Hugo_Symbol Entrez_Gene_Id Center NCBI_Build Chromosome Start_position End_position Strand Variant_Classification Variant_Type Reference_Allele Tumor_Seq_Allele1 Tumor_Seq_Allele2 dbSNP_RS dbSNP_Val_Status Tumor_Sample_Barcode Matched_Norm_Sample_Barcode Match_Norm_Seq_Allele1 Match_Norm_Seq_Allele2 Tumor_Validation_Allele1 Tumor_Validation_Allele2 Match_Norm_Validation_Allele1 Match_Norm_Validation_Allele2 Verification_Status Validation_Status Mutation_Status Sequencing_Phase Sequence_Source Validation_Method Score BAM_file Sequencer Tumor_Sample_UUID Matched_Norm_Sample_UUID transcript_name strand transcript_status amino_acid_change ucsc_cons normal_depth normal_vaf tumor_depth tumor_vaf rna_depth rna_vaf polyphen sift condel domain RPL22 6146 ucsc.edu 37 1 6257785 6257785 + Frame_Shift_Del DEL T - - novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_000983.3 -1 reviewed p.K15fs 1 - - - - - - - - - HMMPfam_Ribosomal_L22e UBE4B 10277 genome.wustl.edu 37 1 10166449 10166449 + Missense_Mutation SNP T T C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001105562.1 +1 reviewed p.V335A 0.999 110 0% 138 29% 0 - unknown(0) deleterious(0.05) - NULL C1orf127 148345 genome.wustl.edu 37 1 11008706 11008706 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e ENST00000377008 -1 known p.R329W 0.000 65 0% 76 26.3% 0 - probably_damaging(0.994) deleterious(0) deleterious(0.897) NULL SPEN 23013 genome.wustl.edu 37 1 16260726 16260726 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_015001.2 +1 reviewed p.P2664L 0.963 68 0% 103 28.2% 8 37.5% unknown(0) deleterious(0) - NULL CROCC 9696 genome.wustl.edu 37 1 17275003 17275003 + Nonsense_Mutation SNP G G T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_014675.3 +1 validated p.E898* 1.000 20 0% 19 31.6% 3 0% - - - NULL C1QC 714 genome.wustl.edu 37 1 22973824 22973824 + Missense_Mutation SNP C C A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001114101.1 +1 reviewed p.P96T 0.752 112 0% 96 31.2% 51 0% benign(0.15) tolerated(0.09) neutral(0.309) HMMPfam_Collagen UBXN11 91544 genome.wustl.edu 37 1 26609197 26609197 + Missense_Mutation SNP A A G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_183008.2 -1 reviewed p.L412P 0.017 170 0.6% 210 31.4% 78 46.1% probably_damaging(0.999) deleterious(0) deleterious(0.935) superfamily_Ubiquitin-like ARID1A 8289 genome.wustl.edu 37 1 27057919 27057919 + Nonsense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_006015.4 +1 reviewed p.Q543* 1.000 510 0.2% 593 35.6% 5 20% - - - NULL KIAA0754 643314 genome.wustl.edu 37 1 39879411 39879411 + Silent SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_015038.1 +1 predicted p.S1158 0.002 34 0% 63 28.6% 0 - - - - NULL SCMH1 22955 genome.wustl.edu 37 1 41494275 41494275 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001031694.2 -1 validated p.A613V 1.000 68 0% 76 28.9% 51 35.2% benign(0.153) tolerated(0.22) neutral(0.056) HMMPfam_SAM_1,HMMSmart_SM00454,superfamily_SAM/Pointed domain DMBX1 127343 genome.wustl.edu 37 1 46978132 46978132 + Missense_Mutation SNP C C T rs181379491 by1000genomes TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_147192.2 +1 reviewed p.A372V 0.995 11 0% 29 31% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_OAR STIL 6491 genome.wustl.edu 37 1 47755160 47755160 + Missense_Mutation SNP G G T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001048166.1 -1 reviewed p.P324T 0.000 108 0% 114 17.5% 1 0% benign(0.027) tolerated(0.05) neutral(0.347) NULL SH3GLB1 51100 genome.wustl.edu 37 1 87181535 87181535 + Missense_Mutation SNP G G C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_016009.3 +1 validated p.L67F 1.000 77 0% 84 33.3% 34 35.2% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_BAR,HMMSmart_SM00721 MTMR11 10903 genome.wustl.edu 37 1 149901206 149901206 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_181873.3 -1 validated p.G577S 0.976 232 0% 446 20.2% 13 23% benign(0.023) tolerated(0.15) neutral(0.242) NULL LCE1B 353132 genome.wustl.edu 37 1 152785259 152785259 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_178349.1 +1 validated p.H113Y 0.976 77 0% 187 17.1% 0 - unknown(0) - - NULL GATAD2B 57459 genome.wustl.edu 37 1 153788766 153788767 + Frame_Shift_Del DEL CT CT - novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 CT CT Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_020699.2 -1 validated p.S400fs 1.000:1.000 - - - - - - - - - NULL ARHGEF11 9826 genome.wustl.edu 37 1 156941579 156941579 + Silent SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_198236.1 -1 reviewed p.P204 0.122 149 0% 349 19.5% 2 0% - - - NULL ETV3 2117 genome.wustl.edu 37 1 157095156 157095156 + Nonsense_Mutation SNP G G T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001145312.1 -1 validated p.S339* 0.791 125 0% 246 21.5% 6 33.3% - - - NULL ATF6 22926 genome.wustl.edu 37 1 161751785 161751785 + Silent SNP T T C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_007348.2 +1 validated p.C81 0.837 220 0.5% 413 21.5% 21 23.8% - - - NULL ADCY10 55811 genome.wustl.edu 37 1 167805660 167805660 + Missense_Mutation SNP T T C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_018417.4 -1 reviewed p.I1066V 0.007 167 0% 319 19.1% 0 - benign(0.01) tolerated(0.77) neutral(0.002) NULL GORAB 92344 genome.wustl.edu 37 1 170521409 170521409 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_152281.2 +1 reviewed p.R331C 0.000 150 0% 371 22.1% 10 30% benign(0.043) deleterious(0.05) neutral(0.348) NULL KLHL20 27252 genome.wustl.edu 37 1 173702998 173702998 + Missense_Mutation SNP T T C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_014458.3 +1 reviewed p.V57A 1.000 251 0% 625 21.4% 5 20% benign(0) tolerated(1) - superfamily_POZ domain TNN 63923 genome.wustl.edu 37 1 175066648 175066648 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_022093.1 +1 validated p.V562M 0.907 120 0% 220 13.2% 0 - benign(0) tolerated(0.08) neutral(0.300) HMMPfam_fn3,HMMSmart_SM00060,superfamily_Fibronectin type III ANGPTL1 9068 genome.wustl.edu 37 1 178834480 178834480 + Silent SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_004673.3 -1 reviewed p.K144 1.000 228 0% 486 59.3% 3 33.3% - - - NULL ABL2 27 genome.wustl.edu 37 1 179087847 179087847 + Silent SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_007314.3 -1 reviewed p.Y366 0.986 191 0% 438 17.8% 4 0% - - - HMMPfam_Pkinase_Tyr,HMMSmart_SM00219,HMMSmart_SM00220,superfamily_Protein kinase-like (PK-like) LHX4 89884 genome.wustl.edu 37 1 180241030 180241030 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_033343.2 +1 reviewed p.R223C 1.000 192 0% 434 21.2% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) NULL TPR 7175 genome.wustl.edu 37 1 186329097 186329097 + Missense_Mutation SNP T T C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_003292.2 -1 reviewed p.Q408R 1.000 234 0% 475 20.6% 7 14.2% possibly_damaging(0.916) tolerated(0.47) neutral(0.378) NULL KIF14 9928 genome.wustl.edu 37 1 200573062 200573062 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_014875.2 -1 validated p.E590K 1.000 223 0% 494 15% 0 - probably_damaging(0.954) tolerated(0.15) deleterious(0.639) HMMPfam_Kinesin,HMMSmart_KISc,superfamily_SSF52540 PPFIA4 8497 genome.wustl.edu 37 1 203023240 203023241 + Frame_Shift_Ins INS - - GC rs10635298 byCluster;by1000genomes TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 - - Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e ENST00000447715 +1 known p.P584fs 0.005:0.000 - - - - - - - - - NULL HHIPL2 79802 genome.wustl.edu 37 1 222705345 222705345 + Silent SNP A A G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_024746.3 -1 validated p.H562 0.850 233 0% 573 19.2% 