54955736G>T	ENST00000173898.7	+	12	2691	c.2579G>T	c.(2578-2580)aGt>aTt	p.S860I	TRO_ENST00000399736.1_Intron|TRO_ENST00000375041.2_Missense_Mutation_p.S463I|TRO_ENST00000420798.2_Missense_Mutation_p.S391I|TRO_ENST00000319167.8_Intron|TRO_ENST00000375022.4_Intron	NM_001039705.1	NP_001034794.1	Q12816	TROP_HUMAN	trophinin	860	62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						GCTGGCTTTAGTGGTGTACTC	0.562000													15	24					3.52763e-06	1.91306e-05	0.000566183	1	0
SLC35F1	222553	broad.mit.edu	37	6	118228990	118228992	+	In_Frame_Del	DEL	GCG	GCG	-			TCGA-ET-A39P-01A-21D-A19J-08	TCGA-ET-A39P-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	34172376-3070-445a-af3c-29481e93ac41	0ebea3ce-cb3b-4026-98a1-486b6d1e2e06	g.chr6:118228990_118228992delGCG	ENST00000360388.4	+	1	302_304	c.101_103delGCG	c.(100-105)agc>a	p.SG34del		NM_001029858.3	NP_001025029.2	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	34					transport	integral to membrane				breast(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(226;0.217)		GCCGAGGGCAGCGGCGGCGGCGG	0.744													3	4	---	---	---	---