Hugo_Symbol Entrez_Gene_Id Center NCBI_Build Chromosome Start_position End_position Strand Variant_Classification Variant_Type Reference_Allele Tumor_Seq_Allele1 Tumor_Seq_Allele2 dbSNP_RS dbSNP_Val_Status Tumor_Sample_Barcode Matched_Norm_Sample_Barcode Match_Norm_Seq_Allele1 Match_Norm_Seq_Allele2 Tumor_Validation_Allele1 Tumor_Validation_Allele2 Match_Norm_Validation_Allele1 Match_Norm_Validation_Allele2 Verification_Status Validation_Status Mutation_Status Sequencing_Phase Sequence_Source Validation_Method Score BAM_file Sequencer Tumor_Sample_UUID Matched_Norm_Sample_UUID transcript_name strand transcript_status amino_acid_change ucsc_cons normal_depth normal_vaf tumor_depth tumor_vaf rna_depth rna_vaf polyphen sift condel domain MTOR 2475 genome.wustl.edu 37 1 11272451 11272451 + Missense_Mutation SNP A A C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_004958.3 -1 reviewed p.V1160G 0.998 164 0% 158 22.2% 8 0% benign(0.312) deleterious(0) deleterious(0.542) superfamily_ARM-type_fold VPS13D 55187 genome.wustl.edu 37 1 12337745 12337745 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_015378.2 +1 reviewed p.S1367L 0.002 261 0% 241 12.9% 0 - benign(0.001) tolerated(0.3) neutral(0.029) NULL IL28RA 163702 genome.wustl.edu 37 1 24485984 24485984 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_170743.2 -1 reviewed p.C217Y 0.998 219 0% 163 17.2% 1 100% probably_damaging(0.963) deleterious(0) deleterious(0.850) superfamily_Fibronectin type III SRRM1 10250 genome.wustl.edu 37 1 24989289 24989289 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005839.3 +1 validated p.S541C 0.998 313 0% 331 38.4% 75 46.6% unknown(0) deleterious(0.03) - NULL WDTC1 23038 genome.wustl.edu 37 1 27623546 27623546 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_015023.3 +1 validated p.Q318 1.000 82 0% 50 40% 19 89.4% - - - superfamily_WD40 repeat-like CLSPN 63967 genome.wustl.edu 37 1 36226214 36226214 + Silent SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_022111.2 -1 reviewed p.G436 0.000 191 0% 222 33.3% 0 - - - - NULL MACF1 23499 genome.wustl.edu 37 1 39913369 39913369 + Missense_Mutation SNP T T A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_033044.2 +1 reviewed p.F5032L 1.000 308 0% 276 43.1% 8 37.5% possibly_damaging(0.849) tolerated(0.2) neutral(0.375) HMMPfam_Spectrin,HMMSmart_SPEC,superfamily_Spectrin PABPC4 8761 genome.wustl.edu 37 1 40030780 40030780 + Nonsense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001135653.1 -1 reviewed p.Q415* 1.000 54 0% 38 15.8% 143 2% - - - NULL HIVEP3 59269 genome.wustl.edu 37 1 42047354 42047354 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_024503.3 -1 validated p.E1039Q 1.000 97 0% 53 26.4% 0 - probably_damaging(0.998) deleterious(0.01) deleterious(0.880) NULL SZT2 23334 genome.wustl.edu 37 1 43893716 43893716 + Missense_Mutation SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_015284.2 +1 predicted p.M383I 1.000 120 0% 73 20.5% 4 0% benign(0.147) tolerated(0.74) neutral(0.014) NULL PTPRF 5792 genome.wustl.edu 37 1 44084388 44084388 + Missense_Mutation SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_002840.3 +1 reviewed p.T1487A 1.000 108 0% 88 11.4% 246 11.7% possibly_damaging(0.939) tolerated(0.34) neutral(0.408) HMMPfam_Y_phosphatase,HMMSmart_SM00194,superfamily_(Phosphotyrosine protein) phosphatases II ZSWIM5 57643 genome.wustl.edu 37 1 45524299 45524299 + Nonsense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_020883.1 -1 validated p.Q412* 1.000 293 0% 294 13.6% 0 - - - - NULL ATPAF1 64756 genome.wustl.edu 37 1 47118297 47118297 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_022745.3 -1 reviewed p.E182K 0.987 71 0% 95 33.7% 4 75% benign(0.002) tolerated(0.42) neutral(0.014) HMMPfam_ATP11 ZCCHC11 23318 genome.wustl.edu 37 1 52991588 52991588 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001009881.1 -1 validated p.T122I 0.273 403 0% 318 15.4% 0 - benign(0.013) deleterious(0.03) neutral(0.365) NULL HEATR8 374977 genome.wustl.edu 37 1 55119398 55119398 + Missense_Mutation SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001039464.2 +1 validated p.T267A 0.000 316 0% 274 13.9% 3 33.3% benign(0.004) tolerated(0.47) neutral(0.011) NULL USP24 23358 genome.wustl.edu 37 1 55590188 55590188 + Silent SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_015306.2 -1 validated p.S1198 0.990 293 0% 272 15.8% 0 - - - - NULL WLS 79971 genome.wustl.edu 37 1 68697917 68697917 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001002292.2 -1 validated p.L22 0.451 391 0% 348 35.6% 23 56.5% - - - NULL ELTD1 64123 genome.wustl.edu 37 1 79470814 79470814 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_022159.3 -1 validated p.G38E 0.931 177 0% 113 26.5% 4 0% benign(0.033) tolerated(0.14) neutral(0.251) HMMSmart_EGF HS2ST1 9653 genome.wustl.edu 37 1 87569114 87569114 + Splice_Site SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_012262.3 +1 reviewed e6-1 1.000 202 0% 184 13.6% 0 - - - - - BRDT 676 genome.wustl.edu 37 1 92446848 92446848 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001726.3 +1 validated p.E592Q 1.000 171 0% 156 32.7% 0 - benign(0.188) tolerated(0.26) neutral(0.052) NULL DR1 1810 genome.wustl.edu 37 1 93826137 93826137 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001938.2 +1 reviewed p.A158T 1.000 79 0% 107 18.7% 14 14.2% unknown(0) tolerated(0.24) - NULL CDC14A 8556 genome.wustl.edu 37 1 100843120 100843120 + Silent SNP A A T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_033312.2 +1 reviewed p.G53 1.000 175 0% 183 38.8% 0 - - - - superfamily_(Phosphotyrosine protein) phosphatases II VAV3 10451 genome.wustl.edu 37 1 108152585 108152585 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006113.4 -1 reviewed p.V661 0.999 110 0% 139 11.5% 11 27.2% - - - superfamily_SH3-domain SARS 6301 genome.wustl.edu 37 1 109756675 109756675 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006513.2 +1 reviewed p.E21Q 1.000 34 0% 37 29.7% 37 51.3% benign(0.244) tolerated(0.07) neutral(0.344) superfamily_tRNA-binding arm,HMMPfam_Seryl_tRNA_N CSF1 1435 genome.wustl.edu 37 1 110466651 110466651 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_000757.4 +1 validated p.R470C 0.000 159 0% 93 17.2% 7 0% probably_damaging(0.997) deleterious(0.02) deleterious(0.849) HMMPfam_CSF-1 CD53 963 genome.wustl.edu 37 1 111434981 111434981 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_000560.3 +1 reviewed p.C26 0.997 161 0% 173 12.1% 26 0% - - - HMMPfam_Tetraspannin MAGI3 260425 genome.wustl.edu 37 1 114201836 114201836 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001142782.1 +1 validated p.L922 1.000 286 0% 269 12.3% 4 25% - - - HMMPfam_PDZ,HMMSmart_PDZ,superfamily_PDZ OLFML3 56944 genome.wustl.edu 37 1 114523945 114523945 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_020190.2 +1 validated p.A259T 0.028 162 0% 142 14.1% 35 2.8% possibly_damaging(0.901) tolerated(0.39) neutral(0.373) HMMPfam_OLF,HMMSmart_SM00284 CSDE1 7812 genome.wustl.edu 37 1 115277082 115277082 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001130523.1 -1 validated p.G203E 1.000 208 0% 174 10.9% 28 21.4% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_CSD,HMMSmart_SM00357,superfamily_Nucleic acid-binding proteins TSHB 7252 genome.wustl.edu 37 1 115576077 115576077 + Missense_Mutation SNP G G A rs121918669 TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_000549.3 +1 reviewed p.E32K 0.997 287 0% 291 38.5% 0 - possibly_damaging(0.638) deleterious(0) deleterious(0.668) HMMSmart_SM00068,HMMPfam_Cys_knot,superfamily_Cystine-knot cytokines NOTCH2 4853 genome.wustl.edu 37 1 120510712 120510712 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_024408.2 -1 reviewed p.E418K 1.000 146 0% 132 33.3% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_EGF_CA,PatternScan_EGF_CA,superfamily_SSF57196 TCHH 7062 genome.wustl.edu 37 1 152082770 152082770 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_007113.2 -1 provisional p.G975R 0.000 482 0% 506 30.2% 1 0% unknown(0) - - NULL FLG2 388698 genome.wustl.edu 37 1 152331234 152331234 + Missense_Mutation SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001014342.2 -1 provisional p.P43T 0.981 278 0% 372 54% 0 - unknown(0) deleterious(0) - HMMPfam_S_100,superfamily_SSF47473 JTB 10899 genome.wustl.edu 37 1 153949481 153949481 + Missense_Mutation SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006694.3 -1 validated p.E31G 0.481 179 0% 185 12.4% 213 8.9% benign(0.277) deleterious(0.01) neutral(0.435) HMMPfam_JTB RIT1 6016 genome.wustl.edu 37 1 155880523 155880525 + In_Frame_Del DEL GCT GCT - novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 GCT GCT Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006912.4 -1 validated p.S10in_frame_del 0.013:0.015:0.001 - - - - - - - - - NULL MEF2D 4209 genome.wustl.edu 37 1 156452272 156452272 + Missense_Mutation SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005920.2 -1 provisional p.Y72C 1.000 128 0% 95 10.5% 41 0% probably_damaging(1) deleterious(0.02) deleterious(0.883) superfamily_SRF-like ATF6 22926 genome.wustl.edu 37 1 161816356 161816356 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_007348.2 +1 validated p.Q435H 0.999 353 0% 628 25% 12 50% probably_damaging(0.957) deleterious(0.03) deleterious(0.765) NULL RXRG 6258 genome.wustl.edu 37 1 165370627 165370627 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006917.3 -1 reviewed p.R422H 1.000 77 0% 163 16.6% 1 0% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Hormone_recep,HMMSmart_HOLI,superfamily_Str_ncl_receptor POU2F1 5451 genome.wustl.edu 37 1 167370776 167370776 + Missense_Mutation SNP C C A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_002697.2 +1 provisional p.T490K 0.965 52 0% 91 11% 6 0% possibly_damaging(0.922) deleterious(0) deleterious(0.816) NULL F5 2153 genome.wustl.edu 37 1 169509950 169509950 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_000130.4 -1 reviewed p.L1460V 0.205 242 0% 338 25.4% 0 - benign(0.235) tolerated(0.2) neutral(0.073) HMMPfam_LSPR TNR 7143 genome.wustl.edu 37 1 175331805 175331805 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_003285.2 -1 validated p.H950Y 0.998 142 0% 198 12.1% 0 - benign(0) tolerated(1) - superfamily_Fibronectin type III ABL2 27 genome.wustl.edu 37 1 179087824 179087824 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_007314.3 -1 reviewed p.R374P 1.000 179 0% 198 27.3% 1 0% probably_damaging(0.988) deleterious(0) deleterious(0.882) HMMPfam_Pkinase_Tyr,HMMSmart_SM00219,HMMSmart_SM00220,superfamily_Protein kinase-like (PK-like) SWT1 54823 genome.wustl.edu 37 1 185259804 185259804 + Splice_Site SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001105518.1 +1 validated e18-2 0.990 182 0% 302 12.6% 0 - - - - - KCNT2 343450 genome.wustl.edu 37 1 196251447 196251447 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_198503.2 -1 validated p.L913V 1.000 130 0% 137 23.4% 0 - probably_damaging(0.974) deleterious(0.01) deleterious(0.822) NULL F13B 2165 genome.wustl.edu 37 1 197026294 197026294 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001994.2 -1 reviewed p.P340 0.002 240 0% 371 29.1% 0 - - - - HMMPfam_Sushi,HMMSmart_CCP,superfamily_Complement_control_module NEK7 140609 genome.wustl.edu 37 1 198233334 198233334 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_133494.2 +1 validated p.A114V 1.000 376 0% 624 10.9% 2 50% probably_damaging(0.999) deleterious(0.01) deleterious(0.896) HMMSmart_S_TKc,superfamily_Kinase_like,HMMPfam_Pkinase FAM58BP 339521 genome.wustl.edu 37 1 200182989 200182989 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001105517.1 +1 provisional p.V100M 1.000 237 0% 291 13.1% 0 - - - - HMMSmart_CYCLIN,superfamily_Cyclin_like PPP1R12B 4660 genome.wustl.edu 37 1 202400721 202400721 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_032105.2 +1 reviewed p.S372F 1.000 450 0% 582 28.4% 0 - unknown(0) deleterious(0.03) - NULL SLC26A9 115019 genome.wustl.edu 37 1 205892261 205892261 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_134325.2 -1 reviewed p.K574 0.981 151 0% 148 28.4% 1 0% - - - HMMPfam_STAS,superfamily_STAS IL24 11009 genome.wustl.edu 37 1 207072831 207072831 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006850.2 +1 reviewed p.E71K 0.029 60 0% 111 24.3% 0 - benign(0.138) tolerated(0.7) neutral(0.013) superfamily_4_helix_cytokine RPS6KC1 26750 genome.wustl.edu 37 1 213341260 213341260 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_012424.3 +1 validated p.R299W 0.998 207 0.5% 378 11.6% 4 50% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_MIT,HMMSmart_SM00745 USH2A 7399 genome.wustl.edu 37 1 215821980 215821980 + Silent SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_206933.2 -1 reviewed p.T4824 0.268 127 0% 207 11.6% 0 - - - - superfamily_Fibronectin type III GPATCH2 55105 genome.wustl.edu 37 1 217793126 217793126 + Missense_Mutation SNP T T G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_018040.2 -1 provisional p.S258R 1.000 199 0% 279 14% 11 9% probably_damaging(0.997) tolerated(0.1) deleterious(0.752) NULL EPRS 2058 genome.wustl.edu 37 1 220208271 220208271 + Silent SNP C C A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_004446.2 -1 reviewed p.L72 0.970 136 0% 196 26.5% 13 15.3% - - - superfamily_GST_C_like NVL 4931 genome.wustl.edu 37 1 224482034 224482034 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 ENST00000469968 -1 known p.E303K 1.000 126 0% 178 23% 10 30% - - - HMMSmart_SM00382,HMMPfam_AAA,PatternScan_AAA,superfamily_P-loop containing nucleoside triphosphate hydrolases ENAH 55740 genome.wustl.edu 37 1 225706923 225706923 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001008493.1 -1 validated p.R260T 1.000 1610 0% 2101 25.5% 49 34.6% unknown(0) deleterious(0.01) - NULL TARBP1 6894 genome.wustl.edu 37 1 234608513 234608513 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005646.3 -1 reviewed