0 - - - - superfamily_Quino_gluc_DH DNAH14 127602 genome.wustl.edu 37 1 225268286 225268286 + Missense_Mutation SNP A A G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001373.1 +1 validated p.D991G 0.999 195 0% 351 19.1% 0 - possibly_damaging(0.553) deleterious(0.03) deleterious(0.553) HMMPfam_DHC_N2 OBSCN 84033 genome.wustl.edu 37 1 228474642 228474642 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001098623.1 +1 reviewed p.R3149Q 0.000 30 0% 89 20.2% 0 - possibly_damaging(0.781) tolerated(0.61) neutral(0.296) HMMSmart_SM00408,HMMSmart_SM00409,HMMPfam_I-set,superfamily_Immunoglobulin EGLN1 54583 genome.wustl.edu 37 1 231503381 231503381 + Missense_Mutation SNP A A G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_022051.2 -1 reviewed p.Y384H 1.000 237 0.4% 581 20.5% 47 19.1% probably_damaging(0.979) deleterious(0) deleterious(0.867) HMMPfam_2OG-FeII_Oxy,HMMSmart_SM00702 KIAA1383 54627 genome.wustl.edu 37 1 232942711 232942711 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_019090.2 +1 validated p.R648C 0.995 53 0% 107 15.9% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) NULL GNG4 2786 genome.wustl.edu 37 1 235715440 235715440 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001098721.1 -1 validated p.R66H 1.000 185 0% 433 18.5% 2 0% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_G-gamma,HMMSmart_SM00224,superfamily_Transducin (heterotrimeric G protein) gamma chain FMN2 56776 genome.wustl.edu 37 1 240370309 240370309 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_020066.4 +1 validated p.V733I 0.000 78 0% 200 17% 0 - unknown(0) tolerated(0.51) - NULL ZNF238 10472 genome.wustl.edu 37 1 244217659 244217659 + Nonsense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_205768.2 +1 validated p.R195* 1.000 74 0% 136 19.1% 12 58.3% - - - NULL RRM2 6241 genome.wustl.edu 37 2 10262812 10262812 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e ENST00000360566 +1 known p.A23T 0.000 60 0% 50 18% 0 - benign(0.003) - - NULL FAM59B 150946 genome.wustl.edu 37 2 26407195 26407195 + Missense_Mutation SNP C C A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e ENST00000380681 +1 known p.L273M 1.000 28 0% 65 38.5% 0 - probably_damaging(0.997) deleterious(0.01) deleterious(0.872) NULL OTOF 9381 genome.wustl.edu 37 2 26739428 26739428 + Missense_Mutation SNP C C A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_194248.2 -1 reviewed p.G123C 0.987 73 0% 105 32.4% 0 - possibly_damaging(0.948) deleterious(0.02) deleterious(0.774) superfamily_C2 domain (Calcium/lipid-binding domain CaLB) BIRC6 57448 genome.wustl.edu 37 2 32640933 32640933 + Silent SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_016252.3 +1 reviewed p.S858 0.999 37 0% 50 28% 1 0% - - - NULL STRN 6801 genome.wustl.edu 37 2 37193439 37193439 + Silent SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_003162.2 -1 validated p.L56 1.000 11 0% 11 63.6% 0 - - - - HMMPfam_Striatin ZFP36L2 678 genome.wustl.edu 37 2 43452828 43452829 + Frame_Shift_Ins INS - - CGTCC novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 - - Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_006887.4 -1 reviewed p.P38fs 1.000:1.000 - - - - - - - - - HMMPfam_Tis11B_N STAMBP 10617 genome.wustl.edu 37 2 74074753 74074753 + Silent SNP A A G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_006463.3 +1 reviewed p.L205 0.830 235 0% 301 32.9% 54 44.4% - - - NULL IGKV1-8 28942 genome.wustl.edu 37 2 89292362 89292362 + Silent SNP C C A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e ENST00000495489 -1 known p.L12 0.998 360 0% 412 29.9% 0 - - - - NULL ANKRD36 375248 genome.wustl.edu 37 2 97911110 97911110 + Missense_Mutation SNP A A G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e ENST00000461153 +1 known p.S1399G 0.329 400 0% 463 16.4% 1 0% benign(0.009) deleterious(0) neutral(0.445) NULL EIF5B 9669 genome.wustl.edu 37 2 99985889 99985889 + Missense_Mutation SNP A A C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_015904.3 +1 reviewed p.E474D 0.464 281 0% 270 35.9% 103 44.6% possibly_damaging(0.791) tolerated(0.12) deleterious(0.557) NULL ENSG00000152117 0 genome.wustl.edu 37 2 132258753 132258753 + Splice_Site SNP G G T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e ENST00000416745 +1 known NULL 1.000 149 0% 138 26.8% 0 - - - - - GPR39 2863 genome.wustl.edu 37 2 133402852 133402852 + Silent SNP G G T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001508.2 +1 validated p.T345 1.000 150 0% 182 31.3% 24 62.5% - - - superfamily_Family A G protein-coupled receptor-like RIF1 55183 genome.wustl.edu 37 2 152320461 152320461 + Missense_Mutation SNP A A G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_018151.4 +1 reviewed p.E1476G 0.996 23 0% 41 22% 2 50% benign(0.001) tolerated(0.14) neutral(0.249) superfamily_ARM repeat DYNC1I2 1781 genome.wustl.edu 37 2 172584350 172584350 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001378.1 +1 provisional p.T339I 1.000 281 0% 352 30.7% 28 39.2% benign(0.005) deleterious(0.04) neutral(0.349) HMMSmart_SM00320,superfamily_WD40 repeat-like ANKAR 150709 genome.wustl.edu 37 2 190541625 190541625 + Missense_Mutation SNP G G T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_144708.3 +1 validated p.A66S 1.000 207 0% 214 21% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_Ankyrin repeat PGAP1 80055 genome.wustl.edu 37 2 197709253 197709253 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_024989.3 -1 validated p.P778S 0.205 30 0% 25 40% 1 100% benign(0.016) tolerated(0.57) neutral(0.007) NULL BMPR2 659 genome.wustl.edu 37 2 203420981 203420981 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001204.6 +1 reviewed p.D865N 1.000 157 0% 219 27.9% 6 33.3% probably_damaging(1) deleterious(0) deleterious(0.945) NULL PECR 55825 genome.wustl.edu 37 2 216904016 216904016 + Missense_Mutation SNP C C A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_018441.5 -1 validated p.K298N 0.001 263 0% 281 30.2% 16 50% unknown(0) deleterious(0) - NULL HDLBP 3069 genome.wustl.edu 37 2 242194546 242194546 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_005336.3 -1 validated p.A370T 0.997 313 0% 345 29% 128 39.8% benign(0) tolerated(0.47) neutral(0.011) HMMSmart_KH,HMMPfam_KH_1,superfamily_SSF54791 FARP2 9855 genome.wustl.edu 37 2 242381014 242381014 + Frame_Shift_Del DEL G G - novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e ENST00000413432 +1 known p.C172fs 0.054 - - - - - - - - - NULL SCN10A 6336 genome.wustl.edu 37 3 38753913 38753913 + Silent SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_006514.2 -1 validated p.G1276 0.626 126 0% 159 29.6% 0 - - - - HMMPfam_Ion_trans,superfamily_SSF81324 BSN 8927 genome.wustl.edu 37 3 49691964 49691964 + Silent SNP A A C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_003458.3 +1 reviewed p.R1659 0.971 122 0% 194 27.3% 0 - - - - NULL MUSTN1 389125 genome.wustl.edu 37 3 52867764 52867764 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_205853.2 -1 validated p.A4V 0.997 149 0% 189 28.6% 8 12.5% probably_damaging(0.959) tolerated(0.12) deleterious(0.663) NULL SUCLG2 8801 genome.wustl.edu 37 3 67546346 67546346 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_003848.3 -1 reviewed p.A313V 1.000 173 0% 245 28.6% 25 48% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Ligase_CoA,superfamily_CoA_ligase,PatternScan_SUCCINYL_COA_LIG_3 B4GALT4 8702 genome.wustl.edu 37 3 118931503 118931503 + Nonsense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_003778.3 -1 reviewed p.R310* 1.000 153 0% 220 11.8% 34 0% - - - HMMPfam_Galactosyl_T_2,superfamily_Nucleotide-diphospho-sugar transferases CHST2 9435 genome.wustl.edu 37 3 142840774 