p.L326 0.956 346 0% 329 30.4% 0 - - - - NULL RGS7 6000 genome.wustl.edu 37 1 240964786 240964786 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_002924.4 -1 validated p.R461K 1.000 49 0% 75 22.7% 0 - possibly_damaging(0.893) tolerated(0.08) deleterious(0.652) NULL C1orf101 257044 genome.wustl.edu 37 1 244724243 244724243 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001130957.1 +1 validated p.D435H 0.998 478 0% 537 25.7% 1 0% probably_damaging(0.985) deleterious(0) deleterious(0.877) NULL OR2M2 391194 genome.wustl.edu 37 1 248343991 248343991 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001004688.1 +1 provisional p.C235Y 0.001 581 35.1% 809 41.3% 0 - benign(0) deleterious(0) neutral(0.445) HMMPfam_7tm_1,superfamily_SSF81321 KIF3C 3797 genome.wustl.edu 37 2 26203894 26203894 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_002254.6 -1 validated p.S298F 1.000 66 0% 56 32.1% 5 0% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Kinesin,HMMSmart_SM00129,superfamily_P-loop containing nucleoside triphosphate hydrolases CCDC164 92749 genome.wustl.edu 37 2 26667815 26667815 + Silent SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_145038.2 +1 validated p.S465 0.796 56 0% 86 14% 7 28.5% - - - NULL TRMT61B 55006 genome.wustl.edu 37 2 29093016 29093016 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_017910.3 -1 validated p.S43L 0.002 85 0% 100 34% 11 36.3% possibly_damaging(0.915) deleterious(0) deleterious(0.811) NULL CEBPZ 10153 genome.wustl.edu 37 2 37443343 37443343 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005760.2 -1 validated p.D774H 0.997 118 0% 196 28.1% 3 66.6% benign(0.007) tolerated(0.12) neutral(0.261) superfamily_ARM repeat ANXA4 307 genome.wustl.edu 37 2 70008650 70008650 + Splice_Site SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001153.3 +1 reviewed e1-2 0.802 75 0% 91 48.4% 46 100% - - - - ATP6V1B1 525 genome.wustl.edu 37 2 71185536 71185536 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001692.3 +1 reviewed p.P116L 1.000 60 0% 69 31.9% 2 0% probably_damaging(0.954) deleterious(0.01) deleterious(0.803) superfamily_SSF52540 INO80B 83444 genome.wustl.edu 37 2 74683309 74683309 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_031288.2 +1 validated p.Q150 1.000 43 0% 55 60% 66 63.6% - - - NULL CTNNA2 1496 genome.wustl.edu 37 2 80808928 80808928 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_004389.3 +1 validated p.A664V 1.000 109 0% 161 10.6% 28 3.5% possibly_damaging(0.671) tolerated(0.07) deleterious(0.557) HMMPfam_Vinculin IGKV2-24 28923 genome.wustl.edu 37 2 89476584 89476584 + Missense_Mutation SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 ENST00000484817 -1 known p.L11I 0.019 113 0% 180 22.2% 5 0% benign(0.224) deleterious(0.04) neutral(0.371) NULL ARID5A 10865 genome.wustl.edu 37 2 97218196 97218196 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 ENST00000359765 +1 known p.E583K 0.002 11 0% 11 72.7% 17 29.4% unknown(0) - - NULL IL18RAP 8807 genome.wustl.edu 37 2 103040591 103040591 + Missense_Mutation SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_003853.2 +1 reviewed p.I131V 0.162 162 0% 265 10.9% 0 - benign(0.008) deleterious(0.04) neutral(0.349) superfamily_Immunoglobulin NEB 4703 genome.wustl.edu 37 2 152385777 152385777 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_004543.4 -1 reviewed p.P5527S 0.996 97 1% 136 14% 0 - possibly_damaging(0.749) tolerated(0.12) deleterious(0.536) HMMSmart_SM00227 NEB 4703 genome.wustl.edu 37 2 152476071 152476071 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_004543.4 -1 reviewed p.T3346I 0.948 216 0.5% 310 26.1% 0 - benign(0.005) tolerated(0.3) neutral(0.029) HMMSmart_SM00227 DPP4 1803 genome.wustl.edu 37 2 162879283 162879283 + Silent SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001935.3 -1 reviewed p.T350 0.006 418 0% 501 11% 0 - - - - HMMPfam_DPPIV_N,superfamily_Dipeptidyl peptidase IV/CD26 N-terminal domain GRB14 2888 genome.wustl.edu 37 2 165365277 165365277 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_004490.2 -1 reviewed p.P301L 1.000 198 0% 245 13.1% 10 10% benign(0.029) deleterious(0) neutral(0.446) HMMPfam_PH,HMMSmart_PH,superfamily_SSF50729 TTC21B 79809 genome.wustl.edu 37 2 166775800 166775800 + Missense_Mutation SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_024753.3 -1 validated p.S554G 1.000 383 0% 513 10.9% 1 0% possibly_damaging(0.728) deleterious(0) deleterious(0.710) HMMSmart_SM00028,superfamily_TPR-like NFE2L2 4780 genome.wustl.edu 37 2 178098807 178098807 + Missense_Mutation SNP T T G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006164.3 -1 validated p.T80P 1.000 180 0% 185 24.9% 12 41.6% benign(0.002) deleterious(0.01) neutral(0.406) NULL TTN 7273 genome.wustl.edu 37 2 179584021 179584021 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 ENST00000356127 -1 known p.Q6788 0.683 332 0% 498 11.2% 0 - - - - HMMSmart_SM00406,HMMSmart_SM00408,HMMSmart_SM00409,HMMPfam_I-set TTN 7273 genome.wustl.edu 37 2 179613887 179613887 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_133379.3 -1 reviewed p.A4414T 0.000 195 0% 308 10.4% 0 - benign(0.29) deleterious(0) deleterious(0.534) NULL TTN 7273 genome.wustl.edu 37 2 179615378 179615378 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_133379.3 -1 reviewed p.D3917H 0.003 121 0% 225 54.2% 0 - benign(0) deleterious(0.03) neutral(0.364) NULL COL4A3 1285 genome.wustl.edu 37 2 228147127 228147127 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_000091.3 +1 reviewed p.G845 0.946 184 0% 268 10.1% 0 - - - - HMMPfam_Collagen CAB39 51719 genome.wustl.edu 37 2 231624777 231624777 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001130849.1 +1 validated p.E21K 1.000 117 0% 180 57.8% 4 50% benign(0.002) deleterious(0.04) neutral(0.349) HMMPfam_Mo25,superfamily_ARM repeat BHLHE40 8553 genome.wustl.edu 37 3 5025139 5025139 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_003670.2 +1 reviewed p.A334V 1.000 147 0% 107 18.7% 145 12.4% probably_damaging(0.991) deleterious(0) deleterious(0.889) NULL FBXL2 25827 genome.wustl.edu 37 3 33416781 33416781 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_012157.3 +1 reviewed p.R220H 1.000 133 0% 160 17.5% 4 25% benign(0.006) tolerated(0.53) neutral(0.007) superfamily_SSF52047 TRANK1 9881 genome.wustl.edu 37 3 36899357 36899357 + Missense_Mutation SNP A A T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_014831.2 -1 provisional p.I25N 1.000 219 0% 238 10.9% 0 - probably_damaging(0.99) deleterious(0) deleterious(0.886) NULL NKTR 4820 genome.wustl.edu 37 3 42684034 42684034 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005385.3 +1 reviewed p.S1363N 1.000 86 0% 115 14.8% 15 26.6% unknown(0) deleterious(0) - NULL ZNF167 55888 genome.wustl.edu 37 3 44598780 44598780 + Missense_Mutation SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_018651.2 +1 validated p.W81R 0.959 113 0% 85 10.6% 1 0% probably_damaging(0.999) tolerated(0.83) deleterious(0.491) HMMPfam_SCAN,HMMSmart_SM00431 SMARCC1 6599 genome.wustl.edu 37 3 47734759 47734759 + Silent SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_003074.3 -1 validated p.P399 0.733 177 0% 154 15.6% 7 0% - - - NULL LMOD3 56203 genome.wustl.edu 37 3 69168953 69168953 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_198271.3 -1 validated p.E185K 0.000 90 0% 77 31.2% 0 - benign(0.011) tolerated(0.87) neutral(0.001) NULL FILIP1L 11259 genome.wustl.edu 37 3 99567441 99567441 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_182909.2 -1 validated p.A1027T 1.000 425 0% 497 15.3% 19 0% benign(0) tolerated(0.15) neutral(0.241) NULL FILIP1L 11259 genome.wustl.edu 37 3 99568912 99568912 + Silent SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_182909.2 -1 validated p.T536 0.989 275 0% 260 14.6% 1 0% - - - HMMPfam_CortBP2 GPR128 84873 genome.wustl.edu 37 3 100373721 100373721 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_032787.2 +1 validated p.L474 0.995 321 0% 364 13.7% 0 - - - - HMMPfam_7tm_2 FAM55C 91775 genome.wustl.edu 37 3 101520472 101520472 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001134456.1 +1 validated p.D163N 1.000 100 0% 116 40.5% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Neurexophilin,superfamily_E set domains SPICE1 152185 genome.wustl.edu 37 3 113169351 113169351 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_144718.3 -1 validated p.A719T 0.000 122 0% 100 17% 8 0% benign(0.06) tolerated(0.44) neutral(0.017) NULL KIAA1407 57577 genome.wustl.edu 37 3 113737541 113737541 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_020817.1 -1 predicted p.L383F 0.426 856 0% 909 37.8% 3 33.3% probably_damaging(1) deleterious(0.02) deleterious(0.883) NULL TPRA1 131601 genome.wustl.edu 37 3 127292499 127292499 + Missense_Mutation SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001142646.1 -1 validated p.S275G 0.000 23 0% 12 33.3% 75 12% unknown(0) - - NULL PIK3R4 30849 genome.wustl.edu 37 3 130452772 130452772 + Missense_Mutation SNP A A C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_014602.2 -1 validated p.L357R 1.000 489 0% 415 38.3% 0 - probably_damaging(0.999) deleterious(0) deleterious(0.935) superfamily_ARM-type_fold NCK1 4690 genome.wustl.edu 37 3 136664466 136664466 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006153.3 +1 reviewed p.A90T 1.000 300 0% 266 15.8% 12 0% unknown(0) tolerated(0.19) - superfamily_SH3 HLTF 6596 genome.wustl.edu 37 3 148786078 148786078 + Silent SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_003071.3 -1 reviewed p.H313 1.000 242 0% 216 10.6% 0 - - - - HMMPfam_SNF2_N,HMMSmart_SM00487,superfamily_P-loop containing nucleoside triphosphate hydrolases FAM194A 131831 genome.wustl.edu 37 3 150377704 150377704 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_152394.3 -1 validated p.R656K 0.000 240 0% 213 41.3% 0 - benign(0.001) tolerated(0.54) neutral(0.007) NULL ZBBX 79740 genome.wustl.edu 37 3 167083710 167083710 + Silent SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_024687.2 -1 validated p.S79 0.357 83 0% 106 23.6% 0 - - - - NULL PIK3CA 5290 genome.wustl.edu 37 3 178928079 178928079 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006218.2 +1 reviewed p.E453Q 1.000 189 0% 147 38.8% 1 100% probably_damaging(0.991) tolerated(0.22) deleterious(0.486) HMMPfam_PI3K_C2,superfamily_C2_CaLB PIK3CA 5290 genome.wustl.edu 37 3 178936082 178936082 + Missense_Mutation SNP G G C rs121913273 TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006218.2 +1 reviewed p.E542Q 1.000 105 0% 126 32.5% 0 - probably_damaging(0.998) tolerated(0.31) deleterious(0.501) HMMPfam_PI3Ka,HMMSmart_PI3Ka,superfamily_ARM-type_fold ATP13A5 344905 genome.wustl.edu 37 3 193019018 193019018 + Silent SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_198505.2 -1 provisional p.S919 0.186 268 0% 297 11.8% 0 - - - - superfamily_SSF81665 ATP13A4 84239 genome.wustl.edu 37 3 193174813 193174813 + Nonsense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 ENST00000428352 -1 known p.W270* 1.000 156 0% 139 18% 0 - benign(0.187) tolerated(0.23) neutral(0.059) superfamily_Metal cation-transporting ATPase ATP-binding domain N MUC4 4585 genome.wustl.edu 37 3 195516480 195516480 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_018406.5 -1 reviewed p.P657 0.000 129 0% 115 40.9% 0 - - - - NULL PIGZ 80235 genome.wustl.edu 37 3 196675280 196675280 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_025163.2 -1 reviewed p.S163F 0.672 38 0% 32 21.9% 10 20% possibly_damaging(0.805) deleterious(0) deleterious(0.748) HMMPfam_Glyco_transf_22 HTT 3064 genome.wustl.edu 37 4 3190765 3190765 + Missense_Mutation SNP C C A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_002111.6 +1 reviewed p.F1771L 1.000 233 0% 200 40.5% 3 33.3% probably_damaging(0.964) tolerated(0.25) neutral(0.443) NULL LAP3 51056 genome.wustl.edu 37 4 17609072 17609072 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_015907.2 +1 validated p.H474Y 0.992 118 0% 96 41.7% 120 30.8% possibly_damaging(0.829) tolerated(0.45) neutral(0.327) HMMPfam_Peptidase_M17,superfamily_Zn-dependent exopeptidases LRRC66 339977 genome.wustl.edu 37 4 52883573 52883573 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001024611.1 -1 provisional p.F69 0.005 202 0% 184 39.7% 0 - - - - superfamily_SSF52058 CLOCK 9575 genome.wustl.edu 37 4 56342166 56342166 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_004898.2 -1 reviewed p.F104L 1.000 106 0% 100 34% 0 - probably_damaging(0.997) deleterious(0) deleterious(0.911) superfamily_HLH helix-loop-helix DNA-binding domain UTP3 57050 genome.wustl.edu 37 4 71554690 71554690 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_020368.2 +1 validated p.G99E 0.001 49 0% 54 22.2% 42 23.8% benign(0) tolerated(0.64) neutral(0.003) NULL STBD1 8987 genome.wustl.edu 37 4 77230489 77230489 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_003943.3 +1 validated p.S138F 0.036 173 0% 136 37.5% 1 100% probably_damaging(0.998) deleterious(0) deleterious(0.919) NULL ARHGAP24 83478 genome.wustl.edu 37 4 86916302 86916302 + Nonsense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001025616.2 +1 validated p.R499* 0.653 280 0% 281 12.1% 0 - - - - NULL PKD2 5311 genome.wustl.edu 37 4 88986631 88986631 + Nonsense_Mutation SNP C C T rs121918040 TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_000297.2 +1 reviewed p.R742* 1.000 258 0% 276 35.1% 7 0% - - - superfamily_SSF47473 KIAA1109 84162 genome.wustl.edu 37 4 123156175 123156175 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_015312.3 +1 reviewed p.D1191H 1.000 187 0% 189 29.6% 0 - possibly_damaging(0.531) deleterious(0.03) deleterious(0.543) NULL KIAA1109 84162 genome.wustl.edu 37 4 123160911 123160913 + In_Frame_Del DEL GAG GAG - novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 GAG GAG Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_015312.3 +1 reviewed p.R1360in_frame_del 