142840774 + Silent SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_004267.3 +1 validated p.A372 0.041 26 0% 38 39.5% 68 38.2% - - - HMMPfam_Sulfotransfer_1,superfamily_P-loop containing nucleoside triphosphate hydrolases P2RY1 5028 genome.wustl.edu 37 3 152554110 152554110 + Missense_Mutation SNP T T C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_002563.2 +1 reviewed p.V180A 1.000 336 0% 443 28.9% 0 - benign(0.001) tolerated(0.39) neutral(0.016) HMMPfam_7tm_1,superfamily_SSF81321 SLC7A14 57709 genome.wustl.edu 37 3 170201117 170201117 + Silent SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_020949.2 -1 validated p.D367 1.000 99 0% 131 24.4% 0 - - - - HMMPfam_AA_permease NLGN1 22871 genome.wustl.edu 37 3 173997312 173997312 + Silent SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_014932.2 +1 reviewed p.D507 1.000 77 0% 116 28.4% 0 - - - - HMMPfam_COesterase,superfamily_SSF53474 PIK3CA 5290 genome.wustl.edu 37 3 178936095 178936095 + Missense_Mutation SNP A A G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_006218.2 +1 reviewed p.Q546R 1.000 146 0% 159 27% 9 11.1% probably_damaging(0.998) deleterious(0.05) deleterious(0.820) HMMPfam_PI3Ka,HMMSmart_PI3Ka,superfamily_ARM-type_fold WDR1 9948 genome.wustl.edu 37 4 10079466 10079466 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_017491.3 -1 reviewed p.D494N 0.998 62 0% 72 36.1% 262 38.1% possibly_damaging(0.623) tolerated(0.16) neutral(0.276) HMMSmart_SM00320,superfamily_WD40 repeat-like PAICS 10606 genome.wustl.edu 37 4 57319885 57319885 + Missense_Mutation SNP T T G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001079525.1 +1 reviewed p.W364G 1.000 256 0% 329 33.7% 83 46.9% benign(0.221) tolerated(0.48) neutral(0.033) HMMPfam_AIRC,superfamily_N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase PurE) SRP72 6731 genome.wustl.edu 37 4 57356749 57356749 + Silent SNP T T C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_006947.3 +1 validated p.D480 1.000 127 0% 164 26.8% 49 40.8% - - - superfamily_SSF48452 BMP2K 55589 genome.wustl.edu 37 4 79747214 79747214 + Missense_Mutation SNP G G C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_198892.1 +1 reviewed p.V68L 1.000 213 0% 276 34.4% 1 0% possibly_damaging(0.887) deleterious(0.04) deleterious(0.696) HMMSmart_SM00219,HMMSmart_SM00220,superfamily_Protein kinase-like (PK-like),HMMPfam_Pkinase RAP1GDS1 5910 genome.wustl.edu 37 4 99355205 99355205 + Missense_Mutation SNP T T C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001100426.1 +1 validated p.L521S 1.000 163 0% 206 32% 18 44.4% benign(0.181) tolerated(0.17) neutral(0.075) superfamily_ARM repeat TET2 54790 genome.wustl.edu 37 4 106155403 106155404 + Frame_Shift_Del DEL TC TC - rs112510990 TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 TC TC Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001127208.1 +1 validated p.S104fs 1.000:1.000 - - - - - - - - - NULL CAST 831 genome.wustl.edu 37 5 96073629 96073629 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001750.5 +1 reviewed p.T259M 0.045 208 0% 199 27.6% 33 27.2% probably_damaging(0.98) tolerated(0.08) deleterious(0.724) HMMPfam_Calpain_inhib PCDHB15 56121 genome.wustl.edu 37 5 140626784 140626784 + Silent SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_018935.2 +1 reviewed p.L546 0.682 83 0% 97 40.2% 4 0% - - - HMMPfam_Cadherin,HMMSmart_CA,superfamily_Cadherin KIF4B 285643 genome.wustl.edu 37 5 154394962 154394962 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001099293.1 +1 provisional p.H515Y 1.000 95 0% 123 35% 0 - probably_damaging(0.996) tolerated(0.1) deleterious(0.748) NULL RMND5B 64777 genome.wustl.edu 37 5 177574768 177574768 + Silent SNP C C A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_022762.3 +1 provisional p.S334 0.006 228 0% 384 37% 42 28.5% - - - superfamily_RING/U-box RREB1 6239 genome.wustl.edu 37 6 7231900 7231900 + Missense_Mutation SNP A A G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001003699.3 +1 reviewed p.T1190A 1.000 35 0% 35 20% 4 50% possibly_damaging(0.882) tolerated(0.52) neutral(0.353) NULL DSP 1832 genome.wustl.edu 37 6 7568701 7568701 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_004415.2 +1 reviewed p.R433H 1.000 194 0% 214 27.1% 8 37.5% probably_damaging(0.999) tolerated(0.06) deleterious(0.813) superfamily_Spectrin repeat ZNF193 7746 genome.wustl.edu 37 6 28195035 28195035 + Missense_Mutation SNP T T C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_006299.3 +1 provisional p.L58P 0.304 125 0% 158 31.6% 5 60% probably_damaging(0.991) deleterious(0) deleterious(0.889) HMMPfam_SCAN,HMMSmart_SM00431 ZBTB12 221527 genome.wustl.edu 37 6 31868022 31868022 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_181842.2 -1 validated p.A354V 0.996 89 0% 105 33.3% 16 25% benign(0.079) tolerated(0.09) neutral(0.302) PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers MCM3 4172 genome.wustl.edu 37 6 52131452 52131452 + Silent SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_002388.3 -1 reviewed p.Y705 1.000 224 0% 260 28.8% 52 42.3% - - - NULL TRAM2 9697 genome.wustl.edu 37 6 52368020 52368020 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_012288.3 -1 reviewed p.R363Q 1.000 303 0% 313 27.5% 1 100% probably_damaging(0.998) tolerated(0.12) deleterious(0.735) NULL PRDM13 59336 genome.wustl.edu 37 6 100056633 100056633 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_021620.3 +1 validated p.G54E 1.000 85 0% 86 25.6% 0 - probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMSmart_SET MICAL1 64780 genome.wustl.edu 37 6 109774991 109774991 + Silent SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_022765.3 -1 validated p.L106 1.000 73 0% 79 38% 2 0% - - - HMMPfam_FAD_binding_3,superfamily_FAD/NAD(P)-binding domain ENPP3 5169 genome.wustl.edu 37 6 131962630 131962630 + Silent SNP A A G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_005021.3 +1 reviewed p.G38 0.446 284 0% 320 29.7% 230 47.8% - - - NULL THBS2 7058 genome.wustl.edu 37 6 169623486 169623486 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_003247.2 -1 reviewed p.A953V 1.000 142 0% 196 32.7% 3 0% possibly_damaging(0.848) tolerated(0.28) neutral(0.357) superfamily_SSF103647 CHST12 55501 genome.wustl.edu 37 7 2472865 2472865 + Silent SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_018641.3 +1 validated p.R197 0.189 18 0% 30 30% 20 25% - - - HMMPfam_Sulfotransfer_2 NPSR1 387129 genome.wustl.edu 37 7 34851396 34851396 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e ENST00000381544 +1 known p.R99C 0.930 357 0% 477 29.4% 0 - unknown(0) - - NULL GRM3 2913 genome.wustl.edu 37 7 86416163 86416163 + Missense_Mutation SNP G G T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_000840.2 +1 reviewed p.R352L 0.985 91 0% 132 37.9% 0 - possibly_damaging(0.531) tolerated(0.17) neutral(0.238) HMMPfam_ANF_receptor,superfamily_Periplasmic binding protein-like I LRWD1 222229 genome.wustl.edu 37 7 102106430 102106430 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_152892.1 +1 provisional p.D83N 0.948 68 0% 114 29.8% 45 55.5% probably_damaging(0.993) tolerated(0.14) deleterious(0.700) superfamily_SSF52058 ATXN7L1 222255 genome.wustl.edu 37 7 105254802 105254804 + In_Frame_Del DEL GAG GAG - rs150182467 by1000genomes TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 GAG GAG Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_020725.1 -1 validated p.S661in_frame_del 0.098:0.098:0.097 - - - - - - - - - NULL SLC35G5 83650 genome.wustl.edu 37 8 11188688 11188688 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_054028.1 +1 reviewed p.L25F 0.166 327 0% 378 31.7% 0 - possibly_damaging(0.945) tolerated(0.1) deleterious(0.676) NULL UNC5D 137970 genome.wustl.edu 37 8 35406998 35406998 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_080872.2 +1 validated p.V98I 0.636 89 0% 114 37.7% 0 - benign(0.001) tolerated(0.28) neutral(0.032) superfamily_Immunoglobulin GPR124 25960 genome.wustl.edu 37 8 37687496 37687496 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_032777.8 +1 validated p.A228T 0.482 31 0% 46 19.6% 11 0% possibly_damaging(0.818) tolerated(0.23) neutral(0.350) HMMSmart_SM00082,superfamily_L domain-like MRPL15 29088 genome.wustl.edu 37 8 55049192 55049192 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_014175.3 +1 reviewed p.R77Q 0.432 88 0% 114 28.1% 70 54.2% possibly_damaging(0.551) tolerated(0.23) neutral(0.229) HMMPfam_Ribosomal_L15,superfamily_SSF52080 C8orf34 116328 genome.wustl.edu 37 8 69552714 69552714 + Missense_Mutation SNP G G T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_052958.1 +1 predicted p.K292N 1.000 133 0% 151 33.1% 4 0% probably_damaging(0.999) tolerated(0.12) deleterious(0.751) NULL FAM83A 84985 genome.wustl.edu 37 8 124206356 124206356 + Silent SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_032899.4 +1 validated p.S247 0.005 288 0.7% 305 31.1% 0 - - - - HMMPfam_DUF1669,superfamily_Phospholipase D/nuclease PSCA 8000 genome.wustl.edu 37 8 143763382 143763382 + Silent SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_005672.4 +1 reviewed p.L68 0.001 63 0% 74 32.4% 5 80% - - - HMMPfam_UPAR_LY6,HMMSmart_SM00134,superfamily_Snake toxin-like TOP1MT 116447 genome.wustl.edu 37 8 144392279 144392279 + Silent SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_052963.1 -1 reviewed p.T554 0.010 179 0% 192 35.4% 26 61.5% - - - superfamily_DNA_brk_join_enz,HMMSmart_TOPEUc,PatternScan_TOPOISOMERASE_I_EUK C8orf73 642475 genome.wustl.edu 37 8 144650010 144650010 + Missense_Mutation SNP C C A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001100878.1 -1 validated p.G605C 1.000 85 0% 86 34.9% 28 35.7% probably_damaging(1) tolerated(0.1) deleterious(0.786) superfamily_ARM-type_fold PUF60 22827 genome.wustl.edu 37 8 144899617 144899617 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_078480.1 -1 reviewed p.A343V 1.000 32 0% 43 30.2% 105 42.8% probably_damaging(0.988) tolerated(0.1) deleterious(0.724) NULL SLC39A4 55630 genome.wustl.edu 37 8 145640383 145640383 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_130849.2 -1 reviewed p.S260N 0.001 44 0% 56 23.2% 6 0% benign(0.001) tolerated(1) - NULL RFX3 5991 genome.wustl.edu 37 9 3248069 3248069 + Missense_Mutation SNP T T C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_134428.1 -1 reviewed p.Q644R 1.000 168 0% 191 28.8% 12 58.3% benign(0.104) tolerated(0.09) neutral(0.304) NULL INSL6 11172 genome.wustl.edu 37 9 5185551 5185551 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_007179.2 -1 reviewed p.R18W 0.000 35 0% 44 25% 0 - probably_damaging(0.999) deleterious(0.04) deleterious(0.839) superfamily_Insulin-like WNK2 65268 genome.wustl.edu 37 9 96030927 96030927 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_006648.3 +1 reviewed p.R1311K 1.000 98 0% 123 26.8% 14 42.8% possibly_damaging(0.855) tolerated(0.07) deleterious(0.649) NULL COL15A1 1306 genome.wustl.edu 37 9 101748083 101748083 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001855.3 +1 reviewed p.A113T 0.995 96 0% 110 29.1% 18 0% probably_damaging(0.999) deleterious(0.01) deleterious(0.896) HMMSmart_LamG,HMMSmart_TSPN,superfamily_ConA_like_lec_gl,HMMPfam_Laminin_G_2 ZNF462 58499 genome.wustl.edu 37 9 109691850 109691850 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_021224.4 +1 validated p.R1886H 1.000 163 0% 213 31.5% 0 - benign(0.031) tolerated(0.05) neutral(0.347) superfamily_beta-sandwich domain of Sec23/24 TRIM32 22954 genome.wustl.edu 37 9 119461052 119461052 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001099679.1 +1 reviewed p.R344Q 1.000 88 0% 80 36.2% 9 55.5% possibly_damaging(0.656) tolerated(0.26) neutral(0.265) NULL DNM1 1759 genome.wustl.edu 37 9 130981011 130981011 + Splice_Site SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_004408.2 +1 reviewed e3+1 1.000 44 0% 41 39% 0 - - - - - GOLGA2 2801 genome.wustl.edu 37 9 131019783 131019783 + Nonsense_Mutation SNP C C A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_004486.4 -1 reviewed p.E887* 1.000 235 0% 287 34.5% 19 10.5% - - - NULL SETX 23064 genome.wustl.edu 37 9 135205517 135205517 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_015046.5 -1 reviewed p.V490I 0.989 112 0% 171 28.7% 2 0% probably_damaging(0.998) deleterious(0) deleterious(0.919) NULL TRDMT1 1787 genome.wustl.edu 37 10 17196680 17196680 + Missense_Mutation SNP A A G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_004412.5 -1 reviewed p.V314A 1.000 192 0% 248 33.5% 1 100% benign(0.124) tolerated(0.44) neutral(0.022) superfamily_S-adenosyl-L-methionine-dependent methyltransferases LOC645954 645954 genome.wustl.edu 37 10 30982471 30982471 + RNA SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e XR_017086.3 +1 model NULL 1.000 92 1.1% 121 19.8% 0 - - - - - ZNF25 219749 genome.wustl.edu 37 10 38241061 38241061 + Silent SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_145011.2 -1 provisional p.E455 0.002 189 0% 215 27.4% 0 - - - - NULL C10orf71 118461 genome.wustl.edu 37 10 50533701 50533701 + Silent SNP C C A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001135196.1 +1 validated p.S1037 0.027 53 0% 63 15.9% 0 - - - - NULL PCDH15 65217 genome.wustl.edu 37 10 55973783 55973783 + Silent SNP A A G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001142763.1 -1 reviewed p.F342 1.000 138 0% 145 29.7% 0 - - - - HMMPfam_Cadherin,HMMSmart_SM00112,superfamily_Cadherin-like USP54 159195 genome.wustl.edu 37 10 75305336 75305336 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_152586.3 -1 provisional p.R112H 1.000 180 0% 270 10.7% 4 50% benign(0.01) deleterious(0) neutral(0.445) superfamily_Cysteine proteinases RGR 5995 genome.wustl.edu 37 10 86017664 86017664 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_002921.3 +1 reviewed p.P220S 1.000 158 0.6% 229 31% 0 - probably_damaging(1) tolerated(0.81) deleterious(0.500) HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like PTEN 5728 genome.wustl.edu 37 10 89717672 89717672 + Nonsense_Mutation SNP C C T rs121909219 byCluster TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e ENST00000371953 +1 known p.R233* 0.984 255 0% 297 29.3% 44 15.9% - - - superfamily_C2 domain (Calcium/lipid-binding domain CaLB),HMMPfam_PTEN_C2 UBTD1 80019 genome.wustl.edu 37 10 99329914 99329914 + Silent SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_024954.3 +1 provisional p.Y106 0.979 16 0% 32 46.9% 47 53.1% - - - NULL SORCS1 114815 genome.wustl.edu 37 10 108371764 108371764 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001013031.1 -1 reviewed p.R980C 1.000 206 0% 250 32.4% 0 - probably_damaging(0.99) deleterious(0.04) deleterious(0.790) NULL C10orf90 118611 genome.wustl.edu 37 10 128193440 128193440 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001004298.2 -1 validated p.P110L 0.000 68 0% 73 38.4% 0 - benign(0.005) tolerated(1) - NULL TH 7054 genome.wustl.edu 37 11 2185588 2185588 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_199292.2 -1 reviewed p.V488M 0.999 86 0% 100 38% 0 - probably_damaging(0.997) deleterious(0) deleterious(0.911) HMMPfam_Biopterin_H,superfamily_Aromatic aminoacid monoxygenases catalytic and oligomerization domains RHOG 391 genome.wustl.edu 37 11 3848954 3848954 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001665.3 -1 validated p.P139S 0.926 64 0% 106 32.1% 111 