1.000:1.000:1.000 - - - - - - - - - NULL HHIP 64399 genome.wustl.edu 37 4 145633221 145633221 + Missense_Mutation SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_022475.1 +1 reviewed p.Y474C 1.000 221 0% 221 17.2% 1 0% probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_Soluble quinoprotein glucose dehydrogenase FBXW7 55294 genome.wustl.edu 37 4 153244092 153244092 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_033632.2 -1 reviewed p.R689W 1.000 305 0% 394 39.3% 15 26.6% probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_SM00320 TIGD4 201798 genome.wustl.edu 37 4 153691222 153691222 + Missense_Mutation SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_145720.2 -1 reviewed p.S312Y 1.000 245 0% 140 43.6% 0 - probably_damaging(0.99) deleterious(0.04) deleterious(0.790) HMMPfam_DDE CTSO 1519 genome.wustl.edu 37 4 156864317 156864317 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001334.2 -1 reviewed p.E79Q 1.000 308 0% 289 35.3% 1 100% probably_damaging(0.997) deleterious(0.04) deleterious(0.815) superfamily_SSF54001 ETFDH 2110 genome.wustl.edu 37 4 159627897 159627897 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_004453.2 +1 reviewed p.H529D 1.000 273 0% 260 38.1% 26 46.1% probably_damaging(0.998) deleterious(0) deleterious(0.919) HMMPfam_ETF_QO FSTL5 56884 genome.wustl.edu 37 4 162459356 162459356 + Missense_Mutation SNP A A T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_020116.3 -1 validated p.I425N 1.000 544 0% 705 16.6% 0 - probably_damaging(0.998) deleterious(0) deleterious(0.919) HMMPfam_I-set,superfamily_SSF48726 MFAP3L 9848 genome.wustl.edu 37 4 170913164 170913164 + Missense_Mutation SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_021647.6 -1 validated p.Q199K 1.000 194 0% 162 11.7% 6 16.6% benign(0) deleterious(0) neutral(0.445) NULL GALNTL6 442117 genome.wustl.edu 37 4 173873355 173873355 + Missense_Mutation SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001034845.2 +1 validated p.W439C 1.000 38 0% 51 11.8% 0 - probably_damaging(0.997) tolerated(0.19) deleterious(0.516) superfamily_Nucleotide-diphospho-sugar transferases PLEKHG4B 153478 genome.wustl.edu 37 5 163424 163424 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_052909.3 +1 validated p.M723I 0.586 24 0% 18 50% 0 - benign(0.005) tolerated(0.45) neutral(0.012) NULL SLC12A7 10723 genome.wustl.edu 37 5 1057616 1057616 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006598.2 -1 validated p.S999C 0.012 45 0% 32 25% 37 43.2% benign(0.005) deleterious(0.03) neutral(0.364) NULL ADAMTS12 81792 genome.wustl.edu 37 5 33535025 33535025 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_030955.2 -1 reviewed p.E1507K 0.408 174 0% 182 47.8% 0 - probably_damaging(0.982) tolerated(0.41) neutral(0.442) HMMPfam_TSP_1,HMMSmart_SM00209,superfamily_TSP-1 type 1 repeat EMB 133418 genome.wustl.edu 37 5 49699124 49699124 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_198449.2 -1 reviewed p.L255 0.998 275 0% 284 37.7% 0 - - - - HMMSmart_SM00409,superfamily_Immunoglobulin ISL1 3670 genome.wustl.edu 37 5 50685569 50685569 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_002202.2 +1 reviewed p.E190K 1.000 41 0% 30 20% 0 - probably_damaging(1) deleterious(0.02) deleterious(0.883) HMMPfam_Homeobox,HMMSmart_SM00389,superfamily_Homeodomain-like MOCS2 4338 genome.wustl.edu 37 5 52396255 52396255 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_004531.3 -1 reviewed p.P163S 1.000 124 0% 129 20.2% 21 38% probably_damaging(1) deleterious(0.01) deleterious(0.905) superfamily_Mb_biosynth_MoaE FST 10468 genome.wustl.edu 37 5 52780976 52780976 + Missense_Mutation SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_013409.1 +1 reviewed p.Y291H 0.998 200 0% 187 13.9% 1 0% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Kazal_1,HMMSmart_SM00280,superfamily_Kazal-type serine protease inhibitors JMY 133746 genome.wustl.edu 37 5 78596042 78596042 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_152405.4 +1 validated p.D532N 1.000 194 0% 220 41.4% 0 - benign(0.273) deleterious(0.02) neutral(0.412) NULL RASA1 5921 genome.wustl.edu 37 5 86627205 86627205 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_002890.1 +1 reviewed p.R194C 1.000 212 0% 226 11.1% 6 0% probably_damaging(1) deleterious(0.04) deleterious(0.849) HMMPfam_SH2,HMMSmart_SM00252,superfamily_SH2 domain TMEM161B 153396 genome.wustl.edu 37 5 87516531 87516531 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_153354.3 -1 provisional p.H99Y 1.000 201 0% 183 34.4% 0 - possibly_damaging(0.916) tolerated(0.13) deleterious(0.619) HMMPfam_Tmemb_161AB GPR98 84059 genome.wustl.edu 37 5 89953958 89953958 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_032119.3 +1 reviewed p.E1539K 1.000 343 0% 287 12.2% 0 - probably_damaging(0.999) deleterious(0) deleterious(0.935) NULL TNFAIP8 25816 genome.wustl.edu 37 5 118728551 118728551 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_014350.2 +1 validated p.Q24 1.000 39 0% 35 34.3% 0 - - - - HMMPfam_DUF758 RAD50 10111 genome.wustl.edu 37 5 131973808 131973808 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005732.3 +1 reviewed p.E1171K 1.000 114 0% 106 41.5% 20 40% possibly_damaging(0.832) deleterious(0.05) deleterious(0.662) HMMPfam_SMC_N,superfamily_P-loop containing nucleoside triphosphate hydrolases TXNDC15 79770 genome.wustl.edu 37 5 134223686 134223686 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 ENST00000508779 +1 known p.A119V 0.000 78 0% 53 13.2% 47 23.4% - - - NULL MATR3 9782 genome.wustl.edu 37 5 138652768 138652768 + Missense_Mutation SNP C C A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_018834.4 +1 reviewed p.P386T 1.000 98 0% 136 11.8% 44 20.4% probably_damaging(0.996) tolerated(0.38) deleterious(0.479) NULL ANKHD1-EIF4EBP3 404734 genome.wustl.edu 37 5 139908085 139908085 + Missense_Mutation SNP C C A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_020690.4 +1 reviewed p.P1852T 1.000 320 0% 303 36.3% 26 46.1% probably_damaging(0.98) deleterious(0) deleterious(0.869) NULL PCDHA4 56144 genome.wustl.edu 37 5 140188392 140188392 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_018907.2 +1 reviewed p.A540 0.648 57 0% 39 35.9% 0 - - - - HMMPfam_Cadherin,HMMSmart_SM00112,superfamily_Cadherin-like PCDHA7 56141 genome.wustl.edu 37 5 140215581 140215581 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_018910.2 +1 reviewed p.R538H 0.988 38 0% 30 20% 0 - possibly_damaging(0.667) deleterious(0.02) deleterious(0.619) HMMPfam_Cadherin,HMMSmart_SM00112,superfamily_Cadherin-like PCDHB1 29930 genome.wustl.edu 37 5 140432167 140432167 + Missense_Mutation SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_013340.2 +1 reviewed p.I371T 0.971 132 0% 126 13.5% 0 - benign(0.01) deleterious(0) neutral(0.445) HMMPfam_Cadherin,HMMSmart_CA,superfamily_Cadherin PCDHB3 56132 genome.wustl.edu 37 5 140481165 140481165 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_018937.2 +1 reviewed p.A311V 0.000 105 0% 62 12.9% 0 - benign(0) tolerated(0.26) neutral(0.034) HMMPfam_Cadherin,HMMSmart_SM00112,superfamily_Cadherin-like PCDHGB6 56100 genome.wustl.edu 37 5 140788156 140788156 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_018926.2 +1 reviewed p.H129 0.289 144 0% 70 32.9% 0 - - - - HMMSmart_SM00112,PatternScan_CADHERIN_1,superfamily_Cadherin-like PCDHGB6 56100 genome.wustl.edu 37 5 140788505 140788505 + Nonsense_Mutation SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_018926.2 +1 reviewed p.E246* 0.018 58 0% 34 38.2% 0 - - - - superfamily_Cadherin-like TCERG1 10915 genome.wustl.edu 37 5 145890170 145890170 + Missense_Mutation SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006706.3 +1 reviewed p.T1088A 1.000 91 0% 86 19.8% 24 12.5% unknown(0) deleterious(0.01) - NULL SLC36A1 206358 genome.wustl.edu 37 5 150838428 150838428 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_078483.2 +1 reviewed p.P25 0.056 94 0% 90 23.3% 1 0% - - - NULL TSPAN17 26262 genome.wustl.edu 37 5 176079857 176079857 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 ENST00000507471 +1 known p.S66L 1.000 350 0% 233 32.2% 25 40% - - - superfamily_Tetraspanin,HMMPfam_Tetraspannin NHP2 55651 genome.wustl.edu 37 5 177576828 177576828 + Missense_Mutation SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001034833.1 -1 reviewed p.Q81R 0.975 76 0% 41 12.2% 220 15.9% benign(0.003) tolerated(0.21) neutral(0.044) NULL MAPK9 5601 genome.wustl.edu 37 5 179666941 179666941 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_002752.4 -1 reviewed p.A348V 0.995 115 0% 116 15.5% 14 7.1% possibly_damaging(0.903) deleterious(0.03) deleterious(0.722) superfamily_Protein kinase-like (PK-like) BTNL3 10917 genome.wustl.edu 37 5 180432363 180432363 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_197975.1 +1 validated p.H298Y 0.009 294 0% 303 39.9% 0 - probably_damaging(0.963) deleterious(0) deleterious(0.850) HMMSmart_PRY TUBB2A 7280 genome.wustl.edu 37 6 3156348 3156348 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001069.2 -1 validated p.P32 1.000 184 10.3% 157 12.1% 5 0% - - - HMMPfam_Tubulin,superfamily_Tubulin nucleotide-binding domain-like LYRM4 57128 genome.wustl.edu 37 6 5216907 5216907 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_020408.4 -1 validated p.E51Q 0.998 338 0% 476 56.1% 11 72.7% benign(0.253) tolerated(0.38) neutral(0.043) HMMPfam_Complex1_LYR HIST1H3D 8351 genome.wustl.edu 37 6 26197400 26197400 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_003530.3 -1 reviewed p.R27G 1.000 71 0% 58 24.1% 6 50% benign(0.159) - - superfamily_Histone-fold OR2J3 442186 genome.wustl.edu 37 6 29080229 29080229 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001005216.2 +1 validated p.L188V 0.021 298 0% 436 28% 0 - probably_damaging(0.992) tolerated(0.16) deleterious(0.507) HMMPfam_7tm_1,superfamily_SSF81321 MDC1 9656 genome.wustl.edu 37 6 30675937 30675937 + Missense_Mutation SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_014641.2 -1 reviewed p.R807G 0.042 602 0% 831 11.2% 1 100% possibly_damaging(0.717) - - NULL TNXB 7148 genome.wustl.edu 37 6 32017805 32017805 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_019105.6 -1 reviewed p.V3135I 0.533 106 0% 103 54.4% 1 0% possibly_damaging(0.888) tolerated(0.39) neutral(0.363) HMMPfam_fn3,HMMSmart_SM00060,superfamily_Fibronectin type III AGER 177 genome.wustl.edu 37 6 32151709 32151709 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001136.3 -1 reviewed p.L36 0.963 105 0% 93 57% 1 100% - - - HMMSmart_SM00408,HMMSmart_SM00409,HMMPfam_ig,superfamily_Immunoglobulin NOTCH4 4855 genome.wustl.edu 37 6 32182003 32182003 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_004557.3 -1 reviewed p.T684M 0.975 397 0% 519 10.8% 0 - probably_damaging(1) deleterious(0.02) deleterious(0.883) HMMSmart_SM00181,PatternScan_EGF_1,PatternScan_EGF_2,superfamily_EGF/Laminin UHRF1BP1 54887 genome.wustl.edu 37 6 34802570 34802570 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_017754.3 +1 validated p.D201N 1.000 214 0% 268 55.2% 1 100% probably_damaging(0.999) deleterious(0.01) deleterious(0.896) NULL ABCC10 89845 genome.wustl.edu 37 6 43412951 43412951 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_033450.2 +1 reviewed p.V949I 0.962 120 0% 121 12.4% 12 16.6% benign(0.001) tolerated(0.27) neutral(0.034) HMMPfam_ABC_membrane,superfamily_ABC_TM_1 GPR116 221395 genome.wustl.edu 37 6 46826150 46826150 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001098518.1 -1 validated p.L1164F 1.000 105 0% 128 10.9% 1 0% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_7tm_2 GPR110 266977 genome.wustl.edu 37 6 46977303 46977303 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_153840.2 -1 validated p.R623H 1.000 100 0% 164 11% 2 0% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_7tm_2 BMP5 653 genome.wustl.edu 37 6 55623845 55623845 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_021073.2 -1 reviewed p.N391 1.000 235 0% 404 10.6% 0 - - - - HMMPfam_TGF_beta,HMMSmart_TGFB,superfamily_SSF57501 DST 667 genome.wustl.edu 37 6 56470074 56470074 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 ENST00000370769 -1 known p.D2907N 0.007 118 0.8% 128 54.7% 0 - benign(0.184) deleterious(0.03) neutral(0.382) PatternScan_RIBOSOMAL_L23 DST 667 genome.wustl.edu 37 6 56473404 56473404 + Nonsense_Mutation SNP C C A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 ENST00000370769 -1 known p.E1797* 0.973 67 0% 83 57.8% 0 - - - - HMMPfam_Plectin,HMMSmart_SM00250,superfamily_Plakin repeat FAM135A 57579 genome.wustl.edu 37 6 71235110 71235110 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001105531.2 +1 validated p.E579K 1.000 280 0% 390 63.8% 0 - probably_damaging(0.996) deleterious(0) deleterious(0.906) NULL DOPEY1 23033 genome.wustl.edu 37 6 83851647 83851647 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_015018.2 +1 validated p.R1808K 1.000 182 0% 222 61.7% 2 100% probably_damaging(0.994) tolerated(0.45) neutral(0.464) NULL SNX14 57231 genome.wustl.edu 37 6 86257068 86257068 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_153816.3 -1 reviewed p.Q320 1.000 103 0% 147 27.9% 2 0% - - - NULL MDN1 23195 genome.wustl.edu 37 6 90426508 90426508 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_014611.1 -1 provisional p.E2202K 1.000 207 0% 211 24.6% 0 - possibly_damaging(0.69) tolerated(0.64) neutral(0.250) HMMSmart_SM00382,superfamily_P-loop containing nucleoside triphosphate hydrolases CCNC 892 genome.wustl.edu 37 6 99994344 99994344 + Missense_Mutation SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005190.3 -1 reviewed p.L202P 1.000 198 0% 281 11.7% 85 15.2% probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMSmart_SM00385,superfamily_Cyclin-like TRDN 10345 genome.wustl.edu 37 6 123539787 123539787 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006073.2 -1 validated p.G717S 0.035 37 0% 60 51.7% 0 - unknown(0) deleterious(0) - NULL