31.5% benign(0.001) tolerated(0.31) neutral(0.027) HMMSmart_SM00176,HMMSmart_SM00173,HMMSmart_SM00174,HMMSmart_SM00175,HMMPfam_Ras,superfamily_P-loop containing nucleoside triphosphate hydrolases OR52K1 390036 genome.wustl.edu 37 11 4510457 4510457 + Missense_Mutation SNP C C A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001005171.2 +1 validated p.F109L 0.479 207 0% 324 31.5% 0 - possibly_damaging(0.47) tolerated(0.33) neutral(0.179) HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like OR10A2 341276 genome.wustl.edu 37 11 6891832 6891832 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001004460.1 +1 provisional p.E283K 0.999 81 0% 143 34.3% 0 - possibly_damaging(0.697) deleterious(0) deleterious(0.695) superfamily_SSF81321 KCNC1 3746 genome.wustl.edu 37 11 17757888 17757888 + Silent SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001112741.1 +1 reviewed p.R113 0.984 22 0% 26 42.3% 0 - - - - superfamily_POZ domain TMEM138 51524 genome.wustl.edu 37 11 61135511 61135511 + Silent SNP A A G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e ENST00000451389 +1 known p.T139 0.000 109 0% 184 26.6% 2 50% - - - NULL SLC22A12 116085 genome.wustl.edu 37 11 64367308 64367308 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_144585.2 +1 reviewed p.A411T 0.000 20 0% 28 32.1% 0 - benign(0.001) tolerated(0.22) neutral(0.042) HMMPfam_MFS_1,superfamily_MFS general substrate transporter EHBP1L1 254102 genome.wustl.edu 37 11 65346593 65346593 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001099409.1 +1 validated p.R50H 1.000 73 0% 91 35.2% 24 41.6% probably_damaging(1) deleterious(0) deleterious(0.945) NULL ZDHHC24 254359 genome.wustl.edu 37 11 66311324 66311324 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_207340.1 -1 provisional p.R137Q 1.000 39 0% 53 34% 54 40.7% probably_damaging(0.999) deleterious(0.01) deleterious(0.896) HMMPfam_zf-DHHC SHANK2 22941 genome.wustl.edu 37 11 70336399 70336399 + Nonsense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_012309.3 -1 reviewed p.R250* 1.000 214 0% 263 33.1% 1 0% - - - NULL GAB2 9846 genome.wustl.edu 37 11 77937537 77937537 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_080491.2 -1 reviewed p.A394V 1.000 558 0% 678 28.9% 1 0% probably_damaging(1) tolerated(0.12) deleterious(0.760) NULL FAT3 120114 genome.wustl.edu 37 11 92565052 92565052 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001008781.2 +1 validated p.T3249I 1.000 160 0% 253 24.9% 0 - benign(0.037) tolerated(0.56) neutral(0.009) HMMPfam_Cadherin,superfamily_Concanavalin A-like lectins/glucanases,superfamily_Cadherin-like ARHGAP42 143872 genome.wustl.edu 37 11 100784255 100784255 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_152432.2 +1 provisional p.A153T 1.000 40 0% 37 21.6% 0 - benign(0) tolerated(0.44) neutral(0.013) NULL MMP10 4319 genome.wustl.edu 37 11 102647384 102647384 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_002425.2 -1 reviewed p.R249H 0.995 263 0% 329 32.2% 13 15.3% benign(0.001) tolerated(0.62) neutral(0.004) "HMMPfam_Peptidase_M10,HMMSmart_SM00235,superfamily_Metalloproteases (""zincins"") catalytic domain" PPP2R1B 5519 genome.wustl.edu 37 11 111608179 111608179 + Missense_Mutation SNP A A G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_181699.2 -1 reviewed p.M635T 0.013 148 0% 162 26.5% 4 25% benign(0) tolerated(1) - NULL PPP2R1B 5519 genome.wustl.edu 37 11 111636973 111636973 + Missense_Mutation SNP T T C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_181699.2 -1 reviewed p.Q38R 1.000 162 0% 155 26.5% 8 25% possibly_damaging(0.576) tolerated(0.24) neutral(0.235) superfamily_ARM-type_fold MCAM 4162 genome.wustl.edu 37 11 119185693 119185693 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_006500.2 -1 validated p.E84K 0.003 34 0% 57 21.1% 30 0% benign(0.062) tolerated(0.06) neutral(0.327) HMMSmart_SM00409,HMMPfam_V-set,superfamily_Immunoglobulin OR10S1 219873 genome.wustl.edu 37 11 123847741 123847741 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001004474.1 -1 provisional p.V220M 0.072 78 0% 97 35.1% 0 - probably_damaging(0.999) tolerated(0.08) deleterious(0.790) HMMPfam_7tm_1,superfamily_Family A G protein-coupled receptor-like CDON 50937 genome.wustl.edu 37 11 125888230 125888230 + Missense_Mutation SNP A A G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_016952.4 -1 validated p.V212A 1.000 241 0.4% 326 31% 1 0% probably_damaging(0.997) deleterious(0.01) deleterious(0.872) superfamily_Immunoglobulin AKAP3 10566 genome.wustl.edu 37 12 4736445 4736445 + Missense_Mutation SNP C C A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_006422.2 -1 reviewed p.Q541H 1.000 91 0% 126 34.1% 0 - probably_damaging(0.996) deleterious(0) deleterious(0.906) HMMPfam_AKAP_110,HMMSmart_SM00807 C1RL 51279 genome.wustl.edu 37 12 7249070 7249070 + Missense_Mutation SNP C C A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_016546.2 -1 validated p.G461W 0.985 131 0% 176 34.7% 48 37.5% probably_damaging(0.999) deleterious(0.01) deleterious(0.896) HMMPfam_Trypsin,HMMSmart_Tryp_SPc,superfamily_Pept_Ser_Cys KRAS 3845 genome.wustl.edu 37 12 25398284 25398284 + Missense_Mutation SNP C C T rs121913529 byCluster TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_033360.2 -1 reviewed p.G12D 1.000 343 0.3% 393 30.5% 3 66.6% possibly_damaging(0.886) deleterious(0) deleterious(0.791) HMMSmart_SM00176,HMMSmart_SM00173,HMMSmart_SM00174,HMMSmart_SM00175,HMMPfam_Ras,superfamily_P-loop containing nucleoside triphosphate hydrolases KCNH3 23416 genome.wustl.edu 37 12 49943891 49943891 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_012284.1 +1 validated p.R566H 0.999 39 0% 34 35.3% 2 0% probably_damaging(1) deleterious(0) deleterious(0.945) superfamily_cNMP_binding TSFM 10102 genome.wustl.edu 37 12 58190347 58190347 + Missense_Mutation SNP A A C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_005726.5 +1 reviewed p.E320A 0.893 155 0% 230 32.2% 78 41% unknown(0) tolerated(0.06) - NULL CTDSP2 10106 genome.wustl.edu 37 12 58217771 58217771 + Silent SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_005730.3 -1 validated p.D202 1.000 80 0% 89 39.3% 36 19.4% - - - HMMPfam_NIF,HMMSmart_SM00577,superfamily_HAD-like MDM2 4193 genome.wustl.edu 37 12 69233373 69233373 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_002392.3 +1 reviewed p.S413N 1.000 131 0% 171 33.9% 25 56% probably_damaging(1) tolerated(0.19) deleterious(0.549) NULL CCT2 10576 genome.wustl.edu 37 12 69980553 69980553 + Silent SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_006431.2 +1 reviewed p.I33 0.974 157 0% 140 27.1% 48 37.5% - - - superfamily_GroEL equatorial domain-like KCNC2 3747 genome.wustl.edu 37 12 75442063 75442063 + Silent SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_139137.2 -1 reviewed p.P550 1.000 380 0% 474 29.3% 0 - - - - NULL LOC100287749 100287749 genome.wustl.edu 37 12 109889345 109889345 + Silent SNP T T C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e XM_002343211.1 +1 model p.C91 0.000 173 0.6% 204 31.9% 8 12.5% - - - NULL BRAP 8315 genome.wustl.edu 37 12 112103457 112103457 + Silent SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_006768.3 -1 reviewed p.R294 1.000 126 0% 227 35.2% 7 42.8% - - - HMMSmart_RING,HMMPfam_zf-C3HC4,superfamily_SSF57850 NOS1 4842 genome.wustl.edu 37 12 117665447 117665447 + Splice_Site SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_000620.2 -1 reviewed e22-1 1.000 129 0% 157 36.3% 0 - - - - - CLIP1 6249 genome.wustl.edu 37 12 122825809 122825809 + Missense_Mutation SNP C C A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_002956.2 -1 validated p.G637W 1.000 314 0% 396 26.3% 18 38.8% probably_damaging(0.996) deleterious(0) deleterious(0.906) NULL MPHOSPH9 10198 genome.wustl.edu 37 12 123679113 123679113 + Silent SNP A A G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_022782.2 -1 validated p.S535 1.000 226 0% 258 28.3% 2 50% - - - NULL DNAH10 196385 genome.wustl.edu 37 12 124417928 124417928 + Silent SNP T T C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_207437.3 +1 validated p.P4331 0.001 50 2% 47 25.5% 4 75% - - - HMMPfam_Dynein_heavy PROZ 8858 genome.wustl.edu 37 13 113826130 113826130 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_003891.1 +1 provisional p.R305H 0.000 49 0% 55 14.5% 1 100% benign(0.003) tolerated(0.08) neutral(0.300) HMMPfam_Trypsin,HMMSmart_SM00020,superfamily_Trypsin-like serine proteases MYH7 4625 genome.wustl.edu 37 14 23896494 23896494 + Missense_Mutation SNP C C A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_000257.2 -1 reviewed p.K637N 0.649 88 0% 113 26.5% 0 - benign(0.013) deleterious(0.03) neutral(0.365) HMMPfam_Myosin_head,HMMSmart_SM00242,superfamily_P-loop containing nucleoside triphosphate hydrolases NUBPL 80224 genome.wustl.edu 37 14 32295834 32295834 + Splice_Site SNP G G T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_025152.2 +1 validated e8-1 1.000 161 0% 216 29.2% 0 - - - - - LRFN5 145581 genome.wustl.edu 37 14 42356745 42356745 + Missense_Mutation SNP T T C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_152447.3 +1 validated p.L306P 1.000 235 0% 249 11.2% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_IGc2,HMMPfam_I-set,superfamily_SSF48726 FSCB 84075 genome.wustl.edu 37 14 44974511 44974511 + Missense_Mutation SNP C C G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_032135.3 -1 validated p.Q560H 0.000 33 0% 35 20% 0 - unknown(0) tolerated(0.09) - NULL NIPA2 81614 genome.wustl.edu 37 15 23006735 23006735 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001008860.2 -1 reviewed p.A190V 1.000 88 0% 119 29.4% 27 29.6% benign(0.077) deleterious(0) neutral(0.450) HMMPfam_DUF803 LOC728310 728310 genome.wustl.edu 37 15 29088506 29088523 + RNA DEL CTCCTGATCCCGTAGCTC CTCCTGATCCCGTAGCTC - novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 CTCCTGATCCCGTAGCTC CTCCTGATCCCGTAGCTC Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e XR_078490.1 -1 model NULL 0.220:0.284:0.294:0.271:0.220:0.227:0.201:0.214:0.229:0.214:0.212:0.219:0.322:0.587:0.890:0.940:0.965:0.985 - - - - - - - - - - TTBK2 146057 genome.wustl.edu 37 15 43069417 43069417 + Silent SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_173500.3 -1 reviewed p.S407 0.997 140 0% 176 29% 2 0% - - - NULL CSK 1445 genome.wustl.edu 37 15 75091753 75091753 + Missense_Mutation SNP A A G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001127190.1 +1 validated p.H128R 1.000 40 0% 57 22.8% 69 42% probably_damaging(0.999) deleterious(0) deleterious(0.935) HMMPfam_SH2,HMMSmart_SM00252,superfamily_SH2 domain FAM174B 400451 genome.wustl.edu 37 15 93173572 93173572 + Silent SNP C C G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_207446.2 -1 validated p.S116 0.006 302 0% 424 35.1% 14 50% - - - HMMPfam_DUF1180 PCSK6 5046 genome.wustl.edu 37 15 101910712 101910712 + Nonsense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e ENST00000331826 -1 known p.Q516* 0.864 54 0% 84 39.3% 1 0% - - - superfamily_Galactose-binding domain-like AMDHD2 51005 genome.wustl.edu 37 16 2578480 2578480 + Missense_Mutation SNP C C A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_015944.3 +1 validated p.P297H 0.998 23 0% 44 34.1% 20 55% benign(0.386) tolerated(0.24) neutral(0.161) superfamily_Metalo_hydrolase,superfamily_SSF51556 NAGPA 51172 genome.wustl.edu 37 16 5075682 5075682 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_016256.2 -1 reviewed p.A449T 0.920 63 0% 93 30.1% 14 21.4% benign(0) tolerated(1) - NULL C16orf72 29035 genome.wustl.edu 37 16 9185957 9185957 + Missense_Mutation SNP A A G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_014117.2 +1 validated p.H19R 1.000 63 0% 44 22.7% 12 41.6% possibly_damaging(0.512) tolerated(0.18) neutral(0.228) NULL TNRC6A 27327 genome.wustl.edu 37 16 24788441 24788441 + Silent SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_014494.2 +1 reviewed p.P117 0.006 36 0% 54 33.3% 0 - - - - NULL LOC100289169 100289169 genome.wustl.edu 37 16 29063641 29063641 + Silent SNP C C A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e XM_002343436.1 +1 model p.P81 0.195 40 0% 51 29.4% 0 - - - - HMMPfam_NPIP NUP93 9688 genome.wustl.edu 37 16 56864491 56864491 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_014669.3 +1 validated p.R327C 1.000 183 0% 299 34.4% 16 56.2% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Nic96 FUK 197258 genome.wustl.edu 37 16 70497655 70497655 + Missense_Mutation SNP T T C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_145059.2 +1 reviewed p.L71P 1.000 52 0% 50 18% 11 45.4% probably_damaging(1) deleterious(0) deleterious(0.945) NULL MBTPS1 8720 genome.wustl.edu 37 16 84132698 84132698 + Silent SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_003791.2 -1 reviewed p.T127 0.015 342 0% 424 28.5% 22 36.3% - - - superfamily_Pept_S8_S53 KLHL36 79786 genome.wustl.edu 37 16 84690772 84690772 + Missense_Mutation SNP T T C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_024731.2 +1 provisional p.L120P 1.000 102 0% 150 34.7% 8 37.5% probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_SM00225,superfamily_POZ domain,HMMPfam_BTB TNFSF12 8742 genome.wustl.edu 37 17 7460647 7460647 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_003809.2 +1 reviewed p.G244R 0.990 59 0% 56 35.7% 90 37.7% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_TNF,HMMSmart_SM00207,superfamily_TNF-like LOC100289291 100289291 genome.wustl.edu 37 17 11514810 11514810 + Missense_Mutation SNP C C A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e XM_002343480.1 -1 model p.Q81H 0.385 25 0% 16 31.2% 0 - - - - NULL MYO1D 4642 genome.wustl.edu 37 17 31203812 31203812 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_015194.1 -1 provisional p.A27T 1.000 43 0% 29 31% 1 0% benign(0.043) tolerated(0.13) neutral(0.255) HMMPfam_Myosin_head,HMMSmart_SM00242,superfamily_P-loop containing nucleoside triphosphate hydrolases ZNF830 91603 genome.wustl.edu 37 17 33288789 33288789 + Silent SNP T T G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_052857.3 +1 validated p.T68 1.000 138 0% 185 24.3% 9 88.8% - - - HMMSmart_SM00451,PatternScan_ZINC_FINGER_C2H2_1 STAT5B 6777 genome.wustl.edu 37 17 40354415 40354415 + Missense_Mutation SNP T T C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_012448.3 -1 reviewed p.D727G 1.000 124 0% 135 10.4% 40 17.5% benign(0.025) tolerated(0.13) neutral(0.254) NULL CACNA1G 8913 genome.wustl.edu 37 17 48697144 48697166 + Frame_Shift_Del DEL CTGCCTTCCCTTCTGCCCCCAGC CTGCCTTCCCTTCTGCCCCCAGC - novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 CTGCCTTCCCTTCTGCCCCCAGC CTGCCTTCCCTTCTGCCCCCAGC Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_018896.3 +1 validated p.A1962fs 1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:0.998:0.999:0.998:0.962:0.981:0.992:0.992:0.994:0.997:0.983:0.995:0.999:1.000 - - - - - - - - - NULL CA10 56934 genome.wustl.edu 37 17 49731057 49731057 + Missense_Mutation SNP A A T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001082533.1 -1 reviewed p.V169D 1.000 177 0.6% 212 28.3% 0 - possibly_damaging(0.458) deleterious(0) deleterious(0.595) HMMPfam_Carb_anhydrase,superfamily_Carbonic anhydrase ACE 1636 genome.wustl.edu 37 17 61566372 61566372 + Silent SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_000789.2 +1 reviewed p.R840 0.000 110 0% 127 31.5% 12 