PTPRK 5796 genome.wustl.edu 37 6 128840283 128840283 + Nonsense_Mutation SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 ENST00000368202 -1 known p.S35* 0.000 12 0% 19 21.1% 1 0% - - - NULL TAAR6 319100 genome.wustl.edu 37 6 132891739 132891739 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_175067.1 +1 reviewed p.T93 0.380 192 0% 303 23.8% 0 - - - - HMMPfam_7tm_1,superfamily_SSF81321 EYA4 2070 genome.wustl.edu 37 6 133783489 133783489 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_004100.4 +1 reviewed p.L152V 1.000 210 0% 272 57.7% 0 - probably_damaging(0.994) tolerated(0.15) deleterious(0.693) NULL LTV1 84946 genome.wustl.edu 37 6 144165625 144165625 + Silent SNP T T G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_032860.3 +1 provisional p.P2 1.000 198 0% 259 56.4% 10 60% - - - NULL SASH1 23328 genome.wustl.edu 37 6 148865932 148865932 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_015278.3 +1 validated p.T1109M 0.990 17 0% 27 55.6% 1 0% probably_damaging(1) deleterious(0) deleterious(0.945) NULL SYNJ2 8871 genome.wustl.edu 37 6 158497759 158497759 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_003898.3 +1 reviewed p.P798 1.000 102 0% 99 15.2% 2 0% - - - HMMSmart_SM00128,HMMPfam_Exo_endo_phos,superfamily_DNase I-like CARD11 84433 genome.wustl.edu 37 7 2984010 2984010 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_032415.3 -1 validated p.L174 1.000 97 0% 93 11.8% 1 0% - - - NULL ACTB 60 genome.wustl.edu 37 7 5567994 5567994 + Frame_Shift_Del DEL G G - novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001101.3 -1 reviewed p.Y240fs 0.568 - - - - - - - - - HMMPfam_Actin,HMMSmart_SM00268,superfamily_Actin-like ATPase domain ZNF680 340252 genome.wustl.edu 37 7 63981624 63981624 + Nonsense_Mutation SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_178558.4 -1 validated p.S503* 0.001 194 0% 300 21.7% 3 33.3% - - - HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers FGL2 10875 genome.wustl.edu 37 7 76826058 76826058 + Missense_Mutation SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006682.2 -1 reviewed p.N286K 0.190 278 0% 315 10.8% 1 0% probably_damaging(1) deleterious(0.01) deleterious(0.905) HMMPfam_Fibrinogen_C,HMMSmart_SM00186,superfamily_Fibrinogen C-terminal domain-like PTPN12 5782 genome.wustl.edu 37 7 77214887 77214887 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_002835.3 +1 reviewed p.E137Q 1.000 237 0% 392 54.8% 8 50% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Y_phosphatase,HMMSmart_PTPc,superfamily_SSF52799 ENSG00000207094 0 genome.wustl.edu 37 7 88078455 88078455 + RNA SNP C C A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 ENST00000384366 -1 novel NULL 0.011 51 0% 70 14.3% 0 - - - - - LMTK2 22853 genome.wustl.edu 37 7 97833412 97833412 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_014916.3 +1 reviewed p.A1466V 0.395 57 0% 78 16.7% 5 0% benign(0.011) deleterious(0) neutral(0.445) NULL DNAJC2 27000 genome.wustl.edu 37 7 102963017 102963017 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_014377.1 -1 reviewed p.E292Q 1.000 70 0% 53 30.2% 13 23% unknown(0) tolerated(0.25) - NULL RELN 5649 genome.wustl.edu 37 7 103202136 103202136 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005045.3 -1 reviewed p.G1791E 1.000 174 0% 232 12.1% 0 - probably_damaging(1) deleterious(0.01) deleterious(0.905) PatternScan_EGF_1,PatternScan_EGF_2,HMMPfam_EGF_2,superfamily_SSF57196 COG5 10466 genome.wustl.edu 37 7 107204360 107204360 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006348.3 -1 validated p.I25M 0.926 25 0% 17 29.4% 0 - benign(0.278) - - NULL PTPRZ1 5803 genome.wustl.edu 37 7 121638061 121638061 + Splice_Site SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_002851.2 +1 reviewed e10+1 1.000 67 0% 88 37.5% 0 - - - - - UBN2 254048 genome.wustl.edu 37 7 138968631 138968631 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_173569.3 +1 validated p.Q911E 1.000 227 0% 356 30.3% 4 0% possibly_damaging(0.812) tolerated(0.26) neutral(0.340) NULL DENND2A 27147 genome.wustl.edu 37 7 140259537 140259537 + Missense_Mutation SNP C C A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_015689.3 -1 validated p.K620N 1.000 59 0% 75 17.3% 7 0% benign(0.15) tolerated(0.18) neutral(0.069) HMMPfam_uDENN,HMMSmart_SM00800 ZNF746 155061 genome.wustl.edu 37 7 149172576 149172576 + Splice_Site SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 ENST00000458143 -1 known e7-2 1.000 56 0% 50 10% 0 - - - - - USP17L7 392197 genome.wustl.edu 37 8 11990295 11990295 + Silent SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 ENST00000416902 -1 known p.L408 0.023 209 0% 336 28.6% 0 - - - - NULL PPP3CC 5533 genome.wustl.edu 37 8 22386044 22386044 + Silent SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005605.3 +1 provisional p.L365 1.000 75 0% 168 46.4% 10 40% - - - superfamily_SSF56300 SLC20A2 6575 genome.wustl.edu 37 8 42294518 42294518 + Silent SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006749.3 -1 provisional p.G504 1.000 30 0% 50 14% 40 5% - - - HMMPfam_PHO4 TRPA1 8989 genome.wustl.edu 37 8 72958768 72958768 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_007332.2 -1 reviewed p.E681K 0.987 230 0% 417 10.8% 0 - benign(0.016) tolerated(0.74) neutral(0.002) NULL RUNX1T1 862 genome.wustl.edu 37 8 92999165 92999165 + Missense_Mutation SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_175634.1 -1 reviewed p.H343N 1.000 238 0% 409 36.2% 2 0% benign(0.018) tolerated(0.44) neutral(0.013) HMMPfam_NHR2 RGS22 26166 genome.wustl.edu 37 8 101076043 101076043 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_015668.3 -1 validated p.S318F 0.032 358 0% 604 38.4% 1 100% possibly_damaging(0.923) tolerated(0.08) deleterious(0.672) NULL VLDLR 7436 genome.wustl.edu 37 9 2646528 2646528 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_003383.3 +1 reviewed p.S560F 1.000 120 0% 105 35.2% 3 33.3% probably_damaging(0.993) deleterious(0) deleterious(0.895) HMMPfam_Ldl_recept_b,HMMSmart_SM00135,superfamily_YWTD domain VCP 7415 genome.wustl.edu 37 9 35067979 35067979 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_007126.3 -1 reviewed p.V71I 1.000 165 0% 117 11.1% 151 1.9% benign(0.005) tolerated(0.11) neutral(0.272) HMMPfam_CDC48_N,superfamily_ADC-like PIGO 84720 genome.wustl.edu 37 9 35092041 35092041 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_032634.2 -1 reviewed p.R615W 0.227 84 0% 53 30.2% 8 62.5% probably_damaging(0.998) deleterious(0) deleterious(0.919) NULL LOC730110 730110 genome.wustl.edu 37 9 35148106 35148106 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 XM_002342891.1 -1 model p.K334 0.932 132 0% 137 38% 0 - - - - HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers FRMPD1 22844 genome.wustl.edu 37 9 37740768 37740768 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_014907.2 +1 validated p.S748N 0.051 64 0% 41 19.5% 0 - benign(0.002) tolerated(0.15) neutral(0.241) NULL VPS13A 23230 genome.wustl.edu 37 9 79835225 79835225 + Silent SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_033305.2 +1 reviewed p.V305 1.000 138 0% 179 16.2% 0 - - - - NULL TLE4 7091 genome.wustl.edu 37 9 82333698 82333698 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_007005.3 +1 validated p.A468T 1.000 115 0% 92 15.2% 8 12.5% benign(0.226) deleterious(0) neutral(0.467) superfamily_WD40 repeat-like FRMD3 257019 genome.wustl.edu 37 9 85863431 85863431 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_174938.4 -1 validated p.G399D 1.000 126 0% 142 14.1% 0 - benign(0.002) deleterious(0.01) neutral(0.406) NULL NANS 54187 genome.wustl.edu 37 9 100823096 100823096 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_018946.3 +1 reviewed p.K55N 1.000 142 0% 86 37.2% 112 32.1% probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMPfam_NeuB,superfamily_Aldolase TEX10 54881 genome.wustl.edu 37 9 103109502 103109502 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_017746.3 -1 validated p.Q123E 1.000 259 0% 164 25% 4 25% - - - HMMPfam_HEAT,superfamily_ARM-type_fold C9orf125 84302 genome.wustl.edu 37 9 104238683 104238683 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_032342.1 -1 provisional p.R231H 1.000 137 0% 102 32.4% 0 - possibly_damaging(0.814) tolerated(0.21) neutral(0.351) NULL PPP3R2 5535 genome.wustl.edu 37 9 104357045 104357045 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_147180.2 -1 provisional p.P56 0.413 106 0% 77 13% 0 - - - - superfamily_SSF47473 ACTL7B 10880 genome.wustl.edu 37 9 111616967 111616967 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006686.3 -1 reviewed p.C415Y 1.000 48 0% 39 12.8% 0 - possibly_damaging(0.8) deleterious(0) deleterious(0.746) HMMPfam_Actin,HMMSmart_SM00268,superfamily_Actin-like ATPase domain EPB41L4B 54566 genome.wustl.edu 37 9 112025342 112025342 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_019114.3 -1 validated p.L207V 1.000 37 0% 19 36.8% 1 0% possibly_damaging(0.782) deleterious(0.01) deleterious(0.699) HMMPfam_FERM_M,superfamily_Second domain of FERM,HMMSmart_SM00295 RGS3 5998 genome.wustl.edu 37 9 116359103 116359103 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_144488.4 +1 reviewed p.T1156M 0.996 24 0% 28 25% 61 9.8% probably_damaging(0.998) deleterious(0) deleterious(0.919) HMMPfam_RGS,HMMSmart_SM00315,superfamily_Regulator of G-protein signaling RGS TNC 3371 genome.wustl.edu 37 9 117846669 117846669 + Silent SNP T T A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_002160.2 -1 validated p.T650 0.002 94 0% 84 15.5% 25 0% - - - HMMPfam_fn3,HMMSmart_FN3,superfamily_FN_III-like ZMYND11 10771 genome.wustl.edu 37 10 255984 255984 + Missense_Mutation SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006624.4 +1 reviewed p.E51G 1.000 282 0% 383 13.3% 14 0% probably_damaging(0.978) tolerated(0.16) deleterious(0.480) NULL FAM208B 54906 genome.wustl.edu 37 10 5789701 5789701 + Silent SNP C C A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_017782.4 +1 validated p.S1439 0.931 184 0% 185 10.3% 7 0% - - - NULL CUBN 8029 genome.wustl.edu 37 10 17147460 17147460 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001081.3 -1 reviewed p.C409Y 1.000 150 0% 235 15.3% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) PatternScan_ASX_HYDROXYL,HMMSmart_SM00179,HMMPfam_EGF,HMMSmart_SM00181,superfamily_EGF/Laminin KIAA1462 57608 genome.wustl.edu 37 10 30336741 30336741 + Missense_Mutation SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_020848.2 -1 validated p.M1V 0.991 87 0% 88 11.4% 1 100% probably_damaging(0.998) deleterious(0) deleterious(0.919) NULL MTPAP 55149 genome.wustl.edu 37 10 30630501 30630501 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_018109.3 -1 validated p.R76W 0.997 290 0% 340 10.9% 4 25% probably_damaging(1) deleterious(0) deleterious(0.945) NULL ARHGAP12 94134 genome.wustl.edu 37 10 32115232 32115232 + Missense_Mutation SNP C C A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_018287.5 -1 provisional p.W510C 1.000 133 0.8% 246 13.4% 3 0% probably_damaging(0.989) deleterious(0.04) deleterious(0.788) HMMPfam_PH,HMMSmart_SM00233,superfamily_PH domain-like CSGALNACT2 55454 genome.wustl.edu 37 10 43654240 43654240 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_018590.3 +1 provisional p.H247Y 1.000 151 0% 238 13% 2 0% probably_damaging(0.99) deleterious(0.01) deleterious(0.847) HMMPfam_CHGN,superfamily_Nucleotide-diphospho-sugar transferases MAPK8 5599 genome.wustl.edu 37 10 49635122 49635122 + Splice_Site SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_139047.1 +1 reviewed e9-1 1.000 112 0% 180 14.4% 0 - - - - - ERCC6 2074 genome.wustl.edu 37 10 50740606 50740606 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_000124.2 -1 reviewed p.S135 0.009 61 0% 72 19.4% 9 0% - - - NULL MSS51 118490 genome.wustl.edu 37 10 75185580 75185580 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001024593.1 -1 validated p.A353V 1.000 68 0% 109 15.6% 2 0% possibly_damaging(0.837) deleterious(0.02) deleterious(0.703) NULL SH2D4B 387694 genome.wustl.edu 37 10 82329948 82329948 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_207372.2 +1 validated p.D75H 0.973 100 0% 187 54% 0 - probably_damaging(0.984) deleterious(0.01) deleterious(0.836) NULL PTEN 5728 genome.wustl.edu 37 10 89692895 89692895 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 ENST00000371953 +1 known p.G127R 1.000 329 0% 546 84.2% 19 84.2% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_DSPc,HMMSmart_SM00404,PatternScan_TYR_PHOSPHATASE_1,superfamily_(Phosphotyrosine protein) phosphatases II PIK3AP1 118788 genome.wustl.edu 37 10 98412557 98412557 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_152309.2 -1 validated p.D204N 0.005 435 0% 493 53.1% 1 0% benign(0.02) tolerated(0.19) neutral(0.051) NULL PI4K2A 55361 genome.wustl.edu 37 10 99416602 99416602 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_018425.2 +1 provisional p.E265K 1.000 288 0% 378 57.7% 9 44.4% benign(0.006) tolerated(0.81) neutral(0.001) HMMPfam_PI3_PI4_kinase SEC31B 25956 genome.wustl.edu 37 10 102248652 102248652 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_015490.3 -1 reviewed p.A1084V 0.397 73 0% 80 13.8% 3 0% benign(0.282) tolerated(0.13) neutral(0.339) NULL CNNM2 54805 genome.wustl.edu 37 10 104678816 104678816 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_017649.3 +1 validated p.T193 1.000 31 0% 54 16.7% 4 0% - - - NULL WDR96 80217 genome.wustl.edu 37 10 105926278 105926278 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_025145.5 -1 provisional p.E1003K 1.000 292 0% 397 11.8% 3 0% probably_damaging(0.977) tolerated(0.19) neutral(0.468) superfamily_WD40 repeat-like RAB11FIP2 22841 genome.wustl.edu 37 10 119799729 119799729 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_014904.2 -1 validated p.S234F 1.000 182 0% 205 26.8% 1 100% possibly_damaging(0.703) tolerated(0.09) deleterious(0.549) NULL OR51F2 