25% - - - "HMMPfam_Peptidase_M2,superfamily_Metalloproteases (""zincins"") catalytic domain" QRICH2 84074 genome.wustl.edu 37 17 74271928 74271928 + Silent SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_032134.1 -1 provisional p.S1652 0.071 161 0% 174 30.5% 9 22.2% unknown(0) deleterious(0) - NULL TK1 7083 genome.wustl.edu 37 17 76171144 76171144 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_003258.4 -1 validated p.G167D 1.000 55 0% 95 10.5% 22 4.5% possibly_damaging(0.951) tolerated(0.1) deleterious(0.680) HMMPfam_TK RPTOR 57521 genome.wustl.edu 37 17 78921118 78921118 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_020761.2 +1 reviewed p.G1078S 1.000 115 0% 123 23.6% 5 40% probably_damaging(1) tolerated(0.11) deleterious(0.772) HMMSmart_SM00320,superfamily_WD40 repeat-like DSG4 147409 genome.wustl.edu 37 18 28991147 28991147 + Silent SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001134453.1 +1 reviewed p.A716 0.000 216 0% 294 37.1% 0 - - - - NULL PIAS2 9063 genome.wustl.edu 37 18 44409714 44409714 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_004671.2 -1 validated p.P440L 0.494 254 0% 355 29.6% 6 83.3% benign(0.001) deleterious(0.01) neutral(0.406) NULL KATNAL2 83473 genome.wustl.edu 37 18 44625628 44625628 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_031303.2 +1 validated p.A337V 1.000 111 0% 140 40% 9 33.3% probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_AAA,HMMPfam_AAA,superfamily_SSF52540 SMAD7 4092 genome.wustl.edu 37 18 46447954 46447954 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_005904.2 -1 provisional p.V357I 1.000 199 0% 262 22.9% 8 50% probably_damaging(1) deleterious(0.01) deleterious(0.905) HMMPfam_MH2,HMMSmart_DWB,superfamily_SMAD_FHA SERPINB13 5275 genome.wustl.edu 37 18 61259600 61259600 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_012397.3 +1 validated p.V82I 0.845 181 0.6% 172 26.2% 0 - benign(0.003) tolerated(0.62) neutral(0.004) HMMPfam_Serpin,HMMSmart_SM00093,superfamily_Serpins FBXO15 201456 genome.wustl.edu 37 18 71807496 71807496 + Silent SNP A A G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001142958.1 -1 reviewed p.H56 0.005 106 0% 106 31.1% 2 0% - - - NULL CNDP2 55748 genome.wustl.edu 37 18 72178113 72178113 + Silent SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_018235.2 +1 validated p.D174 0.965 272 0.4% 325 27.7% 246 48.3% - - - HMMPfam_Peptidase_M20,superfamily_SSF53187 GAMT 2593 genome.wustl.edu 37 19 1399885 1399885 + Silent SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_138924.1 -1 reviewed p.V78 0.987 49 0% 56 39.3% 44 40.9% - - - superfamily_SSF53335 LOC55908 55908 genome.wustl.edu 37 19 11350343 11350343 + Missense_Mutation SNP G G T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_018687.6 +1 validated p.W63C 0.010 41 0% 59 40.7% 0 - benign(0) tolerated(0.46) neutral(0.012) NULL LOC100287986 100287986 genome.wustl.edu 37 19 15695367 15695367 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e XM_002343618.1 -1 model p.G488R 0.930 16 0% 21 33.3% 1 0% - - - NULL CYP4F12 66002 genome.wustl.edu 37 19 15794482 15794482 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_023944.2 +1 reviewed p.R276H 0.127 112 0% 141 32.6% 1 0% benign(0.015) tolerated(0.13) neutral(0.253) HMMPfam_p450,superfamily_Cytochrome P450 LOC388514 388514 genome.wustl.edu 37 19 15871165 15871165 + RNA SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e XR_017598.3 -1 model NULL 0.999 10 0% 20 40% 0 - - - - - ELL 8178 genome.wustl.edu 37 19 18561593 18561593 + Silent SNP G G T rs35245196 byCluster;byFrequency TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_006532.3 -1 validated p.R387 0.000 42 0% 47 27.7% 5 60% - - - NULL GATAD2A 54815 genome.wustl.edu 37 19 19576203 19576203 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_017660.3 +1 provisional p.R17W 0.646 203 0% 269 36.1% 12 50% probably_damaging(0.985) deleterious(0.03) deleterious(0.796) NULL ZNF429 353088 genome.wustl.edu 37 19 21688578 21688578 + Splice_Site SNP T T C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001001415.2 +1 provisional e1+2 0.080 133 0% 118 27.1% 0 - - - - - ZNF599 148103 genome.wustl.edu 37 19 35251044 35251044 + Missense_Mutation SNP T T C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001007248.2 -1 validated p.H221R 1.000 143 0% 218 16.1% 0 - benign(0.145) deleterious(0) neutral(0.457) HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers MLL4 9757 genome.wustl.edu 37 19 36227689 36227689 + Missense_Mutation SNP A A C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_014727.1 +1 reviewed p.S2420R 1.000 184 0% 270 28.1% 24 50% possibly_damaging(0.847) - - HMMPfam_FYRC,HMMSmart_SM00542 NPHS1 4868 genome.wustl.edu 37 19 36340451 36340451 + Splice_Site SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_004646.3 -1 reviewed e6+1 1.000 103 0% 127 27.6% 0 - - - - - CYP2B7P1 1556 genome.wustl.edu 37 19 41442352 41442352 + RNA SNP C C A rs3745219 byCluster;byFrequency TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NR_001278.1 +1 provisional NULL 0.859 370 0% 450 30% 0 - - - - - MEGF8 1954 genome.wustl.edu 37 19 42838352 42838352 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001410.2 +1 validated p.G182D 1.000 17 0% 23 34.8% 0 - probably_damaging(1) deleterious(0) deleterious(0.945) HMMSmart_EGF,HMMPfam_EGF_2 CEACAM16 388551 genome.wustl.edu 37 19 45209134 45209134 + Silent SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001039213.2 +1 validated p.L371 0.338 156 0% 215 28.8% 0 - - - - NULL EXOC3L2 90332 genome.wustl.edu 37 19 45731255 45731255 + Silent SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_138568.3 -1 validated p.G90 0.231 76 0% 107 27.1% 4 0% - - - HMMPfam_Sec6 C5AR1 728 genome.wustl.edu 37 19 47823977 47823977 + Missense_Mutation SNP C C A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001736.3 +1 validated p.L315I 0.466 97 0% 123 35.8% 4 25% possibly_damaging(0.52) tolerated(0.16) neutral(0.234) superfamily_Family A G protein-coupled receptor-like KLK5 25818 genome.wustl.edu 37 19 51453255 51453255 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001077491.1 -1 reviewed p.S64N 0.006 73 0% 96 33.3% 0 - benign(0.196) tolerated(0.12) neutral(0.279) superfamily_Trypsin-like serine proteases ZNF701 55762 genome.wustl.edu 37 19 53085611 53085611 + Missense_Mutation SNP A A G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_018260.2 +1 validated p.Q100R 0.000 119 0% 153 29.4% 0 - probably_damaging(0.998) tolerated(0.34) deleterious(0.497) NULL ZNF814 730051 genome.wustl.edu 37 19 58386142 58386142 + Missense_Mutation SNP G G T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001144989.1 -1 validated p.P206T 0.000 210 0% 306 36.3% 3 0% benign(0) tolerated(0.59) neutral(0.004) NULL ZNF418 147686 genome.wustl.edu 37 19 58438971 58438971 + Missense_Mutation SNP T T C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_133460.1 -1 provisional p.E193G 0.000 156 0% 216 35.2% 2 0% benign(0.001) tolerated(1) - NULL ZNF324B 388569 genome.wustl.edu 37 19 58966424 58966424 + Missense_Mutation SNP C C A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e ENST00000391696 +1 known p.P28H 0.001 9 0.000 20 0.350 0 - unknown(0) - - NULL TMX4 56255 genome.wustl.edu 37 20 7967973 7967973 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_021156.2 -1 provisional p.V193I 0.024 256 0% 215 31.6% 24 50% benign(0.157) tolerated(0.07) neutral(0.333) NULL THBD 7056 genome.wustl.edu 37 20 23029302 23029302 + Silent SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_000361.2 -1 reviewed p.C280 0.345 25 0% 22 36.4% 6 0% - - - HMMSmart_SM00179,HMMPfam_EGF,HMMSmart_SM00181,superfamily_EGF/Laminin CST2 1470 genome.wustl.edu 