119694 genome.wustl.edu 37 11 4843610 4843610 + Missense_Mutation SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001004753.1 +1 provisional p.L332P 0.000 233 0% 272 13.6% 0 - possibly_damaging(0.797) deleterious(0) deleterious(0.744) NULL OR52N1 79473 genome.wustl.edu 37 11 5809686 5809686 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001001913.1 -1 provisional p.A121T 1.000 273 0% 325 10.8% 0 - probably_damaging(0.971) deleterious(0) deleterious(0.857) HMMPfam_7tm_1,superfamily_SSF81321 OR2AG2 338755 genome.wustl.edu 37 11 6789286 6789286 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001004490.1 -1 provisional p.L301 0.010 130 0% 143 39.9% 0 - - - - superfamily_SSF81321 C11orf41 25758 genome.wustl.edu 37 11 33564727 33564727 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_012194.1 +1 validated p.D243N 0.001 379 0% 351 38.7% 0 - benign(0.323) tolerated(0.11) neutral(0.373) NULL CRY2 1408 genome.wustl.edu 37 11 45877632 45877632 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_021117.3 +1 validated p.R126 0.999 170 0% 195 18.5% 3 33.3% - - - HMMPfam_DNA_photolyase,superfamily_DNA_photolyase_N TRIM48 79097 genome.wustl.edu 37 11 55036790 55036790 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_024114.3 +1 validated p.L217 0.161 89 0% 97 37.1% 0 - - - - NULL OR8K3 219473 genome.wustl.edu 37 11 56086301 56086301 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001005202.1 +1 provisional p.V173 0.000 199 0% 211 11.8% 0 - - - - HMMPfam_7tm_1,superfamily_SSF81321 OR5M9 390162 genome.wustl.edu 37 11 56230204 56230204 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001004743.1 -1 provisional p.R225H 0.000 65 0% 79 12.7% 0 - benign(0.062) deleterious(0.04) neutral(0.353) HMMPfam_7tm_1,superfamily_SSF81321 LOC100287520 100287520 genome.wustl.edu 37 11 58862133 58862133 + Silent SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 XM_002343089.1 +1 model p.P298 0.032 40 0% 43 34.9% 0 - - - - HMMPfam_Gly_acyl_tr_C,superfamily_Acyl-CoA N-acyltransferases (Nat) AHNAK 79026 genome.wustl.edu 37 11 62295517 62295517 + Silent SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001620.1 -1 validated p.L2124 0.002 557 0% 394 42.9% 0 - - - - NULL METTL12 751071 genome.wustl.edu 37 11 62434441 62434441 + Missense_Mutation SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001043229.1 +1 validated p.Y214C 0.000 103 0% 67 10.4% 1 100% benign(0.253) tolerated(0.17) neutral(0.085) superfamily_SSF53335 CHKA 1119 genome.wustl.edu 37 11 67832039 67832039 + Silent SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001277.2 -1 reviewed p.T395 0.997 69 0% 87 14.9% 3 33.3% - - - superfamily_Protein kinase-like (PK-like) PCF11 51585 genome.wustl.edu 37 11 82876841 82876841 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_015885.3 +1 validated p.R301K 1.000 63 0% 65 16.9% 2 0% possibly_damaging(0.495) tolerated(0.19) neutral(0.215) NULL CCDC89 220388 genome.wustl.edu 37 11 85396685 85396685 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_152723.1 -1 provisional p.S163 0.085 159 0% 156 15.4% 3 66.6% - - - NULL KIAA1377 57562 genome.wustl.edu 37 11 101834422 101834422 + Missense_Mutation SNP T T A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_020802.2 +1 validated p.F886I 0.001 197 0% 242 16.9% 1 0% benign(0.013) tolerated(0.39) neutral(0.017) NULL CWF19L2 143884 genome.wustl.edu 37 11 107263578 107263578 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_152434.2 -1 validated p.S554F 1.000 178 0% 156 35.3% 1 0% probably_damaging(1) deleterious(0) deleterious(0.945) NULL DDX10 1662 genome.wustl.edu 37 11 108550233 108550233 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_004398.2 +1 reviewed p.R265H 1.000 297 0% 216 14.8% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_SM00487,superfamily_P-loop containing nucleoside triphosphate hydrolases LAYN 143903 genome.wustl.edu 37 11 111425943 111425943 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_178834.3 +1 provisional p.E196K 0.358 182 0% 147 28.6% 1 0% probably_damaging(0.971) tolerated(0.08) deleterious(0.713) NULL CRYAB 1410 genome.wustl.edu 37 11 111779667 111779667 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001885.1 -1 reviewed p.E117Q 1.000 84 0% 105 31.4% 16 25% probably_damaging(0.953) tolerated(0.08) deleterious(0.697) HMMPfam_HSP20,superfamily_HSP20-like chaperones DRD2 1813 genome.wustl.edu 37 11 113287604 113287604 + Silent SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_000795.3 -1 reviewed p.L171 0.996 35 0% 33 42.4% 0 - - - - HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like FAM55B 120406 genome.wustl.edu 37 11 114569354 114569354 + Silent SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_182495.5 +1 validated p.E240 0.011 191 0% 241 40.2% 0 - - - - NULL SIK3 23387 genome.wustl.edu 37 11 116732609 116732609 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_025164.3 -1 validated p.L649F 1.000 28 0% 31 51.6% 5 40% probably_damaging(0.998) deleterious(0) deleterious(0.919) superfamily_Protein kinase-like (PK-like) OR8D2 283160 genome.wustl.edu 37 11 124189805 124189805 + Missense_Mutation SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001002918.1 -1 provisional p.C97R 0.995 347 0% 429 18.6% 0 - probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like SLC6A13 6540 genome.wustl.edu 37 12 336796 336796 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_016615.2 -1 provisional p.F290 0.972 61 0% 43 32.6% 0 - - - - HMMPfam_SNF CACNA1C 775 genome.wustl.edu 37 12 2800290 2800290 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_199460.2 +1 reviewed p.A2197 0.238 15 0.000 9 0.556 2 100% - - - NULL PTMS 5763 genome.wustl.edu 37 12 6878783 6878783 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_002824.4 +1 validated p.K20 1.000 268 0% 153 47.7% 200 34% - - - HMMPfam_Prothymosin GPR162 27239 genome.wustl.edu 37 12 6933210 6933210 + Missense_Mutation SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_019858.1 +1 reviewed p.E49G 1.000 50 0% 44 18.2% 22 0% probably_damaging(0.98) tolerated(0.06) deleterious(0.746) HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like GPR162 27239 genome.wustl.edu 37 12 6933545 6933545 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_019858.1 +1 reviewed p.E161K 1.000 69 0% 56 35.7% 7 71.4% benign(0.417) tolerated(0.08) neutral(0.435) HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like C1RL 51279 genome.wustl.edu 37 12 7249115 7249115 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_016546.2 -1 validated p.H446Y 0.000 173 0% 129 40.3% 50 34% benign(0.045) deleterious(0.04) neutral(0.351) HMMPfam_Trypsin,HMMSmart_Tryp_SPc,superfamily_Pept_Ser_Cys A2ML1 144568 genome.wustl.edu 37 12 9000181 9000181 + Nonsense_Mutation SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_144670.3 +1 validated p.G574* 1.000 318 0% 279 14.7% 1 0% - - - HMMPfam_A2M_N_2 PTPRO 5800 genome.wustl.edu 37 12 15650224 15650224 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_030667.1 +1 reviewed p.S132C 1.000 277 0% 328 37.8% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) NULL ABCC9 10060 genome.wustl.edu 37 12 21968779 21968779 + Missense_Mutation SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005691.2 -1 reviewed p.I1314T 1.000 169 0% 175 12.6% 0 - possibly_damaging(0.616) deleterious(0.01) deleterious(0.620) superfamily_P-loop containing nucleoside triphosphate hydrolases ASUN 55726 genome.wustl.edu 37 12 27066558 27066558 + Missense_Mutation SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_018164.2 -1 validated p.N546S 1.000 660 0% 727 16.6% 6 0% benign(0) tolerated(0.48) neutral(0.011) HMMPfam_DUF2151 C12orf71 728858 genome.wustl.edu 37 12 27234159 27234159 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001080406.1 -1 inferred p.R253K 0.252 297 0% 312 34.3% 0 - benign(0.035) deleterious(0) neutral(0.447) NULL BICD1 636 genome.wustl.edu 37 12 32481304 32481304 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001714.2 +1 reviewed p.L639 1.000 234 0% 219 37.9% 5 80% - - - HMMPfam_BicD ZNF641 121274 genome.wustl.edu 37 12 48736909 48736909 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_152320.2 -1 validated p.V388 0.982 164 0% 126 38.1% 3 66.6% - - - HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers ARF3 377 genome.wustl.edu 37 12 49333820 49333820 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001659.2 -1 reviewed p.K73 1.000 263 0% 286 39.9% 146 36.3% - - - HMMSmart_SM00175,HMMSmart_SM00178,HMMSmart_SM00177,HMMPfam_Arf,superfamily_P-loop containing nucleoside triphosphate hydrolases SMARCD1 6602 genome.wustl.edu 37 12 50482365 50482365 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_003076.4 +1 reviewed p.S239F 1.000 128 0% 80 51.2% 2 0% probably_damaging(0.999) deleterious(0) deleterious(0.935) NULL DIP2B 57609 genome.wustl.edu 37 12 51100376 51100376 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_173602.2 +1 validated p.R821Q 1.000 178 0% 186 42.5% 3 0% probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_Acetyl-CoA synthetase-like KRT5 3852 genome.wustl.edu 37 12 52911523 52911523 + Nonsense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_000424.3 -1 reviewed p.Q315* 1.000 236 0% 171 14% 14 0% - - - HMMPfam_Filament SP1 6667 genome.wustl.edu 37 12 53776703 53776703 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_138473.2 +1 validated p.A324 1.000 112 0% 63 12.7% 12 25% - - - NULL PCBP2 5094 genome.wustl.edu 37 12 53865533 53865533 + Missense_Mutation SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005016.5 +1 reviewed p.V336F 1.000 127 0% 139 12.9% 687 10.1% probably_damaging(1) tolerated(0.05) deleterious(0.845) HMMSmart_KH,HMMPfam_KH_1,superfamily_SSF54791 GPR84 53831 genome.wustl.edu 37 12 54757432 54757434 + In_Frame_Del DEL GAG GAG - novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 GAG GAG Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_020370.2 -1 validated p.L68in_frame_del 1.000:1.000:1.000 - - - - - - - - - HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like GTSF1 121355 genome.wustl.edu 37 12 54854203 54854203 + Nonsense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_144594.2 -1 validated p.R149* 1.000 96 0% 98 15.3% 0 - - - - HMMPfam_UPF0224 LRP1 4035 genome.wustl.edu 37 12 57537558 57537558 + Frame_Shift_Del DEL A A - novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_002332.2 +1 reviewed p.Q142fs 0.854 - - - - - - - - - HMMSmart_SM00179,HMMPfam_EGF,HMMSmart_SM00181,superfamily_EGF/Laminin LRP1 4035 genome.wustl.edu 37 12 57587773 57587773 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_002332.2 +1 reviewed p.D2632 0.964 25 0% 16 50% 6 33.3% - - - HMMPfam_Ldl_recept_a,HMMSmart_SM00192,PatternScan_LDLRA_1,superfamily_LDL receptor-like module,superfamily_YWTD domain LEMD3 23592 genome.wustl.edu 37 12 65639661 65639661 + Silent SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_014319.4 +1 reviewed p.C838 1.000 233 0% 265 12.8% 0 - - - - superfamily_SSF54928 C12orf50 160419 genome.wustl.edu 37 12 88380176 88380176 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_152589.1 -1 predicted p.V279M 1.000 193 0% 194 17.5% 0 - benign(0.203) deleterious(0) neutral(0.464) NULL GALNT4 8693 genome.wustl.edu 37 12 89917242 89917242 + Missense_Mutation SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_003774.3 -1 reviewed p.H362R 0.999 157 0% 117 34.2% 46 43.4% probably_damaging(0.996) deleterious(0) deleterious(0.906) superfamily_Nucleotide-diphospho-sugar transferases BTBD11 121551 genome.wustl.edu 37 12 108004113 108004113 + Missense_Mutation SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001018072.1 +1 validated p.I597T 1.000 141 0% 123 16.3% 4 0% probably_damaging(0.978) deleterious(0) deleterious(0.865) superfamily_Ankyrin repeat WSCD2 9671 genome.wustl.edu 37 12 108589662 108589662 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_014653.2 +1 validated p.R18H 1.000 266 0% 222 16.7% 1 0% probably_damaging(1) deleterious(0.02) deleterious(0.883) NULL SSH1 54434 genome.wustl.edu 37 12 109192929 109192929 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_018984.3 -1 validated p.R399H 1.000 35 0% 21 23.8% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_DSPc,PatternScan_TYR_PHOSPHATASE_1,HMMSmart_SM00195,superfamily_(Phosphotyrosine protein) phosphatases II UNG 7374 genome.wustl.edu 37 12 109540693 109540693 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_080911.1 +1 reviewed p.H195Y 1.000 142 0% 134 35.1% 5 40% benign(0.341) tolerated(0.1) neutral(0.394) HMMPfam_UDG,superfamily_DNA glycosylase HVCN1 84329 genome.wustl.edu 37 12 111089095 111089095 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001040107.1 -1 validated p.F190 0.198 104 0% 66 33.3% 7 0% - - - superfamily_Voltage-gated potassium channels NAA25 80018 genome.wustl.edu 37 12 112486205 112486205 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_024953.3 -1 reviewed p.E591Q 1.000 153 0% 124 31.5% 0 - probably_damaging(0.983) tolerated(0.59) neutral(0.433) HMMPfam_NatB_MDM20 MSI1 4440 genome.wustl.edu 37 12 120796839 120796839 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_002442.2 -1 reviewed p.L140 0.999 5 0.000 8 0.750 30 50% - - - HMMPfam_RRM_1,HMMSmart_SM00360,superfamily_RNA-binding domain RBD GOLGA3 2802 genome.wustl.edu 37 12 133372632 133372632 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005895.3 -1 reviewed p.G759S 0.993 37 0% 31 22.6% 5 40% benign(0.003) tolerated(0.73) neutral(0.002) NULL ZNF10 7556 genome.wustl.edu 37 12 133732954 133732954 + Missense_Mutation SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_015394.4 +1 reviewed p.E374D 1.000 295 0% 300 14.7% 2 0% possibly_damaging(0.542) deleterious(0.01) deleterious(0.589) superfamily_C2H2 and C2HC zinc fingers MTMR6 9107 genome.wustl.edu 37 13 25827978 25827980 + In_Frame_Del DEL GAA GAA - novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 GAA GAA Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_004685.3 -1 validated p.L423in_frame_del 1.000:1.000:1.000 - - - - - - - - - HMMSmart_SM00404,superfamily_(Phosphotyrosine protein) phosphatases II STARD13 90627 genome.wustl.edu 37 13 33704321 33704321 + Nonsense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_178006.3 -1 validated p.R165* 0.008 85 1.2% 84 44% 1 0% - - - NULL NBEA 26960 genome.wustl.edu 37 13 35731269 35731269 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_015678.4 +1 validated p.I902M 0.745 306 0% 355 36.6% 0 - possibly_damaging(0.558) deleterious(0.01) deleterious(0.596) superfamily_ARM repeat MAB21L1 4081 genome.wustl.edu 37 13 36049381 36049381 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005584.4 -1 reviewed p.R299W 1.000 137 0% 90 11.1% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Mab-21 FREM2 341640 genome.wustl.edu 37 13 39263884 39263884 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_207361.4 +1 reviewed p.Q801H 1.000 74 0% 54 13% 0 - possibly_damaging(0.858) tolerated(0.07) deleterious(0.650) NULL FREM2 341640 genome.wustl.edu 37 13 39451260 39451260 + Missense_Mutation SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_207361.4 +1 reviewed p.D2851Y 1.000 227 0% 194 22.7% 2 50% possibly_damaging(0.889) deleterious(0.03) deleterious(0.714) NULL FNDC3A 22862 genome.wustl.edu 37 13 49705294 49705294 + Nonsense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001079673.1 +1 validated p.R92* 1.000 414 0% 508 11.4% 11 9% - - - NULL RNASEH2B 79621 genome.wustl.edu 37 13 51509022 51509022 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_024570.2 +1 reviewed p.G108E 0.996 31 0% 41 17.1% 16 6.2% probably_damaging(1) deleterious(0.05) deleterious(0.845) HMMPfam_RNase_H2-Ydr279 CLN5 1203 genome.wustl.edu 37 13 77574798 77574798 + Silent SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006493.2 +1 reviewed p.T306 0.996 195 0% 163 15.3% 5 40% - - - NULL MYCBP2 23077 genome.wustl.edu 37 13 77779466 77779466 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_015057.4 -1 validated p.F1218 0.998 459 0% 410 36.6% 0 - - - - HMMPfam_PHR MBNL2 10150 genome.wustl.edu 37 13 97928589 97928589 + Missense_Mutation SNP T T A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_144778.2 +1 reviewed p.C34S 1.000 345 0% 344 12.2% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_zf-CCCH,HMMSmart_ZnF_C3H1 RNF113B 140432 genome.wustl.edu 37 13 98829117 98829117 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_178861.4 -1 validated p.P125L 1.000 53 0% 32 15.6% 0 - benign(0) deleterious(0) neutral(0.445) NULL GRTP1 79774 genome.wustl.edu 37 13 113980340 113980340 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_024719.2 -1 validated p.A210V 0.877 65 0% 50 22% 16 18.7% benign(0) tolerated(0.63) neutral(0.004) HMMPfam_TBC,HMMSmart_SM00164,superfamily_Ypt/Rab-GAP domain of gyp1p CHD8 57680 genome.wustl.edu 37 14 21883749 21883749 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_020920.3 -1 reviewed p.R372Q 1.000 181 0% 215 20% 0 - probably_damaging(0.998) deleterious(0.01) deleterious(0.880) HMMPfam_Chromo,HMMSmart_SM00298,superfamily_Chromo domain-like OR10G2 26534 genome.wustl.edu 37 14 22102377 22102377 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001005466.1 -1 validated p.V208I 0.276 81 64.2% 101 88.1% 1 0% benign(0) tolerated(0.19) neutral(0.050) HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like EFS 10278 genome.wustl.edu 37 14 23829934 23829934 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005864.2 -1 reviewed p.L43 0.985 40 0% 30 13.3% 4 0% - - - HMMPfam_SH3_1,HMMSmart_SM00326,superfamily_SH3-domain PSMC6 5706 genome.wustl.edu 37 14 53184802 53184802 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_002806.3 +1 reviewed p.T192R 1.000 184 0% 221 58.8% 39 56.4% probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_SM00382,HMMPfam_AAA,superfamily_P-loop containing nucleoside triphosphate hydrolases SOCS4 122809 genome.wustl.edu 37 14 55510841 55510841 + Missense_Mutation SNP T T A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_080867.2 +1 reviewed p.L361Q 1.000 148 0% 171 11.1% 0 - probably_damaging(1) deleterious(0.01) deleterious(0.905) HMMPfam_SH2,HMMSmart_SM00252,superfamily_SH2 domain SPTB 6710 genome.wustl.edu 37 14 65271728 65271728 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001024858.2 -1 reviewed p.D77N 1.000 108 0% 108 35.2% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_CH,HMMSmart_CH,superfamily_Calponin-homology ARG2 384 genome.wustl.edu 37 14 68108941 68108941 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001172.3 +1 reviewed p.P75A 1.000 73 0% 108 62% 12 50% benign(0) tolerated(0.7) neutral(0.002) HMMPfam_Arginase,superfamily_Arginase/deacetylase TMEM63C 57156 genome.wustl.edu 37 14 77709340 77709340 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_020431.2 +1 validated p.A428T 0.996 34 0% 42 21.4% 0 - probably_damaging(0.995) tolerated(0.26) deleterious(0.492) HMMPfam_DUF221 SEL1L 6400 genome.wustl.edu 37 14 81970624 81970624 + Nonsense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005065.4 -1 validated p.Q179* 1.000 104 0% 164 15.2% 6 0% - - - NULL TTC8 123016 genome.wustl.edu 37 14 89338740 89338740 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_144596.2 +1 reviewed p.A431T 1.000 151 0% 303 12.2% 82 10.9% possibly_damaging(0.561) deleterious(0.01) deleterious(0.597) HMMPfam_TPR_2,HMMSmart_TPR,superfamily_SSF48452 RAB42P1 646996 genome.wustl.edu 37 14 90358521 90358521 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 ENST00000389290 +1 known p.K121 1.000 14 0% 14 50% 2 0% - - - HMMSmart_SM00173,HMMSmart_SM00174,HMMSmart_SM00175,HMMPfam_Ras,superfamily_P-loop containing nucleoside triphosphate hydrolases FAM181A 90050 genome.wustl.edu 37 14 94394670 94394670 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_138344.3 +1 predicted p.F75 0.819 40 0% 32 15.6% 13 7.6% - - - NULL PAPOLA 10914 genome.wustl.edu 37 14 97029169 97029169 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_032632.3 +1 validated p.T694I 1.000 384 0% 695 10.9% 16 0% benign(0) tolerated(0.19) neutral(0.050) NULL TRPM1 4308 genome.wustl.edu 37 15 31339455 31339455 + Splice_Site SNP C C A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_002420.4 -1 reviewed e13-1 1.000 136 0% 122 41.8% 0 - - - - - PGBD4 161779 genome.wustl.edu 37 15 34395598 34395598 + Nonsense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_152595.4 +1 validated p.W289* 0.059 99 0% 67 41.8% 0 - - - - NULL MAP1A 4130 genome.wustl.edu 37 15 43814043 43814043 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_002373.5 +1 reviewed p.V124 1.000 85 0% 40 55% 0 - - - - NULL STRC 161497 genome.wustl.edu 37 15 43992657 43992657 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 ENST00000381686 -1 known p.S1626C 0.993 84 0% 76 39.5% 0 - - - - NULL DUOX1 53905 genome.wustl.edu 37 15 45442849 45442849 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_017434.3 +1 reviewed p.V946 0.988 40 0% 36 36.1% 6 50% - - - superfamily_EF-hand SMAD3 4088 genome.wustl.edu 37 15 67473722 67473722 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005902.3 +1 reviewed p.R268C 1.000 70 0% 35 14.3% 7 28.5% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_MH2,HMMSmart_SM00524,superfamily_SMAD/FHA domain GRAMD2 196996 genome.wustl.edu 37 15 72458982 72458982 + Silent SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001012642.2 -1 validated p.T178 0.409 62 0% 44 11.4% 0 - - - - NULL CSPG4 1464 genome.wustl.edu 37 15 75974769 75974769 + Silent SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001897.4 -1 reviewed p.L1605 0.900 11 0% 15 46.7% 5 0% - - - NULL FURIN 5045 genome.wustl.edu 37 15 91419549 91419549 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_002569.2 +1 reviewed p.R81H 0.508 34 0% 35 11.4% 19 42.1% benign(0.031) tolerated(0.2) neutral(0.051) superfamily_Prot_inh_propept C15orf32 145858 genome.wustl.edu 37 15 93015450 93015450 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_153040.2 +1 predicted p.G24 0.002 113 0% 78 37.2% 0 - - - - NULL LRRK1 79705 genome.wustl.edu 37 15 101598252 101598252 + Missense_Mutation SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_024652.3 +1 validated p.M1529V 1.000 92 0% 73 12.3% 1 0% benign(0.156) deleterious(0.02) neutral(0.397) NULL PTX4 390667 genome.wustl.edu 37 16 1537911 1537911 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001013658.1 -1 provisional p.V63M 0.235 91 0% 77 14.3% 0 - possibly_damaging(0.697) deleterious(0.01) deleterious(0.655) NULL PPL 5493 genome.wustl.edu 37 16 4935090 4935090 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_002705.4 -1 reviewed p.A1189V 1.000 130 0% 102 10.8% 15 13.3% probably_damaging(0.999) tolerated(0.7) deleterious(0.492) NULL CIITA 4261 genome.wustl.edu 37 16 11002910 11002910 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_000246.3 +1 reviewed p.A894 0.834 71 0% 46 17.4% 2 0% - - - superfamily_RNI-like ZC3H7A 29066 genome.wustl.edu 37 16 11876172 11876172 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_014153.2 -1 provisional p.Q13H 1.000 197 0% 217 38.2% 4 75% benign(0.011) tolerated(0.24) neutral(0.038) NULL BFAR 51283 genome.wustl.edu 37 16 14755894 14755894 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_016561.2 +1 validated p.S310F 0.001 146 0% 159 42.8% 8 25% benign(0) tolerated(0.7) neutral(0.002) NULL OTOA 146183 genome.wustl.edu 37 16 21721417 21721417 + Missense_Mutation SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_144672.3 +1 reviewed p.H438R 1.000 68 0% 49 14.3% 0 - benign(0.025) tolerated(0.35) neutral(0.022) NULL CACNG3 10368 genome.wustl.edu 37 16 24372969 24372969 + Nonsense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006539.2 +1 reviewed p.R245* 1.000 247 0% 233 15.9% 0 - - - - NULL SEZ6L2 26470 genome.wustl.edu 37 16 29909192 29909192 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_201575.2 -1 validated p.E65Q 0.999 80 0% 58 34.5% 17 52.9% unknown(0) deleterious(0) - NULL PRR14 78994 genome.wustl.edu 37 16 30667468 30667468 + Nonsense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_024031.2 +1 provisional p.R532* 1.000 47 0% 28 25% 40 7.5% - - - NULL NUP93 9688 genome.wustl.edu 37 16 56782202 56782202 + Nonsense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_014669.3 +1 validated p.Q15* 1.000 82 0% 70 32.9% 10 20% - - - NULL NLRC5 84166 genome.wustl.edu 37 16 57059749 57059749 + Silent SNP C C T rs184144107 by1000genomes TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_032206.3 +1 validated p.N298 0.009 145 0% 118 11% 9 0% - - - HMMPfam_NACHT,superfamily_P-loop containing nucleoside triphosphate hydrolases KATNB1 10300 genome.wustl.edu 37 16 57786832 57786832 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005886.2 +1 reviewed p.D283N 1.000 19 0% 14 50% 39 46.1% benign(0) tolerated(1) - superfamily_WD40_like CNOT1 23019 genome.wustl.edu 37 16 58620653 58620653 + Splice_Site SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_016284.3 -1 validated e6-1 1.000 31 0% 25 20% 0 - - - - - CTCF 10664 genome.wustl.edu 37 16 67645326 67645326 + Nonsense_Mutation SNP T T A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006565.2 +1 reviewed p.Y197* 1.000 180 0% 160 36.9% 5 0% - - - NULL CTCF 10664 genome.wustl.edu 37 16 67645327 67645327 + Nonsense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006565.2 +1 reviewed p.Q198* 1.000 182 0% 160 36.2% 5 0% - - - NULL NFAT5 10725 genome.wustl.edu 37 16 69724931 69724931 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_138713.2 +1 reviewed p.K621N 1.000 313 0% 303 34% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) NULL AARS 16 genome.wustl.edu 37 16 70310477 70310477 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001605.2 -1 reviewed p.E131K 0.999 115 0% 129 44.2% 11 63.6% possibly_damaging(0.445) deleterious(0.04) deleterious(0.494) HMMPfam_tRNA-synt_2c,superfamily_SSF55681 SF3B3 23450 genome.wustl.edu 37 16 70569300 70569300 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_012426.4 +1 reviewed p.R268C 1.000 520 0% 588 15.8% 15 6.6% possibly_damaging(0.726) deleterious(0.04) deleterious(0.613) NULL ZFHX3 463 genome.wustl.edu 37 16 72993947 72993947 + Missense_Mutation SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006885.3 -1 reviewed p.P33H 1.000 67 0% 42 11.9% 2 50% unknown(0) - - NULL ANKRD11 29123 genome.wustl.edu 37 16 89347301 89347301 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_013275.4 -1 validated p.F1883 0.995 67 0% 67 32.8% 9 33.3% - - - NULL ANKRD11 29123 genome.wustl.edu 37 16 89351374 89351374 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_013275.4 -1 validated p.H526Y 0.991 34 0% 32 34.4% 6 50% possibly_damaging(0.805) deleterious(0) deleterious(0.748) superfamily_Ankyrin repeat ZMYND15 84225 genome.wustl.edu 37 17 4647529 4647529 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001136046.1 +1 provisional p.V514M 0.982 148 0% 84 32.1% 3 0% probably_damaging(1) deleterious(0.05) deleterious(0.845) NULL ZNF594 84622 genome.wustl.edu 37 17 5085301 5085301 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_032530.1 -1 validated p.E751K 0.176 461 0% 418 38.3% 0 - benign(0.244) deleterious(0.01) neutral(0.430) superfamily_SSF57667 PFAS 5198 genome.wustl.edu 37 17 8171997 8171997 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_012393.2 +1 reviewed p.D1177H 0.999 26 0% 18 33.3% 36 47.2% benign(0.104) tolerated(0.12) neutral(0.269) superfamily_Class I glutamine amidotransferase-like PFAS 5198 genome.wustl.edu 37 17 8172026 8172026 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_012393.2 +1 reviewed p.Q1186 0.042 19 0% 11 36.4% 34 11.7% - - - superfamily_Class I glutamine amidotransferase-like MYH8 4626 genome.wustl.edu 37 17 10301856 10301856 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_002472.2 -1 reviewed p.Q1361 1.000 240 0% 237 35.9% 0 - - - - HMMPfam_Myosin_tail_1 ALDH3A1 218 genome.wustl.edu 37 17 19646691 19646691 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_000691.4 -1 reviewed p.A83V 0.000 102 0% 65 20% 64 15.6% benign(0.408) tolerated(0.14) neutral(0.382) HMMPfam_Aldedh,superfamily_ALDH-like NF1 4763 genome.wustl.edu 37 17 29654613 29654613 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001042492.2 +1 reviewed p.E1789K 1.000 166 0% 164 45.1% 1 100% benign(0.107) deleterious(0.01) neutral(0.414) NULL CCR7 1236 genome.wustl.edu 37 17 38715169 38715170 + Frame_Shift_Ins INS - - A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 - - Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001838.2 -1 reviewed p.V13fs 0.991:0.989 - - - - - - - - - NULL KRT39 390792 genome.wustl.edu 37 17 39114913 39114913 + Missense_Mutation SNP C C A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_213656.3 -1 reviewed p.K472N 1.000 383 0% 411 14.8% 0 - probably_damaging(0.998) deleterious(0) deleterious(0.919) NULL KRT33A 3883 genome.wustl.edu 37 17 39502770 39502770 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_004138.2 -1 reviewed p.L343V 1.000 169 0% 115 34.8% 1 100% probably_damaging(0.998) deleterious(0) deleterious(0.919) HMMPfam_Filament KRT17 3872 genome.wustl.edu 37 17 39780553 39780553 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_000422.2 -1 reviewed p.G70D 0.880 52 0% 31 12.9% 20 0% probably_damaging(0.996) tolerated(0.1) deleterious(0.748) NULL FZD2 2535 genome.wustl.edu 37 17 42635704 42635704 + Silent SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001466.2 +1 reviewed p.L216 1.000 20 0% 20 45% 18 55.5% - - - NULL PLEKHM1 9842 genome.wustl.edu 37 17 43522967 43522967 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_014798.2 -1 reviewed p.Q902 1.000 108 0% 66 33.3% 3 33.3% - - - NULL PLEKHM1 9842 genome.wustl.edu 37 17 43552641 43552641 + Missense_Mutation SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_014798.2 -1 reviewed p.S250P 1.000 86 0% 79 15.2% 2 0% probably_damaging(0.997) deleterious(0) deleterious(0.911) NULL ITGB3 3690 genome.wustl.edu 37 17 45363782 45363782 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_000212.2 +1 reviewed p.V257 1.000 160 0% 104 42.3% 0 - - - - HMMPfam_Integrin_beta,HMMSmart_SM00187,superfamily_vWA-like KPNB1 3837 genome.wustl.edu 37 17 45753824 45753824 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 ENST00000290158 +1 known p.L654 1.000 82 0% 100 42% 56 53.5% - - - superfamily_ARM repeat CDK5RAP3 80279 genome.wustl.edu 37 17 46053334 46053334 + Silent SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_176096.1 +1 reviewed p.E251 1.000 47 4.3% 40 10% 168 0% - - - HMMPfam_DUF773 NFE2L1 4779 genome.wustl.edu 37 17 46136797 46136797 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_003204.2 +1 validated p.R705C 0.976 91 0% 63 12.7% 125 9.6% benign(0.217) deleterious(0) neutral(0.466) HMMSmart_SM00338,HMMPfam_bZIP_2 WFIKKN2 124857 genome.wustl.edu 37 17 48917271 48917271 + Missense_Mutation SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_175575.5 +1 reviewed p.A208S 0.003 65 0% 39 10.3% 0 - benign(0) tolerated(0.48) neutral(0.011) superfamily_SSF48726 ENSG00000188755 0 genome.wustl.edu 37 17 60351161 60351161 + Nonsense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 ENST00000339120 -1 known p.Q52* 0.001 114 0% 64 12.5% 0 - - - - NULL TANC2 26115 genome.wustl.edu 37 17 61498668 61498668 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_025185.3 +1 validated p.S1775 1.000 230 0% 226 22.1% 0 - - - - NULL RGS9 8787 genome.wustl.edu 37 17 63206717 63206717 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_003835.3 +1 reviewed p.I467 1.000 107 0% 94 37.2% 1 0% - - - NULL UNK 85451 genome.wustl.edu 37 17 73818574 73818574 + Missense_Mutation SNP C C A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001080419.1 +1 provisional p.N694K 1.000 50 0% 31 12.9% 7 14.2% possibly_damaging(0.496) tolerated(0.17) neutral(0.225) NULL FBF1 85302 genome.wustl.edu 37 17 73915839 73915839 + Frame_Shift_Del DEL C C - novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001080542.1 -1 provisional p.R668fs 0.310 - - - - - - - - - NULL QRICH2 84074 genome.wustl.edu 37 17 74288462 74288462 + Silent SNP T T G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_032134.1 -1 provisional p.A616 0.000 75 0% 74 20.3% 9 0% - - - NULL QRICH2 84074 genome.wustl.edu 37 17 74288463 74288463 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_032134.1 -1 provisional p.A616V 0.000 75 0% 75 21.3% 9 0% benign(0) tolerated(0.84) neutral(0.001) NULL DNAH17 8632 genome.wustl.edu 37 17 76499007 76499007 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 ENST00000389840 -1 known p.E1677 0.999 14 0% 19 57.9% 0 - - - - NULL FOXK2 3607 genome.wustl.edu 37 17 80529717 80529717 + Missense_Mutation SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_004514.3 +1 reviewed p.Y294H 0.996 90 0% 81 18.5% 7 14.2% probably_damaging(0.999) deleterious(0) deleterious(0.935) "HMMPfam_Fork_head,HMMSmart_SM00339,superfamily_""Winged helix"" DNA-binding domain" MC2R 4158 genome.wustl.edu 37 18 13885368 13885368 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_000529.2 -1 reviewed p.F50L 0.057 78 0% 66 40.9% 0 - benign(0) tolerated(0.5) neutral(0.010) HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like MIB1 57534 genome.wustl.edu 37 18 19429276 19429276 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_020774.2 +1 validated p.A838V 1.000 214 0% 208 14.4% 2 50% benign(0.001) tolerated(0.29) neutral(0.029) HMMSmart_RING,superfamily_SSF57850 FAM59A 64762 genome.wustl.edu 37 18 29850243 29850243 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_022751.1 -1 provisional p.A557V 0.137 51 0% 68 13.2% 4 0% benign(0) tolerated(0.33) neutral(0.024) NULL FAM59A 64762 genome.wustl.edu 37 18 29867530 29867530 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_022751.1 -1 provisional p.R344C 1.000 140 0% 149 18.1% 4 0% probably_damaging(1) deleterious(0) deleterious(0.945) NULL SMAD2 4087 genome.wustl.edu 37 18 45372165 45372165 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001003652.2 -1 reviewed p.G335E 1.000 143 0% 160 33.8% 19 47.3% possibly_damaging(0.74) deleterious(0.02) deleterious(0.654) HMMPfam_MH2,HMMSmart_SM00524,superfamily_SMAD/FHA domain DCC 1630 genome.wustl.edu 37 18 51057016 51057016 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005215.3 +1 reviewed p.A1446V 1.000 151 0% 177 14.7% 0 - possibly_damaging(0.482) tolerated(0.08) neutral(0.460) NULL NARS 4677 genome.wustl.edu 37 18 55276596 55276596 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_004539.3 -1 validated p.G191D 1.000 166 0% 155 14.8% 177 15.2% possibly_damaging(0.924) tolerated(0.12) deleterious(0.633) HMMPfam_tRNA_anti,superfamily_Nucleic_acid_OB ZNF532 55205 genome.wustl.edu 37 18 56587677 56587677 + Nonsense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_018181.4 +1 validated p.Q720* 0.998 259 0.4% 187 38% 5 40% - - - NULL NETO1 81832 genome.wustl.edu 37 18 70417697 70417697 + Missense_Mutation SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_138966.2 -1 reviewed p.Q381K 1.000 253 0% 260 42.7% 0 - benign(0) tolerated(1) - NULL TJP3 27134 genome.wustl.edu 37 19 3728407 3728407 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_014428.1 +1 provisional p.A12T 0.000 23 0% 19 21.1% 0 - benign(0.003) deleterious(0) neutral(0.445) NULL PLIN5 440503 genome.wustl.edu 37 19 4529803 4529803 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001013706.2 -1 validated p.S111L 0.995 63 0% 30 16.7% 2 100% probably_damaging(0.99) deleterious(0.02) deleterious(0.825) HMMPfam_Perilipin CATSPERD 257062 genome.wustl.edu 37 19 5754211 5754211 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_152784.3 +1 validated p.L411F 0.008 178 0% 217 46.5% 0 - possibly_damaging(0.815) deleterious(0) deleterious(0.752) NULL CRB3 92359 genome.wustl.edu 37 19 6466977 6466977 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_174881.2 +1 reviewed p.E106K 0.998 74 0% 67 41.8% 52 40.3% possibly_damaging(0.609) deleterious(0) deleterious(0.655) NULL SH2D3A 10045 genome.wustl.edu 37 19 6759643 6759643 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005490.2 -1 validated p.A153V 0.644 178 0% 125 12.8% 11 0% benign(0.009) tolerated(0.06) neutral(0.323) NULL OR2Z1 284383 genome.wustl.edu 37 19 8841568 8841568 + Missense_Mutation SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001004699.1 +1 provisional p.Y60H 1.000 119 0% 128 14.1% 0 - possibly_damaging(0.906) deleterious(0) deleterious(0.804) HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like MUC16 94025 genome.wustl.edu 37 19 9057186 9057186 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_024690.2 -1 validated p.S10087F 0.000 123 0% 153 37.3% 0 - unknown(0) - - NULL ELOF1 84337 genome.wustl.edu 37 19 11664859 11664859 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_032377.3 -1 validated p.V52M 0.978 373 0% 227 13.2% 57 14% probably_damaging(0.982) deleterious(0.03) deleterious(0.791) HMMPfam_Elf1 CACNA1A 773 genome.wustl.edu 37 19 13370418 13370418 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001127222.1 -1 reviewed p.L1450 1.000 46 0% 32 15.6% 0 - - - - HMMPfam_Ion_trans,superfamily_Voltage-gated potassium channels SYDE1 85360 genome.wustl.edu 37 19 15224597 15224597 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_033025.4 +1 provisional p.H677 1.000 98 0% 42 14.3% 9 0% - - - NULL NWD1 284434 genome.wustl.edu 37 19 16918919 16918919 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001007525.2 +1 validated p.R1285H 0.180 68 0% 68 14.7% 7 14.2% possibly_damaging(0.937) tolerated(0.06) deleterious(0.706) superfamily_WD40 repeat-like LRRC25 126364 genome.wustl.edu 37 19 18507465 18507465 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_145256.2 -1 validated p.A103 0.000 15 0% 10 60% 2 0% - - - superfamily_SSF52075 ZNF429 353088 genome.wustl.edu 37 19 21719549 21719549 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001001415.2 +1 provisional p.E232K 0.016 143 0% 137 34.3% 1 100% possibly_damaging(0.436) tolerated(0.38) neutral(0.159) HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_ZnF_C2H2,superfamily_SSF57667 KIAA0355 9710 genome.wustl.edu 37 19 34818453 34818453 + Missense_Mutation SNP A A T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_014686.3 +1 validated p.D278V 1.000 126 0% 96 16.7% 1 0% probably_damaging(1) deleterious(0) deleterious(0.945) NULL KIAA0355 9710 genome.wustl.edu 37 19 34819055 34819055 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_014686.3 +1 validated p.T368M 1.000 93 0% 68 10.3% 2 0% possibly_damaging(0.642) tolerated(0.6) neutral(0.230) NULL UBA2 10054 genome.wustl.edu 37 19 34949693 34949693 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005499.2 +1 validated p.P422R 1.000 150 0% 121 31.4% 12 16.6% possibly_damaging(0.674) deleterious(0.03) deleterious(0.604) superfamily_MoeB FXYD7 53822 genome.wustl.edu 37 19 35642229 35642229 + Missense_Mutation SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_022006.1 +1 reviewed p.I45T 0.986 263 0% 233 15.9% 0 - benign(0.007) deleterious(0.01) neutral(0.406) HMMPfam_ATP1G1_PLM_MAT8 FFAR2 2867 genome.wustl.edu 37 19 35941333 35941333 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005306.2 +1 reviewed p.N239 0.935 166 0% 155 44.5% 1 100% - - - HMMPfam_7tm_1,superfamily_SSF81321 APLP1 333 genome.wustl.edu 37 19 36370034 36370034 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001024807.1 +1 reviewed p.A591V 0.984 26 0% 21 38.1% 4 25% benign(0.002) tolerated(1) - NULL YIF1B 90522 genome.wustl.edu 37 19 38798306 38798306 + Missense_Mutation SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001039672.2 -1 validated p.Y209C 1.000 20 0% 12 33.3% 105 44.7% probably_damaging(0.997) deleterious(0) deleterious(0.911) HMMPfam_YIF1 RYR1 6261 genome.wustl.edu 37 19 38964084 38964084 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_000540.2 +1 reviewed p.S1278C 1.000 73 0% 42 19% 0 - probably_damaging(0.981) - - NULL ZNF546 339327 genome.wustl.edu 37 19 40519604 40519604 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_178544.3 +1 validated p.L143F 0.111 50 0% 52 13.5% 0 - benign(0) tolerated(0.66) neutral(0.003) NULL ZNF180 7733 genome.wustl.edu 37 19 44988631 44988631 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_013256.3 -1 validated p.Q50E 0.958 93 0% 73 28.8% 0 - benign(0.273) tolerated(0.09) neutral(0.326) NULL CEACAM19 56971 genome.wustl.edu 37 19 45179693 45179693 + Missense_Mutation SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_020219.3 +1 validated p.R192I 0.996 181 0% 168 15.5% 0 - probably_damaging(0.965) deleterious(0.02) deleterious(0.790) NULL CBLC 23624 genome.wustl.edu 37 19 45303699 45303699 + Nonstop_Mutation SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_012116.3 +1 validated p.