37 20 23807136 23807136 + Silent SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001322.2 -1 reviewed p.E54 0.025 249 0% 264 30.3% 2 0% - - - HMMPfam_Cystatin,HMMSmart_CY,superfamily_SSF54403 GDF5 8200 genome.wustl.edu 37 20 34022222 34022222 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_000557.2 -1 reviewed p.R331C 0.976 25 0% 35 42.9% 8 62.5% possibly_damaging(0.755) deleterious(0) deleterious(0.723) HMMPfam_TGFb_propeptide C20orf132 140699 genome.wustl.edu 37 20 35769657 35769657 + Missense_Mutation SNP T T C novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e ENST00000400441 -1 known p.T466A 0.992 356 0% 437 32.7% 1 100% benign(0.031) tolerated(0.34) neutral(0.025) superfamily_ARM repeat KIAA1755 85449 genome.wustl.edu 37 20 36855589 36855589 + Silent SNP C C A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001029864.1 -1 predicted p.A673 0.000 108 0% 122 23% 1 0% - - - NULL ARFGEF2 10564 genome.wustl.edu 37 20 47591335 47591335 + Silent SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_006420.2 +1 reviewed p.C566 1.000 264 0% 362 28.7% 6 66.6% - - - superfamily_ARM-type_fold UMODL1 89766 genome.wustl.edu 37 21 43549899 43549899 + Missense_Mutation SNP G G A rs188624715 by1000genomes TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_173568.3 +1 validated p.R1384Q 0.055 209 0.5% 280 37.9% 0 - probably_damaging(0.994) deleterious(0.01) deleterious(0.858) NULL C21orf33 8209 genome.wustl.edu 37 21 45564807 45564807 + Missense_Mutation SNP G G T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_004649.6 +1 reviewed p.K261N 0.032 104 0% 135 41.5% 213 42.7% benign(0) tolerated(0.31) neutral(0.027) superfamily_Class I glutamine amidotransferase-like LOC100288065 100288065 genome.wustl.edu 37 22 18064090 18064090 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e XM_002344192.1 -1 model p.A235V 0.000 111 0% 138 32.6% 0 - - - - NULL CCDC116 164592 genome.wustl.edu 37 22 21989099 21989099 + Silent SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_152612.2 +1 provisional p.S249 0.001 41 0% 75 42.7% 0 - - - - NULL TTC28 23331 genome.wustl.edu 37 22 28501666 28501667 + Frame_Shift_Ins INS - - T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 - - Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001145418.1 -1 validated p.L969fs 1.000:1.000 - - - - - - - - - HMMPfam_TPR_1,HMMSmart_TPR,superfamily_SSF48452 ELFN2 114794 genome.wustl.edu 37 22 37770696 37770696 + Silent SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_052906.3 -1 validated p.A293 0.000 252 0% 367 30.2% 0 - - - - HMMSmart_FN3 TSPO 706 genome.wustl.edu 37 22 43558925 43558925 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_007311.3 +1 reviewed p.H53Y 0.078 38 0% 33 21.2% 294 33.3% unknown(0) - - NULL CELSR1 9620 genome.wustl.edu 37 22 46929884 46929884 + Missense_Mutation SNP G G T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_014246.1 -1 reviewed p.L1062M 1.000 125 0% 147 30.6% 11 36.3% probably_damaging(1) deleterious(0) deleterious(0.945) HMMPfam_Cadherin,HMMSmart_SM00112,superfamily_Cadherin-like CELSR1 9620 genome.wustl.edu 37 22 46930182 46930182 + Silent SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e ENST00000454637 -1 known p.P337L 0.821 65 1.5% 116 28.4% 5 0% - - - HMMPfam_Cadherin,HMMSmart_SM00112,superfamily_Cadherin-like ASB9 140462 genome.wustl.edu 37 X 15262645 15262645 + Missense_Mutation SNP A A G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001031739.2 -1 reviewed p.F290L 0.970 291 0% 394 28.4% 2 0% probably_damaging(1) deleterious(0.01) deleterious(0.905) HMMPfam_SOCS_box YY2 404281 genome.wustl.edu 37 X 21875370 21875370 + Silent SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_206923.3 +1 reviewed p.C256 0.004 73 0% 80 38.8% 1 100% - - - HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers GK 2710 genome.wustl.edu 37 X 30739014 30739014 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001128127.1 +1 reviewed p.A462V 1.000 213 0% 264 32.6% 7 0% benign(0.195) deleterious(0.04) neutral(0.367) HMMPfam_FGGY_C,superfamily_SSF53067 CHST7 56548 genome.wustl.edu 37 X 46434060 46434060 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_019886.2 +1 reviewed p.V232M 0.089 66 0% 97 28.9% 1 0% probably_damaging(0.962) tolerated(0.18) neutral(0.461) HMMPfam_Sulfotransfer_1,superfamily_SSF52540 WDR45 11152 genome.wustl.edu 37 X 48932828 48932828 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_007075.3 -1 reviewed p.R315C 0.999 74 0% 99 37.4% 203 0% probably_damaging(0.962) deleterious(0.05) deleterious(0.750) superfamily_WD40_like CXorf67 340602 genome.wustl.edu 37 X 51150586 51150586 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e ENST00000342995 +1 known p.A240T 0.000 17 0% 18 50% 0 - probably_damaging(0.994) tolerated(0.68) neutral(0.454) NULL SSX7 280658 genome.wustl.edu 37 X 52682011 52682011 + Nonsense_Mutation SNP G G T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_173358.2 -1 reviewed p.Y31* 0.038 547 0% 569 29.2% 0 - - - - HMMSmart_KRAB,superfamily_Krueppel-associated_box USP51 158880 genome.wustl.edu 37 X 55513612 55513612 + Missense_Mutation SNP T T G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 T T Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_201286.3 -1 validated p.K587N 1.000 139 0% 210 35.2% 0 - probably_damaging(0.99) deleterious(0.03) deleterious(0.806) HMMPfam_UCH,superfamily_SSF54001 MTMR8 55613 genome.wustl.edu 37 X 63565045 63565045 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_017677.3 -1 reviewed p.A249T 1.000 375 0% 499 31.1% 6 100% unknown(0) tolerated(0.08) - HMMPfam_Myotub-related,superfamily_(Phosphotyrosine protein) phosphatases II AR 367 genome.wustl.edu 37 X 66765966 66765966 + Silent SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_000044.2 +1 reviewed p.G326 0.119 40 0% 51 41.2% 0 - - - - HMMPfam_Androgen_recep FAM155B 27112 genome.wustl.edu 37 X 68749609 68749609 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_015686.2 +1 validated p.R410H 0.002 555 0% 702 32.5% 3 0% benign(0) tolerated(0.23) neutral(0.042) NULL AWAT2 158835 genome.wustl.edu 37 X 69263813 69263813 + Missense_Mutation SNP C C T rs180949354 by1000genomes TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001002254.1 -1 reviewed p.R77H 0.004 108 0.9% 124 30.6% 0 - possibly_damaging(0.643) tolerated(0.11) deleterious(0.497) HMMPfam_DAGAT TAF1 6872 genome.wustl.edu 37 X 70614068 70614068 + Missense_Mutation SNP C C T novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 C C Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_004606.3 +1 reviewed p.R1147W 1.000 282 0% 404 32.4% 5 80% probably_damaging(1) deleterious(0) deleterious(0.945) NULL RBMXL3 139804 genome.wustl.edu 37 X 114426349 114426349 + Missense_Mutation SNP A A G novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 A A Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001145346.1 +1 validated p.Y782C 0.899 61 0% 62 29% 0 - possibly_damaging(0.88) deleterious(0) deleterious(0.788) NULL AKAP14 158798 genome.wustl.edu 37 X 119048782 119048782 + Missense_Mutation SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_178813.5 +1 reviewed p.V128I 0.008 215 0% 256 35.5% 3 33.3% possibly_damaging(0.936) tolerated(1) neutral(0.382) NULL PNCK 139728 genome.wustl.edu 37 X 152937461 152937461 + Silent SNP G G A novel TCGA-D1-A17A-01A-11D-A12J-09 TCGA-D1-A17A-10A-01D-A12J-09 G G Unknown Untested Somatic Phase_IV WXS none 1 dbGAP Illumina GAIIx fe0579ed-ad65-469c-a8ff-65ee615c617f 7f349408-01b5-43e5-b8c3-52a69aa34d9e NM_001039582.3 -1 validated p.G179 0.029 55 0% 91 34.1% 1 0% - - - HMMSmart_SM00219,HMMSmart_SM00220,superfamily_Protein kinase-like (PK-like),HMMPfam_Pkinase