*475L 0.146 43 0% 23 52.2% 10 40% - - - NULL ARHGAP35 2909 genome.wustl.edu 37 19 47424529 47424529 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_004491.4 +1 reviewed p.S866F 1.000 182 0% 167 43.1% 3 0% probably_damaging(1) deleterious(0) deleterious(0.945) NULL DHX34 9704 genome.wustl.edu 37 19 47856590 47856590 + Missense_Mutation SNP C C A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_014681.5 +1 reviewed p.D101E 1.000 106 0% 123 13% 6 33.3% possibly_damaging(0.64) tolerated(0.15) neutral(0.465) NULL PTOV1 53635 genome.wustl.edu 37 19 50363335 50363335 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 ENST00000221557 +1 known p.S323L 1.000 51 0% 30 40% 521 38% benign(0.202) deleterious(0) neutral(0.464) NULL ZNF701 55762 genome.wustl.edu 37 19 53086496 53086496 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_018260.2 +1 validated p.S395L 0.022 286 0.3% 224 39.3% 3 33.3% benign(0.018) deleterious(0.02) neutral(0.384) HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_Multiheme cytochromes ZNF701 55762 genome.wustl.edu 37 19 53086580 53086580 + Nonsense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_018260.2 +1 validated p.S423* 0.003 216 0% 176 34.1% 2 0% - - - HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_Multiheme cytochromes ZNF347 84671 genome.wustl.edu 37 19 53644595 53644595 + Missense_Mutation SNP C C A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_032584.2 -1 validated p.A496S 0.000 400 0% 362 19.6% 1 0% benign(0.002) tolerated(0.4) neutral(0.016) HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers DPRX 503834 genome.wustl.edu 37 19 54139865 54139865 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001012728.1 +1 validated p.H67Y 0.165 240 0.4% 221 35.7% 0 - probably_damaging(0.962) deleterious(0) deleterious(0.850) HMMPfam_Homeobox,HMMSmart_HOX,superfamily_Homeodomain_like,PatternScan_HOMEOBOX_1 LILRB3 11025 genome.wustl.edu 37 19 54725731 54725731 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001081450.1 -1 reviewed p.H209 0.001 32 0% 27 37% 0 - - - - superfamily_Immunoglobulin NLRP13 126204 genome.wustl.edu 37 19 56413470 56413470 + Missense_Mutation SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_176810.2 -1 validated p.L907P 0.389 271 0% 263 14.1% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_SSF52047 ZNF274 10782 genome.wustl.edu 37 19 58718566 58718566 + Frame_Shift_Del DEL A A - novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 ENST00000424679 +1 known p.V246fs 0.990 - - - - - - - - - HMMPfam_SCAN,HMMSmart_SM00431 IDH3B 3420 genome.wustl.edu 37 20 2640681 2640681 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006899.2 -1 reviewed p.E304Q 1.000 176 0% 170 38.2% 82 31.7% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Iso_dh,superfamily_Isocitrate/Isopropylmalate dehydrogenase-like C20orf141 128653 genome.wustl.edu 37 20 2795931 2795931 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_080739.2 +1 validated p.R34H 0.000 95 0% 68 44.1% 0 - benign(0.365) tolerated(0.2) neutral(0.165) NULL VPS16 64601 genome.wustl.edu 37 20 2841918 2841918 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_022575.2 +1 reviewed p.Q267H 1.000 82 0% 51 33.3% 39 56.4% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Vps16_N FOXA2 3170 genome.wustl.edu 37 20 22564874 22564874 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_021784.4 -1 reviewed p.G15R 1.000 19 0% 21 23.8% 18 66.6% probably_damaging(0.999) tolerated(0.07) deleterious(0.809) NULL TOP1 7150 genome.wustl.edu 37 20 39746810 39746810 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_003286.2 +1 reviewed p.P608 0.982 84 0% 74 47.3% 23 52.1% - - - superfamily_DNA breaking-rejoining enzymes,HMMSmart_SM00435,HMMPfam_Topoisom_I ZFP64 55734 genome.wustl.edu 37 20 50705140 50705140 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_199427.2 -1 validated p.S340N 1.000 85 0% 67 23.9% 4 25% possibly_damaging(0.463) tolerated(0.17) neutral(0.211) HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers TSHZ2 128553 genome.wustl.edu 37 20 51870060 51870060 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_173485.4 +1 validated p.L21 0.990 105 0% 103 41.7% 0 - - - - NULL SS18L1 26039 genome.wustl.edu 37 20 60736530 60736530 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_198935.1 +1 validated p.L90 1.000 10 0.000 6 0.667 9 22.2% - - - NULL PCMTD2 55251 genome.wustl.edu 37 20 62904609 62904609 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_018257.2 +1 validated p.R248C 1.000 119 0% 97 13.4% 6 16.6% probably_damaging(0.999) deleterious(0) deleterious(0.935) NULL ATP5J 522 genome.wustl.edu 37 21 27102015 27102015 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001003701.1 -1 reviewed p.A39T 1.000 74 0% 58 10.3% 125 20.8% probably_damaging(0.996) tolerated(0.18) deleterious(0.518) HMMPfam_ATP-synt_F6 CLDN8 9073 genome.wustl.edu 37 21 31587725 31587725 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_199328.2 -1 reviewed p.L173 0.002 110 0% 137 10.2% 0 - - - - HMMPfam_PMP22_Claudin TIAM1 7074 genome.wustl.edu 37 21 32513461 32513461 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_003253.2 -1 validated p.A1250V 0.014 132 0% 91 12.1% 1 0% benign(0.184) tolerated(0.2) neutral(0.066) superfamily_SSF50729 SYNJ1 8867 genome.wustl.edu 37 21 34038274 34038274 + Silent SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_003895.3 -1 validated p.A708 0.354 139 0% 124 15.3% 0 - - - - HMMSmart_SM00128,HMMPfam_Exo_endo_phos,superfamily_DNase I-like SON 6651 genome.wustl.edu 37 21 34923934 34923934 + Silent SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_138927.1 +1 reviewed p.S799 0.983 300 1.3% 235 17.4% 12 0% - - - NULL BRWD1 54014 genome.wustl.edu 37 21 40568895 40568895 + Missense_Mutation SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_018963.3 -1 reviewed p.N2034D 0.000 278 0% 286 17.1% 3 33.3% benign(0.014) tolerated(0.48) neutral(0.011) superfamily_WD40 repeat-like TMPRSS2 7113 genome.wustl.edu 37 21 42851136 42851136 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005656.3 -1 reviewed p.A216T 0.007 39 0% 32 18.8% 6 0% possibly_damaging(0.743) tolerated(0.47) neutral(0.284) HMMSmart_SM00202,superfamily_SRCR-like NDUFV3 4731 genome.wustl.edu 37 21 44323719 44323719 + Silent SNP C C A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_021075.3 +1 reviewed p.P199 0.000 163 0% 166 18.7% 11 9% - - - NULL TRPM2 7226 genome.wustl.edu 37 21 45825042 45825042 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_003307.3 +1 reviewed p.D852 0.564 4 0.000 7 0.857 3 33.3% - - - HMMPfam_Ion_trans SERPIND1 3053 genome.wustl.edu 37 22 21141329 21141329 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_000185.3 +1 reviewed p.R492T 0.951 203 0% 142 40.1% 2 0% probably_damaging(0.998) deleterious(0) deleterious(0.919) HMMPfam_Serpin,HMMSmart_SM00093,superfamily_Serpins SNAP29 9342 genome.wustl.edu 37 22 21242113 21242113 + Nonsense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_004782.3 +1 reviewed p.R256* 0.995 138 0% 109 16.5% 4 0% - - - HMMPfam_SNARE,HMMSmart_t_SNARE ZNF280B 140883 genome.wustl.edu 37 22 22842983 22842983 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_080764.2 -1 reviewed p.K247 0.678 306 0% 317 36.6% 0 - - - - NULL CABIN1 23523 genome.wustl.edu 37 22 24459602 24459602 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_012295.2 +1 reviewed p.A626V 1.000 106 0% 79 17.7% 10 10% probably_damaging(1) tolerated(0.25) deleterious(0.537) HMMSmart_TPR,superfamily_SSF48452 MYO18B 84700 genome.wustl.edu 37 22 26222380 26222380 + Silent SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_032608.5 +1 reviewed p.L900 0.996 134 0% 173 48% 0 - - - - HMMSmart_SM00242,superfamily_P-loop containing nucleoside triphosphate hydrolases THOC5 8563 genome.wustl.edu 37 22 29907222 29907222 + Silent SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001002877.1 -1 validated p.L621 1.000 167 0% 169 17.2% 64 9.3% - - - NULL EP300 2033 genome.wustl.edu 37 22 41574607 41574607 + Nonsense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001429.3 +1 reviewed p.Q2298* 1.000 160 0% 151 15.9% 124 18.5% - - - NULL RANGAP1 5905 genome.wustl.edu 37 22 41657482 41657482 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_002883.2 -1 reviewed p.D195N 0.997 46 0% 57 35.1% 35 34.2% probably_damaging(0.979) deleterious(0.05) deleterious(0.767) superfamily_SSF52047 ASMTL 8623 genome.wustl.edu 37 X 1546993 1546993 + Silent SNP C C T rs147986045 by1000genomes TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_004192.3 -1 reviewed p.G177 0.856 11 0% 15 46.7% 16 50% - - - HMMPfam_Maf,superfamily_Maf/Ham1 KAL1 3730 genome.wustl.edu 37 X 8553319 8553319 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_000216.2 -1 reviewed p.R282H 1.000 138 0% 151 11.9% 1 0% possibly_damaging(0.676) tolerated(0.31) neutral(0.268) superfamily_FN_III-like TBL1X 6907 genome.wustl.edu 37 X 9659749 9659749 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001139466.1 +1 reviewed p.S249 0.615 49 0% 29 34.5% 0 - - - - HMMSmart_SM00320,superfamily_WD40 repeat-like,PatternScan_WD_REPEATS_1,HMMPfam_WD40 SYAP1 94056 genome.wustl.edu 37 X 16775342 16775342 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_032796.3 +1 validated p.D281H 0.952 128 0% 134 45.5% 15 100% probably_damaging(1) tolerated(0.1) deleterious(0.786) NULL CXorf23 256643 genome.wustl.edu 37 X 19971141 19971141 + Nonsense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_198279.3 -1 validated p.Q532* 1.000 214 0% 210 37.1% 2 0% - - - NULL YY2 404281 genome.wustl.edu 37 X 21874611 21874611 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_206923.3 +1 reviewed p.S3 0.029 197 0% 140 14.3% 0 - - - - NULL TAB3 257397 genome.wustl.edu 37 X 30872918 30872918 + Silent SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_152787.3 -1 reviewed p.P288 0.997 93 0% 81 14.8% 0 - - - - NULL ZNF182 7569 genome.wustl.edu 37 X 47835841 47835841 + Missense_Mutation SNP T T G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006962.1 -1 reviewed p.K549Q 1.000 207 0% 157 38.2% 0 - probably_damaging(0.985) deleterious(0) deleterious(0.877) HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_ZnF_C2H2,superfamily_SSF57667 PIM2 11040 genome.wustl.edu 37 X 48772300 48772300 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_006875.3 -1 reviewed p.D198N 1.000 82 0% 44 31.8% 43 0% possibly_damaging(0.545) tolerated(0.1) deleterious(0.471) HMMSmart_S_TKc,superfamily_Kinase_like,HMMPfam_Pkinase OTUD5 55593 genome.wustl.edu 37 X 48792074 48792074 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_017602.3 -1 reviewed p.R274W 0.997 297 0% 286 14% 49 0% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_OTU,superfamily_Cysteine proteinases FOXP3 50943 genome.wustl.edu 37 X 49110513 49110513 + Missense_Mutation SNP C C A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_014009.3 -1 reviewed p.G278C 0.820 25 0% 24 54.2% 11 0% possibly_damaging(0.949) tolerated(0.05) deleterious(0.738) NULL GPR173 54328 genome.wustl.edu 37 X 53106091 53106092 + Frame_Shift_Ins INS - - A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 - - Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_018969.5 +1 reviewed p.I97fs 1.000:1.000 - - - - - - - - - HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like GNL3L 54552 genome.wustl.edu 37 X 54577482 54577482 + Missense_Mutation SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_019067.5 +1 reviewed p.K288E 1.000 152 0% 122 23% 3 0% possibly_damaging(0.949) deleterious(0) deleterious(0.838) HMMPfam_MMR_HSR1,superfamily_SSF52540 AR 367 genome.wustl.edu 37 X 66942693 66942693 + Missense_Mutation SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_000044.2 +1 reviewed p.Q825R 1.000 122 0% 137 12.4% 1 0% possibly_damaging(0.879) deleterious(0) deleterious(0.787) HMMPfam_Hormone_recep,HMMSmart_SM00430,superfamily_Nuclear receptor ligand-binding domain EDA 1896 genome.wustl.edu 37 X 69253328 69253328 + Missense_Mutation SNP G G A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001399.4 +1 reviewed p.E292K 1.000 171 0% 164 42.1% 1 100% probably_damaging(0.998) deleterious(0) deleterious(0.919) HMMPfam_TNF,superfamily_TNF-like AWAT2 158835 genome.wustl.edu 37 X 69263053 69263053 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001002254.1 -1 reviewed p.L171 1.000 43 0% 30 26.7% 0 - - - - HMMPfam_DAGAT BMP2KL 347359 genome.wustl.edu 37 X 73405798 73405798 + Missense_Mutation SNP A A G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 ENST00000373488 +1 known p.K15R 1.000 42 0% 38 18.4% 0 - benign(0.006) tolerated(0.06) neutral(0.323) NULL NXF2 56001 genome.wustl.edu 37 X 101581387 101581387 + Missense_Mutation SNP G G C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_017809.3 +1 reviewed p.E614Q 0.000 292 0% 251 33.9% 0 - benign(0.003) tolerated(0.4) neutral(0.016) HMMPfam_TAP_C,HMMSmart_TAP_C,superfamily_UBA_like KIAA1210 57481 genome.wustl.edu 37 X 118223410 118223410 + Missense_Mutation SNP C C G novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_020721.1 -1 validated p.E595Q 0.002 272 0% 214 37.4% 0 - possibly_damaging(0.812) - - NULL STAG2 10735 genome.wustl.edu 37 X 123227872 123227872 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001042749.1 +1 validated p.R1195C 1.000 164 0% 188 13.3% 15 0% probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_ARM-type_fold MAGEC1 9947 genome.wustl.edu 37 X 140993418 140993418 + Silent SNP C C A novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005462.4 +1 reviewed p.S76 0.975 1096 0% 837 25.4% 0 - - - - NULL MAGEC1 9947 genome.wustl.edu 37 X 140993946 140993946 + Silent SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005462.4 +1 reviewed p.F252 0.208 2418 0% 1824 16.2% 0 - - - - NULL SLITRK2 84631 genome.wustl.edu 37 X 144905469 144905469 + Missense_Mutation SNP T T C novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_001144003.2 +1 reviewed p.L509P 0.998 146 0% 106 14.2% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_SM00369,superfamily_L domain-like CXorf40A 91966 genome.wustl.edu 37 X 148628451 148628451 + Missense_Mutation SNP G G T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_178124.4 +1 validated p.K140N 0.010 115 0% 106 16% 14 14.2% possibly_damaging(0.895) deleterious(0.01) deleterious(0.758) NULL MAMLD1 10046 genome.wustl.edu 37 X 149638875 149638875 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_005491.3 +1 reviewed p.P344S 1.000 111 0% 77 16.9% 2 0% probably_damaging(0.995) tolerated(0.19) deleterious(0.507) NULL GABRQ 55879 genome.wustl.edu 37 X 151806718 151806718 + Missense_Mutation SNP C C T novel TCGA-BK-A0C9-01A-11W-A027-09 TCGA-BK-A0C9-10A-01W-A027-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx 0eed8eb4-5cc7-452a-bf14-a6064ddad3d2 a9a993b0-2321-4131-ac05-bdfb27c49e11 NM_018558.2 +1 reviewed p.A21V 0.845 87 0% 52 11.5% 0 - possibly_damaging(0.842) deleterious(0) deleterious(0.766) NULL